Clinical trials: Varicose Vein Disease
Venous Leg Ulcer (VLU)
OCM™ Treatment With Routine Care in Venous Leg Ulcers Compared to Routine Care Treatment Alone.
The purpose of the study is to assess the use of OCM™ for the treatment of vascular leg ulcers (VLUs). The study seeks to evaluate the results of treating VLUs with OCM™ plus routine care and compression for complete wound…
- Trial name
- NCT07754526
- Testing
- Omeza OCM™ Wound Matrix, Routine Care
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Omeza, LLC
TIPS, Portal Hypertension
TIPS for Complicated Portal Hypertension Related to Porto-Sinusoidal Vascular Disease
Porto-sinusoidal Vascular Disease (PSVD) is characterized by a portal hypertension (PH) without cirrhosis. This can induce PH complications, like digestive hemorrhage from esophageal or gastric varices, ascites, or even portal…
- Conditions
- TIPS, Portal Hypertension, Porto-Sinusoidal Vascular Disease, Refractory Ascite
- Trial name
- TIPS-PSVD (NCT07163689)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Varicose Veins, Varicose Veins of Lower Limb
The Evaluation of the Pathophysiology of Varicose Veins in Pregnancy
Varicose veins (VV) are the early sign of Chronic venous insufficiency (CVI) which are characterised by abnormal tortuosity and dilatation of superficial veins of lower limb extremities.
- Conditions
- Varicose Veins, Varicose Veins of Lower Limb, Chronic Venous Insufficiency, Varicose; Vessel
- Trial name
- NCT05058989
- Testing
- Advanced ultrasound measurements (Duplex ultrasound (DUS) and Vector flow imaging (VFI), Clinical interventions and procedures
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Varicose Veins
Validity of Electronic Diary for Monitoring Varicose Veins Symptoms
The purpose of this study is to contribute to the validation of an electronic daily diary to assess symptoms in patients with varicose veins.
- Trial name
- NCT01200199
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Boston Scientific Corporation
Varicose Ulcer
A Post-Marketing Clinical Study of Apligraf for Venous Leg Ulcers
Single site clinical study utilizing the novel technology of microarrays to identify and characterize the molecular mechanisms through which Apligraf promotes healing of venous leg ulcers.
- Trial name
- NCT00648674
- Testing
- Apligraf
- Sponsor
- Organogenesis
Venous Leg Ulcer, Diabetic Foot
AQUACEL® Ag+ Extra™ vs Cutimed® Sorbact®
Study is to provide a blinded assessment of wound closure status utilizing photographs collected as per standard of care (SOC) during the AAA RCT (WC-22-435).
- Trial name
- NCT07308678
- Where
- Germany
- Volunteers
- 105 people
- Sponsor
- ConvaTec Inc.
Debridement Care, Leg Ulcer
Effectiveness of Musicotherapy in Reducing Pain Induced by Leg Ulcer Care
Venous leg ulcer is the final stage of chronic venous disease and only develops due to advanced chronic venous insufficiency. The problems caused by venous disease are initially minor and often neglected, but can impact the…
- Conditions
- Debridement Care, Leg Ulcer, Leg Ulcers Venous, Pain
- Trial name
- MUS-ICAT (NCT06153589)
- Testing
- Musicotherapy
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital Center of Martinique
Ulcer Venous, Ulcer Foot
Efficacy of a New Composition (BU002) for Debridement of Chronic Cutaneous Ulcers
This study is testing a new liquid treatment for people with long-lasting (chronic) wounds, such as venous leg ulcers or diabetic foot ulcers.
- Trial name
- NCT07607106
- Testing
- BU002, Polyhexanide 0.1% and betaine 0.1% gel
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Universidad del Desarrollo
Varicose Veins, Insufficiency of Great Saphenous Vein
Clinical Trial of Endovenous 940 and 1470 Laser Ablation for Treating Great Saphenous Veins
A clinical randomized controlled trial, comparing 2 endovenous laser ablation (EVLA) techniques in patients with insufficiency of the great saphenous vein (GSV).
