Clinical trials: Varicose Vein Disease
Skin Ulcer Venous Stasis Chronic, Mixed Arteriovenous Leg Ulcer
Pilot Study Comparing NatroxTM Topical Oxygen Therapy to A Placebo in the Management of Non-Healing Leg Ulcers
The purpose of this study is to determine the effectiveness of the NatroxTM Topical Oxygen device versus a placebo in patients with non-healing leg ulceration in conjunction with standard best practice.
- Trial name
- NCT01913704
- Testing
- NatroxTM Device
- Where
- 2 sites in Czechia
- Sponsor
- Inotec AMD Limited
Varicose Veins, Cicatrix
Juvista (Avotermin) in Scars Following Varicose Vein Removal
This trial is being undertaken to investigate the efficacy and safety of Juvista in the improvement of scar appearance when administered to approximated wound margins following varicose vein surgery.
- Trial name
- NCT00430326
- Testing
- Avotermin
- Where
- 21 sites in Belgium, Latvia and 2 more
- Volunteers
- 156 people
- Sponsor
- Renovo
Venous Ulcers
Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers
This study will test the safety and efficacy of nitric oxide gas in the treatment of venous leg ulcers
- Trial name
- NCT00545298
- Testing
- Nitric Oxide - same dose 6 wks, Nitric Oxide modified treatment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Nitric BioTherapeutics, Inc
Chronic Venous Insufficiency, Varicose Veins of Lower Limb
Evaluation of Pain Associated With Chronic Venous Insufficiency
Chronic venous insufficiency occurs when your leg veins don't allow blood to flow back up to your heart. Normally, the valves in your veins make sure that blood flows toward your heart.
- Trial name
- NCT04794712
- Testing
- Venous reflux tools (Ultrasound and Photo plethysmography (PPG))
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Imperial College London
Chronic Wounds, Diabetic Foot Ulcer
Subcutaneous Dexpanthenol Administration and Wound Epithelialization
Chronic wounds are wounds that do not heal properly over time and can significantly reduce quality of life. Common types include diabetic foot ulcers, venous leg ulcers, and arterial ulcers.
- Conditions
- Chronic Wounds, Diabetic Foot Ulcer, Venous Leg Ulcers, Arterial Ulcer
- Trial name
- DEXPAN-WOUND (NCT07395674)
- Testing
- Dexpanthenol, Standard Wound Care
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dilara CANBAY OZDEMIR
Venous Disease
Perforator Vein Injection for Symptomatic Venous Disease
The primary objective of this study is to compare two treatment strategies for symptomatic venous stasis disease with and without venous ulcer. These treatments are compression therapy alone vs.
- Trial name
- Dillavou (NCT03363633)
- Testing
- sodium tetradecyl sulfate, Compression
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ellen Dillavou
Wounds, Pressure Ulcer
Kerecis Real-World Fish Skin Graft Registry
Multi-center, observational (i.e., non-interventional), open-label, real-world Registry on the Use of Kerecis Devices
- Conditions
- Wounds, Pressure Ulcer, Diabetic Foot Ulcer, Venous Leg Ulcer
- Trial name
- ISACOD (NCT06384183)
- Testing
- Kerecis Fish Skin Graft
- Where
- 6 sites in United States
- Volunteers
- 600 people
- Sponsor
- Kerecis Ltd.
Varicose Veins
Efficacy of the SALFOAM 3% Method Compared to the Conventional Polidocanol Foam Method (Tessari Method) for Treating Lower Limb Varicose Veins
This clinical trial aims to assess the efficacy and safety of the SALFOAM 3% method, which involves saline wash, polidocanol 3% foam injection, and extrinsic compression using Lidstop®, in comparison with the conventional Tessari…
- Trial name
- SALFOAM 3% (NCT06667570)
- Testing
- SALFOAM 3%, Control Group
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- Lidiane Rocha
Varicose Veins of Lower Limb, Great Saphenous Vein (GSV) With Venous Reflux Disease
Endovenous Laser Ablation With 1940 nm Versus 1470 nm
1. Study Design: A single-blind, prospective, randomized controlled trial (RCT) conducted at Kafrelsheikh University Hospital to compare the efficacy and safety of 1940 nm vs. 1470 nm diode lasers for EVLA. 2.
- Trial name
- EVLA (NCT07603570)
- Testing
- EVLA for SFJ with laser 1470, EVLA for SFJ with laser 1940
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Kafrelsheikh University
Varicose Veins
A Study of Soundscapes for Patient Wellbeing
The purpose of this study is to assess the impact of immersive soundscape on patient pain, stress, anxiety, heart rate and blood pressure during an outpatient vascular surgery procedure.
