Clinical trials: Variability
Individuality
Can Omega-3 Improve Heart Rate Variability Measurement?
Heart rate variability can represent physiological and psychological levels via sympathetic and parasympathetic variables on autonomic nervous function.
- Trial name
- HRV (NCT02768636)
- Testing
- Omega-3
- Where
- 2 sites in Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vachira Phuket Hospital
Disordered Eating, Stress
Biofeedback for CHAMPS
As a result of the COVID-19 pandemic, the degree of burnout and consequential negative psychological effects experienced by healthcare providers has been substantially exacerbated.
- Trial name
- NCT04921228
- Testing
- Heart rate variability biofeedback
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Villanova University
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Laryngoscopy
The Effect of Rocuronium on the Response of Composite Variability Index (CVI) to Laryngoscopy
Eighty subjects will be recruited from those scheduled for surgery requiring general anesthesia at St Vincent's Hospital. Subjects must have American Society of Anesthesiologists (ASA) status of 1 or 2 (be fairly healthy), a BMI…
- Trial name
- NCT00926718
- Testing
- remifentanil infusion, rocuronium dose + remifentanil infusion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- St. Vincent's Medical Center
Sleep
Stable Sleep Pattern Before Sleep Loss
Sleep is now recognized as important for disease prevention. Too little or too much sleep contributes to cardiovascular disease. Leading health organizations recommend adults sleep 7-9 hours per night for optimal health.
- Trial name
- NCT06201390
- Testing
- Sleep consistency
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Cardiovascular Disease
Sources of the Variability of the Response to Fluindione in Elderly Patients (PREPA)
We propose to study the pharmacokinetic (PK) and pharmacodynamic (PD) components of the response to fluindione, the main oral anticoagulant used in France, in patients over 80.
- Trial name
- NCT00313469
- Where
- 2 sites in France
- Volunteers
- 152 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vagal Nerve Stimulation, Autonomic Nervous System
Vagal Response and Cardiac Autonomic Modulation. Insides From Cryoballoon Ablation
The investigators sought to evaluate the incidence and influence of vagal response observed during cryoballoon-based pulmonary vein isolation on the cardiac autonomic nervous system (CANS) and ablation outcomes in paroxysmal…
- Conditions
- Vagal Nerve Stimulation, Autonomic Nervous System, Catheter Ablation
- Trial name
- NCT04896424
- Testing
- cryoballoon-based pulmonary veins isolation
- Volunteers
- 296 people
- Sponsor
- Pomeranian Medical University Szczecin
Chronic Obstructive Pulmonary Disease
Perception of Symptom Variability in COPD
The objective of the study is to assess patient's perception with stable state COPD on symptom variability and to describe how symptom variability impacts daily quality of life in Chinese COPD patient with moderate, severe or…
- Trial name
- NCT01753427
- Where
- 6 sites in China
- Volunteers
- 1,058 people
- Sponsor
- AstraZeneca
Older Adult
Heart Rate Variability Biofeedback in Older Adults
Older adults will be randomly assigned to an active heart rate variability biofeedback condition and a "sham" control condition.
- Trial name
- NCT05902286
- Testing
- OSC+, OSC-
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Duchenne Muscular Dystrophy
Heart Rate Variability in Individuals With Duchenne Muscular Dystrophy
A cross-sectional study was carried out, in which 40 boys, aged 11 to 18 years, were evaluated. The recruitment of groups was carried out at the neuromuscular disease outpatient clinic of the Federal University of São Paulo…
- Trial name
- NCT04740554
- Testing
- Duchenne Muscular Dystrophy group with Deflazacort, Duchenne Muscular Dystrophy group with Prednisone/Predisolone, Duchenne Muscular Dystrophy group without Corticosteroids therapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hemophilia A
Evaluation of a Standardized Protocol for Thrombin Generation Assay
This study is aims at determining the inter laboratory variation when using the thrombin generation assay calibrated automated thrombogram (TGA CAT). It is thus, not a clinical trial in its usual meaning.
- Trial name
- NCT03313531
- Testing
- Thrombin Generation Assay, Treatment with recombinant coagulation factor
- Where
- Sweden
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Lund University
Parkinson Disease
The WalkingTall Study: Comparing WalkingTall With Parkinson's Disease (WalkingTall-PD) With Mobility-plus to Reduce Falls and Improve Mobility.
