Clinical trials: Valvular Heart Surgery
Valvular Heart Disease, Ischemic Heart Disease
Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery
The purpose of this study is to determine Isoflurane's dose-dependent effect on left ventricular (LV) systolic function in cardiac surgery.
- Trial name
- NCT01819012
- Testing
- Isoflurane 1.0 MAC, Isoflurane 1.5 MAC, Isoflurane 2.0 MAC
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Konkuk University Medical Center
Aortic Valve Stenosis, Cardiovascular Diseases
Comparison of TAVR With SAVR in Younger Low Surgical Risk Patients With Severe Aortic Stenosis
A randomized clinical trial investigating transcatheter (TAVR) versus surgical (SAVR) aortic valve replacement in patients 75 years of age or younger suffering from severe aortic valve stenosis.
- Conditions
- Aortic Valve Stenosis, Cardiovascular Diseases, Heart Diseases, Heart Valve Diseases
- Trial name
- NOTION-2 (NCT02825134)
- Testing
- Transcatheter aortic valve replacement, Surgical aortic valve replacement
- Where
- 9 sites in Denmark, Finland and 3 more
- Volunteers
- 376 people
- Sponsor
- Ole De Backer
Heart; Dysfunction Postoperative, Cardiac Surgery
Clinical Assessment of Nonin 7600 Near Infrared Spectroscopy (NIRS) Tissue Oximetry During Cardiovascular Surgery
An observational study designed to evaluate the performance of a new Near Infrared Spectroscopy (NIRS) tissue oximeter device in the clinical setting, including a cerebral sensor and peripheral sensor.
- Trial name
- NCT01289470
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nonin Medical, Inc
Valvular Heart Disease
Prehabilitation and Heart Valve Surgery
To evaluate the impact of prehabilitation on quality of recovery in heart valve surgery. To evaluate the effects of Mild to moderate valvular diseases with Newyork Heart Association (NYHA) grade I and II .
- Trial name
- NCT04993963
- Testing
- Cycle Ergometery Training (Prehabilitation), Control Standard Group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Heart Valvular Disease, Minimally Invasive Cardiac Surgery
SPSIP Block and Opioid Use After MICS
This prospective, randomized, controlled, single-center clinical study aims to evaluate the effectiveness of the Serratus Posterior Superior Intercostal Plane Block (SPSIPB) in perioperative pain management among patients…
- Conditions
- Heart Valvular Disease, Minimally Invasive Cardiac Surgery, Postoperative Pain Management, Serratus Posterior Superior Intercostal Plane Block
- Trial name
- SPSIPB-MICS (NCT07259824)
- Testing
- Serratus Posterior Superior Intercostal Plane Block (SPSIPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara City Hospital Bilkent
Age Problem, Aortic Valve Disease
Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders
In Italy, life expectancy at birth has reached 80 years in men and 85 in women; in about 50 years, life expectancy at the age of 80 has increased by an extraordinary 61% and 55%, respectively, due to more effective therapies and…
- Conditions
- Age Problem, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- FRASER-VD (NCT03365453)
- Testing
- frailty evaluation
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- University Hospital of Ferrara
Heart Disease, Aging
Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.
Background: The prevalence of both senile cardiac amyloidosis (CA) and aortic stenosis (AS) markedly increases with age. Aortic stenosis increases left ventricular pressure overload.
- Conditions
- Heart Disease, Aging, Amyloidosis, Aortic Valve Stenosis
- Trial name
- AMYLOCARTESIAN (NCT02260466)
- Testing
- a basal LV septum biopsy
- Where
- 5 sites in France
- Volunteers
- 186 people
- Sponsor
- French Cardiology Society
Atrial Fibrillation, Valvular Heart Disease
Concomitant Surgical Atrial Fibrillation Ablation in Double Valve Replacement
Current European Society of Cardiology Guidelines recommend concomitant atrial fibrillation (AF) ablation for all symptomatic patients undergoing other cardiac surgeries, but the safety and potential benefits of concomitant…
- Trial name
- NCT03163836
- Testing
- double valve replacement, surgical ablation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Valvular Heart Disease, Aortic Arch Aneurysm
The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.
The aim of the study is to evaluate the effects of intermittent hypoxic-hyperoxic training (IHHT) to protect myocardium against perioperative myocardial injury during cardiac surgery using cardiopulmonary bypass.
- Conditions
- Valvular Heart Disease, Aortic Arch Aneurysm, Surgery
- Trial name
- NCT04833283
- Testing
- ReOxy Cardio device, intermittent hypoxic-hyperoxic training ( IHHT), ReOxy Cardio device
- Where
- Russia
- Volunteers
- 115 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Valvular Heart Disease
Impact of Positive End-expiratory Pressure on Hepatic Venous Flow
The purpose of this study is to determine the difference in the impact of moderate positive end-expiratory pressure (PEEP) on hepatic venous flow Doppler in patients undergoing cardiac surgery: conventional versus protective…
- Trial name
- NCT02700581
- Testing
- low PEEP conventional ventilation, moderate PEEP conventional ventilation, low PEEP protective ventilation
- Volunteers
- 15 people
- Sponsor
- Konkuk University Medical Center
Heart Valve Diseases
Depth of Anesthesia in Cardiac Surgery
The aim of our study was to evaluate the significance of monitoring anesthetic depth for the conduct of anesthesia and the early postoperative period in patients subjected to surgical correction of combined valvular disorders.
- Trial name
- NCT01524354
- Testing
- maintenance of anesthesia
- Volunteers
- 28 people
- Sponsor
- Northern State Medical University
Respiration Disorders
Impact of Positive End Maximum Voluntary Ventilation and Dyspnea Index in Patients After Valvular Heart Surgery
Pulmonary mechanics are further disturbed after cardiothoracic surgery that manifests like restrictive pathology, which may persist for weeks to months postoperatively.
- Trial name
- NCT05267067
- Testing
- respiratory exercises
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Atrial Fibrillation
Cardiac Surgical Treatment by Radiofrequency Ablation on Valvular Patients: Efficacy at 3 Months
The objective of the study is to evaluate the efficacy of the epicardial or endocardial radiofrequency ablation in the treatment of atrial fibrillation.
- Trial name
- NCT00259623
- Testing
- Radiofrequency ablation
- Where
- 5 sites in France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Toulouse
Valvular Heart Disease, Aortic Disease
Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery
CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression.
- Trial name
- NCT02136979
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Konkuk University Medical Center
Primary Valvular Heart Disease With Comorbid Coronary Artery Disease, Planned to Undergo Elective On-pump Valve Surgery Due to Primary Mitral and/or Aortic Valvular Heart Disease
Quantitative Flow Ratio (QFR) Guided Coronary Artery Bypass Grafting for Patients Undergoing Primary Valve Surgery With Concomitant Coronary Artery Disease
This is a multicenter, prospective, randomized, blinded, controlled clinical study in patients with planned primary valvular surgery and comorbid coronary artery lesions with diameter stenosis of ≥ 50%, to compare the…
- Trial name
- FAVOR IV-QVAS (NCT03977129)
- Testing
- QFR-guided strategy, CAG-guided strategy
- Where
- 12 sites in China
- Volunteers
- 792 people
- Sponsor
- Ruijin Hospital
Hemorrhage, Valvular Heart Surgery
Dose-ranging Study of Tranexamic Acid in Valve Surgery
Cardiac surgical procedures account for a large amount of allogeneic transfusion. Tranexamic acid (TA), a synthetic antifibrinolytic drug, has been shown to reduce blood loss and transfusion requirements in cardiac surgery with…
- Trial name
- NCT01191554
- Testing
- Tranexamic Acid
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Valve Diseases
Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery
Pulmonary dysfunction after cardiac surgery with CPB remains to be a problem complicating the postoperative course of the patients.
- Trial name
- NCT01427621
- Testing
- remote ischemic pre and postconditioning (RIPC)
- Volunteers
- 54 people
- Sponsor
- Yonsei University
Cardiomyopathy, Cardiovascular Diseases
Improving Mitral Repair for Functional Mitral Regurgitation
The investigators are interested in determining the best surgical technique to correct functional mitral regurgitation, as there is currently not one technique that is established to work better than the other.
- Conditions
- Cardiomyopathy, Cardiovascular Diseases, Congestive Heart Failure, Coronary Artery Disease
- Trial name
- IMPROVE-FMR (NCT03366649)
- Testing
- Undersizing Mitral Annuloplasty, Papillary Muscle Approximation
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Emory University
Cardiovascular Diseases, Valvular Heart Disease
Hypertonic Saline for Fluid Resuscitation After Cardiac Surgery
Background: Volume replacement strategies and type of fluid used in patients undergoing cardiac surgery have changed during the last years.
- Trial name
- HERACLES (NCT03280745)
- Testing
- Hypertonic saline, 0.9% saline
- Where
- Switzerland
- Volunteers
- 165 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Valve Diseases
Conventional Versus Mini-Sternotomy for Aortic Valve Surgery
Minimally-invasive operative techniques have been introduced in cardiac surgery. These techniques may have several advantages such as a decrease in post operative pain, lower morbidity and mortality, faster recovery, and a…
- Trial name
- NCT00221663
- Testing
- surgery techniques (sternotomy for aortic valve replacement)
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux