Clinical trials: Vascular Anomalies
Cerebrovascular Accident, Stroke, Acute
Fabry and Stroke Epidemiological Protocol (FASEP): Risk Factors In Ischemic Stroke Patients With Fabry Disease
More than one million people in Europe suffer from a stroke every day. Normally older people have a stroke, but also a significant number of younger people between 18 and 55 years.
- Conditions
- Cerebrovascular Accident, Stroke, Acute, Cerebral Stroke
- Trial name
- FASEP (NCT01182818)
- Where
- 14 sites in Germany, Poland
- Volunteers
- 1,000 people
- Sponsor
- University of Rostock
Students, Spinal Cord Injury
Group Coaching Study for Life Goals
This study plans to implement's group coaching with neurodivergent STEM undergraduate students, individuals with spinal cord injuries and their caregivers, and individuals with Ehler's Danlos Syndrome.
- Conditions
- Students, Spinal Cord Injury, Ehlers Danlos Syndrome, Care Givers
- Trial name
- NCT07083713
- Testing
- Group Coaching
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Lymphangioma, Lymphatic Malformations
Bleomycin as an Effective and Curative Adjunct Therapy for Lymphangioma
Lymphatic malformations (LM), or lymphangiomas, are common vascular anomalies in children, most often occurring in the head and neck, less commonly in the axilla, abdomen, thorax, groin, and extremities.
- Trial name
- NCT06943703
- Testing
- Sclerotherapy with intralesional bleomycin injection
- Where
- Vietnam
- Volunteers
- 809 people
- Sponsor
- National Children's Hospital, Vietnam
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies
This phase II trial studies how well giving fludarabine phosphate, melphalan, and low-dose total-body irradiation (TBI) followed by donor peripheral blood stem cell transplant (PBSCT) works in treating patients with hematologic…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT01529827
- Testing
- fludarabine phosphate, melphalan, total-body irradiation
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Roswell Park Cancer Institute
Hemophilia A With Inhibitor, Hemophilia A With Anti Factor VIII
Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitors
This Phase I/II clinical study will evaluate the safety and efficacy of valoctocogene roxaparvovec in patients with severe haemophilia A and inhibitors to FVIII.
- Trial name
- GENEr8-INH (NCT04684940)
- Testing
- Valoctocogene roxaparvovec
- Where
- 9 sites in United States, Brazil and 5 more
- Volunteers
- 10 people
- Sponsor
- BioMarin Pharmaceutical
Acute Myocardial Infarction (AMI), STEMI - ST Elevation Myocardial Infarction (MI)
Effect of Dapagliflozin Administration on the Apoptosis Levels of Patients With Acute Myocardial Infarction
The currently known Sodium-Glucose Transporter 2 (SGLT-2) inhibitors are recognized not only for their effects on improving intravascular glucose levels but also for their cardioprotective effects, including improvements in…
- Conditions
- Acute Myocardial Infarction (AMI), STEMI - ST Elevation Myocardial Infarction (MI), NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
- Trial name
- DAPOPTOSIS-MI (NCT06615674)
- Testing
- Forxiga® 10 mg Film-Coated Tablet, manufactured by AstraZeneca Pharmaceuticals LP, USA for AstraZeneca Pharmaceuticals Co. Ltd., China imported by PT AstraZeneca Indonesia, Indonesia
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Yoga Yudhistira
Fabry Disease
Sophisticated Assessment of Disease Burden in Patients With Fabry Disease
To detect early signs of cardiac and metabolic alterations as well as to evaluate the progression of cardiac and metabolic impairments in mildly affected patients with Fabry Disease using high sensitive diagnostic methods.
- Trial name
- SOPHIA (NCT01210196)
- Testing
- MRI
- Where
- 11 sites in Belgium, Czechia and 4 more
- Volunteers
- 36 people
- Sponsor
- Shire
Mucopolysaccharidosis, Fabry Disease
Non-invasive Assessment of Intraocular Pressure in MPS by Use of the Ocular Response Analyzer.
The aim of the present study is to compare intraocular pressure (IOP) values assessed with Ocular Response Analyzer to the classical gold standard of IOP measurement, to Goldmann applanation tonometry by mucopolysacchyridosis…
- Trial name
- MPSORA (NCT01695161)
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Intrauterine Growth Restriction
Thromboelastography (TEG) In the Intrauterine Growth Restriction (IUGR) Neonatal Population by Gestational Age
The investigators aim to improve the understanding of TEG in this population in an effort to improve outcomes in a population at high risk in both the presence and absence of blood product transfusions.
