Clinical trials: Vascular Conditions
Arterial Occlusive Disease, Ulcers
Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia
The purpose of this study is to evaluate whether intramuscular injections of NL003 into the calf is safe and effective in the treatment of critical limb ischemia
- Conditions
- Arterial Occlusive Disease, Ulcers, Ischemia, Peripheral Vascular Disease
- Trial name
- NL003CLI-II (NCT01548378)
- Testing
- NL003, Normal Saline
- Where
- 9 sites in China
- Volunteers
- 200 people
- Sponsor
- Beijing Northland Biotech. Co., Ltd.
Stroke, Spasticity, Muscle
Effects of PNF and Static Stretching on Architecture and Viscoelastic Properties of Hemiplegic Elbow
The patients who were diagnosed with stroke in governmental/university/private hospitals, and who needed rehabilitation because of the increased flexor tone in the elbow joint, decreased range of motion and/or decreased function…
- Trial name
- NCT05626790
- Testing
- Exercise, PNF Stretching, Prolonged Stretching
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istanbul University - Cerrahpasa
Cardiogenic Shock, Acute Myocardial Infarction
National Cardiogenic Shock Initiative
This study evaluates the use of early mechanical circulatory support in patients presenting with acute myocardial infarction and cardiogenic shock.
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCSI (NCT03677180)
- Where
- 75 sites in United States
- Volunteers
- 406 people
- Sponsor
- Henry Ford Health System
Peripheral Arterial Disease, Intermittent Claudication
Exercise Training in Individuals With Peripheral Arterial Disease
In this controlled trial, patients with peripheral arterial disease will be randomized to either maximal walking, submaximal walking, or usual care groups.
- Trial name
- NCT02642276
- Testing
- Exercise training
- Where
- Slovenia
- Volunteers
- 36 people
- Sponsor
- University Medical Centre Ljubljana
Relapsed or Refractory Multiple Myeloma
A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
The purpose of the study is to compare Mezigdomide (CC-92480/BMS-986348) with carfilzomib and dexamethasone (MeziKD) against carfilzomib and dexamethasone (Kd) in the treatment of RRMM: SUCCESSOR-2.
- Trial name
- SUCCESSOR-2 (NCT05552976)
- Testing
- Mezigdomide, Carfilzomib, Dexamethasone
- Where
- 204 sites in United States, Argentina and 25 more
- Volunteers
- 606 people
- Sponsor
- Bristol-Myers Squibb
Arrhythmia, Cardiovascular Diseases
Coronary Artery Bypass Graft (CABG) Patch Trial
To test the hypothesis that implantable cardioverter defibrillator (ICD) therapy will improve survival in coronary heart disease patients at high risk of death, especially arrhythmic death.
- Conditions
- Arrhythmia, Cardiovascular Diseases, Coronary Disease, Death, Sudden, Cardiac
- Trial name
- NCT00000540
- Testing
- defibrillators, implantable
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Traumatic Brain Injury, Subarachnoid Hemorrhage
Comparison of Narcotrend and Cerebral Function Analysing Monitor in Intensive Care to Monitor Seizures and Deep Sedation
A study in the use of the Narcotrend depth of anaesthesia monitor to record a) seizures, and b) monitor a level of sedation referred to as 'burst suppression', in sedated patients in the adult and paediatric intensive care.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Haemorrhage, Encephalitis
- Trial name
- NCT06067750
- Testing
- Narcotrend compared to Cerebral Function Analysing Monitor (CFAM)
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Coronary Artery Disease
Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors
Ticagrelor currently represents the most tested and commonly used P2Y12 inhibitor monotherapy following percutaneous coronary intervention.
- Trial name
- SWAP-7 (NCT06691191)
- Testing
- Ticagrelor 90 mg, Prasugrel 10 mg
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Florida
Coronary Artery Disease, Myocardial Ischemia
Assessment of Loading With the P2Y12 Inhibitor Ticagrelor or Clopidogrel to Halt Ischemic Events in Patients Undergoing Elective Coronary Stenting
The new P2Y12 inhibitors prasugrel (Efient®-Effient®) and ticagrelor (Brilique®-Brilinta®) have shown promising results in the respective TRITON and PLATO trials making of prasugrel and ticagrelor recommended first line…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Myocardial Infarction, Stent Thrombosis
- Trial name
- ALPHEUS (NCT02617290)
- Testing
- Ticagrelor, Clopidogrel
- Where
- France
- Volunteers
- 1,900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Venous Thromboembolism
The Role of Platelet TLRs in Platelet Activation During VTE
Venous thromboembolic disease (VTE) is a frequent and potentially serious pathology. Therapeutic management has improved considerably over the last few decades, enabling the application of codified management in line with the…
- Trial name
- ROT-PLAT-VTE (NCT06257290)
- Testing
- blood sample
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ischemic Stroke, Intracerebral Hemorrhage
China Stroke Registry for Patients With Traditional Chinese Medicine
The CASES-TCM study is a prospective, multicenter, observational study, which will enroll 20,000 patients with acute stroke (ischemic stroke or intracerebral hemorrhage) within 7 days of symptom onset.
- Trial name
- CASES-TCM (NCT04921397)
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Dongzhimen Hospital, Beijing
Lower Urinary Tract Symptoms
Effect of Enhanced External Counterpulsation on Lower Urinary Tract Symptoms
The purpose of this study is to access the effects of Enhanced External Counterpulsation treatment on lower urinary tract symptoms in patients with benign prostatic hyperplasia.
- Trial name
- EECPLUTS (NCT01815697)
- Testing
- Enhanced External Counterpulsation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Atrial Fibrillation, Hypertension
Ganglionated Plexi Ablation vs Renal Denervation in Patients Undergoing Pulmonary Vein Isolation
The investigators have conducted a prospective, double-blind, randomized study to assess the comparative safety and efficacy of two different strategies, PVI plus Renal Denervation (RD) versus PVI plus GP ablation, in patients…
- Trial name
- NCT01898910
- Testing
- PVI+renal denervation, PVI + GP ablation, Optimal medial therapy (OMT)
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Obesity
Effect of Acute Dietary Supplementation With Grape Seed Extract on Aortic Stiffness, Arterial Pressure, and Blood Vessel Dilation in Collegiate Obese Individuals at Rest
This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation.
- Trial name
- NCT04389060
- Testing
- Grape seed extract
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- California Baptist University
Chronic Kidney Disease (Stages 3b-5)
Effect of Probiotic Supplementation on Renal Function, Vascular Calcification and Alterations in Bone Mineral Metabolism in Patients With Chronic Kidney Disease
INTRODUCTION You have been asked to participate in a research study of patients with chronic kidney disease to assess whether a probiotic supplement (a commercially available product that is not a medication) can help slow the…
- Trial name
- MICKID (NCT07260682)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Leukemia, Lymphoma
Chemotherapy Plus Donor White Blood Cell Infusion in Treating Patients With Relapsed Hematologic Cancer Following Donor Peripheral Stem Cell Transplantation
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. White blood cells from donors may be able to prevent graft-versus-host disease in patients with hematologic…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00005946
- Testing
- filgrastim, therapeutic allogeneic lymphocytes, cyclophosphamide
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Pre-Eclampsia, HELLP Syndrome
Evaluation of the Serum Markers sFLt1 and PlGF for the Prediction of the Complications of the Placental Vascular Pathologies in the 3rd Quarter of the Pregnancy.
The pre-eclampsia is a frequent pathology, concerning approximately 5 % of the pregnancies.The pre-eclampsia can evolve into severe maternal and\or foetal complications and is a major cause of mortality.
- Conditions
- Pre-Eclampsia, HELLP Syndrome, Fetal Death, Eclampsia
- Trial name
- PRECOPE (NCT03455387)
- Testing
- sampling of the serum marker sFlt1 and PlGF
- Where
- 7 sites in France
- Volunteers
- 233 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Acute Coronary Syndrome, Chest Pain
Use of Visual Decision Aid for Shared Decision Making in Chest Pain
This study aims to evaluate the use of the chest pain choice (CPC) decision aid as a tool to facilitate discussion between the patient and his/her attending physician with regard to subsequent management plans.
- Conditions
- Acute Coronary Syndrome, Chest Pain, Myocardial Infarction, Angina Pectoris
- Trial name
- NCT03674021
- Testing
- Chest Pain Choice visual aid
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National University Hospital, Singapore
Hyperlipidemia, Metabolic Syndrome X
Low Fat Plant-Based Supplemented Diet Effects on Risk Factors for Chronic Non-communicable Diseases
The effect of a diet free from animal-sourced nutrients on a variety of risk factors for chronic non-communicable diseases in weight reduction programs is not well established.
- Trial name
- LFPBDS2 (NCT02905448)
- Testing
- Low fat plant-based nutrition
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Barbara Jakše s.p.
Acute Ischemic Stroke
Safety and Efficacy Evaluation of the iNstroke 4F Thromboaspiration Catheter in Patients With Acute Ischaemic Stroke Due to Primary Distal Medium Vessel Occlusions (DMVO)
Prospective, Single-arm, Multi-centre Study to Evaluate the Efficacy and Safety of the iNstroke 4F Thromboaspiration Catheter in Patients with Acute Ischaemic Stroke due to Primary Distal Medium Vessel Occlusions.
- Trial name
- 4-NiVO (NCT07357285)
- Testing
- Thromboaspiration catheter
- Where
- 11 sites in Germany, Hungary and 1 more
- Volunteers
- 57 people
- Sponsor
- iVascular S.L.U.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.