Clinical trials: Vascular
Hypertension
Antihypertensive Efficacy and Safety of Approved Drugs in Japanese Patients With Essential Hypertension (Banyu Study)(0954A-302)
The purpose of this study is to evaluate antihypertensive (lowering blood pressure) effectiveness of three combinations of approved study drugs compared to both study drugs being given alone.
- Trial name
- NCT00092209
- Testing
- MK0954A, hydrochlorothiazide (+) losartan potassium
- Volunteers
- 840 people
- Sponsor
- Organon and Co
Blood Pressure, Stroke, Ischemic
Integrated Telehealth After Stroke Care
In this pilot trial, the investigator will compare early post-stroke BP management using an integrated Telehealth After Stroke Care (iTASC), to usual care with a primary outcome of BP control defined by the mean 24-hr blood…
- Conditions
- Blood Pressure, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- iTASC (NCT05049109)
- Testing
- Integrated Telehealth After Stroke Care, Usual post-stroke follow-up care
- Where
- United States
- Sponsor
- Columbia University
Multiple Myeloma in Relapse, Multiple Myeloma
Early Patient Access Single Named Patient Program for the Use of Ulocuplumab for the Treatment of Multiple Myeloma
Participant that has been diagnosed with Relapsed/ Refractory Multiple Myeloma and are currently participating in a clinical trial which is closing. This research study is studying Ulocuplumab as a possible treatment.
- Trial name
- NCT02666209
- Testing
- Ulocuplumab, Lenalidomide, Bortezomib
- Where
- United States
- Sponsor
- Dana-Farber Cancer Institute
Stroke
Effect of Body Awarness Therapy on Balance and Coordination in Stroke
Stroke is sudden disruption in central nervous system function due to disturbance of the blood flow circulation in the brain. Cerebrovascular accident (CVA), is the second most leading cause of mortality (5.5 million cases…
- Trial name
- NCT05958732
- Testing
- Somato-sensorial exercises therapy, Conventional Therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Shifa Tameer-e-Millat University
Coronary Artery Disease
BIOFLOW-INDIA Safety and Clinical PerFormance of the Drug Eluting ORSIRO Stent in Single de Novo Coronary Artery Lesions
The objective of this clinical investigation is to assess the safety and clinical performance of the Orsiro Limus Eluting Stent System in Indian subjects with single de-novo coronary artery lesions.
- Trial name
- NCT01426139
- Testing
- Percutaneous Coronary Intervention Biotronik Orsiro DES
- Where
- 4 sites in India
- Volunteers
- 120 people
- Sponsor
- Biotronik AG
Mitral Valve Insufficiency, Mitral Valve Regurgitation
Feasibility Study of a Percutaneous Mitral Valve Repair System.
Prospective, multi-center, Phase I study of the Evalve Cardiovascular Valve Repair System (CVRS) in the treatment of mitral valve regurgitation. Patients will undergo 30-day, 6 month, 12 month, and 5 year clinical follow-up.
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation
- Trial name
- EVEREST(I) (NCT00209339)
- Testing
- Percutaneous mitral valve repair (MitraClip Implant)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Abbott Medical Devices
Hypertension
Tolerance to Target Doses of Thiazides in Actual Practice: A Feasibility Study
This is a pilot study of a method to compare common, FDA-approved drugs in a clinic. Instead of putting single patients into one of two drug groups, the investigators will assign the doctors who prescribe these drugs for high…
- Trial name
- NCT01235377
- Testing
- Favor one of two thiazides for new prescriptions & attempt target dose
- Where
- 5 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VA Pharmacy Benefits Management Strategic Healthcare Group
Aging, Menopause
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.
- Conditions
- Aging, Menopause, Hypoxia, Vasodilation
- Trial name
- NCT06417177
- Testing
- Propranolol, Gemtesa
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Traumatic Brain Injury
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure…
- Trial name
- NCT05951777
- Testing
- Autologous HB-adMSCs, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Hope Biosciences LLC
Chronic Ischemic Cardiomyopathy, Coronary Artery Bypass Surgery
Human Umbilical Cord Stroma MSC in Myocardial Infarction
The purpose of this phase 1/2 clinical trial is to evaluate the efficacy and safety of allogeneic human umbilical cordstroma derived multipotent stem cells (hUCS-MSCs) in myocardial infarction (MI).
