Clinical trials: Valvular Surgery
Valvular Heart Disease, Aortic Arch Aneurysm
The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.
The aim of the study is to evaluate the effects of intermittent hypoxic-hyperoxic training (IHHT) to protect myocardium against perioperative myocardial injury during cardiac surgery using cardiopulmonary bypass.
- Conditions
- Valvular Heart Disease, Aortic Arch Aneurysm, Surgery
- Trial name
- NCT04833283
- Testing
- ReOxy Cardio device, intermittent hypoxic-hyperoxic training ( IHHT), ReOxy Cardio device
- Where
- Russia
- Volunteers
- 115 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Coronary Artery Diseases, Valvular Heart Diseases
Clinical and Hospital Stay Effects of Reiki and Manual Therapy After Open Heart Surgery
Reiki is an energy-based healing therapy using light touch. Manual therapy is a technique using light effleurage. These complimentary healing services are utilized to promote relaxation, sleep, improve emotions, and decrease…
- Trial name
- NCT05853250
- Testing
- Reiki/manual therapy
- Where
- United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Patients Undergoing Valvular Heart Surgery
Associations of Postoperative Hemoglobin With AKI-AKD Trajectories
The investigators aimed to investigate the association of postoperative hemoglobin levels with acute kidney injury and acute kidney disease after valvular heart surgery, with a focus on acute kideny disease.
- Trial name
- NCT07907198
- Where
- South Korea
- Volunteers
- 4,230 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Valvular Diseases
Factors Affect Outcomes in Cardiovascular Surgery
Identify factors that contribute to perioperative morbidity and mortality in patients undergoing cardiac surgery that involves cardiopulmonary bypass.
- Conditions
- Coronary Artery Disease, Valvular Diseases, Vascular Diseases
- Trial name
- NCT01932411
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of California, Davis
Acute Kidney Injury
The Effects of Dexmedetomidine on Postoperative Renal Function in Valvular Heart Surgery
The purpose of study is to compare the incidence of acute kidney injury in patients receiving perioperative dexmedetomidine or placebo undergoing valvular heart surgery.
- Trial name
- NCT01886079
- Testing
- dexmedetomidine, Saline
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Valvular Heart Disease
Normothermia Versus Hypothermia for Valvular Surgery Patients
Cardiopulmonary bypass (CPB) has been used successfully for cardiac surgery for over half a century. Hypothermia became a ubiquitous practice for adult patients undergoing CPB.
- Trial name
- NCT01338961
- Testing
- Hypothermic CPB
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Heart Valvular Disease, Minimally Invasive Cardiac Surgery
SPSIP Block and Opioid Use After MICS
This prospective, randomized, controlled, single-center clinical study aims to evaluate the effectiveness of the Serratus Posterior Superior Intercostal Plane Block (SPSIPB) in perioperative pain management among patients…
- Conditions
- Heart Valvular Disease, Minimally Invasive Cardiac Surgery, Postoperative Pain Management, Serratus Posterior Superior Intercostal Plane Block
- Trial name
- SPSIPB-MICS (NCT07259824)
- Testing
- Serratus Posterior Superior Intercostal Plane Block (SPSIPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara City Hospital Bilkent
Atrial Fibrillation, AFib
Stroke Feasibility Study
This is a feasibility study to assess the safety and efficacy of the AtriCure AtriClip when placed via Minimally Invasive Surgical Deployment to the Left Atrial Appendage.
- Trial name
- NCT01997905
- Testing
- AtriClip LAA Exclusion Device
- Where
- 7 sites in United States
- Volunteers
- 13 people
- Sponsor
- AtriCure, Inc.
Postoperative Cognitive Dysfunction
Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon, which affect patients' short-term and long-term outcome.
- Trial name
- NCT02931877
- Testing
- sevoflurane, propofol
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xinqiao Hospital of Chongqing
Acute Kidney Injury, Surgery-Complications
Precision Medicine in Cardiovascular Surgery Associated Acute Kidney Injury
The goal of this prospective observational study is to define a risk profile for cardiovascular surgery associated acute kidney injury (AKI), using clinical patient characteristics, operation parameters as well as blood and urine…
- Conditions
- Acute Kidney Injury, Surgery-Complications, Frailty
- Trial name
- PEAK (NCT06471621)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Kidney Injury
The Effects of Statin on Postoperative Renal Function in Valvular Heart Surgery: a Randomized, Placebo-controlled Study
The aim of this study is to examine the association between preoperative statin treatment and the incidence of postoperative acute kidney injury(AKI) in patients undergoing valvular heart surgery.
