Clinical trials: Variability
Fluid Responsiveness Predictability, Hemodynamic Monitoring
Comparison of Acoustic Variability Index (AVI) and Pulse Pressure Variation (PPV) for Predicting Fluid Responsiveness in Mechanically Ventilated Patients
The goal of this clinical trial is to learn if a new medical device called ResQ works to predict fluid needs in adults undergoing surgery under general anesthesia.
- Conditions
- Fluid Responsiveness Predictability, Hemodynamic Monitoring, Anesthesia, General
- Trial name
- NCT07516470
- Testing
- Biological Signal Processing Device for Acoustic Variability Index, Patient monitor for pulse pressure variation, Hemodynamic monitor for cardiac Output and stroke volume variation
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- Signal House Co., Ltd.
Anesthesia, General, Fluid Therapy
Management of Intraoperative Fluids in Ambulatory Surgery
This is a single-center prospective randomized control trial (RCT) to determine whether the continuous monitoring of the plethysmographic variability index (PVI) during low-risk surgeries, can be used to optimize the…
- Conditions
- Anesthesia, General, Fluid Therapy, Ambulatory Surgical Procedures
- Trial name
- MIFAS (NCT03193320)
- Testing
- Fluid therapy protocol
- Where
- Venezuela
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Policlinica Metropolitana
Type 2 Diabetes Mellitus
Comparison of Vildagliptin vs. Glimepiride on Glucose Variability in Metformin Uncontrolled Type 2 Diabetic Patients
Compare the effect of Vildagliptin plus Metformin versus Glimepiride plus Metformin on glucose variability in T2DM patients.
- Trial name
- VARIABLE (NCT01910441)
- Testing
- Vildagliptin, Glimepiride, Metformin
- Volunteers
- 95 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease (COPD)
European Non-interventional Study in Chronic Obstructive Pulmonary Disease (COPD) Patients
This study is investigating how patients with severe stable state COPD perceive the variability of their symptoms throughout the day, the week and the year; the impact of these variations on their daily activities or sleep…
- Trial name
- NCT00722267
- Where
- 606 sites in Austria, Belgium and 15 more
- Volunteers
- 7,400 people
- Sponsor
- AstraZeneca
Muscle Soreness, Delayed-onset Muscle Soreness
Effects of ReWin(d) Supplementation on the Recovery of DOMS Induced by Acute Exercice
The study will assess the recovery and performance of young athletes suffering from muscle damage induced by physical exercise. Model by comparing the safety and efficacy of ReWin(d) supplemention during 4 weeks to placebo over…
- Trial name
- NCT03961022
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Natural Origins
Chronic Obstructive Pulmonary Disease
A Cross-sectional Study of COPD and Symptom Variability in MEA Countries
This non-interventional study aims at assessing stable GOLD C and D COPD patient's perception of daily and weekly symptoms variability and their impact on daily activities.
- Trial name
- COPVAR (NCT03425760)
- Volunteers
- 3,254 people
- Sponsor
- AstraZeneca
Anemia
A Study of MIRCERA for the Intrapetient Variability of Hemoglobin Levels in Patients With Chronic Renal Anemia (RIVAL)
This retrospective observational study will assess the incidence of hemoglobin cycling in chronic kidney disease (stage 3, 4, and 5) patients with renal anemia treated with Mircera (methoxy polyethylene glycol-epoetin beta).
- Trial name
- NCT01356589
- Where
- 33 sites in Greece
- Volunteers
- 1,288 people
- Sponsor
- Hoffmann-La Roche
Arteriosclerosis Obliterans
Preoperative Heart Rate Variability and Baroreflex Sensitivity in ASO Patients During Various Sleep Stages
The goal of this study is to evaluate the possible preoperative predictive value of altered heart rate variability (HRV) and baroreflex sensitivity in different sleep stages for postoperative adverse cardiac events (i.e.
- Trial name
- Barosleep (NCT00712946)
- Where
- Finland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Diabetes
Pharmacodynamic and Pharmacokinetic Variability of a Basal Insulin (0000-168)
The purpose of this study is to evaluate whether the within-subject variation in duration of action and time-action profile of glargine measured by isoglycemic clamp will be below prespecified levels.
- Trial name
- NCT01152242
- Testing
- Isoglycemic Clamp, Comparator: insulin glargine
- Volunteers
- 36 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus
Trial to Evaluate the Efficacy on Glycemic Variability and Safety of Gemigliptin Compared With Dapagliflozin Added on Metformin Alone or Diabetes Medication Naïve Patient in Type 2 Diabetes Mellitus (Stable II Study)
The objective of this study is to evaluate the efficacy on glycemic variability and safety of gemigliptin 50 mg orally administered once daily for 12 weeks compared with Dapagliflozin 10mg in patients with type 2 diabetes…
- Trial name
- NCT03202563
- Testing
- Gemigliptin 50mg, Dapagliflozin 10mg, Diet/exercise questionnaire
- Where
- South Korea
- Volunteers
- 71 people
- Sponsor
- LG Chem
Blood Pressure, Cardiac Output
Caretaker Hemodynamic Parameters Validation
Comparison studies comparing hemodynamic parameters provided by the Caretaker against respective Gold Standard references.
