Clinical trials: Valvular Surgery
Aortic Aneurysm and Dissection, Coronary Artery Disease (CAD)
Effects of Myofascial Release on Cardiac Patients After Median Sternotomy
After deciding to join this study and signing the informed consent form, participants will undergo the following interventions: All participants will receive a preoperative assessment (Tp) before surgery.
- Conditions
- Aortic Aneurysm and Dissection, Coronary Artery Disease (CAD), Valve Heart Disease
- Trial name
- NCT07649330
- Testing
- myofascial release+Routine Physical Therapy, Routine Physical therapy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Siou-Pin Huang
Heart Diseases, ASD - Atrial Septal Defect
Abbott Structural Heart Device Registry
The Abbott Structural Heart (SH) Registry is being conducted to confirm the safety and performance of Abbott's SH devices in a post-market, real-world setting.
- Conditions
- Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
- Trial name
- SH-Registry (NCT06590467)
- Testing
- Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices
- Where
- 36 sites in United States, Denmark and 8 more
- Volunteers
- 2,500 people
- Sponsor
- Abbott Medical Devices
Endocarditis, Coagulation Disorder
The ENDOCARDITIS AUMC Data Collection
The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.
- Conditions
- Endocarditis, Coagulation Disorder, Valve Disease, Heart
- Trial name
- ENDO_AUMC (NCT05139589)
- Testing
- None, observational
- Where
- Netherlands
- Volunteers
- 3,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Rheumatic Heart Disease With Valvulitis
Minimal Invasive Approaches For Aortic Valvular and Subvalvular Surgeries
To compare intraoperative and immediate postoperative outcomes of mini-sternotomy versus mini-thoracotomy as less invasive techniques in patients with isolated aortic valvular and subvalvular disease requiring surgery according…
- Trial name
- NCT06696560
- Testing
- Minimal Invasive Approaches in Aortic surgeries.
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Yahia Abd almonem Sayed
Acute Kidney Injury
Effect of Erythropoietin on the Incidence of Acute Kidney Injury Following Complex Valvular Heart Surgery
Acute kidney injury (AKI) frequently occurs after cardiac surgery using cardiopulmonary bypass (CPB). Recombinant human erythropoietin (rHuEPO) is known to provide organ protection against ischemia-reperfusion injury through its…
- Trial name
- NCT01758861
- Testing
- EPO group
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Yonsei University
Heart Valve Diseases
Depth of Anesthesia in Cardiac Surgery
The aim of our study was to evaluate the significance of monitoring anesthetic depth for the conduct of anesthesia and the early postoperative period in patients subjected to surgical correction of combined valvular disorders.
- Trial name
- NCT01524354
- Testing
- maintenance of anesthesia
- Volunteers
- 28 people
- Sponsor
- Northern State Medical University
Aortic Regurgitation Disease, Aortic Valve Calcification
Valvular Assessment of New Generation Aortic Replacement Devices
The VANGUARD study is an open-label, prospective, randomized trial comparing the long-term outcomes of two advanced bioprosthetic aortic valves, Dafodil® and INSPIRIS Resilia®, in patients undergoing aortic valve replacement…
- Conditions
- Aortic Regurgitation Disease, Aortic Valve Calcification, Bicuspid Aortic Valve Disease
- Trial name
- VANGUARD (NCT06688448)
- Testing
- Dafodil prosthesis, Aortic Valve Replacement - Inspires Resilia prosthesis
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Intensive Care Unit, Coronary Artery Bypass Grafting (CABG)
Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients
The MODIFY CSX study is a prospective, randomized, placebo-controlled trial conducted in heart centers in Germany and Italy. A total of 550 high-risk cardiac surgery patients will receive either 0.20 g fish oil/kg body weight…
- Conditions
- Intensive Care Unit, Coronary Artery Bypass Grafting (CABG), High Risk Patients, Cardiopulmonary Bypass
- Trial name
- MODIFY CSX (NCT06279793)
- Testing
- Fish Oil, Intravenous 0.9% Sodium Chloride
- Where
- 10 sites in Germany
- Volunteers
- 550 people
- Sponsor
- GCP-Service International West GmbH
Mitral Regurgitation, Tricuspid Regurgitation
Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study
ARB-PMCF is a multicenter, observational study of the safety and performance of Abbott annuloplasty devices used in surgical repair of mitral and tricuspid valve regurgitation.
