Clinical trials: Variability
Multiple Sclerosis
Effects of Fingolimod on Heart Rhythm and Heart Rate Variability in Patients With Multiple Sclerosis
The current study sought to prolong the observational interval after initiating medication with fingolimod and to measure the long-term effects of fingolimod on HR and HRV as an indicator of autonomic nervous system function in…
- Trial name
- FINGORHYMS (NCT03216915)
- Testing
- Gilenya®; Novartis Pharmaceuticals Corporation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Intradialytic Hypotension
Applying Pulse Wave Analysis to Predict Intradialytic Hypotension
Intradialytic hypotension (IDH) is a common complication during hemodialysis in patients with chronic kidney disease and may increase the mortality.
- Trial name
- NCT04180514
- Testing
- intradialytic hypotension episode
- Volunteers
- 70 people
- Sponsor
- China Medical University, Taiwan
Cystic Fibrosis
Glycemic Monitoring in Cystic Fibrosis
Current guidelines on the diagnoses and management of cystic fibrosis (CF) related diabetes recommend treatment for diabetes based on diagnostic criteria derived from adults with type 2 diabetes.
- Trial name
- GEM (NCT02211235)
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Postoperative Delirium, Postoperative Agitation
Emergence Agitation in Paediatric Day Care Surgery
Emergence agitation is a significant and persistent challenge in paediatric anaesthesia, especially in children of preschool age.
- Conditions
- Postoperative Delirium, Postoperative Agitation, Anesthesia, Pain Monitoring
- Trial name
- NCT06571890
- Testing
- Narcotrend bispectral index anaesthesia monitor, Mdoloris Anaesthesia Nociception Monitor
- Where
- Denmark
- Volunteers
- 93 people
- Sponsor
- University of Southern Denmark
Renal Anemia
Variability of Hemoglobin Levels After Kidney Transplantation
The purpose of this study es to determine hemoglobin variability in kidney transplant recipients with chronic renal anemia.
- Trial name
- NCT02041208
- Testing
- kidney transplantation
- Where
- 22 sites in Spain
- Volunteers
- 368 people
- Sponsor
- Sociedad Española de Trasplante
Post-induction Hypotension (PIH), Geriatric Patient
Incidence and Risk Factors of Post-Induction Hypotension in Geriatric Cancer Patients
This observational clinical study aims to investigate the incidence and risk factors of post-induction hypotension (PIH) in geriatric cancer patients undergoing surgery under general anesthesia.
- Conditions
- Post-induction Hypotension (PIH), Geriatric Patient, Oncologic Disease, Hemodynamic Effects of General Anesthesia
- Trial name
- NCT07294040
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Dolunay ARIK
Anxiety, Psychological Stress
Film-Based Music Therapy With AI-Generated Verbal Guidance for Anxiety in Young Adults
This study aims to examine whether music-based relaxation combined with different types of verbal guidance can help reduce anxiety and improve emotional well-being in young adults.
- Conditions
- Anxiety, Psychological Stress, Emotional Regulation
- Trial name
- EAST-MUSIC (NCT07359950)
- Testing
- Music Listening With AI-Generated Eastern Imagery Verbal Guidance, Music Listening With Standard Verbal Guidance, Music-Only Relaxation
- Where
- China
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Wen Li
Acute Coronary Syndrome
Heart Rate Variability as a Predictor of Ischemic Heart Disease
Identification of patients who are at highest risk for heart attack is an important task for emergency medicine physicians. Currently, physicians use a variety of different scoring systems to stratify their risk for having a…
- Trial name
- NCT02959788
- Testing
- Heart rate variability
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Iowa
Rowing
Comparison of the Effects of Long-Term Rowing Training in Professional Rowers
This study aims to compare the effects of long-term rowing training on aerobic capacity, physical fitness, heart rate variability, and psychological performance in novice rowers, professional rowers, and healthy controls.
- Trial name
- NCT07752927
- Testing
- Rowing Ergometer Training for Novice Rowers, High-Performance Rowing Ergometer Training
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Neuromuscular Blockade, Residual Curarisation, Postoperative
Provider Variability in the Use of Neuromuscular Blocking Drugs and Reversal
The use of neuromuscular blocking agents during surgery is associated with postoperative respiratory complications and increased risk of readmission to the hospital following ambulatory surgery.
- Conditions
- Neuromuscular Blockade, Residual Curarisation, Postoperative, Surgery Under General Anaesthesia
- Trial name
- NCT03585348
- Testing
- Neuromuscular blocking agents
- Where
- 2 sites in United States
- Volunteers
- 265,537 people
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy, Healthy Participants
Neck Static Stretching Acutely Reduces Blood Pressure Through Reduction of Tissue Stiffness
Stretching is usually done to improve flexibility and joint movement. Recent research suggests that stretching may also affect the body's heart and blood vessels.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects, Healthy Volunteers
- Trial name
- NCT07197047
- Testing
- Neck static stretching
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Stroke
Tai Chi Training in Stroke Survivors
People with stroke suffer from different impairments, including the ability to dual-tasking, increased arterial stiffness, and dysfunction of the autonomic nervous system.
- Trial name
- NCT03252236
- Testing
- Tai Chi, Conventional exercise
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The Hong Kong Polytechnic University
Fluid Responsiveness
Accuracy of Pulse Pressure Variation and of Pleth Variability Index to Predict the Response to a Fluid Challenge
The aim of this study is to compare the accuracy of Pleth Variability Index (Radical 7 device) and of Pulse Pressure Variation (Nexfin device) with the Doppler measurement of stroke volume (esophageal Doppler) to detect the…
- Trial name
- Nexfin2 (NCT02040948)
- Testing
- - Nexfin (Pulse Pressure Variation) - Radical 7 (Pleth Variability Index) - CardioQ (stroke volume)
- Where
- 2 sites in France
- Volunteers
- 68 people
- Sponsor
- Hopital Foch
Pharmacologic Action
Genetic Variability in CYP2D6 in U.S Active Duty Population
The investigator proposes to 2D6 (Cytochrome P-450 Isoenzyme 2D6) genotype and phenotype a group of active duty service members and assess the effects on primaquine metabolism.
- Trial name
- NCT02960568
- Testing
- Primaquine
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Diabetes Mellitus, Type 2
The Effect of Soliqua on Glucose Variability in Type 2 Patients Among South Asians
The overall objective of this study is to compare the effects of Soliqua, a titratable combination of insulin and GLP-1 receptor agonist in a single pen versus Glargine U100 insulin (Basaglar or Lantus) and gliclazide MR, both…
- Trial name
- VARIATION 2 SA (NCT03819790)
- Testing
- Basal insulin glargine and lixisenatide, Basal insulin Basaglar/Lantus + gliclazide MR, Metformin
- Where
- 3 sites in Canada
- Volunteers
- 119 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Dementia
Effects of Snoezelen Multisensory Therapy on Older Adults With Dementia
This randomized, controlled, longitudinal clinical trial investigates the effects of Snoezelen Multisensory Therapy (SMT) as an adjunct to standard therapy (ST) in older adults with dementia.
- Trial name
- SMT (NCT07657208)
- Testing
- Snoezelen Multisensory Therapy, Standard Therapy
- Where
- Slovenia
- Volunteers
- 63 people
- Sponsor
- University of Primorska
Diabetes Mellitus, Diabetic Kidney Disease
Basal Plus GLP1-ra on Glycemic Variability in CKD
To compare GLP-1 RA plus basal insulin (BGLP) versus basal-bolus (BB) insulin regimens on glycemic variability (GV) and time in range (TIR) in diabetes patients CKD stage 3-4
- Trial name
- NCT05218915
- Testing
- Dulaglutide, Insulin Degludec, Continuous glucose monitor
- Where
- Hong Kong
- Volunteers
- 95 people
- Sponsor
- Elaine Chow
Complication of Anaesthesia During Labour and Delivery
Plethysmographic Variability Index in Post Spinal Anesthesia Hypotension in Cesarean Section
Full term pregnant female patients presented for elective C.S for single viable fetus will be included in this study. Before anesthesia, the patient will be attached to a monitor of: ECG , heart rate, non invasive blood pressure…
- Trial name
- NCT04010318
- Testing
- Spinal Anesthesia
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Atrial Fibrillation
QT Variability Pre and Post Cardioversion
The purpose of this study is to learn whether the chemicals in the blood and urine are different when the heart is atrial fibrillation compared to normal sinus rhythm.
- Trial name
- DCCV (NCT00885391)
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Vanderbilt University
Autonomic Nervous System Imbalance, Hypovolemia
Autonomic Challenges From Mild Hypovolemia and Mechanical Ventilation
Heart Rate Variability (HRV) analysis has been studied in the critically ill patients although it is affected by several uncontrolled variables in the clinical conditions.
- Conditions
- Autonomic Nervous System Imbalance, Hypovolemia, Positive-Pressure Respiration
- Trial name
- NCT03244891
- Testing
- Increase of central volume, Ventilation mode
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
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