- Conditions
- Blood Pressure, Cardiac Output, Left Ventricular Ejection Time, Heart Rate Variability
- Trial name
- NCT04685733
- Testing
- Non-invasive hemodynamic measurements
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CareTaker Medical LLC
HRV
Measuring Accuracy of Wristband for Registration of ECG RR-Intervals for One Hand, SenceBand in Comparison to Holter
The purpose of the study is to evaluate the measuring accuracy of the Wristband for registration of ECG RR intervals for one hand, SenceBand icompared to the Holter monitor (LabTech Ltd).
- Trial name
- NCT03747861
- Testing
- SenceBand
- Where
- Ukraine
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Planexta, Inc
Heart Failure
Pressure Variability Study
The purpose of this study is to understand how the pressure in the pulmonary artery changes under different conditions of posture, respiration and exertion.
- Trial name
- APVS (NCT02943941)
- Testing
- Reveal LINQ ICM Cardiac Monitor, taped on the subject's chest rather than inserted in the body.
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Aneurysmal Subarachnoid Hemorrhage
Efficacy and Safety Study of a Low-carbohydrate Tube Feed in Critically Ill Patients Under Insulin Therapy
The purpose of this study is to determine the efficacy and safety of a diabetes-specific tube feed in comparison to an isocaloric, isonitrogenous standard enteral formula in critically ill patients receiving insulin treatment for…
- Trial name
- NCT02503527
- Testing
- Diben 1.5 kcal HP, Fresubin HP Energy Fibre (1.5 kcal)
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Fresenius Kabi
Diabetes, Diabetes Mellitus, Type 1
A Trial Assessing Changes in Blood Sugar and the Number of Periods Where Supplementation of Carbohydrate is Needed to Treat Low Blood Sugar, During Two Different Treatment Regimens of NN1250 in Type 1 Diabetics
This trial is conducted in Europe. The aim is to compare changes in blood sugar and the number of periods where carbohydrate supplementation is needed to treat low blood sugar, during two different treatments with NN1250 (insulin…
- Trial name
- NCT00964964
- Testing
- insulin degludec
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Novo Nordisk A/S
Healthy
PK Study to Evaluate Esomeprazole Plasma Levels Following Administration of PN 400
Pharmacokinetic study in healthy subjects with single and repeat b.i.d. dosing of PN 400 tablets from the same drug product batch.
- Trial name
- NCT00599404
- Testing
- PN400
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- POZEN
Heart Rate, Heart Rate Variability
Contactless Measurement of Heart Rate, Heart Rate Variability and Breathing Rate Using Remote Photoplethysmography
The purpose of this study it to evaluate the accuracy of heart rate, heart rate variability and breathing rate measurement with the use of Shen.AI Vitals software developed by MX Labs.
- Conditions
- Heart Rate, Heart Rate Variability, Respiratory Rate
- Trial name
- NCT05889832
- Testing
- measurement of physiological parameters wih Shen.AI Vitals software on various camera-equipped devices (smartphones, tablets, laptops)
- Where
- Poland
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- SHEN.AI spółka z ograniczoną odpowiedzialnością oddział w Polsce
Type 2 Diabetes Mellitus
Effect of 13-Week Treatment With Vildagliptin as Add-On Therapy to Improve Glucose Variability in Type II Diabetes
The purpose of the study is to assess if the addition of vildagliptin as add-on therapy improves glucose variability in type 2 diabetes mellitus (T2DM) patients inadequately controlled with insulin, with special emphasis in…
- Trial name
- VIDA (NCT01862263)
- Testing
- Vildagliptin, Insulin
- Where
- 13 sites in Mexico
- Volunteers
- 191 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes, Obesity
Blood Glucose Stability and Variability on Two Diets
This investigation will examine the effects of consuming a structured, portion-controlled, low-glycemic index diet (commercially available as the Nutrisystem-D program) on several indicators of glycemic stability and variability…
- Trial name
- NCT01443143
- Testing
- Portion-controlled diet, Usual Diet
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Nutrisystem, Inc.
Posttraumatic Stress Disorder
Exploring Mechanisms of Action in MDMA-assisted Psychotherapy for PTSD
The goal of this observational sub-study is to provide information on how MDMA-assisted therapy affects the brain and body of people with chronic PTSD.
- Trial name
- NCT02102802
- Testing
- Midomafetamine, Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Resilient Pharmaceuticals