The purpose of this study is to determine and compare the effectiveness of WalkingTall-PD (the new intervention) against Mobility-plus (a PD appropriate exercise program) with respect to stabilizing gait, reducing step-time…
- Trial name
- WalkingTall-PD (NCT04613141)
- Testing
- WalkingTall-PD, Mobility-plus
- Where
- Australia
- Volunteers
- 62 people
- Sponsor
- Neuroscience Research Australia
Behavior, Social, Autonomic Imbalance
Coping Strategies and Responsiveness to a Brief Online Intervention During COVID-19 Pandemic
The present study investigates the efficacy of a brief and cost-effective video-intervention that combines bottom-up elements of deep breathing and third-wave cognitive behavioral therapy techniques (i.e., mindfulness and…
- Trial name
- NCT04382560
- Testing
- Deep Breathing training, Compassion focused intervention
- Where
- Italy
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Parma
Intensive Care Units, Neonatal, Infant, Newborn
Heterogeneity Index in Neonatologist-performed Lung Ultrasound in Neonates Receiving Respiratory Support - a Pilot Study
Lung ultrasound is an increasingly valuable diagnostic tool in neonatal intensive care due to its safety and accessability. This pilot study investigates whether a quantitative approach - the heterogeneity index, previously only…
- Conditions
- Intensive Care Units, Neonatal, Infant, Newborn, Infant, Premature, Point-of-Care Systems
- Trial name
- NPLUS HI (NCT07117513)
- Where
- 2 sites in Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Anxiety, Heart Rate Variability (HRV)
Anxiety and Physiological Responses in Ambulatory Surgery
This study aims to investigate the effects of music intervention on subjective anxiety and physiological indicators, including heart rate, blood pressure, and heart rate variability, in first-time ambulatory surgery patients, and…
- Conditions
- Anxiety, Heart Rate Variability (HRV), Heart Rate, Blood Pressure
- Trial name
- NCT07476820
- Testing
- Self-selected Music intervention, Fixed-music Music intervention
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Da-Yeh University
Anesthesia, General
The Effects of Dexmedetomidine and Tracheal Intubation on Heart Rate Variability and QTc Interval
The purpose of this study is to investigate effect of dexmedetomidine and tracheal intubation on heart rate variability and QTc interval.
- Trial name
- NCT01584570
- Testing
- 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Sedation During
Composite Variability Index Versus Bispectral Index (BIS)
The aim of this study is to compare the accuracy of the changes in CVI in response to a standardized noxious stimulus during various targeted pseudo-steady-state concentrations of remifentanil and various steady state level of…
- Trial name
- NCT01053611
- Testing
- propofol + remifentanil 0 ng/ml, propofol + remifentanil 2 ng/ml, propofol + remifentanil 4 ng/ml
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- University Medical Center Groningen
Depression
Effects of Fish-oil on Mood and Cognitive Functions of Healthy Individuals
The investigators recently found a positive effect of omega-3 supplements on cognitive function in healthy individuals after 4 weeks (J of Psychopharmacology 2009, 23: 831-840).
- Trial name
- NCT01104194
- Testing
- omega-3 fatty acids supplements (fish oil)
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Breathing Exercises, Auricular Vagus Nerve Stimulation
Breathing Exercises and Auricular Vagus Nerve Stimulation
Introduction: Vagal modulation is achieved directly by transcutaneous auricular vagus nerve stimulation, whereas breathing exercises stimulate arterial baroreceptors.
- Conditions
- Breathing Exercises, Auricular Vagus Nerve Stimulation, Autonomic Nervous System
- Trial name
- NCT06531954
- Testing
- Vagus nerve stimulation, Breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Electricity; Effects, Heart Arrhythmia
Transcutaneous Electrical Stimulation & Sinoatrial Node Function
Transcutaneous electrical stimulation (TES) is used in clinical practice to diagnose or treat a diverse range of medical conditions for over a century.
- Trial name
- TENS&HR (NCT05966922)
- Testing
- Transcutaneous Electrical Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
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