- Trial name
- NCT01909739
- Testing
- atrovastatin
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Valvular Heart Disease
Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Valvular Heart Surgery
One of the most important factor that affects the post op complication of the cardiac surgery is systemic inflammation. Valvular heart surgery requires cardiopulmonary bypass and cardioplegic arrest, which can arouse the…
- Trial name
- NCT02490644
- Testing
- Blood sampling
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Aortic Stenosis, Valvular Heart Disease
Severe Aortic Stenosis in Patients Referred for Valve Surgery
Our main hypothesis on the present study is that new parameters such as risk-taking behavior, patients motivation, health related quality of life, new biomarkers and more precise echocardiography measures in addition to…
- Conditions
- Aortic Stenosis, Valvular Heart Disease, Symptomatic Aortic Stenosis
- Trial name
- SAS (NCT01794832)
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Valvular Cardiac Surgery
A Trial to Evaluate the Effect of Rosuvastatin on Inflammation in Patients Undergoing Isolated Cardiac Valve Surgery
High-dose statin therapy around the time of surgery, decreases inflammation in patients undergoing cardiac valve surgery, and thereby improves clinical outcomes.
- Trial name
- NCT01425398
- Testing
- Rosuvastatin
- Where
- Canada
- Volunteers
- 170 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis
Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and Conventional Valve Surgery Via Sternotomy.
This randomized controlled trial aims to compare early postoperative outcomes between Minimally Invasive Valve Surgery (MIVS) via right thoracotomy and Conventional Valve Surgery via median sternotomy in patients undergoing…
- Conditions
- Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis, Aortic Valve Insufficiency, Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)
- Trial name
- NCT07251660
- Testing
- Minimally Invasive Valve Surgery, Conventional Valve Surgery
- Volunteers
- 32 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
Coronary Artery Disease, Valvular Heart Disease
Prognostic Value of Lung Ultrasound in Predicting Intensive Care Unit Length of Stay in Adult Cardiac Surgery
Being easy, bedside, non-expensive, noninvasive and radiation free, there has been a growing interest in the implementation of lung ultrasound in critical care management in the last decade, cardiac surgery was not an exception…
- Trial name
- NCT04499027
- Testing
- Lung ultrasound scan
- Where
- Egypt
- Volunteers
- 191 people
- Sponsor
- Fayoum University Hospital
Atrial Fibrillation
The Effect of Arrhythmia Surgery on Quality of Life in Patients With Atrial Fibrillation Undergoing Cardiac Surgery
Atrial fibrillation (AF) is connected with an increased morbidity and mortality. In addition, quality of life is diminished due to palpitations, dyspnea, dizziness and syncope.
- Trial name
- NCT00886080
- Testing
- Pulmonary vein isolation using microwave energy
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Mitral Regurgitation, Mitral Valve Disease
AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System
This study will evaluate the safety of the Cardiovalve Transfemoral Mitral Valve System with its associated procedure, and observe the device performance in reducing mitral regurgitation.
- Trial name
- AHEAD (NCT03339115)
- Testing
- Cardiovalve Transfemoral Mitral Valve
- Where
- 11 sites in Germany, Greece and 1 more
- Volunteers
- 30 people
- Sponsor
- Cardiovalve Ltd.
Valvular Endocarditis
Surgical Management of Valvular Endocarditis
This study aims to achieve the following objectives objective 1 : To review the Investigators' experience of surgical management of infective endocarditis (IE) and analyze the outcomes and associated prognostic factors objective…
- Trial name
- NCT04572529
- Testing
- Cardiac Valve replacement
- Volunteers
- 50 people
- Sponsor
- Assiut University
Valvular Disease, Coronary Stenosis
The Scanner in the Coronary Evaluation
Conventional coronary angiography is the recommended procedure in detection of coronary stenosis in patients with heart valve disease referred for surgery.The aim of this prospective study is to assess diagnostic accuracy of…
- Trial name
- NCT00484380
- Testing
- Coronary scanner
- Where
- France
- Volunteers
- 66 people
- Sponsor
- French Cardiology Society