Clinical trials: Vascular; Damage
Cerebral Palsy, Stroke
Spinal Stimulation and Mobility Devices
This research study will combine non-invasive spinal stimulation with an ankle exoskeleton to examine the acute impact of the stimulation on gait in children with cerebral palsy.
- Conditions
- Cerebral Palsy, Stroke, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT05520359
- Testing
- Mobility Device, Spinal Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Cerebral Palsy (CP), Stroke
High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction
The Hawks in Motion (HIM) High Intensity Exercise program is designed to implement the American Physical Therapy Clinical Practice Guidelines and American College of Sports Medicine recommendations for exercise for people with…
- Conditions
- Cerebral Palsy (CP), Stroke, Spinal Cord Injury, Traumatic Brain Injury
- Trial name
- NCT06945835
- Testing
- Participate in high intensity exercise of at least 20 minutes in 60 minutes session of RPE greater than 6.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Hartford
Coronary Artery Disease
Effects of DES Platforms on Markers of Endothelial Damage and Inflammation
Percutaneous coronary intervention (PCI) with stenting may induce endothelial damage/dysfunction and inflammatory reactions, which in turn delay healing and endothelialization and may lead to restenosis and atherosclerosis within…
- Trial name
- PLATFORM (NCT01489202)
- Testing
- platinum chromium everolimus-eluting stent, cobalt chromium everolimus-eluting stent
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Hypertensive Emergency
The Value of TOI in Evaluating Renal Function Damage in Hypertensive Emergency Patients
TOI was used to measure heart rate, respiration, blood pressure, heart rate variability and psychological stress. At the same time, the patient's urine protein, creatinine, urea nitrogen and other indicators were detected.
- Trial name
- NCT06201572
- Testing
- The relationship between TOI composite index and renal function in hypertensive emergency patients was compared
- Volunteers
- 300 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Mechanical Thrombectomy, Acute Ischemic Stroke
High-Dose Atorvastatin for Vascular Wall Protection in Thrombectomy Patients
This project investigates the impact of statins on cerebral vascular wall damage after mechanical thrombectomy. The investigators will undertake a multi-center, prospective, parallel-controlled, open-label, superiority randomized…
- Trial name
- NCT05912686
- Testing
- Atorvastatin 80mg, Atorvastatin 20mg
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Zhongda Hospital
Spinal Cord Injury, Multiple Sclerosis
A Randomized Exercise Trial for Wheelchair Users
People with mobility disabilities are at greater risk than the general population for incurring health problems. Many of these conditions are preventable through behavior and lifestyle changes such as exercise and physical…
- Conditions
- Spinal Cord Injury, Multiple Sclerosis, Muscular Dystrophy, Cerebral Palsy
- Trial name
- NCT00866112
- Testing
- Educational session to promote physical activity, Minimal contact
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- University of Kansas
Stroke, Complication
Electromyography-biofeedback on the Motor Activation of the Extension of the Hand
Background: Biofeedback-Surface electromyography (BIO-SEMG) is a relatively recent physiotherapy technique. Although its use is widespread in sports science and sports performance, its use for the rehabilitation of patients with…
- Trial name
- EMGBIO-ICTUS (NCT03838809)
- Testing
- surface electromyography-biofeedback
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Systemic Vascular Damage
Retinal Microvascularization in OCT-angiography and Systemic Diseases
Systemic diseases are inflammatory, chronic illnesses affecting different organs and altering their function. At present, there are few non-invasive methods for predicting their onset and progression.
- Trial name
- OCTAVA (NCT06613555)
- Testing
- Retinal imaging, Biological check-up
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Chronic Kidney Disease, Diabetic Kidney Disease
"Residual Kidney Function and Oxidative Stress in Incremental vs Standard Peritoneal Dialysis (2 Mexican Centers)"
Title: Comparison of Oxidative Stress and Preservation of Residual Kidney Function Between Incremental and Standard Peritoneal Dialysis in Incident Patients at the Regional General Hospital No.
- Conditions
- Chronic Kidney Disease, Diabetic Kidney Disease, Peritoneal Dialysis (PD), Hypertension
- Trial name
- INSPiRE (NCT07338435)
- Testing
- Standard Peritoneal Dialysis, Incremental Peritonal Dialysis
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Mexicano del Seguro Social
Myocardial Infarction, Reperfusion Injury
Myocardial Infarction Size Reduction With Atorvastatin
The purpose of this study is to determine if oral atorvastatin administered just before percutaneous coronary angioplasty for acute myocardial infarction improves early and late heart function as compared to placebo.
