Clinical trials: Vascular Conditions
Coronary Artery Disease, Myocardial Infarction
Randomized Study to Assess the Effect of ThRombus Aspiration on Flow Area in STEMI Patients
The purpose of the study it to evaluate whether primary percutaneous coronary intervention (primary PCI) with a new thrombectomy device as compared to primary PCI without thrombectomy increases minimal flow area after stenting…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, STEMI
- Trial name
- TROFI (NCT01271361)
- Testing
- primary PCI with thrombectomy, primary PCI without thrombectomy
- Where
- 5 sites in Denmark, France and 2 more
- Volunteers
- 140 people
- Sponsor
- Terumo Europe N.V.
Intracerebral Hemorrhage Lobar
Evacuation of Lobar Intracranial Hemorrhage Using Microsurgical Technique (ELIMINATE)
ELIMINATE is a cohort study, phase 2A, designed to determine whether a standardized microsurgical procedure to evacuate spontaneous lobar intracranial hemorrhage (ICH) is feasible, safe and surgically efficacious in achieving a…
- Trial name
- ELIMINATE (NCT07697742)
- Testing
- Microsurgical hematoma evacuation
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Dr. Michael D Hill
Intermittent Claudication
Invasive Revascularization or Not in Intermittent Claudication
Peripheral arterial disease (PAD) often causes exertion pain in the legs, intermittent claudication (CI) affecting> 10% of individuals> 65 years.
- Trial name
- IRONIC (NCT01219842)
- Testing
- INVASIVE (INV) treatment, Best medical treatment (BMT)
- Where
- Sweden
- Volunteers
- 159 people
- Sponsor
- Sahlgrenska University Hospital
Age Related Macular Degeneration
Evaluation of Wet Age-Related Macular Degeneration (AMD) Genetic Profile Interactions With Ranibizumab Treatment Outcomes
Age Related Macular Degeneration (AMD) is the leading cause of blindness in North America. This condition causes a progressive loss of central vision, the part of your vision that allows you to read, drive and see images in sharp…
- Trial name
- NCT01363570
- Testing
- Ranibizumab
- Where
- 2 sites in Canada
- Volunteers
- 70 people
- Sponsor
- McMaster University
Coronary Artery Disease
Effectiveness of Early Cardiac Rehabilitation
The goal of this experimental study is to compare the effects of early (2nd week) cardiac rehabilitation applied in addition to usual care on functional capacity, quality of life, frailty and body composition in patients…
- Trial name
- NCT06116773
- Testing
- Training, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
STEMI, Anterior MI
Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction
The objective of this study is to assess efficacy and safety of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) therapy started post flow restoration but prior to stenting during percutaneous coronary…
- Trial name
- PiCSO-AMI-I (NCT03625869)
- Testing
- PiCSO
- Where
- 17 sites in Denmark, France and 4 more
- Volunteers
- 145 people
- Sponsor
- Miracor Medical SA
Ehlers-Danlos Syndrome (EDS)
Impact of Ehlers-Danlos Syndrome on Gynaecological Health
Dysmenorrhea is a common problem in gynaecology, significantly impacting patients' quality of life. Ehlers-Danlos syndrome (EDS) is associated with joint hypermobility, tissue fragility and chronic pain.
- Trial name
- GYNESED (NCT07151274)
- Where
- France
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Oncologic Diseases, Coagulation Defect
Study Protocol: Impact of Metamizole (Optalgin®) on Anti-Xa Concentrations in Oncology Patients Receiving DOACs
Evaluation of the Effect of metamizole (Optalgin®) on Anti-Xa Levels in Oncology Patients Receiving Direct Oral Anticoagulants (DOACs)
- Conditions
- Oncologic Diseases, Coagulation Defect, Pain Management
- Trial name
- NCT07384013
- Testing
- metamizole
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rambam Health Care Campus
Diabetic Foot Ulcer
Effect of Virtual Reality on Pain, Anxiety and Vital Signs During Diabetic Foot Care
This study aims to determine the effects of a virtual reality (VR) intervention on pain level, state anxiety, and vital signs during foot care in individuals with diabetic foot ulcers.
- Trial name
- NCT07586423
- Testing
- VR, Standard Diabetic Foot Care
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Malatya Turgut Ozal University
Critical Limb Ischemia, Arterial Occlusive Disease
Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia
The hypothesis behind the trial is the concept that Pregabalin is effective in reducing pain at rest in lower limb ischemia, and the study evaluates active treatment or placebo added to the regular pain regimens for these…
- Conditions
- Critical Limb Ischemia, Arterial Occlusive Disease, Pain, Ischemia
- Trial name
- NCT00403780
- Testing
- pregabalin
- Where
- 3 sites in Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
Stroke, Ischemic, Dysbiosis
A Randomized Double Blinded Placebo Controlled Study on the Effects of Dietary Supplementation With a Probiotic on Stroke Patients
The aim of this study is to determine the effects of an intervention using a commercially available probiotic in a cohort of acute stroke patients.
- Trial name
- PRISE (NCT04954846)
- Testing
- OMNi-BiOTiC SR-9
- Where
- Germany
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
A Multinational Survey-based Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Cardiologists
The purpose of this survey is to collect information for scientific research and to better understand the role of systemic inflammation in identification, treatment and management of patients with ASCVD and CKD.
- Trial name
- FLAME-ASCVD (NCT05755373)
- Testing
- No treatment given
- Where
- India
- Volunteers
- 602 people
- Sponsor
- Novo Nordisk A/S
Sleep Disorder, Cardiovascular Diseases
Dose-effect Relationship of Tai Chi on Health Promotion in Different Age Groups
The purpose of this study is to investigate the physical and mental health status of middle-aged and elderly people of different ages and practicing Tai chi for different periods of time, so as to provide a strong theoretical…
- Conditions
- Sleep Disorder, Cardiovascular Diseases, Hypertension, Cognitive Impairment
- Trial name
- NCT06307483
- Testing
- Taichi group, Exercise group
- Where
- China
- Volunteers
- 499 people
- Sponsor
- Beijing Sport University
Atrial Fibrillation, Deep Vein Thrombosis
Applying Pharmacogenetics to Warfarin Dosing in Chinese Patients
The purpose of this study is to determine whether pharmacogenetic guided dosing of warfarin is promising for the improvement of efficiency, therapeutic efficacy, and, especially, safety of warfarin therapy than a dosing regimen…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism, Heart Valve Disease
- Trial name
- NCT01610141
- Testing
- Genotype-guided warfarin dosing, Non-genotype guided warfarin dosing
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Ischemia Reperfusion Injury, Peripheral Artery Disease
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
In this study, we are trying to see if vitamin B6 can minimize the amplified blood pressure response to exercise following ischemia-reperfusion injury.
- Trial name
- NCT06369350
- Testing
- Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Chronic Limb-Threatening Ischemia
IVUS Guidance in BTK Interventions
Chronic limb-threatening ischemia (CLTI) is a severe form of peripheral artery disease in which very poor blood flow in the arteries below the knee can cause rest pain, non-healing wounds, and even loss of the limb.
- Trial name
- IMAGE-BTK (NCT07731997)
- Testing
- Intravascular ultrasound-guided EVT, Angiography-guided EVT
- Where
- 4 sites in Taiwan
- Volunteers
- 212 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Cardiogenic Shock
Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock
The goal of this clinical trial is to learn if the drug istaroxime works to treat cardiogenic shock due to acute heart failure in adults. It will also learn about the safety of istaroxime.
- Trial name
- RESCUE HF-CS (NCT07583446)
- Testing
- istaroxime
- Where
- Armenia
- Volunteers
- 600 people
- Sponsor
- Seismic Pharmaceuticals Operations LLC
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Prevention of Vasospasm in SAH Through CSF Treatment
The pathophysiological mechanisms of aneurysmal subarachnoid haemorrhage (aSAH) involve early brain injury (EBI) and delayed cerebral ischemia (DCI).
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral, Aneurysmal Subarachnoid Hemorrhage
- Trial name
- PREVAIL (NCT04490161)
- Testing
- intravenous reinstallation of cerebrospinal fluid
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University Innsbruck
ST Elevation Myocardial Infarction, Myocardial Infarction
OCT Versus Angiography for Culprit Lesion Revascularization in Acute Myocardial Infarction PatiEnts
The aim of the study is to compare clinical outcomes between optical coherence tomography-guided versus angiography-guided percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI).
- Trial name
- FRAME-AMI3 (NCT06227754)
- Testing
- Angiography-guided PCI group, Optical coherence tomography-guided PCI group
- Where
- 18 sites in South Korea
- Volunteers
- 1,500 people
- Sponsor
- Chonnam National University Hospital
Coronary Arteriosclerosis, Myocardial Infarction
Determination of the Prevalence and Prognostic Importance of Unrecognized Non-Q-wave Myocardial Infarction by MRI
The first aim of this study is to determine how often unrecognized myocardial infarction occur in patients using a magnetic resonance imaging (MRI) technique (known as delayed enhancement MRI), as compared to the…
- Trial name
- NCT00493168
- Where
- 2 sites in United States
- Volunteers
- 185 people
- Sponsor
- Duke University
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