Clinical trials: Varicose Veins of Lower Limb
Wounds and Injuries, Burns
ACTICOAT™ for the Treatment of Burns and Chronic Wounds
The aim of the study is to evaluate participant reported quality of life, safety, and overall performance with ACTICOAT in a clinical setting.
- Conditions
- Wounds and Injuries, Burns, Pressure Ulcer, Foot Ulcer
- Trial name
- NCT02852148
- Testing
- ACTICOAT
- Where
- 3 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- Smith & Nephew, Inc.
Venous Leg Ulcer, Venous Stasis Ulcer
Evaluation of Bilayered Cellular Matrix (OrCel) for the Treatment of Venous Ulcers
This study was designed to evaluate the clinical benefits and safety of OrCel in the treatment of venous ulcers. OrCel and standard care were compared to standard care alone.
- Trial name
- NCT00270946
- Testing
- Bilayered Cellular Matrix (OrCel)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Ortec International
Venous Leg Ulcer
Early Glue Saphenous Vein Ablation With Compression Versus Compression Alone in the Healing of the Venous Ulcer
The study evaluates the effects of early endovenous glue ablation on ulcer healing in patients with chronic venous ulceration. Half the patients are randomized to receive early endovenous ablation (within 2 weeks) and a half to…
- Trial name
- NCT03666754
- Testing
- Standard therapy arm, Early endovenous glue embolization arm
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Varicose Vein of Lower Limbs
Catheter-directed Foam Sclerotherapy With Tumescence
Foam sclerotherapy has been established as another option of treatment for varicose veins of the lower limbs. Its advantages are the application to patients with high surgical risk and immediate return to usual activities.
- Trial name
- NCT02753270
- Testing
- Short catheter, Long catheter preceded by tumescence
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Venous Thromboses, Venous Stasis
Evaluation of the OsciPulse Rapid Cycling Compression Device Effects on Venous Blood Flow
This study will evaluate the effects on venous blood flow of the investigational device, OsciPulse system, which is an external intermittent limb compression device.
- Trial name
- NCT05087108
- Testing
- OsciPulse system, Reference Therapy 1, Refence Therapy 2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- OsciFlex LLC
Varicose Veins of Lower Limb, Varicose Veins and Edema of Leg
Effects of Kinesio Taping Method on Functional Capacity and Quality of Life in Patients With Chronic Venous Disease
The purpose of this randomised and controlled study is to investigate the effects of Kinesio Taping method and compression stockings, combined with exercise therapy, on pain, edema, functional capacity and quality of life in…
- Conditions
- Varicose Veins of Lower Limb, Varicose Veins and Edema of Leg, Chronic Venous Hypertension Peripheral, Spider Veins
- Trial name
- NCT04148950
- Testing
- Kinesio Tape, Compression Stockings, Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Istanbul University
Oral Antiplatele, Anticoagulant Drugs
Effect of Oral Antiplatelet or Anticoagulant Drugs on Postoperative Bleeding Risk and Venous Closure Rate in Patients With Lower Extremity Varicose Veins After Radiofrequency Ablation
This observational study aims to assess the effect of oral antiplatelet or anticoagulant drugs on key postoperative outcomes in patients with lower extremity varicose veins who have undergone radiofrequency ablation.
- Conditions
- Oral Antiplatele, Anticoagulant Drugs, Lower Extremity Varicose Veins, Radiofrequency Ablation
- Trial name
- NCT07208695
- Testing
- Antiplatelet or Anticoagulant Drugs
- Volunteers
- 40 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Varicose Veins, Pregnancy Related
Graduated Elastic compRession for vAricose Veins in PrEgnancy
This study will be evaluate the clinical efficacy of using graduated compression hosiery for venospecific symptoms, leg edema, and quality of life (QoL) in pregnant women with varicose veins (VV's).
- Conditions
- Varicose Veins, Pregnancy Related, Quality of Life
- Trial name
- GRAPE (NCT05122195)
- Testing
- Compression therapy
- Where
- 2 sites in Belarus
- Volunteers
- 80 people
- Sponsor
- Belarusian State Medical University
Diabetic Ulcers, Venous Leg Ulcer
PMCF Study of Debridement Pad
The design of the study is a clinical trial of Debridement Pad in subjects with superficial, chronic and acute wounds consisting of Diabetic ulcers, Arterial and Venous Leg ulcers, Pressure ulcers, Postoperative wounds healing by…
- Conditions
- Diabetic Ulcers, Venous Leg Ulcer, Arterial Leg Ulcer, Pressure Ulcer
- Trial name
- NCT07255937
- Testing
- Debridement Pad
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- Advanced Medical Solutions Ltd.
Venous Leg Ulcer (VLU)
An Open Label, Single Treatment, Single Arm, Multiple Dose Phase-2 Study to Evaluate the Pharmacokinetics, Safety, and Clinical Performance of EscharEx (EX-03) in Participants With Venous Leg Ulcers
This is a pharmacokinetics (PK) study - the main objective of this study is to assess the PK, safety and clinical performance of 5% EscharEx (EX-03 formulation) in debridement of Venous Leg Ulcers
- Trial name
- NCT07692178
- Testing
- EX-03
- Volunteers
- 20 people
- Sponsor
- MediWound Ltd
Chronic Venous Disorder, Varicose Veins Leg
Prolonged Compression Following Foam Sclerotherapy
Foam-form sclerotherapy is an effective method for eliminating varicose veins, which can be used alone or in combination with other interventions (laser or radiofrequency ablation, cyanoacrylate glue embolization) in the…
- Trial name
- ProCOMFFS (NCT06766968)
- Testing
- Graduated Compression Stocking: 1 month using, Graduated Compression Stocking: 1 week using
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- Pirogov Russian National Research Medical University
Venous Ulcer
Clinical Trial With Adipose Tissue Stem Cells on Biological Matrix for the Treatment of Venous Ulcer of the Lower Limbs
Phase I-II, Multicenter, Randomized, Controlled, Proof of Concept Clinical Trial to determine feasibility, safety and efficacy of the use of Allogenic adipose-derived adult mesenchymal stem cells expanded on fibrinhyaluronic…
- Trial name
- NCT05962931
- Testing
- Bioengineered Artificial Mesenchimal Sheet (BAMS), Standard treatment (Control)
- Where
- 3 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Andalusian Network for Design and Translation of Advanced Therapies
Wounds and Injuries, Venous Leg Ulcer
DURAFIBER Ag Post-Market Clinical Follow-Up
The aim of the study is to evaluate the performance of DURAFIBER Ag and to assess how many bacteria are present in infected wounds over an 8 week period.
- Conditions
- Wounds and Injuries, Venous Leg Ulcer, Infection
- Trial name
- NCT03277131
- Testing
- DURAFIBER Ag
- Where
- 7 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Smith & Nephew, Inc.
Venous Ulcer, Foot Ulcer, Diabetic
Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing
Leg and foot ulcers due to venous disease or diabetes are chronic wounds that can take 6 or more months to heal. Growth factors have been used to try and improve this healing, however, many such studies have failed, and that is…
- Trial name
- NCT02845466
- Testing
- Becaplermin, Promagran Dressing
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Venous Leg Ulcer
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)
The aim of this clinical trial is to investigate the efficacy and safety of allo-APZ2-CVU, administered topically on therapy-resistant non-healing CVUs compared to placebo.
- Trial name
- NCT06489028
- Testing
- allo-APZ2-CVU
- Where
- 15 sites in United States, Austria and 10 more
- Volunteers
- 250 people
- Sponsor
- RHEACELL GmbH & Co. KG
Venous Stasis Ulcers
A Post Marketing Clinical Study Utilizing DermaStream and Saline in Venous Ulcers
An open-label, prospective, controlled, two-step approach, post-marketing clinical study, applying DermaStream with saline streaming, in conjunction with a sustained multi-compression wrap, on healthy individuals and on patients…
- Trial name
- NCT01129986
- Testing
- DermaStream
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- EnzySurge
Varicose Veins of Lower Limb, Varix
Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins
The study is aimed at assessing the dynamics of changes in biochemical markers of venous wall remodeling (type 1 plasminogen activation inhibitor (PAI-1), fibronectin (fibronectin, FN), vimentin (vimentin, VM), von Willebrand…
- Conditions
- Varicose Veins of Lower Limb, Varix, Vascular Diseases, Leg Edema
- Trial name
- NCT06367166
- Testing
- "Venarus®" (diosmin and hesperidin), Endovenous laser ablation (EVLA) with miniphlebectomy, Elastic compression
- Where
- Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
Venous Stasis Ulcer
Efficacy Study of the Application of Low Level Laser Light to Treat Venous Stasis Ulcers
The purpose of this study is to determine whether low level laser light therapy is effective as an adjunctive therapy to the healing of venous stasis leg ulcers.
- Trial name
- NCT01376050
- Testing
- Erchonia ML Scanner (MLS)
- Where
- 2 sites in United States, France
- Volunteers
- 24 people
- Sponsor
- Erchonia Corporation
Venous Leg Ulcer
Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01)
It is hypothesized that application at 4-week intervals of the human umbilical cord tissue TTAX01 to the surface of a well debrided, nonhealing venous leg ulcer (VLU) will result in a high proportion of wounds showing complete…
- Trial name
- NCT03818828
- Testing
- TTAX01, Profore Compression Therapy, Cadexomer Iodine dressing
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- BioTissue Holdings, Inc
Venous Leg Ulcer, Lymphovenous Edema
Lymphovenous Bypass Manage Venous Leg Ulcers
Leg ulcers are areas of epidermal discontinuity in lower limbs with causes of venous, arterial, diabetic, pressure, traumatic, allergic, or inflammation.
- Trial name
- NCT05068258
- Testing
- Lymphovenous bypass, including lymphaticovenular anastomosis/implantation
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- National Taiwan University Hospital