- Trial name
- COLA (NCT01637181)
- Testing
- Endovenous laser ablation (EVLA)
- Where
- Netherlands
- Volunteers
- 142 people
- Sponsor
- Erasmus Medical Center
Venous Leg Ulcer
Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01)
It is hypothesized that application at 4-week intervals of the human umbilical cord tissue TTAX01 to the surface of a well debrided, nonhealing venous leg ulcer (VLU) will result in a high proportion of wounds showing complete…
- Trial name
- NCT03818828
- Testing
- TTAX01, Profore Compression Therapy, Cadexomer Iodine dressing
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- BioTissue Holdings, Inc
Quality of Life, Varicose Veins
Quality of Life and Health Perception After Surgery of Varicose Veins
The aim of this study is to analyze changes in health perception and quality of life in patients after surgery for varicose veins using clinical score VCSS and QoL scores SF12 as general health questionary and Veines QoL/Sym as…
- Trial name
- NCT06290973
- Testing
- surgery of varicose veins
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Venous Leg Ulcer
Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Venous Leg Ulcers
The purpose of this study is to determine the systemic exposure of Granexin® gel after topical application to human subjects' venous leg ulcers.
- Trial name
- NCT02652572
- Testing
- Granexin
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Xequel Bio, Inc.
Hemorrhoid, Hemorrhoidal Disease
Nimsai Herbal for Grade 2-3 Hemorrhoids: A Quadruple-Blind Placebo-Controlled Mechanistic Trial
This randomized, quadruple-blind, placebo-controlled clinical trial evaluates the efficacy and safety of Nimsai Herbal, a proprietary oral phytotherapeutic formulation, in 50 participants aged 18-70 years with endoscopically…
- Trial name
- NAJ2 (NCT07669662)
- Testing
- Nimsai Herbal
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Nimsai Academia
Varicose Veins
Varicose Vein in Patients Under the Age of 40
Varicose veins are a result of valvular insufficiency and presented with twisted, enlarged veins. They not only cause cosmetic concerns but also lead to limb edema, skin pigmentation/lipodermatosclerosis, and even venous ulcers.
- Trial name
- NCT05410912
- Testing
- Great saphenous vein stripping and ambulatory phlebectomy
- Where
- China
- Volunteers
- 168 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Venous Leg Ulcer
Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers
The safety and efficacy of beta glucan products, and specifically TR 987, in the treatment of chronic venous insufficiency ulcers has been established. This study is designed to determine the most efficient method of treatment.
- Trial name
- NCT03154619
- Testing
- 0.1% TR 987
- Where
- 9 sites in United States
- Volunteers
- 80 people
- Sponsor
- SerenaGroup, Inc.
Varicose Veins
Laser Ablation Versus Mechanochemical Ablation Trial
A randomised clinical trial comparing endovenous laser ablation and mechanochemical ablation (ClariVein®) in the management of superficial venous insufficiency.
- Trial name
- LAMA (NCT02627846)
- Testing
- EVLA, ClariVein®, Lidocaine with 1:200,000 epinephrine solution
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Venous Ulcer
Axial Ablation Versus Terminal Interruption of the Reflux Source
This randomised trial aims to compare the effect on ulcer healing of different means of managing venous reflux in the lower limb.
- Trial name
- AAVTIRS (NCT04484168)
- Testing
- Terminal Interruption of the Reflux Source, Axial Ablation
- Where
- Ireland
- Volunteers
- 308 people
- Sponsor
- University College Hospital Galway
Venous Leg Ulcer
Clinical Study Of Affinity Versus SOC In The Management Of VLUs
This prospective, multi-center, randomized, controlled clinical study compares Affinity® plus SOC to SOC alone in subjects with VLUs.
- Trial name
- NCT04901013
- Testing
- Affinity
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Organogenesis
Venous Leg Ulcer
Evaluating the Efficacy of NeoThelium FT in the Treatment of Venous Leg Ulcers
This is a randomized controlled trial evaluating the efficacy of NeoThelium FT in conjunction with standard of care vs. standard of care alone in treating venous leg ulcers.
- Trial name
- NCT06930768
- Testing
- Standard of Care, NeoThelium FT
- Volunteers
- 132 people
- Sponsor
- NuScience Medical Biologics, LLC
Varicose Veins, Surgery
MIcronized Flavonoid Fraction After MechanO-Chemical Ablation
This study will be evaluate the clinical efficacy of micronized purified flavonoid fraction (MPFF) phlebotropic therapy for postoperative pain, venospecific symptoms, and quality of life in patients with incompetent great or…
- Trial name
- MIFFMOCA (NCT04434274)
- Testing
- Micronized Purified Flavonoid Fraction
- Where
- Belarus
- Volunteers
- 100 people
- Sponsor
- Belarusian State Medical University