Clinical trials: Vascular Bleeding
Hemorrhage, Thrombosis
Anticoagulant Therapy During Pacemaker Implantation
There are no established guidelines regarding interruption of warfarin anticoagulant therapy prior to surgical implantation of cardiac pacemakers.
- Conditions
- Hemorrhage, Thrombosis, Embolism
- Trial name
- FINPAC (NCT00479362)
- Testing
- Warfarin, Aspirin, Permanent pacemaker
- Where
- Finland
- Volunteers
- 447 people
- Sponsor
- University of Turku
Acute Non-variceal Upper Gastrointestinal Hemorrhage, Coronary Heart Disease
Timing of Endoscopy in Coronary Heart Disease Patients Taking Antiplatelet Drugs With Acute Non-variceal Upper Gastrointestinal Bleeding
This is a prospective randomized controlled trial (RCT) evaluating the optimal timing of endoscopy in patients with coronary heart disease who are taking antiplatelet drugs and present with acute non-variceal upper…
- Trial name
- PACT-UGIB (NCT07507162)
- Testing
- Urgent Endoscopy (Within 12 Hours of Admission), Early Endoscopy (12-24 Hours After Admission)
- Volunteers
- 212 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Valve Stenosis, Aneurysm of Ascending Aorta
Progel Vascular Sealant
This study is being conducted to evaluate the safety and effectiveness of the Progel Vascular Sealant for use in vascular reconstructions to achieve adjunctive hemostasis by mechanically sealing areas of leakage.
- Conditions
- Aortic Valve Stenosis, Aneurysm of Ascending Aorta, Aortic Valve Disorder, Bicuspid Valve Disorder
- Trial name
- NCT01959503
- Testing
- Progel Vascular Sealant, Gelfoam Plus
- Where
- 19 sites in United States
- Volunteers
- 158 people
- Sponsor
- C. R. Bard
Head Trauma Injury
Mild Head Trauma in the Emergency Room: Assessment of the Risk of Intracranial Hemorrhage in Patients Receving Platelet Inhibitors.
The clinical signs presented by a patient with a mild head injury are highly variable but remain strongly predictive of brain damage.
- Trial name
- Trauma-Head (NCT05589103)
- Where
- France
- Volunteers
- 1,692 people
- Sponsor
- University Hospital, Strasbourg, France
Lung Neoplasms, Esophageal Neoplasms
The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery
The purpose of this study is to determine whether the use of different dose of LMWH compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.
- Conditions
- Lung Neoplasms, Esophageal Neoplasms, Venous Thromboembolism
- Trial name
- NCT01267305
- Testing
- Fondaparinux, Nadroparin Calcium
- Where
- China
- Volunteers
- 362 people
- Sponsor
- Shanghai Zhongshan Hospital
Stroke, Brain Ischemia
A Novel Rural Integrated Care and Early Prevention Model for Older Adults at High Risk of or Living With Stroke in China
This cluster randomized controlled trial aims to evaluate the effectiveness of a novel telemedicine-enabled integrated care model led by rural doctors in reducing cardiovascular and cerebrovascular events among elderly adults…
- Conditions
- Stroke, Brain Ischemia, Cerebral Hemorrhage, Transient Ischemic Attack
- Trial name
- NCT07628283
- Testing
- Enhanced Usual Stroke Care, Digital Health Platform-Supported Integrated Stroke Management
- Where
- 2 sites in China
- Volunteers
- 2,510 people
- Sponsor
- Jiangsu Province (Suqian) Hospital
Acquired Bleeding Disorder, Intracerebral Haemorrhage
Safety and Preliminary Efficacy of Activated Recombinant Human Factor VII for Preventing Early Hematoma Growth in Acute Intracerebral Haemorrhage
This trial is conducted in the United States of America (USA). The aim of this trial is to evaluate the safety and preliminary efficacy of activated recombinant human factor VII (NovoSeven®) for preventing early hematoma growth…
- Trial name
- NCT01563445
- Testing
- activated recombinant human factor VII
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Novo Nordisk A/S
Healthy
The Safety of Autologous Lyophilized Plasma Versus Fresh Frozen Plasma in Healthy Volunteers
A single-site, single-blind study of ascending doses of Lyophilized Plasma in normal healthy volunteers.
- Trial name
- NCT00968487
- Testing
- Lyophilized Plasma, Fresh Frozen Plasma
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- HemCon Medical Technologies, Inc
Meningioma of Brain, Meningioma Surgery
Re-bleeding in Giant Meningioma and Intraoperative Hydroxyethyl Starch (HES) Fluid Therapy
Project Summary: Retrospective Cohort Study 1. Core ObjectiveThe primary goal is to determine if the volume of Hydroxyethyl Starch (HES) 130/0.4 (specifically Voluven® or Volulyte®) administered during the removal of giant…
- Trial name
- GM-HES (NCT07476404)
- Testing
- exposure to Hydroxyethyl Starch (HES) Voluven® or Volulyte® 130/0.4
- Where
- Thailand
- Volunteers
- 300 people
- Sponsor
- Chiang Mai University
Stroke, Ischemia Stroke
Minocycline in Stroke Study at Maimonides
The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older.