- Trial name
- HUC-HEART (NCT02323477)
- Testing
- stem cell transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ankara University
Psoriasis
Effects of Treatment With Biological Agents on Vascular and Cardiac Function in Psoriasis
Psoriasis has been associated with an increasing risk for atherosclerosis. The investigators investigated whether surrogate markers of subclinical atherosclerosis, vascular dysfunction and myocardial dysfunction are impaired in…
- Trial name
- NCT02144857
- Testing
- etanercept, ustekinumab, cyclosporine
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Athens
Stroke, Dysphagia
Volitional Swallowing in Stroke Patients With Chronic Dysphagia
This study will compare several techniques designed to improve the ability to swallow in stroke patients with chronic dysphagia (difficulty swallowing).
- Trial name
- NCT00306501
- Testing
- Swallowing Training
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Preterm Labor, Preterm Birth
MIRACLE of LIFE Study
The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane
- Trial name
- MoL (NCT06074601)
- Testing
- Mirvie Predictive Test for Adverse Pregnancy Outcomes
- Where
- 10 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Mirvie
Cerebrovascular Disorders, Cognition Disorders
Renji Cerebral Small Vessel Disease Corhort Study
We aim to make clear the impact with the mechanisms of variant pathological injuries on the outcomes of CSVD, to find independent imaging markers and establish prediction model of it.
- Trial name
- RCCS (NCT03544801)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Peripheral Arterial Disease, Critical Limb-Threatening Ischaemia
Shockwave ®S4 Catheter IVL to Treat Infrapopliteal Calcified Stenoses and/or Occlusions in CLTI Patients (LEGACY)
The study will evaluate the safety and efficacy of Peripheral Intravascular Lithotripsy system with Shockwave S4 catheter® for the treatment of de novo, re-stenosis or re-occlusive,calcified chronic total occlusion (CTOs) lesions…
- Trial name
- LEGACY (NCT05755412)
- Where
- 6 sites in Italy
- Volunteers
- 9 people
- Sponsor
- EndoCore Lab s.r.l.
Multiple Myeloma, Triple Negative Breast Cancer
Systemic Anti-Cancer Therapy Dose Modifications for Individuals With Duffy Null Phenotype
This study is comprised of a main study, an observational study, and optional survey studies. The main study is being done to see whether using Duffy null specific treatment dosing guidelines can reduce or delay dose…
- Conditions
- Multiple Myeloma, Triple Negative Breast Cancer, Duffy Blood Group, Chemokine Receptor Gene Mutation, Duffy Blood Group, Chemokine Receptor Gene C.-67T>C
- Trial name
- NCT07341867
- Testing
- Dexamethasone, Bortezomib, LENALIDOMIDE
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Andrew Hantel, MD
Intracranial Aneurysm, Aneurysm, Intracranial
Transcranial Doppler Ultrasound Monitoring During Flow-Diverter Embolization
Flow diverters have been approved since 2012 for the treatment of large, wide neck intracranial aneurysms. These devices have been associated with embolic events which cause blockage in a blood vessel and can result in long term…
- Conditions
- Intracranial Aneurysm, Aneurysm, Intracranial, Giant Intracranial Aneurysm
- Trial name
- NCT02354300
- Testing
- TCD Ultrasound
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Menopause
Vascular Effect of Tibolone in the Brachial Artery
The interruption of the secretion of sex steroids occurring during menopause, causes a change in vascular pattern at various levels. As a result, several agencies have side effects that interfere with women's health.
- Trial name
- TDILA (NCT01543399)
- Testing
- Tibolone
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Selmo Geber
Healthy, Diabetes
Safety for 24 Weeks Intake of Korean Red Ginseng in Adults
Korean Red Ginseng appears to adverse events in adults taking 24 weeks Placebo and comparative assessment. And exploratory as Korean Red Ginseng blood sugar control, reduce body fat, URTI prevention, cardiovascular risk, renal…
- Conditions
- Healthy, Diabetes, Hypertension, Hyperlipidemia
- Trial name
- NCT02428998
- Testing
- Korean Red Ginseng
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Korea Ginseng Corporation
Deep Vein Thrombosis, Post-Thrombotic Syndrome
Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial
The purpose of this study is to determine if the use of adjunctive catheter-directed thrombolysis (CDT), which includes the intrathrombus administration of rt-PA (Activase/Alteplase), can prevent post-thrombotic syndrome (PTS) in…
- Conditions
- Deep Vein Thrombosis, Post-Thrombotic Syndrome, Venous Thrombosis
- Trial name
- PHLO (NCT02767232)
- Testing
- Recombinant tissue plasminogen activator (rt-PA), Standard Anticoagulation Therapy
- Sponsor
- University of Colorado, Denver
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