Clinical trials: Variability
Osteoarthritis
Epidemiology of Osteoarthritis (OA) Pain
Chronic pain, by definition, persists over long periods of time, but both sufferers of pain and their caregivers are aware that pain levels can fluctuate greatly over time.
- Trial name
- NCT01557231
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Northwestern University
Long COVID
Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog
This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.
- Trial name
- NCT06614309
- Testing
- Acute Progressive Carbon Dioxide, Acute Intermittent Hypoxia, Training: Progressive Carbon Dioxide Ramping
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Obstructive Apnea, Diagnostic
Night-to-Night Variability of Novel Physiological Parameters in Home Sleep Apnea Testing
Obstructive sleep apnea (OSA) is usually diagnosed from a single night of home sleep apnea testing using the apnea-hypopnea index (AHI).
- Conditions
- Obstructive Apnea, Diagnostic, Sleep Apnea Syndrome (OSAS)
- Trial name
- N2N-OSA (NCT07555119)
- Where
- Switzerland
- Volunteers
- 192 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Resistant Hypertension, Kidney Failure, Chronic
Low-Dose Spironolactone in Hemodialysis Patients With Resistant Hypertension
Many patients on hemodialysis have high blood pressure that does not respond to three or more drugs (resistant hypertension). This pilot study gave a low dose of spironolactone (12.5 mg once daily) for 6 weeks to adults on…
- Conditions
- Resistant Hypertension, Kidney Failure, Chronic, Hemodialysis
- Trial name
- NCT07888504
- Testing
- Spironolactone
- Where
- Indonesia
- Volunteers
- 21 people
- Sponsor
- Universitas Sebelas Maret
Heart Rate Control, Athlete
HRV-based Training Effects in Athletes
Monitoring individual responses to training is an important key factor to prescribe to most effective training programs. Heart-rate variability (HRV) could be used for monitoring the training status of endurance athletes in order…
- Conditions
- Heart Rate Control, Athlete, Emotions
- Trial name
- HRV-btA (NCT04150952)
- Testing
- HRV-based training, TRAD training
- Where
- Spain
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Healthy
Disentangling the Variability of Exercise-induced Hypoalgesia: the Role of Circulatory Compounds
Physical exercise is increasingly recognized as an effective treatment for chronic pain. Studies in humans and animals have shown that a single session of exercise induces a reduction of sensitivity to experimental painful…
- Trial name
- NCT06967714
- Testing
- Exercise
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Older Adults, Cardiovascular Health
Acute Effects of Intermittent Hypoxia-Hyperoxia in Older Adults
The supply of oxygen is essential for energy production, recovery from efforts, and human life. Intermittent Hypoxia-Hyperoxia Exposure (IHHE) is a novel technique in which the subject is exposed to a respiratory environment with…
- Conditions
- Older Adults, Cardiovascular Health, Blood Pressure, Sedentary
- Trial name
- NCT06686238
- Testing
- MITOVIT® Hypoxic Training System
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Sierra Varona SL
Cerebral Small Vessel Diseases
Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function
Multicentre, multinational, prospective randomised, open-label, 3 sequence crossover phase III b clinical trial with blinded endpoint assessment (PROBE-design) in 75 patients with sporadic small vessel diseases (SVDs) and in 30…
- Trial name
- TREAT-SVDs (NCT03082014)
- Testing
- Amlodipine, Losartan, Atenolol
- Where
- 5 sites in Germany, Netherlands and 1 more
- Volunteers
- 101 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Takotsubo Cardiomyopathy
The Role of Sympathetic Tone Regarding the Anatomical and Functional Recovery of the Left Ventricle in TakoTsubo Syndrome
TakoTsubo Syndrome (TTS) constitutes an increasingly recognised, heterogenous clinical entity which is associated with considerable short-term mortality.
- Trial name
- SYMPATAK (NCT04695587)
- Testing
- 123 MIBG scintigraphy testing, MSNA, ABPM
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Hippocration General Hospital
Healthy
PK Study to Evaluate Esomeprazole Plasma Levels Following Administration of PN 400
Pharmacokinetic study in healthy subjects with single and repeat b.i.d. dosing of PN 400 tablets from the same drug product batch.
- Trial name
- NCT00599404
- Testing
- PN400
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- POZEN
Heart Rate Variability, Anxiety
Heart Rate Variability and Music Listening
High anxiety levels may lead to negative outcomes, and previous studies have shown that music listening could reduce periprocedural anxiety and depression.
