Clinical trials: Vascular Conditions
Cerebral Hemorrhage
Intraventricular Rt-PA in Patients With Intraventricular Hemorrhage
This is a study to evaluate how recombinant tissue plasminogen activator (rt-PA) is utilized in patients with intraventricular hemorrhage (IVH).
- Trial name
- NCT00029315
- Testing
- Recombinant Tissue Plasminogen Activator (rt-PA)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Acute Kidney Injury, Hypoxia-Ischemia, Brain
Tissue Oxygenation During Treatment of Infant Congenital Heart Defects
Background: Acute kidney injury (AKI) is a common and serious postoperative complication in children with congenital heart disease.
- Conditions
- Acute Kidney Injury, Hypoxia-Ischemia, Brain, Mesenteric Ischemia
- Trial name
- NCT03941015
- Where
- China
- Volunteers
- 245 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation
NATional TUnisian REgistry of Atrial Fibrillation
A non-interventional, national longitudinal study of atrial fibrillation performed with 91 cardiologists.
- Trial name
- NATURE-AF (NCT03085576)
- Where
- Tunisia
- Volunteers
- 910 people
- Sponsor
- Dacima Consulting
Basal Ganglionic Hemorrhage
Prognostic Factors for Surgical Management of Large Hypertensive Basal Ganglionic Haemorrhage
The aim of this study is to present current and comprehensive recommendations for surgical treatment of this hematoma and to determine the factors that may improve the survival rate
- Trial name
- NCT06309940
- Testing
- Prognostic factors of surgical evacuation of basal ganglionic haemorrhage
- Volunteers
- 25 people
- Sponsor
- Assiut University
ST-segment Elevation Myocardial Infarction
Sonothrombolysis in Patients With STEMI
This study evaluates what effect sonothrombolysis may have on spontaneous reperfusion, microvascular obstruction, left ventricular function and infarct size in patients presenting with their first ST-segment Elevation Myocardial…
- Trial name
- NCT03092089
- Testing
- Definity, (Lipid Microspheres) Intravenous Suspension, Myocardial Contrast Echocardiography, Repurfusion therapy with PPCI
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Harald Becher
Paroxysmal Atrial Fibrillation, Stroke
Using a Personal Heart Rhythm Monitor to Diagnose Paroxsymal Atrial Fibrillation in the Community
This propsective study aims to compare the diagnostic yield of a Personal Heart Rhythm Monitor (PHRM) with an automated cardiac event recorder (ACER) to detect paroxysmal Atrial Fibrillation PAF).
- Trial name
- NCT01867060
- Testing
- Automated Cardiac Event Recorder, Personal Heart Rhythm Monitor
- Where
- United Kingdom
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Parkinson Disease, Diabetes Mellitus
Health Indicators and Patient Reported Outcomes. Identification of Significative Items Aimed at Improving Health Care Procceses.
The objective of this study is to identify key indicators in the follow-up of subjects with different pathologies related to both the person's environment, as well as the perception of their health and general quality of life and…
- Conditions
- Parkinson Disease, Diabetes Mellitus, COVID-19, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- OUTCOMES (NCT05343962)
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Instituto de Biomecanica de Valencia
Myocardial Infarction
The Time Delay Correlated With LV Functions and Heart Failure Incidence in STEMI?!
To find out if the time delays between the first medical contacts till the device has an impact on LV functions estimated by transthoracic Echocardiography and if it's correlated to heart failure incidence in non-diabetic…
- Trial name
- NCT05097755
- Volunteers
- 345 people
- Sponsor
- mustafa Zayan Abdelsayed Mohamed
Corneal Neovascularization, Corneal Graft Failure
A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
The goal of this study is to investigate whether using bevacizumab (Avastin®) is both safe and effective at decreasing the likelihood of a high-risk corneal graft rejection.
- Trial name
- NCT01996826
- Testing
- Avastin® (bevacizumab), 0.9% NaCl & Refresh Liquigel
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Reza Dana, MD
Systemic Inflammatory Response Syndrome, Coronary Arteriosclerosis
Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response
Cardiac surgery using heart and lung machine produces an inflammatory reaction in the body. This leads in few percent of cases to heart, lung, and kidney disturbances that potentially causes death.
- Trial name
- NCT00159926
- Testing
- Cell saver, No cell saver
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease, Delirium
The PATHFINDER Study: A Feasibility Trial
The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery…
- Trial name
- PATHFINDER (NCT04016740)
- Testing
- Ropivacaine, Ketamine, Remifentanil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hemiplegia, Stroke
Evaluation of the Observance and the Tolerance of a Motor Training Program
Transcortical direct current stimulation (tDCS) is an emerging technique in the rehabilitation of hemiplegic patients after stroke.
- Trial name
- ESTIMAH (NCT02844868)
- Testing
- Active tDCS
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sepsis, Blood Coagulation Disorders
Analysis of the Coagulopathy Developed by COVID-19 Infected Patients
Increased D-dimers at admission of COVID-19 infected patients entering hospital due to a severe disease is a risk factor for death.
- Conditions
- Sepsis, Blood Coagulation Disorders, Thrombin, Disseminated Intravascular Coagulation
- Trial name
- COVID-TGT (NCT04356950)
- Testing
- Thrombin generation test assay, Fibrin generation markers assays
- Where
- 4 sites in France
- Volunteers
- 175 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Coronary Syndrome, Myocardial Infarction
Use of Abbott High Sensitivity Troponin I Assay In Acute Coronary Syndromes
Hypothesis: High sensitivity cTnI assays will have improved diagnostic accuracy for type 1 MI compared to contemporary cTnI assays.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Troponin
- Trial name
- UTROPIA (NCT02060760)
- Where
- United States
- Volunteers
- 1,927 people
- Sponsor
- Hennepin Healthcare Research Institute
Obesity, Overweight
A Study Investigating the Effects of Neprinol Study Product on Vascular Function
This open-label study investigated the effectiveness of Neprinol on maintaining healthy cardiovascular health in overweight and obese adults. Subjects took 3 capsules, 3 times per day over a period of 12 weeks.
- Trial name
- NCT02862223
- Testing
- Neoprinol
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Cerebral Hemorrhage, Stroke
The Third, Intensive Care Bundle With Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial
Continued uncertainty exists over benefits of early intensive blood pressure (BP) lowering in acute intracerebral hemorrhage (ICH), related to the non-significant primary outcomes, patient selection, and discordant results of…
- Conditions
- Cerebral Hemorrhage, Stroke, Hypertension, Diabetes
- Trial name
- INTERACT3 (NCT03209258)
- Testing
- Care bundle of active management, Usual care
- Where
- China
- Volunteers
- 7,067 people
- Sponsor
- The George Institute for Global Health, China
ST-segment Elevation Myocardial Infarction
EROSION II: OCT Guided PPCI in STEMI
This protocol describes a prospective, multi-center study intended to test the hypothesis that patients with STEMI caused by plaque rupture or plaque erosion without obstructive stenosis (diameter stenosis <70%) can be stabilized…
- Trial name
- NCT03062826
- Testing
- dual antiplatelet therapy (aspirin + ticagrelor or aspirin + clopidogrel)
- Where
- 16 sites in China
- Volunteers
- 347 people
- Sponsor
- Harbin Medical University
Cerebrovascular Accident
Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke (SENTIS)
The purpose of this study is to assess the safety and efficacy of the NeuroFlo™ catheter for use in patients with ischemic stroke.
- Trial name
- SENTIS (NCT00119717)
- Testing
- NeuroFlo™ catheter, Control
- Where
- 72 sites in United States, Austria and 8 more
- Volunteers
- 515 people
- Sponsor
- CoAxia
Hemodynamic Instability, Vasoplegic Syndrome
Hemodynamic Instability Prevented With Polaramine® Infusion Before Extracorporeal Circulation
This single-institution randomized controlled trial prospective will enrolled 48 patients scheduled for an aortic valve replacement.
- Trial name
- HIPPIE (NCT02675374)
- Testing
- dexchlorpheniramine (Polaramine®) injection
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Bordeaux
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
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