Clinical trials: Vascular; Damage
Blepharospasm, Hemifacial Spasm
Post Marketing Surveillance Study of Dysport
The purpose of this study is to provide further information regarding the risks and benefits of Dysport in marketed indications.
- Conditions
- Blepharospasm, Hemifacial Spasm, Cervical Dystonia, Spasmodic Torticollis
- Trial name
- NCT00210431
- Where
- 36 sites in France, Germany and 1 more
- Volunteers
- 783 people
- Sponsor
- Ipsen
Intra Cerebral Hemorrhage
Feasibility Study of New MRI Protocol in Assessing Early Blood Brain Barrier Disruption (BBBD)in Related to Delay Brain Edema
MRI research Group in the Advanced Technology Center of the Sheba Medical Center has developed an innovative methodology based on leakage (extravasation) contrast agent that allows to map the entire brain with high resolution and…
- Trial name
- BBBD (NCT01830894)
- Testing
- MRI
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
ST Elevation Myocardial Infarction, Coronary Microvascular Dysfunction
CORonary Thrombus Modification to Prevent MIcrovascular Damage in Patients With ST-segment Elevation Myocardial Infarction (The CORMI Trial)
The aim of this study is to evaluate the effects of coronary thrombus modification on preventing the microvascular damage associated with primary percutaneous coronary intervention (PCI), and to limit the associated myocardial…
- Conditions
- ST Elevation Myocardial Infarction, Coronary Microvascular Dysfunction, Percutaneous Coronary Intervention
- Trial name
- NCT07646977
- Testing
- Coronary thrombus modification, Standard stent implantation
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Stroke, Chronic Brain Injury
Automated Stereognosis to Treat Loss of Tactile Function After Brain Injury
Researchers aim to determine whether the ReTrieve system for tactile training can improve tactile function (sense of touch) in the hand after brain injury when used at home for 6 weeks.
- Conditions
- Stroke, Chronic Brain Injury, Peripheral Neuropathy
- Trial name
- ReTrieve (NCT05740553)
- Testing
- ReTrieve Automated Stereognosis System
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas at Dallas
Neoplasms
Health Effects of CArdiac FluoRoscopy and MOderN RadIotherapy in PediatriCs - Radiotherapy
The goal of the HARMONIC-RT study is to evaluate late health and social outcomes of contemporary techniques of external beam radiotherapy in paediatric patients, based on the setting-up of a European, long-term registry…
- Trial name
- HARMONIC-RT (NCT04746729)
- Testing
- No intervention
- Where
- 5 sites in Belgium, Denmark and 2 more
- Volunteers
- 2,670 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Ischemic Postconditioning, Carotid Surgery
Ischemic Postconditioning in Carotid Surgery
Analyzing changes in cerebral oximetry, transcranial Doppler and biomarkers of neuronal ischemic injury and blood-brain barrier integrity assessing the safety and efficacy of ischemic postconditioning in carotid surgery (IPCT).
- Conditions
- Ischemic Postconditioning, Carotid Surgery, Stroke, Carotid Artery Diseases
- Trial name
- BRAIN-SAVE (NCT06359756)
- Testing
- Ischemic postconditioning in carotid surgery, Eversion Carotid Endarterectomy
- Where
- Serbia
- Volunteers
- 40 people
- Sponsor
- Institute for Cardiovascular Diseases Dedinje
Trauma, Coagulopathy
Impact of a Prehospital Identification of Trauma Patients in Need for Damage Control Resuscitation.
Early identification of trauma patients in need for Damage Control Resuscitation (DCR) has potential to be beneficial for general emergency units that are not expected to be ready for this rare situation 24 hours per day, 7 days…
- Conditions
- Trauma, Coagulopathy, Hemorrhage, Emergencies
- Trial name
- NCT03444077
- Testing
- Use of the Trauma Induced Coagulopathy Clinical Score (TICCS) as a diagnostic tool., Regular care, STTTOPPP the bleeding
- Where
- 4 sites in Belgium
- Volunteers
- 400 people
- Sponsor
- University of Liege
Anoxic-Ischemic Encephalopathy
Study for the Improvement of Long-Term Outcome Prediction in Patients in Coma After Cardiac Arrest
The primary objective of HOPE is to improve the accuracy of outcome prediction in anoxic-ischemic encephalopathy following cardiac arrest by bringing under close scrutiny some of the existing methods used for this purpose (e.g.
- Trial name
- HOPE (NCT02231060)
- Where
- 16 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Aneurysmal Subarachnoid Hemorrhage
Early Brain Damage Assessment in Aneurysmal Subarachnoid Haemorrhage in Predicting Cognitive Impairment
the goal of this type of study : observation study is to learn about cerebral edema and hematoma in aneurysmal subarachnoid hemorrhage the main questions it aims to answer are current clinical practices lack predictive models to…
- Trial name
- NCT06172556
- Testing
- Endovascular coiling, Surgical clipping, Mix
- Where
- China
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Hebei Medical University
Systemic Lupus Erythematosus
Aspirin Resistance in Systemic Lupus Erythematosus (SLE)
This study examine whether patients with lupus respond to aspirin , and if not, if that is related to inflammation. We examine the ability of aspirin to inhibit the production of thromboxane in patients with lupus and controls…
- Trial name
- NCT00731302
- Testing
- aspirin and meloxicam
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Ischemia Reperfusion Injury
Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.
Endothelial damage has been reported after ischemia-reperfusion events. This can be characterized by measurements of glycocalyx and endothelial components that are released to blood after the insult.
- Trial name
- NCT03772054
- Testing
- Sevoflurane, Propofol
- Where
- Chile
- Volunteers
- 16 people
- Sponsor
- University of Chile
Diabetic Retinopathy, Diabetic Macular Edema
Exploring the Interaction Between Metabolic Disorders and NLPR3 Inflammasome Activation in DR Inflammatory Damage
Diabetic retinopathy (DR) is one of the most serious microvascular complications of diabetes. Early diagnosis and treatment of diabetes is the key to prevent visual impairment in DR patients.
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, Anti-vascular Endothelial Growth Factor
- Trial name
- DR (NCT06272565)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Hypertension, Ischemic Heart Disease
A Morbidity-Mortality and Remodeling Study With Valsartan
The JIKEI HEART Study has been designed to investigate whether concomitant treatment with valsartan, an angiotensin II receptor blocker (ARB), in addition to conventional treatment, will improve the prognosis of 3000 Japanese…
- Conditions
- Hypertension, Ischemic Heart Disease, Congestive Heart Failure
- Trial name
- NCT00133328
- Testing
- valsartan
- Where
- Japan
- Volunteers
- 3,000 people
- Sponsor
- Jikei University School of Medicine
Malignant Hypertension
Determinants of Malignant Hypertension Onset and Related Target Organ Damages: the HAMA Biobank
The HAMA bank is an initiative aimed at collecting, preparing, and storing biological samples from patients treated for malignant hypertension and included in the HAMA cohort.
- Trial name
- HAMABANK (NCT06629363)
- Testing
- biobank
- Where
- 11 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier de PAU
Cerebral Palsy, Hypoxic-Ischemic Encephalopathy
Early Virtual Intervention for Infants With CP Following HIE Diagnosis
This will be a five year study that will be a prospective, randomized, controlled trial (RCT) to assess the effect of a virtual early intervention care delivery model in the provision of therapy to enhance the neurodevelopmental…
- Conditions
- Cerebral Palsy, Hypoxic-Ischemic Encephalopathy, Brain Injuries, Perinatal Hypoxia
- Trial name
- RECOVER (NCT04913324)
- Testing
- Virtual Care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- The Hospital for Sick Children
Systemic Vascular Damage
Retinal Microvascularization in OCT-angiography and Systemic Diseases
Systemic diseases are inflammatory, chronic illnesses affecting different organs and altering their function. At present, there are few non-invasive methods for predicting their onset and progression.
- Trial name
- OCTAVA (NCT06613555)
- Testing
- Retinal imaging, Biological check-up
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Knee Osteoarthritis
Autologous Stromal Vascular Fraction of Cells for Treatment of Knee Articular Cartilage Dystrophy
Stromal vascular fraction of cells (SVF) will be extracted from lipoaspirate by enzymatic digestion. SVF will be administered in a single dose intraarticularly 4 weeks after arthroscopic debridement.
- Trial name
- NCT02827851
- Testing
- Liposuction, SVF isolation, Intraarticular administration of autologous SVF
- Where
- 4 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Ischemic Stroke
Myocardial Damage In Patients With Cerebral Infarction
Introduction For several years "ischemic" electrocardiographic (ECG) changes in the acute phase of ischemic stroke have been reported. Whether these ECG changes reflect true myocardial ischemia remains controversial.
- Trial name
- NCT00306579
- Volunteers
- 250 people
- Sponsor
- Danish Heart Foundation
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel Reloading in Patients With NSTEACS Undergoing Percutaneous Coronary Intervention on Chronic Clopidogrel Therapy
Patients who developed an acute coronary syndrome despite dual antiplatelet therapy with aspirin and clopidogrel may benefit from a further dose of clopidogrel before a percutaneous coronary intervention.
- Trial name
- NCT01572129
- Testing
- Clopidogrel
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Campus Bio-Medico University
Cerebral Palsy, Periventricular Leukomalacia
A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy
UDI-001 is administered to pediatric patients with cerebral palsy attributed to periventricular leukomalacia (PVL) multiple times to investigate its safety and efficacy.
- Trial name
- NCT04873752
- Testing
- UDI-001
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Rohto Pharmaceutical Co., Ltd.