- Trial name
- NCT00286312
- Testing
- Atorvastatin
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- R&D Cardiologie
Hypoxic-Ischemic Encephalopathy
Clinical Trial of a New Rectum Cooling System on Patients of Hypoxic-ischemic Brain Damage
This study will try to evaluate the effectiveness and safety of a new method for achieving mild hypothermia, i.e.,mild hypothermia therapy through rectum.
- Trial name
- NCT02544542
- Testing
- Rectum cooling system, Hyper-hypothermia blanket
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Stroke, Hemispatial Neglect
Guanfacine for the Treatment of Spatial Neglect and Impaired Vigilance
To find out if spatial neglect following stroke and brain injury can be reduced using guanfacine, a drug that was shown to improve neglect in two stroke patients in a previous pilot study (Malhotra et al, 2006).
- Trial name
- GASNIV (NCT00955253)
- Testing
- Guanfacine
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Imperial College London
Cerebral Palsy, Stroke
Reliability of the Melbourne Assessment
The aim of the study is to investigate the reliability of the Melbourne Assessment.
- Conditions
- Cerebral Palsy, Stroke, Traumatic Brain Injury, Meningomyelocele
- Trial name
- NCT02595411
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Children's Hospital, Zurich
Flaccid Paresis, Spastic Paresis
Comparing Digitally and Traditionally Made Ankle Foot Orthoses
The research is being done to compare two methods of creating AFOs: 1. The traditional method, which involves manually creating a mold from a plaster cast of the client's limb. This is time-consuming and labor-intensive; and 2.
- Conditions
- Flaccid Paresis, Spastic Paresis, Cerebral Palsy, Stroke
- Trial name
- NCT06828653
- Testing
- Part A First Wear Period: Traditional AFO(s), Part A First Wear Period: Digital AFO(s), Part A Second Wear Period: Traditional AFO(s)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Stroke, Cerebral Palsy
Design of an Affordable Gym for Post Stroke Rehabilitation
Rehab in a Crate is a therapy gym designed to be affordable, compact and easily transportable. The purpose of this particular study is to gain feedback on the initial design of the Rehab in a Crate system.
- Conditions
- Stroke, Cerebral Palsy, Healthy
- Trial name
- RehabCares (NCT02820480)
- Testing
- Rehab in a Crate System
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
ST-elevation Myocardial Infarction
Effect of Conditioning on Myocardial Damage in STEMI
The LIPSIA-Conditioning trial is an investigater initiated, randomized, single-center study that will assess the effect of different intrahospital conditioning protocols on myocardial damage assessed by MRI in patients with acute…
- Trial name
- LIPSIA-COND (NCT02158468)
- Testing
- Combined intrahospital pre- and postconditioning, Postconditioning
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University of Leipzig
Cerebral Palsy, Periventricular Leukomalacia
A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy
UDI-001 is administered to pediatric patients with cerebral palsy attributed to periventricular leukomalacia (PVL) multiple times to investigate its safety and efficacy.
- Trial name
- NCT04873752
- Testing
- UDI-001
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Rohto Pharmaceutical Co., Ltd.
Stroke, Acute
Human Urinary Kallidinogenase Improve Short Term Motor Functional Outcome of Acute Ischemia Stroke Patients
Acute cerebral infarction is a common type of ischemic stroke, causing brain dysfunction in patients with high morbidity and disability.
- Trial name
- NCT04102956
- Testing
- Kallikrein
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Second Hospital of Hebei Medical University
Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD)
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program.
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder)
- Trial name
- GEN-HOPE (NCT07493096)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healing Hope International
Cerebral Palsy, Perinatal Stroke
Single-session tDCS in Cerebral Palsy
The goal of this study is to characterize individual responses to a single application of transcranial direct current stimulation (tDCS) in children with unilateral cerebral palsy (UCP), and to test which electrode configuration…
- Conditions
- Cerebral Palsy, Perinatal Stroke, Periventricular Leukomalacia
- Trial name
- NCT03635775
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota