Clinical trials: Varix, Esophageal
Portal Hypertension
Standard Therapy and TIPS for Moderate to High-risk Esophageal and Gastric Variceal Bleeding
Comparison of endoscopic therapy combined with non-selective therapy β Receptor blockers (NSBBs) and TIPS in the treatment of liver cirrhosis The impact of reducing bleeding on the survival of critically ill patients.
- Trial name
- NCT06013670
- Testing
- Endoscopy+NSBBs, Transjugular intrahepatic portosystemic shunt
- Where
- China
- Volunteers
- 86 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Esophageal Varices
Fecal Calprotectin for Prediction of Esophageal Varices in Cirrhotic Patients
The goal of this cross-sectional observational study is to evaluate the accuracy of fecal calprotectin versus non-invasive scores in assessing the presence and grading of esophageal varices in Egyptian patients.
- Trial name
- NCT06908798
- Testing
- fecal calprotectin
- Where
- Egypt
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Tanta University
Gastric Varix
EUS-guided Obturation of High Risk Gastric Varices Versus Standard Endoscopic Treatment
Gastric varices occur in patients with portal hypertension, mostly secondary to liver cirrhosis. Although they bleed less frequently than oesophageal varices, gastric variceal bleeding tends to be more severe with reported higher…
- Trial name
- NCT04222127
- Testing
- EUS guided injection of gastric varices by CYA, Direct endoscopic injection of gastric varices by CYA
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University
Cirrhosis With Esophageal Varices
To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices.
After successful screening of patients based on inclusion criteria, we will measure the baseline Hepatic Venous Pressure Gradient.
- Trial name
- NCT02465645
- Testing
- Carvedilol, Carvedilol + Simvastatin
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis
TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV
To date, there is no treatment strategies for these patients according to American Association of the Study of Liver Disease (AASLD) practice guidelines and Baveno V consensus.
- Conditions
- Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis, Liver Cirrhosis, Bleeding Esophageal Varices
- Trial name
- NCT02853526
- Testing
- TIPS, Propranolol, Endoscopic therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zaibo Jiang
Liver Cirrhosis, Portal Hypertension
Underdilated VCX-TIPS Versus EVL Plus NSBB for Secondary Prophylaxis of Variceal Bleeding in Cirrhosis
Variceal bleeding is a major complication of portal hypertension in patients with cirrhosis and is associated with substantial risks of rebleeding and death.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Gastroesophageal Varices Bleeding, Esophageal Varices
- Trial name
- U-TIPS (NCT07587671)
- Testing
- Underdilated VCX-TIPS, Endoscopic Variceal Ligation, Nonselective Beta-Blockers
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- West China Hospital
Gastric Varices
Secondary Prophylaxis of Gastric Variceal Bleed
The purpose of this study is to study the efficacy of endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration in the prevention of gastric variceal rebleeding and improvement in survival.
- Trial name
- NCT02468206
- Testing
- Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate
- Where
- China
- Volunteers
- 64 people
- Sponsor
- West China Hospital
Esophageal Varices, Portal Hypertension
Improve the Strategies of Endoscopic and Interventional Treatment of Gastroesophageal Hemorrhage in Portal Hypertension
Endoscopic esophageal variceal ligation combined with gastric variceal embolization using tissue glue is currently the first-choice method for preventing rebleeding in patients with cirrhosis and portal hypertension.
- Trial name
- NCT06970509
- Where
- 10 sites in China
- Volunteers
- 1,450 people
- Sponsor
- Shanghai Zhongshan Hospital
Hematemesis, Portal Hypertension
Comparing Two Methods to Stop Vomiting of Blood Using the Endoscope
Band ligation and injection sclerotherapy are two modalities of treatment that are applied using the endoscope. The purpose of this study is to determine which of two methods is better for controlling bleeding from the upper gut.
- Trial name
- NCT01131962
- Testing
- Endoscopic control of hematemesis
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- University of Alexandria
Gastric Varices, Cirrhosis
Efficiency and Safety of Prophylactic Use of Antibiotics in Endoscopic Injection of Tissue Adhesive in Gastric Varices
The purpose of the study is to assess the efficiency and safety of prophylactic use of antibiotics in endoscopic injection of tissue adhesive in gastric varices.
- Trial name
- NCT02693951
- Testing
- Cefotiam
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Liver Disease, Cirrhosis
MBT Versus HVPG in Identifying Responders to Portal Hypertension Therapy
The purpose of this study is to determine the effect on the (carbon 13 labelled(13C)-Methacetin Breath Test (MBT) of i.v. propranolol, a non-selective beta blocker (NSBB) following initial administration and after chronic use of…
- Conditions
- Chronic Liver Disease, Cirrhosis, Esophageal Varices, Portal Hypertension
- Trial name
- NCT01851252
- Testing
- Methacetin (with Breath testing device)
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Meridian Bioscience, Inc.
Esophageal Varices
Transparent Cap-assisted Endoscopic Sclerotherapy
The aim of this study is to evaluate efficacy and safety of transparent cap-assisted endoscopic sclerotherapyI(lauromacrogol injection) in management of esophageal varices.
- Trial name
- NCT02361593
- Testing
- assistance of a transparent cap, without a transparent cap
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Liver Cirrhosis, Portal Hypertension
Accuracy of Magnetically Maneuvered Capsule Endoscopy for Detection of EGV in Patients With Cirrhosis
This is a diagnostic accuracy study. Eligible individuals will be enrolled and asked to undergo ds-MCE and EGD examinations. EGD is the reference standard against which ds-MCE is compared, and it will be performed within 48 hours…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Esophageal Varices, Gastric Varix
- Trial name
- NCT03748563
- Testing
- ds-MCE and EGD
- Where
- 14 sites in China
- Volunteers
- 607 people
- Sponsor
- Changhai Hospital
Esophageal Varices
"Evaluation of the PillCam™ESO Capsule in the Detection of Esophageal Varices
The purpose of the study is to access the accuracy of the PillCam Eso capsule in identifying the presence of suspected esophageal disease in patients undergoing surveillance or screening for esophageal disease by standard…
- Trial name
- MA-37 (NCT00481416)
- Testing
- PillCam Eso
- Where
- 5 sites in United States, Australia and 1 more
- Volunteers
- 318 people
- Sponsor
- Medtronic - MITG
Esophageal Varices, Gastric Varices
Evaluation of Gastroesophageal Varices by Transnasal Endoscopy.
The study aims to evaluate the feasibility of transnasal endoscopy in patients with portal hypertension, cirrhotic and non-cirrhotic.
- Conditions
- Esophageal Varices, Gastric Varices, Hypertension Portal, Liver Cirrhosis
- Trial name
- NCT02767206
- Volunteers
- 50 people
- Sponsor
- Federal University of Minas Gerais
Cirrhosis Portal
Portal Vein Flow Velocity as a Screening Tool for Oesophageal Varices in Cirrhotic Patients
Portal vein flow velocity as screening tool for prediction of oesophageal varices in cirrhotic patient without upper endoscopy
- Trial name
- Portalflow (NCT05228509)
- Where
- 2 sites in Egypt
- Volunteers
- 75 people
- Sponsor
- Peter atef
Esophageal Varices
Enhancing Detection of Small Esophageal Varices by PillCam ESO
Increasing intra-abdominal pressure (IAP) with an abdominal binder will increase pressure within smaller esophageal varices which will therefore enhance the ability of capsule endoscopy to detect these varices better.
- Trial name
- NCT00911131
- Testing
- Capsule endoscopy (PillCam ESO), EGD, Capsule endoscopy (PillCam ESO) with abdominal binder
- Sponsor
- Medical College of Wisconsin
Portal Hypertension, Portal Vein Thrombosis
Preemptive TIPS for Variceal Bleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis
Portal vein thrombosis (PVT) can lead to a further increase in portal venous pressure and increase the risk of rebleeding. Whether patients with acute esophagogastric variceal bleeding with occlusive PVT benefit from preemptive…
- Conditions
- Portal Hypertension, Portal Vein Thrombosis, Esophageal Varix Bleeding, Portosystemic Shunt
- Trial name
- NCT06122753
- Testing
- preemptive TIPS, standard second prophylaxis
- Where
- China
- Volunteers
- 120 people
- Sponsor
- West China Hospital
Bleeding Esophageal Varices, Hepatocellular Carcinoma
Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices
Randomized comparison within the endoscopic esophageal varices ligation versus non-selective beta-blocker in the primary prevention of esophageal variceal bleeding in patients with HCC.
- Trial name
- P-HCC (NCT01970748)
- Testing
- Propranolol, Esophageal variceal ligation
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cirrhoses, Liver, Oesophageal Varices
Beta-blockers for Oesophageal Varices
To determine if carvedilol reduces the rate of variceal haemorrhage in patients with cirrhosis and small oesophageal varices
- Trial name
- BOPPP (NCT03776955)
- Testing
- Carvedilol
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- King's College Hospital NHS Trust