- Conditions
- Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
- Trial name
- ARB-PMCF (NCT04761120)
- Testing
- Abbott SJM Rigid Saddle Ring, Abbott SJM Séguin Ring, Abbott SJM Tailor Ring
- Where
- 17 sites in United States, Estonia and 5 more
- Volunteers
- 550 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation, Valvular Heart Disease
Concomitant Surgical Atrial Fibrillation Ablation in Double Valve Replacement
Current European Society of Cardiology Guidelines recommend concomitant atrial fibrillation (AF) ablation for all symptomatic patients undergoing other cardiac surgeries, but the safety and potential benefits of concomitant…
- Trial name
- NCT03163836
- Testing
- double valve replacement, surgical ablation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
CABG, Aortic Dissection
CLEAR Trial: CA330 Cytokine Adsorption Column for Anticoagulant/Antiplatelet Patients in Non-Elective CPB Surgery.
The goal of this clinical trial is to evaluate whether the CA330 cytokine adsorption column can reduce perioperative severe bleeding adverse events in patients receiving anticoagulant and/or antiplatelet therapy who undergo…
- Conditions
- CABG, Aortic Dissection, Valvular Heart Diseases
- Trial name
- CLEAR (NCT07284199)
- Testing
- CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Anzhen Hospital
Valvular Diseases
Effectiveness of Remote Cardiac Rehab After Surgery for Acquired Heart Valve Disease
The goal of this clinical trial is to learn if home-based cardiac rehabilitation using remote monitoring devices improves exercise capacity in patients after surgery for acquired heart valve diseases.
- Trial name
- NCT06984172
- Testing
- Remote cardiac rehabilitation, Facility-based cardiac rehabilitation
- Where
- Vietnam
- Volunteers
- 44 people
- Sponsor
- Hanoi Medical University
Acute Kidney Injury
The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery
In cases of cardiac surgery or sepsis which cause inflammation, oxidative stress, endothelial injury and vasoplegia, serum vitamin C concentration is sharply decreased.
- Trial name
- NCT04210453
- Testing
- Vitamin C, Control (Normal saline)
- Where
- South Korea
- Volunteers
- 264 people
- Sponsor
- Yonsei University
Infective Endocarditis, Valvular Heart Disease
Inflammatory Mediator Profiles During Heart Valve Replacement Surgery
The study aims at the comparative examination of pre-, intra- and post-operative release profiles of inflammatory and vasoactive mediators in patients undergoing heart valve surgery under cardiopulmonary bypass (CPB) due to…
- Trial name
- Remove-Pilot (NCT02727413)
- Testing
- Blood sample collection, Assessment of signs of organ dysfunction
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Jena University Hospital
Cardiovascular Disease
Remifentanil Anesthesia and Postoperative BIS in Cardiac Surgery
Background: Although remifentanil based anesthesia has been preferred for fast-track cardiac anesthesia, its recovery profile in cognitive function has not been investigated.
- Trial name
- NCT02400879
- Testing
- Remifentanil, sevoflurane and sufentanil
- Volunteers
- 38 people
- Sponsor
- Konkuk University Medical Center
Ischemic Heart Disease, Valvular Heart Disease
Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)
In order to perform heart surgery, a machine called cardiopulmonary bypass (CPB), or more commonly known as a heart-lung machine, is used to maintain the circulation of oxygenated blood needed by the rest of the body and its…
- Conditions
- Ischemic Heart Disease, Valvular Heart Disease, Cardiovascular Diseases, Surgery-Complications
- Trial name
- THERMIC-4 (NCT05996120)
- Testing
- Hypothermic Cardiopulmonary Bypass, Normothermic Cardiopulmonary Bypass
- Where
- 11 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Leicester