- Conditions
- Heart Rate Variability, Anxiety, Depression
- Trial name
- NCT06929208
- Testing
- Electrocardiogram (ECG) monitor, Music listening
- Where
- 3 sites in Singapore
- Volunteers
- 120 people
- Sponsor
- KK Women's and Children's Hospital
Diabetes, Diabetes Mellitus, Type 1
A Trial Assessing Changes in Blood Sugar and the Number of Periods Where Supplementation of Carbohydrate is Needed to Treat Low Blood Sugar, During Two Different Treatment Regimens of NN1250 in Type 1 Diabetics
This trial is conducted in Europe. The aim is to compare changes in blood sugar and the number of periods where carbohydrate supplementation is needed to treat low blood sugar, during two different treatments with NN1250 (insulin…
- Trial name
- NCT00964964
- Testing
- insulin degludec
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Novo Nordisk A/S
Healthy
Effects of Race Pace Based Approach in Recreational Runners
The aim of the study was to compare the performance effects of the intensity demarcation model based on the race pace based approach with the triphasic physiological model and heart rate variability guidelines (HR+HRV)
- Trial name
- 22HUM23661 (NCT06216314)
- Testing
- Heart rate (HR), Race pace based approach (RP), Heart rate + heart rate variability (HRV)
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Metastatic Castration Resistant Prostate Cancer
Study to Determine the Feasibility, Evaluability and Variability in Markers of Drug Action in Castration Resistant Prostate Cancer
This is a biopsy feasibility study in which patients with castration resistant prostate cancer (CRPC) will be asked to donate primary and metastatic tumour tissue (both archival and de novo), blood samples, a urine specimen and…
- Trial name
- BIOMETHS (NCT02424448)
- Testing
- Biopsies, blood and urine samples
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- The Christie NHS Foundation Trust
Heart Failure, Systolic Heart Failure
Clinical Value of Heart Rate Variability Indexes to Predict Outcomes After Exercise Training in Chronic Heart Failure
Controlled exercise training is a valuable therapeutic addition to pharmacological treatment in most patients with chronic heart failure, reducing long-term mortality, preventing cardiac remodeling and improving functional…
- Trial name
- REINCA (NCT02903225)
- Testing
- Cardiac Rehabilitation
- Volunteers
- 40 people
- Sponsor
- Universidad de la Republica
Experimental Pain in Healthy Human Subjects
Intra- and Inter-individual Differences of Pain
Pain is a highly subjective and variable phenomenon. Different persons perceive objectively identical nociceptive stimuli differently.
- Trial name
- NCT05616091
- Testing
- painful stimulation by using a laser device (DEKA Stimul 1340, Calenzano, Italy)
- Where
- Germany
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Free Tissue Flaps
PVI Based Intraoperative Fluid Management in Head and Neck Free Flap Reconstructive Surgeries
Intraoperative fluid given according to BMI in group B and according to pulse oximeter- derived pleth variability index(MASIMO RAINBOW PULSE CO OXIMETRY) in group G.
- Trial name
- NCT03116178
- Testing
- Group G -PVI( Masimo co oximeter) guided fluid therapy, Group B- Body weight guided intravenous fluid @6-8ml/kg
- Volunteers
- 80 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Obesity, Morbid
Glycemic Variability After SASI Versus Roux-en-Y Gastric Bypass
The GLUBARI trial is a prospective, randomized, single-center clinical study comparing two bariatric surgical procedures in adults with morbid obesity: Single Anastomosis Sleeve Ileal Bypass (SASI) and Roux-en-Y Gastric Bypass…
- Trial name
- GLUBARI (NCT07872397)
- Testing
- Single Anastomosis Sleeve Ileal Bypass, Roux-en-Y Gastric Bypass
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Sepsis
Arterial Blood Pressure-complexity in Septic Patients
Arterial blood pressure (ABP) is regulated by multiple, interconnected feedback loops resulting in a variable and complex time course.
- Trial name
- NCT00793078
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bonn
Type 2 Diabetes Mellitus (T2DM)
Brain-Heart Axis in Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus (T2DM) is associated with chronic hyperglycemia and metabolic disturbances that affect not only glucose metabolism but also the central nervous system, autonomic nervous system, and cardiovascular…
- Trial name
- NCT07757308
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Hacettepe University
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