Clinical trials: Vascular
Hypotension
Influence of Preload Dependence on the Effect of Phenylephrine on Cardiac Output
The perioperative hemodynamic management aims to ensure organ perfusion pressure and an oxygen arterial transport adapted to oxygen consumption.
- Trial name
- NCT01730820
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Acute Ischemic Stroke
Phase III Clinical Trial of SHPL-49 Injection in the Treatment of Acute Ischemic Stroke
This study is designed to determine the efficacy and safety of SHPL-49 intravenous infusion in acute ischemic stroke patients.
- Trial name
- SAIL (NCT07241520)
- Testing
- SHPL-49 Injection
- Where
- China
- Volunteers
- 1,096 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Hypertension
An Intervention to Increase Engagement With Hypertension Care for American Indian Patients
The objective of this study is to reduce the effects of stereotype threat on the adherence of American Indian/Alaska Native patients with hypertension.
- Trial name
- NCT04414982
- Testing
- Intervention Values Affirmation, Control Values Affirmation
- Where
- 2 sites in United States
- Volunteers
- 339 people
- Sponsor
- University of Colorado, Denver
Coronary Artery Disease
Comprehensive Assessment on Diagnostic and Prognostic Performance of Coronary Physiological Indices
The objective of the Zhongshan Hospital CONCORDE Registry is to evaluate utility, diagnostic value, and clinical outcomes of coronary physiological indices in an all-comers population of patients with suspected coronary artery…
- Trial name
- CONCORDE (NCT06127420)
- Testing
- coronary physiological indices
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Parkinson's Disease, Autonomic Neuropathy
Effects of Feet Mechanical Stimulation on Cardiovascular Autonomic Profile and Inflammation in Parkinson's Disease
In the present study, investigators test the hypothesis that a controlled mechanical pressure applied on specific sites of both fore-feet (ES) can reduce the inflammatory state and arterial blood pressure in patients with…
- Conditions
- Parkinson's Disease, Autonomic Neuropathy, Inflammation, Hypertension
- Trial name
- parkgo-1 (NCT02608424)
- Testing
- Foot Mechanical Stimulation (Gondola®, CE marking n° 0476)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Clinico Humanitas
Arteriovenous Malformations, Cavernous Angiomas
Influence of MMP on Brain AVM Hemorrhage
Brain vascular malformations, including arteriovenous malformations (AVM), cavernous malformations (CVM) and aneurysms, are a source of life-threatening risk of intracranial hemorrhage. The etiology and pathogenesis are unknown.
- Conditions
- Arteriovenous Malformations, Cavernous Angiomas, Brain Aneurysms
- Trial name
- NCT00783523
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of California, San Francisco
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
A Phase 2b Study of Zagociguat in Patients With MELAS
PRIZM is a Phase 2b randomized, double-blind, placebo-controlled, 3-treatment, 2-period, crossover study evaluating the efficacy and safety of oral zagociguat 15 and 30 mg vs.
- Trial name
- PRIZM (NCT06402123)
- Testing
- zagociguat 15mg, zagociguat 30mg
- Where
- 20 sites in United States, Australia and 4 more
- Volunteers
- 43 people
- Sponsor
- Tisento Therapeutics
Stroke; Sequelae
Efficacy of Massage in Stroke Spasticity
Stroke is one of the common diseases in the elderly. It is the third ranking cause of death and affects health care system in our country. One of the most important consequences of stroke is spasticity.
- Trial name
- NCT01448980
- Testing
- Thai Traditional Massage (TTM), Physical therapy program
- Where
- Thailand
- Volunteers
- 396 people
- Sponsor
- Mahidol University
MINOCA
Plaque Burden and Ischemia in MINOCA
The goal of this clinical trial is to assess coronary artery plaque burden, perivascular inflammation and extent of myocardial ischemia in patients presenting with acute myocardial infarction and non-obstructive coronary artery…
- Trial name
- NCT05681858
- Testing
- CT coronary angiography and [12N] NH3 PET-MR
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Bergen
Traumatic Brain Hemorrhage
SAFETY: Stabilization Points to Third Hospital Line Assessment oF the Impact of the usE of Infrascanner Model 2500 to Provide Decision Support for Diagnosis/Screening of Traumatic Brain InjurY in Ukraine
The Infrascanner model 2500 is a handheld, noninvasive device that is FDA-cleared to detect traumatic intracranial hematomas. FDA clearance K200203 was issued in 2020, K211617 added pediatric age group to the IFU in 2022, and…
- Trial name
- SAFETY (NCT07014748)
- Testing
- Handheld brain hematoma detector
- Where
- 4 sites in United States, Ukraine
- Volunteers
- 600 people
- Sponsor
- InfraScan, Inc.
Coronary Artery Disease, Diabetes Mellitus
Reservoir-Based Polymer-Free Amphilimus-Eluting Stent Versus Polymer-Based Everolimus-Eluting Stent in Diabetic Patients
This study is a prospective, randomized controlled, single blind, two-arm, multicenter clinical evaluation. Diabetic patients (n=112) with de novo coronary artery disease will be randomized to one of the 2 treatment arms: 1)…
- Trial name
- RESERVOIR (NCT01710748)
- Testing
- Polymer-Based Everolimus-Eluting Stent, Polymer-Free Amphilimus-Eluting Stent
- Where
- 4 sites in Spain
- Volunteers
- 112 people
- Sponsor
- Spanish Society of Cardiology
Lung Neoplasms, Respiratory Failure
Clearance Of Mucus In Stents (COMIS)
The goal of this clinical research study is to compare the effects of sodium bicarbonate to normal saline when used for clearing mucus blockage in patients with airway stents.
- Conditions
- Lung Neoplasms, Respiratory Failure, Pneumonia, Acute Coronary Syndromes
- Trial name
- NCT01370278
- Testing
- Normal Saline, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Coronary Artery Disease
Personal Genomics for Preventive Cardiology
The purpose of this study is to see if providing information to a person on their inherited (genetic) risk of cardiovascular disease (CVD) helps to motivate that person to change their diet, lifestyle or medication regimen to…
- Trial name
- NCT01406808
- Testing
- genetic risk score for coronary risk factors
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stanford University
Out-Of-Hospital Cardiac Arrest, Cardiac Arrest
Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest
Comatose patients resuscitated from Out-of-Hospital Cardiac Arrest (OHCA) often develop a complicated systemic inflammatory response and have a poor prognosis with neurological damage being the most common cause of death.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiac Arrest, Cardiac Arrest With Successful Resuscitation, Post Cardiac Arrest Syndrome
- Trial name
- STEROHCA (NCT04624776)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 2 sites in Denmark
- Volunteers
- 158 people
- Sponsor
- Christian Hassager
Retinal Artery Occlusion, Fibrinolysis
EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye
The aim of the EAGLE Study is to compare the efficacy of conservative medical treatment and local intraarterial fibrinolysis in patients with central retinal artery occlusion and to evaluate benefit and risk for the patient of…
- Conditions
- Retinal Artery Occlusion, Fibrinolysis, Visual Acuity, Stroke
- Trial name
- EAGLE (NCT00637468)
- Testing
- Intravenous injection of heparin, Intravenous injection of acetazolamide, Local intra-arterial fibrinolysis
- Where
- 21 sites in Austria, Germany and 1 more
- Volunteers
- 84 people
- Sponsor
- University Hospital Freiburg
Stroke
Effects and Perception of Intensive Virtual Reality Training on Upper Limb Functions After Stroke
Previous literature review shows limited work on upper limb recovery from Virtual Reality device and most of them are pilot studies meta-analysis some Randomized control Trial studies are done but this study will cover mixed…
- Trial name
- NCT05315089
- Testing
- Virtual reality games +conventional exercises, Conventional exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Prognostic Value of the Right Ventricular Function by Portable Ultrasound in Patients With Pulmonary Hypertension.
Pulmonary arterial hypertension (PAH) is a disease characterized by obliteration and remodeling of small-caliber pulmonary arteries, progressively generating an increase in pulmonary vascular resistance, right heart failure, and…
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Cardiac Ultrasound
- Trial name
- NCT05343091
- Testing
- cardiac ultrasound
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Healthy, Diabetes Type 2
Assessment of Three Instruments for the Non-invasive Measurement of Arterial Stiffness.
The ASI Non-Invasive Arterial Stiffness Screening Device (ASI Device) is an investigational device under development for the non-invasive assessment of arterial stiffness.
- Conditions
- Healthy, Diabetes Type 2, Obesity, Coronary Artery Disease
- Trial name
- ASI-2012 (NCT01722474)
- Testing
- ASI Device
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Coronary Artery Disease
Dual-antiplatelet Therapy Strategies for Elective PCI in a Real-world Setting
To assess the safety and efficacy of in-laboratory clopidogrel loading dose administration before ad-hoc PCI versus clopidogrel preloading treatment in patients planned for diagnostic angiography with optional ad-hoc PCI.
- Trial name
- DAPT-FOR-REAL (NCT05559918)
- Where
- 2 sites in Netherlands
- Volunteers
- 1,462 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atherosclerosis, Coronary Artery Disease
Clinical Trial for Dose Finding and Safety of RVX000222 in Subjects With Stable Coronary Artery Disease
The purpose of this study is to investigate dose range, safety and efficacy of RVX000222 in subjects with stable coronary artery disease.
- Trial name
- ASSERT (NCT01058018)
- Testing
- RVX000222
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Resverlogix Corp
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