Clinical trials: Vascular Dementia
Alzheimer Disease
Masitinib in Patients With Mild to Moderate Alzheimer's Disease
The purpose of this study is to assess the safety and efficacy of masitinib for the treatment of mild to moderate Alzheimer's Disease.
- Trial name
- NCT01872598
- Testing
- Masitinib, Standard of care
- Where
- 6 sites in Bulgaria, Greece and 4 more
- Volunteers
- 721 people
- Sponsor
- AB Science
Dementia, Alzheimer Disease
Care Ecosystem: Navigating Patients and Families Through Stages of Care, Extension Trial
This is an extension trial of a prior trial (NCT02213458). Both persons with dementia (PWD) and their caregivers were enrolled as dyads.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT04287738
- Testing
- Navigated Care
- Volunteers
- 912 people
- Sponsor
- University of California, San Francisco
CADASIL, CADASIL (Diagnosis)
RAre, But Not aLone: a Large Italian Network to Empower the Impervious diaGNostic Pathway of Rare cerEbrovascular Diseases (ALIGNED)
Cerebrovascular diseases (CVDs) are one leading cause of morbidity and mortality worldwide. Despite intensive investigations, more than 30% of strokes remain of undetermined origin.
- Conditions
- CADASIL, CADASIL (Diagnosis), Moya Moya Disease, Moyamoya
- Trial name
- ALIGNED (NCT06935578)
- Where
- 17 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Dementia, Alzheimer's Disease
Evaluating the Effects of Music Interventions on Hospitalised People With Dementia
Dementing syndromes are, for the most part, incurable. People with dementia become highly dependent and frequently have to move from their homes into residential aged care facilities.
- Conditions
- Dementia, Alzheimer's Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT00448318
- Testing
- Music Therapy
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- National Ageing Research Institute, Australia
Arterial Stiffness, White Matter Lesions
Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
The ACE Trial, funded by the National Institute on Ageing/National Institutes of Health (NIH), is a multicenter clinical trial. The ACE Trial will determine if taking the dietary supplement Equol could slow the progression of…
- Conditions
- Arterial Stiffness, White Matter Lesions, Cognitive Decline
- Trial name
- ACE (NCT05741060)
- Testing
- S-equol
- Where
- 3 sites in United States
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Akira Sekikawa
Dementia, Stroke
Music Therapy on Cognition in Neurorehabilitation
Music therapy has received more attention with its surging application in neuro-rehabilitation overseas. Given the dearth of music therapy and cognitive rehabilitation research conducted in Malaysia, this pilot study intended to…
- Conditions
- Dementia, Stroke, Traumatic Brain Injury
- Trial name
- NCT06156735
- Testing
- Passive Music Therapy (P), Active Music Therapy (A), Standard Care Control Condition (C)
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- University of Malaya
Dementia, Dementia, Vascular
Home-based Family Caregiver-delivered Music and Reading Interventions for People With Dementia
This international study evaluates the impact of home-based caregiver-delivered music and reading interventions for people with dementia.
- Conditions
- Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia, Mixed
- Trial name
- HOMESIDE (NCT03907748)
- Testing
- Music Intervention, Reading Intervention
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 864 people
- Sponsor
- Anglia Ruskin University
Hypertension, Dementia
BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?
High blood pressure (present in 1 of 5 Canadian adults) increases the risk of heart attack and stroke. Blood pressure lowering pills reduce this risk - but perhaps not optimally.
- Trial name
- NCT04054648
- Testing
- Bedtime administration of the participant's pre-existing antihypertensive medications
- Where
- Canada
- Volunteers
- 776 people
- Sponsor
- University of Alberta
Diabetes (DM), Cardio Vascular Disease
Nut Consumption and Prevention of Non-communicable Diseases: A Global Individual Participant Data Meta-analysis
The relationship between nut consumption and the risk of developing non-communicable diseases (NCDs) has been a subject of growing interest.
- Conditions
- Diabetes (DM), Cardio Vascular Disease, Cancer, Dementia
- Trial name
- NUTPOOL (NCT07205978)
- Where
- 2 sites in Denmark, Spain
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
CADASIL, Cavernous Angioma
Biological Collection of the Rare Diseases of the Brain and Eye Vessels Cohort - 2
CERVCO is the French National Reference Centre for Rare Cerebrovascular and Retinal Diseases, accredited by the Ministry of Health since 2005.
- Conditions
- CADASIL, Cavernous Angioma, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, Small Vessel Disease
- Trial name
- B-MRVC2 (NCT07650110)
- Testing
- Biocollection, Neurological evaluation and Biocollection
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Small Vessel Diseases, Stroke, Lacunar
LACunar Intervention (LACI-2) Trial-2
About 35,000 people each year in the UK have a type of stroke, called 'lacunar' or 'small vessel' stroke, which is different to other common types of stroke and for which there is no proven treatment.
