Clinical trials: Vascular Cognitive Impairment
Stroke
the Clinical Effect of TCM Sniffing Therapy Combined With Electroacupuncture in PSCI
The patients with cognitive impairment after stroke were divided into control group, electroacupuncture group, olfactory therapy group, electroacupuncture combined with olfactory therapy group, and sham group with 35 people in…
- Trial name
- NCT06313866
- Testing
- control, Electronuchal acupuncture group treatment, Smell therapy group treatment
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Hangzhou Medical College
Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage
REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study
The investigators propose to perform serial detailed cognitive, motor, behavioral, and blood collection follow-up using longitudinal structured telephone interviews of an anticipated 350 ICH survivors enrolled in Minimally…
- Conditions
- Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage, ICH, Hemorrhage
- Trial name
- ICH03 (NCT05611918)
- Where
- 26 sites in United States
- Volunteers
- 350 people
- Sponsor
- Johns Hopkins University
Parkinson Disease, Stroke
COMPuter-assisted Self-training to Improve EXecutive Function
This project explores the effects of specialized computer-based cognitive rehabilitation (CBCR) targeting executive functions in three groups of patients: Stroke, Cardiac Arrest and Parkinson's Disease.
- Conditions
- Parkinson Disease, Stroke, Cardiac Arrest, Cognitive Dysfunction
- Trial name
- COMPEX (NCT04229056)
- Testing
- Computer-based cognitive rehabilitation (CBCR), General computer-based cognitive stimulation
- Where
- 2 sites in Denmark
- Volunteers
- 307 people
- Sponsor
- Bispebjerg Hospital
Brain Infarction, Hypertension
Angiotensin II Receptor Blockers (ARB) and ACE Inhibitors (ACEI) on Silent Brain Infarction and Cognitive Decline
The purpose of this study is to elucidate whether or not angiotensin II receptor blockers (ARB) are more beneficial or equal to angiotensin converting enzyme inhibitors (ACEI) on development or progression of silent brain…
- Trial name
- NCT00126516
- Testing
- Angiotensin II Receptor Antagonists, Angiotensin-converting Enzyme Inhibitors
- Where
- Japan
- Volunteers
- 395 people
- Sponsor
- Nara Medical University
Ischaemic Stroke, Cognitive Impairment, Mild
Cognitive Care Bundle for Ischaemic Stroke : A Pilot Randomised Controlled Trial
The goal of this clinical trial is to learn if a set of treatments, called a "cognitive care bundle," can help preserve cognitive ability in people who have had a stroke.
- Trial name
- COGIS (NCT07610291)
- Testing
- Cognitive care bundle, Standard Medical Care (SMC)
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- National University of Malaysia
Cardiovascular Diseases, Mortality
Prospective Cohort Study of 4,837 Post-myocardial Infarction Patients (Alpha Omega Cohort)
The Alpha Omega Cohort is a prospective study of 4,837 state-of-the-art drug-treated Dutch patients aged 60-80 years who had a clinically diagnosed myocardial infarction up to 10 years before enrolment.
- Conditions
- Cardiovascular Diseases, Mortality, Type 2 Diabetes Mellitus, Cognitive Decline
- Trial name
- NCT03192410
- Testing
- Dietary intake, Lifestyle factors, Blood biomarkers
- Where
- Netherlands
- Volunteers
- 4,837 people
- Sponsor
- Wageningen University
Mild Cognitive Impairment, Alzheimer's Disease
Korea Alzheimer's Disease Neuroimaging Initiative
PRIMARY OBJECTIVES -Establish a registry for Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) STUDY DESIGN -This is a non-randomized, natural history, observational, registry study.
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Subcortical Vascular Dementia
- Trial name
- K-ADNI (NCT01979419)
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Korean Alzheimers' Disease Neuroimaing Intitiative
Stroke, Cognitive Impairment
Training Cognition With Neurofeedback After Stroke
Post-stroke cognitive impairment (PSCI) is a common source of invisible disability. The actual techniques of cognitive remediation have been reported to have only a small effect, justifying the need to foster research in this…
- Trial name
- CITRINeS (NCT06852209)
- Testing
- Cognitive remediation therapy, Neuropsychological assessment, Real-time functional MRI neurofeedack (rt-fMRI NF)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Stroke, Cognitive Dysfunction
Transferring Speed of Processing Gains to Everyday Cognitive Tasks After Stroke
This study will compare two approaches to cognitive rehabilitation in adults with stroke with persistent, mild to moderate, cognitive impairment.
- Trial name
- NCT05162781
- Testing
- Speed of Processing Training, Instrumental Activities of Daily Living In-lab Training, Cognitive Transfer Packagke
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Alabama at Birmingham
Ischemic Stroke, Acute
A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
Through a multicenter prospective AIS cohort study, we analyze the potential association of human proteome, microbiome and metabolome alterations with AIS prognosis, searching for key proteins, differential organisms and…
- Trial name
- NCT06584565
- Testing
- microbiome; metabolomics; proteomics
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Sleep Disorder, Cardiovascular Diseases
Dose-effect Relationship of Tai Chi on Health Promotion in Different Age Groups
The purpose of this study is to investigate the physical and mental health status of middle-aged and elderly people of different ages and practicing Tai chi for different periods of time, so as to provide a strong theoretical…
- Conditions
- Sleep Disorder, Cardiovascular Diseases, Hypertension, Cognitive Impairment
- Trial name
- NCT06307483
- Testing
- Taichi group, Exercise group
- Where
- China
- Volunteers
- 499 people
- Sponsor
- Beijing Sport University
Stroke, Hypertension
DELPHI in Subjects at Risk for Stroke and Dementia
The DELPhi system is a software device that is used for the noninvasive evaluation of brain plasticity and connectivity. The DELPhi software uses EEG and TMS devices as accessories.
- Conditions
- Stroke, Hypertension, Diabete Mellitus, Dyslipidemias
- Trial name
- NCT03884647
- Testing
- DELPhI system
- Where
- 4 sites in United States, Israel
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Peanuts for Cardiometabolic, Brain, and Intestinal Health
The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Cognition, Microvascular Function
- Trial name
- NCT06867198
- Testing
- Peanuts
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Georgia State University
Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement
Neuropsychological and Neuroimaging Evaluation of the Cognitive Impairment in Aortic Valve Replacement (ARTiCO)
OBJECTIVE: To evaluate changes in cognitive performance in the early postoperative (1 month) and late (1 year) postoperative period in patients undergoing aortic valve replacement (SVAo) with surgery (SVA_Q) or transcatheter…
- Conditions
- Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement, Surgical Treatment, Cognitive Impairment
- Trial name
- ARTiCO (NCT05235529)
- Testing
- Aortic valve replacement, TAVI
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Germans Trias i Pujol Hospital
Stroke Hemorrhagic, Stroke, Ischemic
The Role of Cognition in Motor Learning After Stroke
Stroke leads to lasting problems in using the upper limb (UL) for everyday life activities. While rehabilitation programs depend on motor learning, UL recovery is less than ideal.
- Conditions
- Stroke Hemorrhagic, Stroke, Ischemic, Cognitive Impairment
- Trial name
- NCT05268861
- Testing
- Error Augmentation Feedback, No Error Augmentation Feedback
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McGill University
Postoperative Cognitive Dysfunction, Cerebrovascular Accident
Neurological Outcome After Minimal Invasive Coronary Artery Bypass Graft
Primary objectives: Assessment of the incidence of postoperative cognitive dysfunction (POCD), cerebrovascular accident (CVA), and delirium after minimal invasive coronary artery bypass grafting (Endo-CABG).
- Conditions
- Postoperative Cognitive Dysfunction, Cerebrovascular Accident, Delirium
- Trial name
- NOMICS (NCT02979782)
- Testing
- Endo-CABG, PCI
- Where
- 2 sites in Belgium
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Vascular Cognitive Impairment, White Matter Lesions
Mechanism of Gamma Oscillation Synchronization in the Prefrontal-hippocampal Circuit for Memory Dysfunction in Patients With White Matter Lesions of Cerebral Small Vessel Disease
The mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease is still unclear. The disrupted synchronization of gamma oscillations in the prefrontal-hippocampal circuit is a potential…
- Conditions
- Vascular Cognitive Impairment, White Matter Lesions, Gamma Oscillation
- Trial name
- NCT07042633
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Biomarker Study: Heart Failure Patients at Risk
In order to determine if NfL can be a prognostic biomarker for VCID, participants will undergo a baseline evaluation consisting of neuropsychological testing and a blood draw with a 12-month follow-up consisting of…
- Conditions
- Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- NCT05336175
- Testing
- Angiotensin 1-7, Saline solution
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Arizona