Clinical trials: Vascular Aging
Progeria
Clinical Studies of Progeria
This study will examine children with Hutchinson-Gilford Progeria syndrome, a genetic disease that causes many changes to the body over time, including heart disease, bone changes, hair loss, and joint and skin changes.
- Trial name
- NCT00094393
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Hypertension, Obesity
The Effect of Oral SPM Supplementation on INflammation-induced Vascular Ageing in Obese Hypertensive Patients
Cardiovascular risk factors such as obesity, diabetes, high blood pressure, high cholesterol, or smoking are associated with an increased risk of events such as myocardial infarction, stroke, or peripheral artery disease.
- Trial name
- SPIN-VA (NCT07038252)
- Testing
- Oral SPM-enriched marine oil (LIPINOVA)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vascular Aging, NAD
Efficacy and Safety of Coenzyme I for Injection on Vascular Aging.
Emerging evidence identifies vascular aging independently predicting cardiovascular events, yet effective clinical interventions remain lacking.
- Trial name
- NCT07328100
- Testing
- Coenzyme I for Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Breast Cancer, Hodgkin Lymphoma
Integrated Actionable Aging Assessment for Cancer Patients Pilot
Aging is the greatest risk factor for cancer incidence and mortality. Geriatric screening is recommended to help with treatment discussions, inform intensity of treatment, and identify supportive care needs.
- Conditions
- Breast Cancer, Hodgkin Lymphoma, Kidney Cancer, Leukemia
- Trial name
- NCT05871008
- Testing
- Assessment tool IA3-CP with SDoH, Assessment tool IA3-CP without SDoH
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Colorado, Denver
Healthy Aging, Vascular Dilation
Effects of a Supplement to Target Ageing Mechanisms on Vascular Function (STAMINA)
In the ageing society, extending the healthy lifespan is a major challenge and a healthy diet may play an import role in maintaining health throughout life.
- Trial name
- STAMINA (NCT06145087)
- Testing
- "NOVOS Core" supplement
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Hypertension, Atherosclerosis
Age-Related Changes in Body Composition
Background: Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age.
- Trial name
- NCT01517113
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Stroke, Insulin Resistance
Trial of Aerobic Exercise Training in Stroke Survivors
The purpose of this study is to examine the effects of treadmill training on inflammation in the skeletal muscle and adipose tissue, insulin action in the skeletal muscle, and whole body glucose metabolism in stroke survivors.
- Conditions
- Stroke, Insulin Resistance, Sedentary Lifestyle
- Trial name
- NCT00891514
- Testing
- Aerobic Exercise, Stretching
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Baltimore VA Medical Center
Aging, Oxidative Stress
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and…
- Conditions
- Aging, Oxidative Stress, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04351113
- Testing
- MITO-AO, PB-125, Passive Leg Movement (PLM)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Joel Trinity
Healthy
Japan Central Aortic Pressure Prospective Study
Purpose of the study 1. The predictive value of central aortic pressure and aortic pulse wave velocity (PWV) in a Japanese population is not known.
- Trial name
- J-CARP (NCT01243840)
- Where
- Japan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Yoshio Matsui
Hypertension
Post-exercise Hypotension After a Power Training Session in Older Adults With Hypertension
The main purpose of the present study was to evaluate the effect of a power training session on office and 24h ambulatory blood pressure in older adults with hypertension.
- Trial name
- NCT03615625
- Testing
- Power Training Session
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in younger versus older transgender women (people who were assigned male at birth but whose gender identity is female).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04066283
- Testing
- No intervention
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertension, Vascular Stiffness
Arterial Stiffness and Blood Pressure
Hypertension is a common and treatable disorder that remains the leading preventable cause of heart disease. Blood pressure treatment relies mainly on upper arm blood pressure readings and ignores blood vessel physiology and…
- Conditions
- Hypertension, Vascular Stiffness, Aging
- Trial name
- LOADED-BP (NCT06495710)
- Testing
- Blood pressure treatment algorithm
- Where
- 3 sites in United States
- Volunteers
- 228 people
- Sponsor
- VA Office of Research and Development
Stroke
Electrotactile Frequency, Amplitude, and Temporal Gap Discrimination in Young Adults, Older Adults, and Stroke Survivors
The purpose of this study is to evaluate and compare sensory discrimination ability for electrotactile stimulation among young adults, older adults, and patients with stroke.
- Trial name
- ESD-NR (NCT07656675)
- Testing
- Electrotactile Sensory Discrimination Tasks
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sungkyunkwan University
Endothelial Dysfunction, Aging
Passive Mobilization and Vascular Function
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF.
- Conditions
- Endothelial Dysfunction, Aging, Bed Rest
- Trial name
- NCT03087643
- Testing
- Passive mobilization - PM
- Where
- 3 sites in Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL
Drug Addiction, Technology Addiction
Relationship of Addictions to Obesity, Physical Activity and Vascular Ageing in Young Adults
This is a cross-sectional observational study whose objective is to analyse the relationship between behavioural addictions and drug addictions with obesity, physical activity, sedentary lifestyle, arterial stiffness and vascular…
- Conditions
- Drug Addiction, Technology Addiction, Young Adult
- Trial name
- NCT05866133
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Peripheral Artery Disease, Peripheral Vascular Disease
ENhancing Exercise With LIGHT to Improve Functioning in PAD
The ENLIGHTEN PAD Trial will collect preliminary data to test whether daily 660 nm light treatment of the lower extremities immediately before home-based walking exercise sessions improves six-minute walk distance at 4-month…
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Disease, Aging, Walking, Difficulty
- Trial name
- ENLIGHTEN PAD (NCT06399900)
- Testing
- Far red light therapy, Home-based walking exercise
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Northwestern University
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in older versus younger transgender men (people who were assigned female at birth but whose gender identity is male).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04237467
- Testing
- No intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sleep Disorders, Circadian Rhythm, Cognitive Impairment
High-frequency tRNS for Sleep Disturbances in Neurocognitive Disorders Due to Vascular Disease
The investigators aim to 1) investigate and compare the safety, efficacy and sustainability of hf-tRNS, tACS and sham transcranial current stimulation (tCS) over left inferior parietal lobe (IPL) in mild neurocognitive disorder…
- Conditions
- Sleep Disorders, Circadian Rhythm, Cognitive Impairment, Vascular Dementia
- Trial name
- NCT06169254
- Testing
- Transcranial current stimulation (tCS)
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Post-traumatic Stress Disorder (PTSD), Cardiovascular Diseases
NightWare and Cardiovascular Health in Veterans With PTSD
The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD).
- Conditions
- Post-traumatic Stress Disorder (PTSD), Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT06419959
- Testing
- NightWare
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development