- Conditions
- Stroke, Ischemia Stroke, Hemorrhagic Strokes, Mortality
- Trial name
- NCT07237048
- Testing
- Minocycline 200mg
- Where
- United States
- Volunteers
- 1,164 people
- Sponsor
- Joyce Chen
Polyvascular Disease, Atherosclerosis
Clinical Register Studying the therApeutic Patient Population With Multifocal Atherosclerosis
Аn international, multicenter, non-interventional real-life clinical practice Register studying the Actual therapeutic patient population with Multifocal Atherosclerosis in the Russian Federation and Eurasian countries
- Conditions
- Polyvascular Disease, Atherosclerosis, Atherosclerosis Generalized, Cardiovascular Diseases
- Trial name
- KAMMA (NCT05189847)
- Where
- Russia
- Volunteers
- 3,059 people
- Sponsor
- Eurasian Association of Therapists
Bleeding, Clot Blood
Aspirin and Hemocompatibility Events in Chronic Advanced Heart Failure Patients With Assist Device
Heart failure is a world epidemic. LVADs are increasingly used as they have demonstrated improved survival rates compared to optimal medical management.
- Trial name
- NCT06655376
- Testing
- Aspirin, Warfarin
- Where
- 3 sites in United States
- Volunteers
- 128 people
- Sponsor
- Columbia University
Postpartum Hemorrhage
Tranexamic Acid and Thromboelastography During Cesarean Delivery
The aim of this study is to characterize the coagulation changes, using thromboelastography (TEG), after prophylactic tranexamic administration during cesarean delivery.
- Trial name
- TA TEG (NCT02026297)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Intracerebral Hemorrhage
Chinese Multicenter Cohort Study of Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage is a severe form of stroke associated with high mortality and long-term disability. The Chinese Multicenter Cohort Study of Intracerebral Hemorrhage (CASA) is a prospective observational…
- Trial name
- CMCS-ICH (NCT07833410)
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Intracerebral Hemorrhage
Minocycline Accelerates Intracerebral Hemorrhage Absorption
Minocycline has been found to reduce cerebral edema secondary to cerebral hemorrhage, promote hematoma absorption, and shorten hematoma absorption time; clinical studies have been conducted to confirm the safety in the treatment…
- Trial name
- MACHA (NCT05630534)
- Testing
- Minocycline, starch
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Acute Stroke
Stroke Recovery Initiative - Registry for Stroke Research Studies
The Stroke Recovery Initiative is a nation-wide participant recruitment registry that connects people who have had a stroke with researchers who are working to develop new approaches to improve recovery after stroke.
- Conditions
- Stroke, Acute Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT03318432
- Where
- United States
- Volunteers
- 60,000 people
- Sponsor
- University of California, San Francisco
Hereditary Hemorrhagic Telangiectasia (HHT), Nosebleeds
Ranibizumab for the Management of Recurrent Nosebleeds in Patients With Hereditary Hemorrhagic Telangiectasia (HHT)
This study is for patients with recurrent epistaxis (nosebleeds) as a result of Hereditary Hemorrhagic Telangiectasia (HHT). The aim is to determine if ranibizumab, topically applied will diminish epistaxis in patients with HHT…
- Trial name
- NCT01406639
- Testing
- Ranibizumab
- Sponsor
- University of California, San Diego
Trauma, Coagulopathy
Impact of a Prehospital Identification of Trauma Patients in Need for Damage Control Resuscitation.
Early identification of trauma patients in need for Damage Control Resuscitation (DCR) has potential to be beneficial for general emergency units that are not expected to be ready for this rare situation 24 hours per day, 7 days…
- Conditions
- Trauma, Coagulopathy, Hemorrhage, Emergencies
- Trial name
- NCT03444077
- Testing
- Use of the Trauma Induced Coagulopathy Clinical Score (TICCS) as a diagnostic tool., Regular care, STTTOPPP the bleeding
- Where
- 4 sites in Belgium
- Volunteers
- 400 people
- Sponsor
- University of Liege
Acute Brain Injury, Traumatic Brain Injury
Effect of Central Venous Catheterization on Brain Pressure in Acute Brain Injury Patients
Acute brain injury (ABI) is a serious condition that can cause a dangerous increase in pressure inside the skull (called intracranial pressure, or ICP), which can harm the brain.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Aneurysmal Subarachnoid Hemorrhage (aSAH)
- Trial name
- CVC-ICP (NCT07704528)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Blood Coagulation Disorders, Hemorrhage
Transfusion of Fresh Frozen Plasma in Non-bleeding Intensive Care Unit (ICU) Patients
With the aim to restrict inappropriate fresh frozen plasma (FFP) transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgroup of intensive care (ICU) patients undergoing an invasive…
- Trial name
- TOPIC (NCT01143909)
- Testing
- omitting FFP transfusion before an intervention
- Where
- 4 sites in Netherlands
- Volunteers
- 81 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)