Clinical trials: Vascular
Delayed Bleeding Post EMR, Large Laterally Spreading Lesion in the Colon
Systematic Description of the Post EMR Defect
To date there are no available data on the utility of the endoscopic mucosal resection (EMR) defect in stratifying the risk of immediate or delayed adverse outcomes, particularly clinically significant post EMR bleeding (CSPEB).
- Conditions
- Delayed Bleeding Post EMR, Large Laterally Spreading Lesion in the Colon, Endoscopic Mucosal Resection
- Trial name
- NCT03117400
- Where
- Australia
- Volunteers
- 482 people
- Sponsor
- Western Sydney Local Health District
Multiple Myeloma
An Open-label, Dose Escalation Study in Japanese Participants With Relapsed/Refractory Multiple Myeloma Who Have Failed Prior Anti Myeloma Treatments
Belantamab mafodotin (GSK2857916) is a first in class, antibody dependent cellular cytotoxicity (ADCC) enhanced, humanized immunoglobulin G1 (IgG1) antibody-drug conjugate (ADC) which binds specifically to B cell maturation…
- Trial name
- NCT03828292
- Testing
- Belantamab mafodotin, Bortezomib, Dexamethasone
- Where
- 4 sites in Japan
- Volunteers
- 15 people
- Sponsor
- GlaxoSmithKline
Stroke, Upper-limb Paresis
Automatic Versus Intentional Movement Exercises to Enhance Arm Functions After Stroke
Many patients retain upper-limb motor impairment following stroke. Most conventional rehabilitation techniques are aimed to improve motor intentional movement by repeated exercises.
- Trial name
- AUTOTAB (NCT01565044)
- Testing
- motor training
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Hypertension
Additional Effects of Pilates Breathing and Diaphragmatic Breathing Combined With Moderate Intensity Continuous Cycling Training on Blood Pressure, Chest Expansion, Pulmonary Function and Quality Of Life in Patients With Hypertension
Hypertension or high blood pressure is defined as when the pressure in the blood vessels is too high. According to Joint National Committee 8 (JNC 8) Guidelines, hypertension is defined as systolic blood pressure level of more…
- Trial name
- NCT07529834
- Testing
- Cycling Training (Moderate-intensity continuous training), Pilates Breathing, Diaphragmatic Breathing
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- Foundation University Islamabad
Acute Coronary Syndrome, Interventional Cardiology
Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention
The present study is aimed to compare the safety and efficacy of Ticagrelor with low-dose Aspirin versus standard dual anti-platelet therapy (DAPT) in patients with acute coronary syndrome (ACS) at high risk for ischemic events…
- Trial name
- LD-ASPIRIN (NCT04240834)
- Testing
- Aspirin, Ticagrelor
- Where
- China
- Volunteers
- 1,220 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Retinal Vein Occlusions
Single Site, Masked, Randomized, Controlled Study to Assess Efficacy of Osurdex as Adjunct to Avastin Compared With Avastin Alone in the Treatment of Patients With Macular Edema Due to Central or Branch Retinal Vein Occlusion
Comparative study to see if treating with Osurdex in addition to Avastin in patients with retinal vein occlusions helps increased visual acuity outcomes
- Trial name
- NCT01085734
- Testing
- Avastin, Osurdex
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maturi, Raj K., M.D., P.C.
Pulmonary Vascular Disorder, Chronic Thromboembolic Pulmonary Hypertension
Exercise Performance on Ambient Air vs. Low-Flow Oxygen Therapy in Pulmonary Vascular Disease (PVD)
The investigators aim to study the effect of SOT in Swiss residents with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH).
- Conditions
- Pulmonary Vascular Disorder, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Arterial Hypertension
- Trial name
- NCT06384534
- Testing
- 6-minute walk distance (6MWD) test on ambient air, 6-minute walk distance test with supplemental oxygen
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Stroke, Seizures
Epilepsy Watch After Vascular Events: Frequency, Outcomes, and Risk Markers
This research aims to determine the frequency of seizures in patients following a stroke, identify risk factors associated with post-stroke seizures, and characterize EEG changes linked to these seizures.
