Clinical trials: Varicose Vein Disease
Varicose Veins
Validity of Electronic Diary for Monitoring Varicose Veins Symptoms
The purpose of this study is to contribute to the validation of an electronic daily diary to assess symptoms in patients with varicose veins.
- Trial name
- NCT01200199
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Boston Scientific Corporation
Varicose Veins, Pregnancy Related
Graduated Elastic compRession for vAricose Veins in PrEgnancy
This study will be evaluate the clinical efficacy of using graduated compression hosiery for venospecific symptoms, leg edema, and quality of life (QoL) in pregnant women with varicose veins (VV's).
- Conditions
- Varicose Veins, Pregnancy Related, Quality of Life
- Trial name
- GRAPE (NCT05122195)
- Testing
- Compression therapy
- Where
- 2 sites in Belarus
- Volunteers
- 80 people
- Sponsor
- Belarusian State Medical University
Diabetic Ulcers, Venous Leg Ulcer
PMCF Study of Debridement Pad
The design of the study is a clinical trial of Debridement Pad in subjects with superficial, chronic and acute wounds consisting of Diabetic ulcers, Arterial and Venous Leg ulcers, Pressure ulcers, Postoperative wounds healing by…
- Conditions
- Diabetic Ulcers, Venous Leg Ulcer, Arterial Leg Ulcer, Pressure Ulcer
- Trial name
- NCT07255937
- Testing
- Debridement Pad
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- Advanced Medical Solutions Ltd.
Varicose Veins
Compression Therapy Following Endothermal Ablation
This study will be looking at the effect of compression therapy in patients having endovenous treatment for truncal incompetence of their varicose veins using either radiofrequency ablation (RFA) or endovenous laser therapy…
- Trial name
- COMETA (NCT02522845)
- Testing
- Class II Compression Stockings (no specific device used)
- Where
- United Kingdom
- Volunteers
- 204 people
- Sponsor
- Imperial College London
Compression; Vein, Patient Satisfaction
Patients Commitment to Compression Therapy
The study Patients Commitment to compression therapy (POMP) is observational, prospective. After the Phlebologist consultation after 1 month and 1 year, a telephone questionnaire is carried out for the patients included in the…
- Trial name
- POMP (NCT04096729)
- Testing
- compression stockings
- Where
- 2 sites in Belarus
- Volunteers
- 400 people
- Sponsor
- Belarusian State Medical University
Venous Leg Ulcer (VLU)
An Open Label, Single Treatment, Single Arm, Multiple Dose Phase-2 Study to Evaluate the Pharmacokinetics, Safety, and Clinical Performance of EscharEx (EX-03) in Participants With Venous Leg Ulcers
This is a pharmacokinetics (PK) study - the main objective of this study is to assess the PK, safety and clinical performance of 5% EscharEx (EX-03 formulation) in debridement of Venous Leg Ulcers
- Trial name
- NCT07692178
- Testing
- EX-03
- Volunteers
- 20 people
- Sponsor
- MediWound Ltd
Chronic Venous Disorder, Varicose Veins Leg
Prolonged Compression Following Foam Sclerotherapy
Foam-form sclerotherapy is an effective method for eliminating varicose veins, which can be used alone or in combination with other interventions (laser or radiofrequency ablation, cyanoacrylate glue embolization) in the…
- Trial name
- ProCOMFFS (NCT06766968)
- Testing
- Graduated Compression Stocking: 1 month using, Graduated Compression Stocking: 1 week using
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- Pirogov Russian National Research Medical University
Venous Ulcer
Clinical Trial With Adipose Tissue Stem Cells on Biological Matrix for the Treatment of Venous Ulcer of the Lower Limbs
Phase I-II, Multicenter, Randomized, Controlled, Proof of Concept Clinical Trial to determine feasibility, safety and efficacy of the use of Allogenic adipose-derived adult mesenchymal stem cells expanded on fibrinhyaluronic…
- Trial name
- NCT05962931
- Testing
- Bioengineered Artificial Mesenchimal Sheet (BAMS), Standard treatment (Control)
- Where
- 3 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Andalusian Network for Design and Translation of Advanced Therapies
Wounds and Injuries, Venous Leg Ulcer
DURAFIBER Ag Post-Market Clinical Follow-Up
The aim of the study is to evaluate the performance of DURAFIBER Ag and to assess how many bacteria are present in infected wounds over an 8 week period.
- Conditions
- Wounds and Injuries, Venous Leg Ulcer, Infection
- Trial name
- NCT03277131
- Testing
- DURAFIBER Ag
- Where
- 7 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Smith & Nephew, Inc.
Venous Ulcer, Foot Ulcer, Diabetic
Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing
Leg and foot ulcers due to venous disease or diabetes are chronic wounds that can take 6 or more months to heal. Growth factors have been used to try and improve this healing, however, many such studies have failed, and that is…
- Trial name
- NCT02845466
- Testing
- Becaplermin, Promagran Dressing
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Venous Leg Ulcer
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)
The aim of this clinical trial is to investigate the efficacy and safety of allo-APZ2-CVU, administered topically on therapy-resistant non-healing CVUs compared to placebo.
- Trial name
- NCT06489028
- Testing
- allo-APZ2-CVU
- Where
- 15 sites in United States, Austria and 10 more
- Volunteers
- 250 people
- Sponsor
- RHEACELL GmbH & Co. KG
Venous Stasis Ulcers
A Post Marketing Clinical Study Utilizing DermaStream and Saline in Venous Ulcers
An open-label, prospective, controlled, two-step approach, post-marketing clinical study, applying DermaStream with saline streaming, in conjunction with a sustained multi-compression wrap, on healthy individuals and on patients…
- Trial name
- NCT01129986
- Testing
- DermaStream
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- EnzySurge
Varicose Veins of Lower Limb, Varix
Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins
The study is aimed at assessing the dynamics of changes in biochemical markers of venous wall remodeling (type 1 plasminogen activation inhibitor (PAI-1), fibronectin (fibronectin, FN), vimentin (vimentin, VM), von Willebrand…
- Conditions
- Varicose Veins of Lower Limb, Varix, Vascular Diseases, Leg Edema
- Trial name
- NCT06367166
- Testing
- "Venarus®" (diosmin and hesperidin), Endovenous laser ablation (EVLA) with miniphlebectomy, Elastic compression
- Where
- Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
Varicose Veins
A Trial to Compare the Outcome of Localised Varicosity Compression for 24 Hours and 5 Days After Foam Sclerotherapy to Truncal Varices
The purpose of this study is to compare the results of foam treatment of varicose veins (foam sclerotherapy) in patients who wear compression bandages for 24 hours or 5 days after treatment.
- Trial name
- NCT00991497
- Testing
- Compression bandaging
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Venous Stasis Ulcer
Efficacy Study of the Application of Low Level Laser Light to Treat Venous Stasis Ulcers
The purpose of this study is to determine whether low level laser light therapy is effective as an adjunctive therapy to the healing of venous stasis leg ulcers.
- Trial name
- NCT01376050
- Testing
- Erchonia ML Scanner (MLS)
- Where
- 2 sites in United States, France
- Volunteers
- 24 people
- Sponsor
- Erchonia Corporation
Venous Leg Ulcer
Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01)
It is hypothesized that application at 4-week intervals of the human umbilical cord tissue TTAX01 to the surface of a well debrided, nonhealing venous leg ulcer (VLU) will result in a high proportion of wounds showing complete…
- Trial name
- NCT03818828
- Testing
- TTAX01, Profore Compression Therapy, Cadexomer Iodine dressing
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- BioTissue Holdings, Inc
Venous Leg Ulcer, Lymphovenous Edema
Lymphovenous Bypass Manage Venous Leg Ulcers
Leg ulcers are areas of epidermal discontinuity in lower limbs with causes of venous, arterial, diabetic, pressure, traumatic, allergic, or inflammation.
- Trial name
- NCT05068258
- Testing
- Lymphovenous bypass, including lymphaticovenular anastomosis/implantation
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- National Taiwan University Hospital
Varicose Ulcer
MIST Ultrasound Therapy Compared to United Kingdom Standard Care for the Treatment of Non-healing Venous Leg Ulcers
Chronic venous leg ulcers (VLUs) impact negatively on patients' quality of life. Standard treatment in the UK for patients with VLUs is compression bandaging or stockings.
- Trial name
- NCT01671748
- Testing
- MIST ultrasound therapy, Standard Care
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- Cardiff and Vale University Health Board
Varicose Ulcer
Endovenous Ablation Combined With Fat Grafting for Venous Ulcers
The aim of this trial is to determine if fat grafting may have applicability to venous ulcers by comparing healing and recurrence rates in patients who receive combined fat grafting and endovenous ablation with patients who…
- Trial name
- NCT05241704
- Testing
- Fat grafting, Endovenous ablation of superficial venous reflux
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- National University of Ireland, Galway, Ireland
Cirrhosis, Portal Hypertension
Efficacy of Long-acting Octreotide (Sandostatin LAR) in Reducing Portal Pressure in Patients With Cirrhosis
Octreotide is used to control variceal bleeding. However, octreotide has to be given through the vein and is effective for less than two hours.
- Conditions
- Cirrhosis, Portal Hypertension, Esophageal Varices
- Trial name
- NCT01188733
- Testing
- Long acting octreotide 10mg, Long acting Octreotide 30mg, Saline
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic