Clinical trials: Varix, Esophageal
Chronic Liver Disease
The SHUNT-V Study for Varices
The purpose of this study is to validate the Disease Severity Index (DSI) from the HepQuant SHUNT Liver Diagnostic Kit (Test) for likelihood of large esophageal varices.
- Trial name
- NCT03583996
- Testing
- HepQuant SHUNT Liver Diagnostic Test
- Where
- 26 sites in United States
- Volunteers
- 306 people
- Sponsor
- HepQuant, LLC
Liver Cirrhosis, Esophageal and Gastric Varices
The Effects of Early Enteral Nutrition on Endoscopic Therapy of Esophagogastric Varices in Liver Cirrhosis
The purpose of this study was to evaluate the safety of early enteral nutrition on endoscopic therapy of esophagogastric varices in Liver Cirrhosis ,and to assess the impact of different eating times on patients, so as to…
- Trial name
- NCT04823780
- Testing
- nutrient solution
- Where
- China
- Volunteers
- 397 people
- Sponsor
- Qilu Hospital of Shandong University
Liver Cirrhosis, Portal Hypertension
Extension Study of Carvedilol RCT Study
Patients who have completed 2-years treatment in RCT Study of carvedilol will receive another 2-years extension therapy, aiming to investigate the long-term efficacy of carvedilol for the prevention of esophageal varices in…
- Trial name
- NCT05021406
- Testing
- Carvedilol 12.5 MG
- Where
- 14 sites in China
- Volunteers
- 240 people
- Sponsor
- Beijing Friendship Hospital
Gastric Varix
Treatment of Gastric Varices Using EUS Guided Techniques
Bleeding from gastric varices (GV) is associated with high mortality. Injection of cyanoacrylate (CYA) using standard gastroscopes has demonstrated higher hemostasis and lower rebleeding rates compared to band ligation or…
- Trial name
- NCT03155256
- Testing
- EUS-guided injection of coils with cyanoacrylate, EUS-guided injection of coils
- Where
- Ecuador
- Volunteers
- 59 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Esophageal and Gastric Varices, Child, Only
HEMOCC Study. Hemostasis in Cirrhotic Children.
Prospective investigations into the role of hemostatic factors in the risk of variceal bleeding among children with chronic liver disease (thromboelastometry e.g) is still required.
- Trial name
- HEMOCC (NCT03244332)
- Testing
- Collecting Clinical Data, Collecting laboratory data
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Esophageal and Gastric Varices, Liver Cirrhosis
Prevention of Esophageal Varices by Beta-Adrenergic Blockers
The purpose of this study is to learn whether timolol is useful in preventing or delaying the appearance of gastroesophageal varices, a complication that may develop in the future as a consequence of liver disease.
- Conditions
- Esophageal and Gastric Varices, Liver Cirrhosis, Portal Hypertension
- Trial name
- NCT00006398
- Testing
- Timolol Maleate
- Where
- 5 sites in United States, Spain and 1 more
- Volunteers
- 213 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Gastric Varices
N-butyl-2-cyanoacrylate, Iso-amyl-2-cyanoacrylate and Hypertonic Glucose With 72% Chromated Glycerin in Gastric Varices
AIM: To compare between n-butyl-2-cyanoacrylate, iso-amyl-2-cyanoacrylate and mixture of 72% chromated glycerin with hypertonic glucose solution in management of gastric varices.
- Trial name
- NCT02330731
- Testing
- injection sclerotherapy for gastric varices
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Gastric Varices Bleeding, Gastric Varix
Combined and Simultaneous Approach for the Treatment of High-risk Gastric Varices Using B-RTO and EVO
The aim of this pilot study is to evaluate the efficacy and safety of combined and simultaneous endoscopic variceal obliteration together with balloon occluded-retrograde transvenous obliteration (B-RTO) for the treatment of…
- Trial name
- BeRTO (NCT03853720)
- Testing
- balloon-occluded retrograde transvenous and endoscopic obliteration of high-risk gastric varices
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Kidney Injury, Cirrhosis
Impact of Nonselective Beta-blocker on Acute Kidney Injury in Cirrhotic Patients With Esophageal Varices
We will include patients with EV and EVB. They will be randomized to EVL vs. NSBB for primary prevention And EVL+long-term NSBB vs. EVL+short-term NSBB for secondary prevention. 150 patients will be included in a 3-year period.
- Conditions
- Acute Kidney Injury, Cirrhosis, Esophageal Varices
- Trial name
- AKI (NCT04074473)
- Testing
- propranolol, Esophageal varice ligation, DC propranolol
- Where
- Taiwan
- Volunteers
- 170 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cirrhosis, Portal Vein Thrombosis
Safety of Anticoagulant Therapy After Endoscopic Treatment
The investigators aimed to verify the efficacy and safety of nadroparin calcium warfarin sequential (NWS) anticoagulation therapy after endoscopic therapy in PVT patients with cirrhosis and AVB.
