Clinical trials: Varix, Esophageal
Esophageal Varices in Cirrhosis of the Liver
Radiomics-based Surrogate of Endoscopy (rEndosc) (CHESS1703)
Esophageal varices (EVs) resulting from portal hypertension are a prevalent complication of cirrhosis with a high mortality when variceal hemorrhage (VH) occurs.
- Trial name
- rEndosc (NCT03373123)
- Testing
- Endoscopy, CTA
- Where
- 9 sites in China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Barrett's Oesophagus, Oesophageal Varices
The Accuracy and Acceptability of Magnet Assisted Capsule Endoscopy in the Diagnosis of Esophageal Pathology: a Pilot Study
A pilot study to assess the accuracy and acceptability of a magnet assisted capsule endoscopy in detecting esophageal pathology compared to standard endoscopy.
- Trial name
- MACE (NCT02852161)
- Testing
- Magnet assissted capsule endoscopy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Cirrhosis, Esophageal Varices
Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders
The goal of this clinical trial is to evaluate whether carvedilol plus endoscopic variceal ligation (EVL) is more effective for the primary prevention of esophageal variceal bleeding than carvedilol alone in carvedilol…
- Trial name
- CVL-NR (NCT06594783)
- Testing
- Carvedilol plus endoscopic variceal ligation, Carvedilol alone
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Esophageal Varices
Upper Endoscopy in Cirrhotic Patients With Upper Gastrointestinal Bleeding
Liver cirrhosis is a common diffuse and persistent liver disease often accompanied by portal hypertension, liver failure, upper gastrointestinal bleeding (UGIB), and other complications.
- Trial name
- Varices (NCT06214234)
- Testing
- Band ligation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Esophageal and Gastric Varices
Development and Validation of an Noninvasive Model for Predicting High Risk Esophageal Varices in Cirrhosis
The aim of the study is to develop and validate a new noninvasive method based on routine examination during clinical practice for predicting high risk esophageal varices in cirrhosis.
- Trial name
- NCT04210297
- Where
- China
- Volunteers
- 245 people
- Sponsor
- Qilu Hospital of Shandong University
Cirrhoses, Liver
Evaluating the Efficacy of Vonoprazan in Preventing Post-Endoscopic Variceal Band Ligation Ulcers: A Randomized Controlled Trial
The goal of this clinical trial is to learn if the medicine vonoprazan can help prevent ulcers that may develop after endoscopic variceal band ligation (EVBL) in adults with liver cirrhosis.
- Trial name
- NCT07267260
- Testing
- Vonoprazan 20 mg
- Where
- Pakistan
- Volunteers
- 154 people
- Sponsor
- King Edward Medical University
Variceal Bleeding, Cirrhosis
Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding
This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.
- Trial name
- NCT00966355
- Testing
- Terlipressin, Somatostatin, Octreotide
- Where
- South Korea
- Volunteers
- 1,034 people
- Sponsor
- Korea University
Bleeding Gastric Varices, Cirrhosis
"Early TIPS" Versus Glue Obliteration to Prevent Rebleeding From Gastric Varices
The primary objective of the study is to demonstrate the superiority of an "early tips" strategy over standard treatment by glue obliteration (G0) in preventing bleeding recurrence or death at one year after a non GOV1 gastric…
- Trial name
- GAVAPROSEC (NCT03705078)
- Testing
- Transjugular Portosytemic Shunt (TIPS), glue obliteration
- Where
- 20 sites in France
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Bleeding Esophageal Varices
Endoscopic Injection Sclerotherapy Versus N-butyl-2-cyanoacrylate Injection
Endoscopic Injection Sclerotherapy vs N-butyl-2-cyanoacrylate Injection
- Trial name
- NCT03388125
- Testing
- Injection Sclerotherapy, N-butyl-2-cyanoacrylate
- Where
- Egypt
- Volunteers
- 113 people
- Sponsor
- Sherief Abd-Elsalam
Variceal Bleeding, Ultrasonography
Ultrasound Prediction of Esophageal Variceal Bleeding Risk
This prospective observational study aims to evaluate the accuracy of using routine abdominal ultrasound to predict the risk of esophageal variceal bleeding in adult patients with liver cirrhosis.
- Conditions
- Variceal Bleeding, Ultrasonography, Esophageal Bleeding, Esophageal Varices
- Trial name
- NCT07571876
- Volunteers
- 165 people
- Sponsor
- Assiut University
Chronic Liver Disease
Liver and Splenic Stiffness in Predicting Esophageal Varices Needing Treatment in MASLD Related Compensated Advanced Chronic Liver Disease.