- Trial name
- NCT04907578
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Vascular Malformation, Arteriovenous Malformation
Diagnostic Imaging of Vascular Malformations Using MSOT and ULM
This clinical study evaluates the efficacy and accuracy of Multispectral Optoacoustic Tomography (MSOT) and Ultrasound Localization Microscopy (ULM) for imaging and diagnosing vascular malformations (venous, arteriovenous…
- Conditions
- Vascular Malformation, Arteriovenous Malformation, Lymphatic Malformation, Venous Malformations
- Trial name
- NCT06994260
- Testing
- Multispectral Optoacoustic Tomography, Ultrasound Localization Microscopy
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital Erlangen
Pulmonary Artery Stenosis, Aortic Coarctation
Minima Stent System Post- Approval Study (PAS)
This Post-Approval Study is a single arm, prospective, multi-center, open-label study of patients treated with the Renata Minima Stent System in the United States.
- Trial name
- NCT06828770
- Testing
- Minima Stent System
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- Renata Medical
Transposition of Great Vessels, Outcome, Fatal
Outcomes of Transposition of the Great Arteries After Arterial Switch Operation
Transposition of the great arteries (TGA) is a complex cyanotic congenital heart disease and patients suffer from a high mortality rate within one year of age without appropriate management.
- Trial name
- NCT05089773
- Testing
- The arterial switch operation
- Where
- 2 sites in China
- Volunteers
- 1,281 people
- Sponsor
- Children's Hospital of Fudan University
Meconium Aspiration Syndrome, Persistent Pulmonary Hypertension of Newborn
Oral Sildenafil in Persistent Pulmonary Hypertension Secondary to Meconium Aspiration Syndrome in Newborns
The purpose of this study is to to study the role of oral Sildenafil in Persistent Pulmonary Hypertension of Newborn (PPHN) secondary to Meconium Aspiration Syndrome (MAS) in newborns and to study risk factors of MAS developing…
- Trial name
- OSiNPH (NCT01757782)
- Testing
- Oral Sildenafil
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Sir Takhtasinhji General Hospital
Silent Stroke, Pulmonary Embolism
Risk of Stroke in Pulmonary Embolism With a Patent Foramen Ovale (PFO)
Pulmonary embolism is associated with a small but definite risk of paradoxical embolism in patients with a patent foramen ovale (PFO).
- Conditions
- Silent Stroke, Pulmonary Embolism, Patent Foramen Ovale
- Trial name
- ICEP (NCT00831259)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Caen
Chronic Myeloproliferative Disorders, Leukemia
Non-Ablative Allo HSCT For Hematologic Malignancies or SAA
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00006379
- Testing
- anti-thymocyte globulin, graft-versus-tumor induction therapy, cyclophosphamide
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Case Comprehensive Cancer Center
Sickle Cell Disease
Blood Collection for Research Related to Certain Diseases Involving Blood Vessels
The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies.
- Trial name
- NCT00047996
- Where
- 2 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anemia, Sickle Cell, Blood Disease
Prevention of Cerebral Infarction in Sickle Cell Anemia - Comprehensive Sickle Cell Center
To conduct a prospective study aimed at the early detection and treatment of cerebral vascular disease prior to irreversible brain injury in young children with sickle cell anemia (SCA).
- Conditions
- Anemia, Sickle Cell, Blood Disease, Cerebrovascular Disorders, Cerebrovascular Accident
- Trial name
- NCT00005327
- Sponsor
- University of Southern California
Pseudoxanthoma Elasticum
The Prevention of Systemic Ectopic Mineralization in Pseudoxanthoma Elasticum
The goal of this randomized clinical trial is to assess the effect of etidronate on ectopic calcification in relatively young patients with Pseudoxanthoma elasticum.
- Trial name
- TEMP-PREVENT (NCT05832580)
- Testing
- Etidronate
- Where
- Netherlands
- Volunteers
- 76 people
- Sponsor
- UMC Utrecht
Type 1 Diabetes
Vascular Function in Adolescent, Diabetic Children
The objectives of this investigator initiated study are to: 1. Determine if and when vascular abnormalities occur during early adolescence 2. Determine if poor diabetic control is related to vascular abnormalities.
- Trial name
- NCT00348179
- Testing
- Measurement of vascular function per SphymgnoCor equipment
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Arteriovenous Malformation, Hereditary Hemorrhagic Telangiectasia
Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding
The purpose of this study is to determine whether Thalidomide is effective in the treatment of arteriovenous malformations in the gastrointestinal tract.
- Conditions
- Arteriovenous Malformation, Hereditary Hemorrhagic Telangiectasia, Hematochezia, Melena
- Trial name
- TAG (NCT00389935)
- Testing
- Thalidomide
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- Northport Veterans Affairs Medical Center