- Conditions
- Cirrhosis, Portal Vein Thrombosis, Esophageal and Gastric Varices, Anticoagulant-induced Bleeding
- Trial name
- NCT04976543
- Testing
- nadroparin calcium-warfarin sequential anticoagulation
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Qilu Hospital of Shandong University
Esophageal Varices
Optimal Time for Follow up After Variceal Band Ligation
Optimal time for follow up after variceal band ligation in cirrhotic patients remains to be determined
- Trial name
- NCT04602663
- Testing
- Esophageal Variceal Band ligation
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Tanta University
Varicose Veins, Chronic Venous Insufficiency
The Influence of Laser Crossectomy With Different Wavelengths on Varicose Vein Progression
Technically successful laser crossectomy will reduce the risk of reflux recurrence at the sapheno-femoral junction without increasing the risk of endovenous heat-induced thrombosis, which may positively impact the likelihood of…
- Trial name
- LACROSS-VVP (NCT07449728)
- Testing
- Laser crossectomy on 1470 nm, Laser crossectomy on 1940 nm, Standard EVLT with a stump
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Pirogov Russian National Research Medical University
Cirrhosis, Esophageal and Gastric Varices
Efficacy of Rifaximin in Treatment of Cirrhotic Gastroesophageal Variceal Bleeding
The purpose of the study is to evaluate the efficacy of Rifaximin in the treatment of cirrhotic gastroesophageal variceal bleeding.
- Conditions
- Cirrhosis, Esophageal and Gastric Varices, Gastrointestinal Hemorrhage
- Trial name
- EoR-GEVB (NCT02964195)
- Testing
- Rifaximin
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute on Chronic Liver Failure
Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ no Esophageal Varices
Acute on chronic liver failure patients with HVPG (Hepatic Venous Pressure Gradient) ≥ 12 mmHg + No/small esophageal varices who present to the Department of Hepatology at Institute of Liver and Billiary Sciences, who meet the…
- Trial name
- NCT02583698
- Testing
- Carvedilol
- Where
- India
- Volunteers
- 136 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Portal Hypertension Related to Cirrhosis, Esophageal Varices
2D-shear Wave Spleen Elastography in Clinically Significant Portal Hypertension and High-risk Varices
The primary objective of this study is to evaluate the role of spleen shear wave elastography (SWE-SSM) for ruling in and ruling out clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic…
- Trial name
- NCT07122622
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Esophageal Varices Secondary to Cirrhosis of Liver
Effects of Somatostatin on Post-endoscopic Portal Hemodynamic in Cirrhotic Patients With Esophageal Gastric Varices
The main complications of cirrhosis are ascites, esophageal varices and hepatic encephalopathy. About 30% to 70% patients with cirrhosis occur esophageal varices, and the most common complication is ascites.
- Trial name
- NCT01426087
- Testing
- Somatostatin, endoscopic therapy
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Yunsheng Yang
Compensated Liver Disease, Esophageal Varices
Baveno VIII Criteria for Portal Hypertension in Egyptian Patients
This prospective observational study aims to validate Baveno VIII criteria for detection of clinically significant portal hypertension and to evaluate additional predictors of esophageal varices in Egyptian patients with…
- Conditions
- Compensated Liver Disease, Esophageal Varices, Portal Hypertension, Chronic Liver Disease
- Trial name
- NCT07842666
- Volunteers
- 125 people
- Sponsor
- Assiut University
Esophageal Varices
Beta Blockers Versus Variceal Band Ligation and Beta Blockers for Primary Prophylaxis of Variceal Bleeding
Patients with scarring of the liver (cirrhosis) and portal hypertension (elevated blood pressure in the liver vasculature) can develop esophageal varices (dilated veins). These have an increased risk of bleeding each year.
- Trial name
- NCT00409084
- Testing
- endoscopic variceal band ligation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Hepatocellular Carcinoma
Comparative Study of Carvedilol Monotherapy Versus Combination Therapy With Endoscopic Variceal Ligation (EVL) for Primary Prophylaxis of Variceal Bleeding in Patients With Hepatocellular Carcinoma With High-Risk Esophageal Varices
Esophageal varices are common in patients with hepatocellular carcinoma (HCC), with an incidence rate of 63% at the time of HCC diagnosis.
- Trial name
- NCT06836778
- Testing
- Carvedilol Tablets, Endoscopic Variceal Ligation
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Esophagogastric Varices
EUS-PPG Alteration After Ligation and Sclerotherapy in Esophageal Varices
Acute variceal bleeding due to cirrhotic portal hypertension is a life-threatening emergency in gastroenterology. Current preventive strategies include non-selective β-blockers (e.g., carvedilol/propranolol), endoscopic therapy…
- Trial name
- NCT07253090
- Testing
- Sclerotherapy for esophageal varices, Ligation for esophageal varices
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine