Clinical trials: Vascular Disease，Peripheral
Diabetes Mellitus, Type 2, Diabetic Foot
Non-invasive Imaging for In-vivo Quantification of Skin Composition and Structure
The goal of this clinical investigation is to explore a non-invasive technology for measuring the microcirculatory structure, composition and function in patients from a primary care population. The main aims are: 1.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Foot, Peripheral Arterial Disease, Skin Cancer
- Trial name
- Spectrum1 (NCT06976073)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille
Multiple Myeloma, Non-Hodgkin's Lymphoma
A Phase II Trial Using Meloxicam Plus Filgrastim in Patients With Multiple Myeloma and Non-Hodgkin's Lymphoma
The trial is an open label Simon optimal two-stage Phase II trial of fixed doses of oral meloxicam and subcutaneous filgrastim to assess the safety and efficacy in mobilizing autologous peripheral blood stem cells (PBSC) from…
- Trial name
- NCT02078102
- Testing
- Meloxicam, Filgrastim
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Sherif S. Farag
Peripheral Arterial Disease, Peripheral Vascular Disease
Clinical Pilot-Study of ProEndoTecc Vascular Grafts as Superficial Femoral Artery Bypass / Interponate
This is a multi-center, clinical pilot-study of ProEndoTecc Vascular Grafts (6, 7 or 8 mm Diameter) as superficial femoral artery bypass/interponate.
- Trial name
- NCT01095237
- Testing
- ProEndoTecc Vascular Graft
- Where
- 12 sites in Germany
- Volunteers
- 33 people
- Sponsor
- NonWoTecc Medical GmbH
Peripheral Artery Disease
DUAL Pathway Inhibition to Improve Endothelial Function in Peripheral Artery Disease
Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis, causing patients to be at high risk of major adverse cardiovascular and limb events.
- Trial name
- DUAL-PAD (NCT04218656)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- 2 sites in Netherlands
- Volunteers
- 159 people
- Sponsor
- Radboud University Medical Center
Multiple Myeloma
VELCADE as Maintenance Treatment in Patients With Multiple Myeloma Following Autologous Peripheral Blood Stem Cell Transplantation (PBSCT)
Protocol DSMM VIII is a multi-center, open-label study evaluating the safety and tolerability, as well as the efficacy, of maintenance treatment with VELCADE (bortezomib) in patients with multiple myeloma with detectable disease…
- Trial name
- NCT00311337
- Testing
- bortezomib
- Where
- 8 sites in Austria, Germany and 1 more
- Volunteers
- 61 people
- Sponsor
- University of Wuerzburg
PAD - Peripheral Arterial Disease
Feasibility Study of the Vessel Restoration System (VRS): ACTIVATE II
Feasibility Study of the Vessel Restoration System (VRS) for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery (SFA) and/or Proximal Popliteal Artery (PPA): ACTIVATE II
- Trial name
- ACTIVATEII (NCT05454995)
- Testing
- Vessel Restoration System (VRS)
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Alucent Biomedical
Peripheral Artery Disease, Peripheral Vascular Diseases
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
Peripheral artery disease (PAD) is associated with elevated oxidative stress, and oxidative stress has been implicated as the cause of reduced endothelial reactivity in individuals with PAD.
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Diseases, Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease
- Trial name
- NCT06319339
- Testing
- Vumerity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Peripheral Arterial Disease, Intermittent Claudication
The Effects of Metformin on Functional Capacity in Individuals With Peripheral Artery Disease-Related Intermittent Claudication
The purpose of this study is to determine the effects of metformin on functional capacity (pain-free and maximum walking times) in individuals with peripheral artery disease (PAD)-related intermittent claudication.
- Trial name
- NCT01799057
- Testing
- Metformin
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- Baker Heart and Diabetes Institute
Aortic Diseases, Aorto-Iliac Atherosclerosis
Use of Shockwave M5+/L6 IVL Catheter (Intravascular Lithotripsy) in Hostile and Calcified Iliac Access
The study will evaluate, in a controlled setting, the efficacy and safety of the intravascular lithotripsy using Shockwave™ M5+/L6 Peripheral Intravascular Lithotripsy Catheter to facilitate delivery of aortic large-bore devices…
- Conditions
- Aortic Diseases, Aorto-Iliac Atherosclerosis, Peripheral Arterial Disease
- Trial name
- SHOCK-ACCESS (NCT05880641)
- Where
- 6 sites in Italy
- Volunteers
- 40 people
- Sponsor
- EndoCore Lab s.r.l.