- Trial name
- LACI-2 (NCT03451591)
- Testing
- Isosorbide Mononitrate XL (ISMN), Cilostazol, ISMN XL and Cilostazol
- Where
- United Kingdom
- Volunteers
- 363 people
- Sponsor
- University of Edinburgh
Memory Disorders, Alzheimer's Disease
Prevention of Cognitive Decline in Alzheimer's Disease by Ingested Interferon Alpha
In this phase I-II parallel design, randomized, double-blind clinical trial we will determine if 3,000 or 30,000 units ingested hrIFN-a prevents deterioration of cognitive functioning in patients with dementia of Alzheimer's type…
- Trial name
- NCT00031018
- Testing
- Aricept, IFN-alpha2A
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Dementia, Dementia, Vascular
Feasibility of the SmartPrompt for Improving Everyday Function in Dementia
Difficulty completing everyday tasks is a primary reason for the high cost of care, loss of caregiver paid hours, and general caregiver burden associated with dementia.
- Conditions
- Dementia, Dementia, Vascular, Dementia Alzheimers, Dementia, Mixed
- Trial name
- SmartPrompt (NCT04313582)
- Testing
- SmartPrompt smartphone application
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Temple University
Alzheimer's Disease, Vascular Neurocognitive Disorder
Validation Study of the ExéSem Battery Designed to Differentiate the Contribution of Executive Functions in Semantic Disorders
This protocol describes a study aimed at evaluating the psychometric properties of the ExéSem battery, developed to differentiate semantic deficits from executive semantic impairments in patients with post-lesional or…
- Conditions
- Alzheimer's Disease, Vascular Neurocognitive Disorder, Progressive Primary Aphasia Semantic Variant, People Without Neurocognitive Disorder
- Trial name
- ExéSemVal (NCT07573046)
- Testing
- ExéSem cognitive battery
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Dementia-related Psychosis
Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis
The purpose of this study is to evaluate the efficacy of pimavanserin compared to placebo in preventing relapse of psychotic symptoms in subjects with dementia-related psychosis who responded to 12 weeks of open label…
- Trial name
- NCT03325556
- Testing
- Pimavanserin 34 mg, Pimavanserin 20 mg
- Where
- 83 sites in United States, Bulgaria and 11 more
- Volunteers
- 392 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Alzheimer Disease, Mild Cognitive Impairment
Longitudinal Cognitive Assessment by BoCA
The Boston Cognitive Assessment (BoCA) is a self-administered online test intended for longitudinal cognitive monitoring. BoCA uses random not-repeating tasks to minimize learning effects.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Vascular Dementia, Frontotemporal Dementia
- Trial name
- BoCA (NCT04114994)
- Testing
- Boston Cognitive Assessment (BoCA)
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Light LLC
Dementia, Movement Disorders
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.
The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner.
- Conditions
- Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy
- Trial name
- NCT07595666
- Testing
- Standard-of-care PET/CT, NeuroEXPLORER
- Where
- Belgium
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Cerebral Small Vessel Diseases, Dementia, Mixed
WHIte MAtter Hyperintensity Shape and Glymphatics
In a society with increased life expectancy, the economic, social and personal burden of dementia increases. Dementia is often caused by a combination of neurovascular and neurodegenerative diseases.
- Conditions
- Cerebral Small Vessel Diseases, Dementia, Mixed, Dementia, Vascular, Mild Cognitive Impairment
- Trial name
- WHIMAS (NCT06010511)
- Testing
- 3T MRI scan, 7T MRI scan, Neuropsychological assessment
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Dementia, Mild Cognitive Impairment
HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
This study will investigate the validity of the HOGAR EEG/PSG monitoring kit designed by Bitbrain as a tool for characterizing and assessing cognitive function in older adults, as well as for detecting and predicting cognitive…
- Conditions
- Dementia, Mild Cognitive Impairment, Dementia Alzheimers, Dementia, Mixed
- Trial name
- Hogar (NCT06993207)
- Testing
- Home Lab
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bitbrain
Stroke, Cognitive Disorders
Post-stroke Cognitive Impairment and Dementia
Projections from epidemiological studies suggest that, among the Western adult population, one in three will present a cerebrovascular accident (stroke), severe cognitive disorders, or both.
- Conditions
- Stroke, Cognitive Disorders, Behavioral Disorders
- Trial name
- GRECogVASC (NCT01339195)
- Testing
- French adaptation of NINDS-Canadian Stroke Network battery
- Where
- 7 sites in France
- Volunteers
- 1,635 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens