Clinical trials: Variceal Hemorrhage
Variceal Hemorrhage
RCT to Determine the Efficacy of Combining Hemospray With Medical Treatment in Acute Variceal Bleeding
INTRODUCTION Acute variceal bleeding (AVB) is a severe complication of portal hypertension in patients with liver cirrhosis. The primary therapy includes the administration of vasoactive drugs, antibiotics and endoscopic therapy…
- Trial name
- NCT03061604
- Testing
- Hemospray, Octreotide, Blood transfusion
- Where
- 2 sites in Belgium, Egypt
- Volunteers
- 105 people
- Sponsor
- Theodor Bilharz Research Institute
Cirrhosis, Esophageal and Gastric Varices
Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis
The APIXABAN-PK trial is a prospective, randomized, single-blind, placebo-controlled study designed to evaluate the efficacy and safety of apixaban in combination with carvedilol versus placebo with carvedilol in preventing…
- Conditions
- Cirrhosis, Esophageal and Gastric Varices, Ascites, Hepatic Encephalopathy
- Trial name
- APIXABAN-PK (NCT07521332)
- Testing
- Apixaban, Carvedilol
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Asian Institute Of Medical Sciences
Cirrhosis
Noninvasive Tests to Predict the Presence of Esophageal Varices in Patients With Liver Cirrhosis
Liver cirrhosis is caused by chronic liver diseases, varices exist in 30 - 60% of patients with liver cirrhosis. Variceal bleeding is one of the most important complications of cirrhosis, accelerating the progression of…
- Trial name
- NCT03513887
- Where
- China
- Volunteers
- 111 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Cirrhosis
Secondary Prophylaxis Gastric Variceal Bleed
The investigators conducted a randomized, controlled trial (RCT) to study the efficacy of beta blockers versus endoscopic cyanoacrylate injection in the prevention of gastric variceal (GOV2 or IGV1) rebleeding and improvement in…
- Trial name
- NCT00888784
- Testing
- Endoscopic Cyanoacrylate injection, beta-blocker (propranolol)
- Where
- India
- Volunteers
- 64 people
- Sponsor
- Govind Ballabh Pant Hospital
Esophageal Varices, Bleeding
EVL (Endoscopic Variceal Ligation) Plus Vasoconstrictor vs.Ligation Plus PPI( Proton Pump Inhibitor) in the Control of Acute Esophageal Variceal Bleeding
Previous studies showed that combination of endoscopic therapy with vasoconstrictor is better than either vasoconstrictor or endoscopic therapy alone in achieving the successful hemostatsis of acute variceal bleeding.
- Trial name
- EVL (NCT01112852)
- Testing
- pantoloc 40 mg, somatostatin or terlipressin
- Volunteers
- 118 people
- Sponsor
- National Science and Technology Council, Taiwan
Liver Cirrhosis, Esophageal and Gastric Varices
Effects of Terlipressin When Usual Somatostatin or Octreotide Dose Fails
To observe and access the Effects and safety of terlipressin or high dose somatostatin/octreotide when usual dose somatostatin/octreotide fail to achieve hemostasis in patients with acute variceal bleeding.
- Conditions
- Liver Cirrhosis, Esophageal and Gastric Varices, Hemorrhage
- Trial name
- CER:T (NCT02311608)
- Testing
- Terlipressin, Usual Dose Somatostatin/Octreotide, High Dose Somatostatin/Octreotide
- Where
- China
- Volunteers
- 1,320 people
- Sponsor
- Shanghai Zhongshan Hospital
Portal Hypertension
Austrian Registry on Transjugular Intrahepatic Portosystemic Shunts
Patients with TIPS will be recruited in this prospective registry study. The clinical course will be documented and biomarkers for prediction of complicatiosn will be assessed.
- Trial name
- AUTIPS (NCT03409263)
- Testing
- Observational study
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Thomas Reiberger
Variceal Bleeding, Portal Hypertension
Construction of a Portal Hypertension Biobank
Esophageal and gastric variceal bleeding (EGVB) is a severe complication of portal hypertension (PH), characterized by high bleeding volume, high rebleeding rate, and high mortality.
- Trial name
- NCT07419724
- Testing
- Endoscopic treatment
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
GastroIntestinal Bleeding, Anemia
Iron Supplementation in Upper Non-variceal Gastrointestinal Bleeding
Anemia is a frequent complication of gastrointestinal bleeding, affecting 61% of the patients. Currently, anemia caused by gastrointestinal bleeding can be treated with iron supplementation.
- Trial name
- FIERCE (NCT05060731)
- Testing
- Oral iron supplementation, Intravenous iron supplementation
- Where
- Hungary
- Volunteers
- 570 people
- Sponsor
- University of Pecs
Liver Cirrhosis, Gastroesophageal Varices
Risk Prediction of Bleeding in Liver Cirrhosis by Combi-elastography
Through the parameters of liver stiffness and spleen stiffness obtained by combi-elastography technique, summarize and analyze the warning index of esophagogastric variceal bleeding in patients with cirrhosis, so as to provide a…
- Conditions
- Liver Cirrhosis, Gastroesophageal Varices, Variceal Hemorrhage
- Trial name
- NCT04640350
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Coagulation Disorder, Cirrhosis, Liver
Heparin Like Effect in Acute Variceal Bleeding
This study attempts to clarify the pathophysiology of haemostasis in relation to the evidence of sepsis in liver disease, and compares the accuracy of various available laboratory tests in assessment of these patients.
- Conditions
- Coagulation Disorder, Cirrhosis, Liver, Variceal Hemorrhage
- Trial name
- NCT04111120
- Testing
- SONOCLOT, coagulation factor assays for VIII/X, XIII, TPA/ PAI
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Portal Hypertension
Multimodal Ultrasound and Portal Hypertension
According to international guidelines, Hepatic Venous Pressure Gradient is the gold standard technique for portal hypertension measurement, but it is invasive and poorly available.
- Trial name
- NCT05789641
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Portal Vein Thrombosis, Anticoagulant Therapy
Direct Oral Novel Anticoagulants for Patients With High-risk Gastroesophageal Variceal Bleeding and Portal Vein Thrombosis
This study aims to explore the safety and efficacy of oral administration of a novel anticoagulant (rivaroxaban) in patients with cirrhosis accompanied by high-risk esophagogastric variceal bleeding and portal vein thrombosis…
- Conditions
- Portal Vein Thrombosis, Anticoagulant Therapy, Variceal Bleeding
- Trial name
- NCT07602062
- Testing
- Rivaroxaban
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Shanghai Zhongshan Hospital