Clinical trials: Variability
Severe Traumatic Brain Injury
Randomized Control Trial to Compare Standard Monitoring and Plethysmographic Variability Index-Guided Fluid Therapy In 64 Severe Traumatic Brain Injury Patients, Aged 18 to 60 Years Old Undergoing Emergency Craniotomies
This randomized control trial aims to assess if Plethysmographic Variability Index (PVI)-based therapy improves patient outcome in terms of reduced amount and type of fluid used, lower postoperative lactate levels, lesser…
- Trial name
- PVI (NCT04664699)
- Testing
- Plethymographic Variability Index, Standard Monitoring
- Where
- Malaysia
- Volunteers
- 64 people
- Sponsor
- Universiti Sains Malaysia
Heart Rate Variability
Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Endurance Performance
The ability of smart phones, aided by wearable devices (e.g. smart watches), to collect a variety of data, including physical activity, heart rate, and other exercise metrics, may provide a unique opportunity to understand…
- Trial name
- NCT06964100
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Diabetes Mellitus, Lipohypertrophy
Glucose Variability in Subclinical Hypertrophy
Evaluation of insulin absorption at sites affected by clinically apparent lipohypertrophy through short-term continuous glucose monitoring has shown inconsistent results and it is yet unknown how or if subclinical lipohypertrophy…
- Trial name
- NCT02748434
- Testing
- Lipohypertrophy, Normal Subcutaneous Tissue
- Where
- 2 sites in Canada
- Volunteers
- 9 people
- Sponsor
- University of British Columbia
Schizophrenia, Physical Activity
A Controlled Study With Remote Web-based Adapted Physical Activity (e-APA) in Psychotic Disorders
In this study, an APA program by web (e-APA) will be offered to two groups of participants (21 patients and 21 healthy volunteers (HV)) in remote video (use of the SAPATIC (Santé Activités Physiques Adaptées utilisant les…
- Conditions
- Schizophrenia, Physical Activity, Schizo Affective Disorder
- Trial name
- PEPSYV@SI (NCT03261817)
- Testing
- Physical activity (APA), Health Education program (HE)
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Obesity, Abdominal
The Impact Of An Intermittent Energy Restricted Diet On Insulin Sensitivity In Men and Women With Central Obesity
An intermittent energy restricted (IER) diet may modify cardio-metabolic disease risk factors compared to an energy-matched continuous energy restricted (CER) diet.
- Trial name
- Met-IER (NCT02679989)
- Testing
- Intermittent Energy Restriction, Continuous Energy Restriction
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King's College London
Pranayama Effect on Autonomic Nervous System, Respiration Variability Effect on Nervous System
Pranayama Practice on the Autonomic Nervous System
The proposed study design will be a randomized, cross-over trial testing different pranayama breathing interventions. Participants (N=40) will perform each of the following five interventions in a randomly assigned order: (1)…
- Trial name
- PYAMA (NCT03280589)
- Testing
- Sheetali/Sheekari Pranayama, Sitting Quietly, Deep breathing
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Pectus Excavatum, Autonomic Dysfunction
Autonomic Dysfunction in Patients With Pectus Excavatum.
Investigators conducted a pilot study to to evaluate the autonomic function in participants with pectus excavatum before and after Nuss surgery.
- Conditions
- Pectus Excavatum, Autonomic Dysfunction, Surgery
- Trial name
- ADPE (NCT03346876)
- Testing
- Nuss surgery
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Stress, Anxiety State
Effectiveness of Heart Rate Variability Biofeedback Training Versus a Meditation Program in Reducing Stress Levels in University Undergraduate Students
The objective of this trial is to evaluate the efficacy of a heart rate variability biofeedback training protocol, compared to a guided meditation program and a control group, in reducing stress and anxiety levels among…
- Trial name
- NCT06457932
- Testing
- Heart rate variability biofeedback training, Guided meditation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Seville
Transplantation, Kidney, Living Donors
Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients
The aim of this study is to determine a comprehensive immune profile of transplant donors and recipients through assessment of immune cell compositions in bone marrow, and lymph nodes.