- Trial name
- NCT05650073
- Testing
- Immersive soundscapes
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Mayo Clinic
Heart Failure，Congestive, Leg Edema
The ROle of Compression StocKings in Heart Failure Patients
Congestive heart failure (CHF) occurs when the heart is weak and not able to effectively pump blood to the body. One of the common manifestations of CHF is fluid overload and swelling of the legs.
- Conditions
- Heart Failure，Congestive, Leg Edema, Venous Insufficiency, Venous Ulcers
- Trial name
- ROCK-HF (NCT06350695)
- Testing
- low grade compression stockings (10-15 mmHg), high grade compression stockings (20-30 mmHg)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Diabetic Foot Ulcer, Venous Leg Ulcer
Assessment of Wound Closure Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers (DFU) and With Living Cellular Skin Substitute in Treating Venous Leg Ulcers (VLU)
In participants with diabetic foot ulcers (DFUs), this study will assess complete wound closure by comparing synthetic hybrid-scale fiber matrix (Restrata®) with standard of care.
- Trial name
- NCT04927702
- Testing
- Synthetic Hybrid-Scale Fiber Matrix, Standard of Care, Living Cellular Skin Substitute
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Acera Surgical, Inc.
Venous Leg Ulcer
A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers
Venous leg ulcers are lower extremity ulcers that develop due to sustained venous hypertension resulting from chronic venous insufficiency.
- Trial name
- NCT03903692
- Testing
- Marine polysaccharide dressing, Carboxymethylcellulose dressing
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Medline Industries
Venous Insufficiency, Varicose Veins
Efficacy and Safety of Endovenous Microwave Ablations for Treatment of Varicose Veins in Singapore
The purpose of this study is to assess change in patient's symptoms before and after Endovenous Microwave Ablation (EMA) as treatment for varicose veins.
- Conditions
- Venous Insufficiency, Varicose Veins, Vascular Diseases
- Trial name
- MAESTRO (NCT04524793)
- Testing
- Questionnaires, Physical examinations
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore General Hospital
Varicose Veins
Microwave Venous Ablation in Comparison to Radiofrequency Ablation, Laser Ablation and Surgical Ligation in Management of Great Saphenous Vein Incompetence
The authors will aim to compare microwave therapy with other lines of management radio-frequency ablation, Laser ablation and surgical ligation; regarding time to recurrence rate, ulcer-free time, and health-related quality of…
- Trial name
- NCT04479956
- Testing
- Varicose vein surgery
- Where
- 2 sites in Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Chronic Liver Disease, Esophageal Varices
Blood Ammonia as Predictor for Esophageal Varices and Risk of Bleeding
Assessment of blood ammonia level as a non-invasive predictor for presence of EV and risk of bleeding
- Trial name
- EV (NCT03212872)
- Testing
- Endoscopy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Venous Insufficiency, Leg Ulcer
The Evaluation of OrCel for the Treatment of Venous Ulcers
This study was designed to confirm the clinical benefits and safety of OrCel in the treatment of venous ulcers. OrCel and standard care are compared to standard care alone.
- Trial name
- NCT00270972
- Testing
- Bilayered Cellular Matrix (OrCel)
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Ortec International
Venous Leg Ulcers
Amnioband and Standard of Care vs. Standard of Care Alone in the Treatment of Venous Leg Ulcers
Lower extremity ulcers pose significant clinical, humanistic and economic burdens on society. Millions of Americans are afflicted with painful, open, draining sores on their lower extremities.
- Trial name
- NCT02609594
- Testing
- Weekly application of Amnioband, Biweekly application of Amnioband, Standard of Care
- Where
- 8 sites in United States
- Volunteers
- 240 people
- Sponsor
- SerenaGroup, Inc.
Venous Leg Ulcer
A Prospective Randomized, Double-Blind, Placebo-Controlled Trial Comparing VitroGro® ECM to Placebo in Patients With Venous Leg Ulcers
The objective of this study is to assess the efficacy and safety of VitroGro® combined with standard care in the treatment of Venous Leg Ulcers (VLUs) compared to Placebo with standard care over the course of the 8-week treatment…
- Trial name
- NCT01982318
- Testing
- VitroGro® ECM, Dulbecco's Phosphate Buffered Saline
- Sponsor
- Tissue Therapies Ltd.
Varicose Veins
Prospective Randomized Trial Comparing the New Endovenous Procedures Versus Conventional Surgery for Varicose Veins Due to Great Saphenous Vein Incompetence
Through a prospective RCT evaluate and compare the three new endovenous methods for great saphenous vein ablation (Radiofrequency, endovenous laser and foam sclerotherapy) versus high ligation and stripping.
- Trial name
- RAFPELS (NCT00621062)
- Testing
- High Ligation of the GSV, Endovenous Laser Ablation, Radiofrequency ablation
- Where
- Sweden
- Volunteers
- 540 people
- Sponsor
- Uppsala University