- Conditions
- Stroke, Seizures, EEG Power Spectra, Serum Biomarkers
- Trial name
- EY-WAVEFORMS (NCT06922734)
- Where
- Slovenia
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Hypertension
Investigating the Role of Ginger Tea ORAC Value in Hypertension Management
The purpose of this study is to evaluate the antihypertensive effects of ginger tea. By examining its impact on blood pressure levels, this research aims to determine whether ginger tea can be an effective, natural adjunct to…
- Trial name
- NCT06762834
- Testing
- Ginger tea, self administred Ginger tea
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Superior University
Stroke
F@ce 2.0 a Mobile Phone-supported and Family-centred Rehabilitation Intervention After Stroke in Uganda
The purpose of the present proposal is to implement and evaluate a new model for mobile phone supported and family-centred rehabilitation intervention (F@ce 2.0) with regard to functioning in activities in daily living and…
- Trial name
- NCT04337034
- Testing
- Mobile phone supported and family-centred rehabilitation, Information and blood pressure measurement
- Where
- 3 sites in Uganda
- Volunteers
- 98 people
- Sponsor
- Karolinska Institutet
Vascular Surgery
Multi-center Register for the Use of the Cor-Knot® Automated Knotting System in Heart Valve Surgery
The Cor-Knot® device is an automated knotting system for valve sutures and prosthetic rings used for more than a year during valve replacements and annuloplasties in cardiac surgery.
- Trial name
- RECORVA (NCT03681834)
- Testing
- Data collection
- Where
- France
- Volunteers
- 557 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hypertension
STITCH (Simplified Therapeutic Intervention To Control Hypertension)
The objective of this study is to assess whether the implementation of a primary treatment algorithm using a fixed dose combination therapy will improve the management of hypertension when compared to usual management.
- Trial name
- NCT00129909
- Testing
- fixed dose combination therapy
- Where
- Canada
- Volunteers
- 2,081 people
- Sponsor
- University of Western Ontario, Canada
Blood Coagulation Disorders, Hemorrhage
Transfusion of Fresh Frozen Plasma in Non-bleeding Intensive Care Unit (ICU) Patients
With the aim to restrict inappropriate fresh frozen plasma (FFP) transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgroup of intensive care (ICU) patients undergoing an invasive…
- Trial name
- TOPIC (NCT01143909)
- Testing
- omitting FFP transfusion before an intervention
- Where
- 4 sites in Netherlands
- Volunteers
- 81 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery
The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury
In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery.
- Conditions
- Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery, Anesthesia, General, Anesthesia, Spinal
- Trial name
- NCT06343259
- Testing
- General Anesthesia, Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Relapsed/Refractory, Multiple Myeloma
A Study to Investigate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of TAK-079 Administered Subcutaneously as a Single Agent in Participants With Relapsed/Refractory (r/r) Multiple Myeloma (MM)
The purpose of this study is to assess the safety and tolerability, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D) of TAK-079 monotherapy and when combined with a backbone regimen of pomalidomide and dexamethasone…
- Trial name
- NCT03439280
- Testing
- Mezagitamab, Pomalidomide, Dexamethasone
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Retinopathy of Prematurity
Vascular Endothelial Growth Factor in Stage V ROP
Vascular Endothelial Growth Factor (VEGF) is a dimeric glycoprotein, naturally expressed in epithelial and tumor cells (1). Normal Retinal vascularization has two phases: In the first fase, cells of mesenquimatous origin form the…
- Trial name
- NCT00500396
- Testing
- Open-Sky Vitrectomy
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Cardiovascular Risk Factor
Choline and Cardiometabolic Health
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular…
- Trial name
- NCT04764162
- Testing
- Choline
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Hypertension
The Effect of Amiloride and Spironolactone in Patients With Hypertension
The investigators wish to investigate the potential effects of potassium. In this study we will examine patients with hypertension and increase their potassium-levels using Amiloride and Spironolactone.
- Trial name
- hass (NCT01388088)
- Testing
- Spironolactone, Amiloride
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- Erling Bjerregaard Pedersen
Cardiovascular Risk Factor
Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans
Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature.
- Trial name
- NCT04101188
- Testing
- Moderate Potassium/Low Sodium Diet, Moderate Potassium/High Sodium Diet, High Potassium/High Sodium Diet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Stroke, Acute, Stroke, Ischemic
Personalized Patient and Caregiver Education After Stroke
This is a randomized pilot trial to evaluate the impact of a customizable stroke education app (vs standard of care discharge education) on patient satisfaction and education retention.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke
- Trial name
- MyStroke (NCT05118503)
- Testing
- Customized education, Standard of care discharge education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
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