- Conditions
- Transplantation, Kidney, Living Donors, Kidney Transplant Recipients
- Trial name
- NCT01150487
- Testing
- bone marrow aspirations, lymph node collection
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Mayo Clinic
Goal Directed Fluid Therapy
Stroke Volume Variation and Plethysmography Variability Index as Goal Directed Fluid Therapy in Major Oncosurgeries
Patients were allotted to two Groups , SVV Guided Fluid Therapy Group received intraoperative fluids to maintain SVV <11 , and PVI Guided Group received intraoperative Fluids to maintain PVI<11
- Trial name
- SVV PVI GDFT (NCT05142163)
- Testing
- Intraoperative SVV Guided Fluid Therapy, Intraoperative PVI Guided Fluid Therapy
- Where
- India
- Volunteers
- 68 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Acute Lung Injury, Adult Respiratory Distress Syndrome
Assessing Respiratory Variability During Mechanical Ventilation in Acute Lung Injury (ALI)
Healthy biological systems are characterized by a normal range of "variability" in organ function. For example, many studies of heart rate clearly document that loss of the normal level of intrinsic, beat-to-beat variability in…
- Trial name
- NCT01083355
- Where
- United States
- Sponsor
- Boston Medical Center
Chronic Instability of Joint
The Influence of Dual Task and Gait Speed on Gait Variability in Patients With Chronic Ankle Instability
Case-control study to evaluate gait parameters during different conditions between patients who suffer from chronic ankle instability and healthy individuals.
- Trial name
- NCT02745834
- Testing
- Gait analysis
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
COVID-19
HEART Rate Variability Biofeedback in LOng COVID-19 (HEARTLOC)
Long COVID is a common but highly debilitating illness which develops after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19).
- Trial name
- HEARTLOC (NCT05228665)
- Testing
- Heart Rate Variability Biofeedback (HRV-B)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Leeds
Transcutaneous Hypoglossal Nerve Stimulation
Assessing Blood Pressure Variability in a Healthy Adult Population During Transcutaneous Hypoglossal Nerve Stimulation With the Zeus Sleep Device
Transcutaneous hypoglossal nerve stimulation is an emerging treatment option for Obstructive Sleep Apnoea (OSA), a sleep condition where breathing is repeatedly limited.
- Trial name
- Zeus-BPV (NCT07917260)
- Testing
- Zeus Sleep device
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Stroke
Backward Walking Observation Training in People With Stroke and Gait Quality in Stroke
Walking impairment is one of the most common and concerning issues for individuals with stroke. Previous studies have often used improvements in walking speed and distance as reference indicators for gait performance progress in…
- Trial name
- NCT06850662
- Testing
- Backward walking observation training, Non-motor observational backward walking training
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Yang Ming Chiao Tung University
Ventricular Tachycardia
Modification of Rhythmic Risk Assessment by Ventricular Tachycardia Ablation
Sudden cardiac death is a frequent cause of cardiovascular mortality. Numerous rhythmic risk assessment criterion have been described targeting the substratum, the cardiac nervous tone or the trigger of arrhythmias.
- Trial name
- NCT03453645
- Testing
- ventricular tachycardia ablation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Substance Use Disorders
Heart Rate Variability Biofeedback for Substance Use Disorder: A Randomized Clinical Trial
Heart rate variability biofeedback (HRVB) is an biobehavioral intervention involving rhythmic breathing at resonance frequency that stimulates cardiovascular regulatory systems to help individuals better regulate affect and…
- Trial name
- NCT05454657
- Testing
- Heart rate variability biofeedback + treatment as usual, Treatment as usual only
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Respiratory Distress Syndrome, Adult
Effects of Positive End-expiratory Pressure and Tidal Volume on Fluid Responsiveness of Acute Respiratory Distress Syndrome
Fluid responsiveness (FR)refers to the ability of heart to increase its stroke volume in response to volume load.Low tidal volume and high PEEP exerts contrast effect on the prediction of fluid responsiveness, the aim of this…
- Trial name
- NCT01716962
- Testing
- Infusion of 6% tetrastarch for a total of 500 ml
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Normovolemic Hemodilution, Cardiac Surgery
Impact of Pleth Variability Index-Guided Acute Normovolemic Hemodilution on Intraoperative Fluid Management and Postoperative Complications in Cardiac Surgery
Acute normovolemic hemodilution (ANH) is a widely used blood conservation strategy in cardiac surgery aimed at reducing intraoperative blood loss and the need for allogeneic blood transfusion.
- Conditions
- Acute Normovolemic Hemodilution, Cardiac Surgery, Postoperative Complication, Pleth Variability Index
- Trial name
- NCT07466082
- Testing
- acute normovolemic hemodilution, PVI dependant acute normovolemic hemodilution
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Healthy Volunteer
A Phase I Study of the Pharmacokinetic Variability and Relative Bioavailability of the Phase 3 and Common Blend Formulations of Eliglustat in Healthy Adult Subjects
The primary objective of this pilot study is to determine the within-subject pharmacokinetic (PK) variability and relative bioavailability of single oral 150-mg doses of eliglustat administered as the Phase 3 formulation (3x50-mg…
- Trial name
- NCT01452542
- Testing
- Eliglustat, common blend proposed commercial formulation, Eliglustat, Phase 3 capsule formulation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Genzyme, a Sanofi Company
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