Patients with chronic liver disease (CLD) are at risk of developing clinically significant portal hypertension (CSPH). In the Baveno VI consensus a new term "compensated advanced chronic liver disease (cACLD)'' has been proposed…
- Trial name
- NCT05044663
- Testing
- No intervention
- Where
- India
- Volunteers
- 325 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Gastric Varices, Portal Hypertension
Injection of Cyanoacrylate+Lipiodol vs Cyanoacrylate+Lauromacrogol in Gastric Varices
The purpose of this randomized study to compare effect of endoscopic injection of a mixture of cyanoacrylate and lipiodol versus cyanoacrylate and lauromacrogol in gastric varices.
- Trial name
- NCT01923064
- Testing
- Lipiodol, Lauromacrogol
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Zhongshan Hospital
Portal Hypertension, Cirrhosis
The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed
Terlipressin and Octreotide are two common agents used as adjuvants in the management of variceal bleeding. Both agents have been claimed equivalent to endoscopic therapy in randomized studies.
- Conditions
- Portal Hypertension, Cirrhosis, Hematemesis, Melena
- Trial name
- NCT00534677
- Testing
- Terlipressin, Octreotide
- Where
- Pakistan
- Volunteers
- 320 people
- Sponsor
- Aga Khan University
Chronic Liver Disease, Esophageal Varices
Blood Ammonia as Predictor for Esophageal Varices and Risk of Bleeding
Assessment of blood ammonia level as a non-invasive predictor for presence of EV and risk of bleeding
- Trial name
- EV (NCT03212872)
- Testing
- Endoscopy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Arteriovenous Malformation, Gastrointestinal Bleed
Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable Coils
The purpose of the Case-Specific Health Care Professional (HCP) Clinical Survey for Concerto Versa™ Detachable Coils, also known as the Concerto Versa HCP Clinical Assessment, is to collect early clinical data from HCPs to assess…
- Conditions
- Arteriovenous Malformation, Gastrointestinal Bleed, Gastric Varices, Hemorrhoid
- Trial name
- NCT07639853
- Testing
- Concerto Versa™ Detachable Coils
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medtronic Endovascular
Esophageal and Gastric Varices
Validation of Esophageal Variceal Grading: A Comparative Study of Upper Gastrointestinal (GI) Endoscopy and Capsule Endoscopy
The purpose of this study is to develop a grading system for esophageal varices using capsule endoscopy in patients with portal hypertension and cirrhosis.
- Trial name
- NCT00475592
- Testing
- Esophageal Capsule Endoscopy, Upper Gastrointestinal Endoscopy
- Where
- United States
- Sponsor
- Johns Hopkins University
Liver Cirrhoses, Variceal Hemorrhage
HVPG-Guided Therapy vs Carvedilol Plus Endotherapy for the Prevention of Esophageal Variceal Rebleeding in Cirrhotic Patients
Variceal bleeding is a major complication of cirrhosis, associated with a hospital mortality rate of 10%-20%. Surviving patients are at high risk for recurrent hemorrhage.
- Conditions
- Liver Cirrhoses, Variceal Hemorrhage, Esophageal Varices
- Trial name
- NCT04254822
- Testing
- Transjugular intrahepatic portosystemic shunt, Carvedilol, Endoscopic variceal ligation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Air Force Military Medical University, China
Esophageal Varices
Noninvasive Methods For Prediction of Esophageal Varices in Children
The aim of this study is to use non-invasive methods to identify patients at risk of developing gastrointestinal varices and correlation of these non-invasive methods with the degree of esophageal varices and the presence or…
- Trial name
- NCT05781828
- Testing
- Detailed abdominal ultrasound
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Liver Cirrhosis, Portal Hypertension
Effect of Administration of Rifaximin on the Portal Pressure of Patients With Liver Cirrhosis and Esophageal Varices
The purpose of this study is to assess whether the add of Rifaximin in patients with liver cirrhosis and esophageal varices treated with a standard therapy with beta blockers, leads to a significant reduction of portal…
- Trial name
- ERASE (NCT02508623)
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Padova
High Risk Esophageal Varices
Spleen Stiffness as a Measure to Assess the REsponse to β Blocker Therapy (SPARE-B)
HVPG is the gold standard for measurement of the presence and severity of portal hypertension. Clinically Significant Portal Hypertension (CSPH) is defined as HVPG ≥ 10 mmHg.
- Trial name
- NCT06050837
- Testing
- No intervention
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Institute of Liver and Biliary Sciences, India