Diabetes, Wounds
Plerixafor in Diabetic Wound Healing
Chronic non-healing wounds represent a major source of morbidity, disability, and mortality in diabetic patients. Diabetes is the leading cause of non-traumatic limb amputations worldwide.
- Conditions
- Diabetes, Wounds, Critical Limb Ischemia
- Trial name
- MOZOBL07740 (NCT02790957)
- Testing
- Plerixafor
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Gian Paolo Fadini
Cardiovascular Diseases, Cerebrovascular Disease
RAndomized Comparison of Efficacy and Safety of Lipid-lowerING With Statin Monotherapy Versus Statin/Ezetimibe Combination for High-risk Cardiovascular Diseases (RACING Trial)
The clinical efficacy of LDL-lowering therapy have been proven with strong evidences and more emphasized. However, there are also growing concerns that high-intensity statin would be related to increased risk of adverse effects.
- Conditions
- Cardiovascular Diseases, Cerebrovascular Disease, Peripheral Atherosclerotic Disease
- Trial name
- NCT03044665
- Testing
- Rosuvastatin, Rosuvastatin plus ezetimibe
- Where
- South Korea
- Volunteers
- 3,780 people
- Sponsor
- Yonsei University
Critical Limb Ischemia
UT-15C SR in the Treatment of Critical Limb Ischemia
This study will evaluate UT-15C sustained release tablets in subjects experiencing ischemic lower limb rest pain related to advanced peripheral arterial disease.
- Trial name
- NCT00445159
- Testing
- UT-15C SR (treprostinil diethanolamine) 1mg oral tablets
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Southern Arizona Vascular Institute
Acute Myeloid Leukemia, Myelodysplasia
Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced Hematopoietic Malignancies
This is a pilot study designed to evaluate the safety and feasibility of performing umbilical cord blood transplants in adults with high-risk hematopoietic malignancies. A novel myeloablative preparative regimen will be used.
- Conditions
- Acute Myeloid Leukemia, Myelodysplasia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia
- Trial name
- NCT00514722
- Testing
- umbilical cord stem cells
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Francisco
Angioplasty, Balloon, Disease, Peripheral Artery
Post-market Registry to Assess the Clinical Performance and Safety of the Passeo-18 Lux in Infrainguinal Arteries
The purpose of his study is to collect short term and long term clinical evaluation data of the Passeo-18 Lux Paclitaxel releasing balloon catheter, subject to patients who visit hospital from arteriosclerosis in the…
- Trial name
- NCT05175703
- Testing
- Passeo-18 Lux Paclitaxel releasing Balloon Catheter
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Peripheral Artery Disease, Femoropopliteal Stenosis
Histological Segmentation of the Superficial Femoral Artery From Microscan to CT Using Artificial Intelligence
The femoropopliteal artery segment (FPAS) is one of the longest arteries in the human body, undergoing torsion, compression, flexion and extension due to lower limb movements.
- Trial name
- CTPred (NCT06260488)
- Testing
- Endovascular surgery
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Thrombophlebitis
POST (Prospective Observational Superfial Thrombophlebitis)
We performed a national cross-sectional and prospective large epidemiological cohort study in patients with ST. Office- and hospital-based vascular medicine French practitioners enrolled all consecutive patients with a…
- Trial name
- POST (NCT00818688)
- Testing
- compression ultrasonography at 3 months
- Where
- 5 sites in France
- Volunteers
- 844 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Peripheral Arterial Disease
Efficacy and Safety of Paclitaxel-eluting Balloons for Below the Knee Peripheral Arterial Disease
Comparing the efficacy and safety of drug-eluting balloons (DEB) for the treatment of below-the-knee peripheral arterial occlusive disease with conventional balloon angioplasty (BA).
- Trial name
- NCT02772224
- Testing
- Drug eluting balloon angioplasty, Conventional balloon angioplasty
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shanghai 10th People's Hospital
Peripheral Arterial Disease
BIO REsponse Adapted Combination Therapy Pilot Study
Both drug-coated balloon and stents have been used for a number of years to treat subjects with Peripheral Artery Disease (PAD) and are recognized as very good treatment methods.
- Trial name
- NCT03547986
- Testing
- Duplex Ultrasound (DUS), IVUS with Intraarterial pressure measurement (IAP) if needed
- Where
- 15 sites in Australia, Austria and 4 more
- Volunteers
- 150 people
- Sponsor
- Biotronik AG
Cancer
Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation
RATIONALE: White blood cells from donors who have been exposed to cytomegalovirus may be able to help prevent this infection from occurring in patients who are undergoing bone marrow or peripheral stem cell transplantation.
- Trial name
- NCT00002673
- Testing
- infection prophylaxis and management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fred Hutchinson Cancer Center
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