Clinical trials: Vascular Disease
Fabry Disease
Novel Diagnostic and Prognostic Predictors in Fabry Cardiomyopathy: Proof of Concept in a Rare Disease
In this work, we address the understanding of the signaling pathways involved in cardiac remodeling in human SCD through molecular imaging analysis with a fibrosis marker.
- Trial name
- FABRyCar (NCT07351136)
- Testing
- PET scan of 68Ga-FAPI
- Volunteers
- 20 people
- Sponsor
- Núcleo de Apoio à Investigação Clínica - FMUP
Peripheral Vascular Diseases, Thrombosis
A Prospective Observational Registry of Peripheral Use of AngioJet Rheolytic Thrombectomy With Mid-Length Catheters
This registry collects observational data about how mid-length AngioJet catheters (ie XPEEDIOR and DVX models) are used in routine clinical practice.
- Conditions
- Peripheral Vascular Diseases, Thrombosis, Venous Thrombosis
- Trial name
- NCT00778336
- Volunteers
- 452 people
- Sponsor
- Boston Scientific Corporation
Hypertension
Dosing Study of the Effects of Nebivolol on Blood Pressure in Black Patients With Mild to Moderate Hypertension
The purpose of this study was to determine if nebivolol is superior to placebo for the treatment of elevated blood pressure in Black patients with mild to moderate hypertension.
- Trial name
- NCT00145236
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Neurocognitive Disorders, Dementia
The Impact of Dementia and Neurocognitive Disorders on Hypertension Treatment in the Elderly
Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension.
- Conditions
- Neurocognitive Disorders, Dementia, Hypertension, Aged, 80 and Over
- Trial name
- TAHOC (NCT05845736)
- Testing
- Antihypertensive Agents
- Where
- France
- Volunteers
- 353 people
- Sponsor
- Central Hospital, Nancy, France
Atherosclerotic Plaque, Diabetes Mellitus, Type 2
Pakistan Study of Premature Coronary Atherosclerosis in Young Adults
Coronary heart disease (CHD) is a major cause of morbidity, disability, mortality, and health expenditures worldwide. A wealth of studies has demonstrated that people of South Asian ancestry have a higher risk of CHD and…
- Conditions
- Atherosclerotic Plaque, Diabetes Mellitus, Type 2, Hypertension, Stroke
- Trial name
- PAKSEHAT (NCT05156736)
- Where
- Pakistan
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tabba Heart Institute
Behcet Disease
Role of Regulatory B Cells in Behçet's Disease
There are limited data about the role of regulatory B cells in Behcet Disease. In this study we aimed to identify the proportions of total B lymphocytes and their regulatory subset in different Behcet Disease phenotype and…
- Trial name
- NCT04376411
- Testing
- Flow-cytometric assay, 2D Echocardiographic analysis, Two-Dimensional speckle tracking echocardiography
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Disease, Heart Diseases
VA HDL Intervention Trial (VA-HIT) Ancillary Study Data Analysis
To evaluate additional cardiovascular risk factors using data from the VA HDL Intervention Trial (VA-HIT).
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Carotid Artery Diseases
- Trial name
- NCT00035711
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Venous Thromboembolism
A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)
This study is researching 2 different experimental drugs called REGN9933 and REGN7508 (called "study drugs"). The study is focused on adults undergoing a placement of a catheter in the vein, also called a 'PICC line'.
- Trial name
- ROXI-CATH (NCT06299111)
- Testing
- REGN9933, REGN7508
- Where
- 23 sites in United States, Bulgaria and 4 more
- Volunteers
- 195 people
- Sponsor
- Regeneron Pharmaceuticals
Peripheral Vascular Diseases, Arterial Occlusive Diseases
Intra-arterial Stem Cell Therapy for Patients With Chronic Limb Ischemia (CLI)
The purposes of this study are to determine whether intra-arterial injection of autologous stem cells is effective in the treatment of chronic limb ischemia (CLI), to characterize stem cell dysfunction in patients with CLI, and…
- Conditions
- Peripheral Vascular Diseases, Arterial Occlusive Diseases, Leg Ulcer, Gangrene
- Trial name
- JUVENTAS (NCT00371371)
- Testing
- Bone marrow punction, BM-MNC infusion
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- UMC Utrecht
Cerebral Hemorrhage
Multimodal Monitoring in Patients With Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral bleeding also known as spontaneous intracerebral hemorrhage (sICH) constitute 10-15 % of all apoplexies.
- Trial name
- NCT02326571
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Christian Kærsmose Friberg
Cardiovascular Diseases, Eclampsia
Calcium for Pre-Eclampsia Prevention (CPEP)
To evaluate the efficacy of 2 grams per day of oral calcium supplementation in reducing the combined incidence of hypertensive disorders of pregnancy: pre-eclampsia, eclampsia, and the HELLP Syndrome (hypertension…
- Conditions
- Cardiovascular Diseases, Eclampsia, Heart Diseases, HELLP Syndrome
- Trial name
- NCT00000534
- Testing
- calcium, dietary supplements
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Aortic Disease
Endovascular Repair of Descending ThoracoAbdominal Aortic Pathologies Using Physician Modified Endovascular Prosthesis
This is an early feasibility study that investigates the outcome of selected patients with complex thoracoabdominal aortic lesions who are suitable for endovascular (within the vessel) repair with a physician-modified Medtronic…
- Trial name
- NCT02524834
- Testing
- Exclusion of thoracoabdominal lesion, Endovascular Device Implant
- Where
- United States
- Sponsor
- Rodney A. White, MD
Hypertension, Blood Pressure
Water Aerobics Session on Blood Pressure of Hypertensive Elderly.
This randomized controlled trial aimed to determine the subacute blood pressure effects of pharmacologically-treated elderly hypertensive patients after a single session of water aerobic exercise.
- Trial name
- NCT04545034
- Testing
- water aerobic exercise
- Where
- 2 sites in Brazil
- Volunteers
- 25 people
- Sponsor
- Centro Universitário de Anapolis
Diabetic Retinopathy, Postoperative Recurrent Vitreous Hemorrhage
A Prospective Study of Ranibizumab in the Treatment of Postoperative Recurrent Vitreous Haemorrhage of Diabetic Retinopathy
Diabetic retinopathy (DR) is one of the main complications in diabetes, the proliferative diabetic retinopathy (PDR) is the most important one of the reasons leading to decreased vision, PDR is the stage of clinical intervention.
- Conditions
- Diabetic Retinopathy, Postoperative Recurrent Vitreous Hemorrhage, Pars Plana Vitrectomy, Ranibizumab
- Trial name
- NCT05248334
- Testing
- Ranibizumab Injection, PPV
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Eye Hospital
Cerebrovascular Disease
Cilostazol-Aspirin Therapy Against Recurrent Stroke With Intracranial Artery Stenosis
Multi-center, open-labelled randomized controlled trial, to study the effect of aspirin plus cilostazol and aspirin alone on the progression of intracranial arterial stenosis, in 200 chronic stroke patients with 50-99% stenosis…
- Trial name
- NCT00333164
- Testing
- Asprin, Cilostazol
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Arthroplasty
ThromboEmbolism Prevention Efficacy and Safety Trial (TEMPEST)
The purpose of this study is to gain additional safety information as well as to determine after the study drug has been given to patients who have undergone total hip replacement surgery, whether the study drug is effective in…
- Trial name
- TEMPEST (NCT00041509)
- Testing
- SB-424323
- Volunteers
- 343 people
- Sponsor
- GlaxoSmithKline
Ischemic Stroke, Intermittent Fasting
Intermittent Fasting Following Acute Ischemic Stroke
Despite numerous kinds of evidence on functional health and CNS protection of intermittent fasting after injuries were found in many brain-, and spinal cord-damaged animal models, there has yet to be any clinical study of…
- Trial name
- NCT03789409
- Testing
- Intermittent Fasting
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Ulsan University Hospital
Intracranial Meningioma
Cognition-preserving Brain Irradiation for Treating Patients With Intracranial Meningioma in the Era of Modern Radiotherapeutic Techniques Including Proton Beam Therapy - a Prospective Study Focusing on Radiological Outcomes and Neurocognitive Endpoints
【Background】For cranial-irradiation-naive patients with intracranial meningiomas at risk of local recurrence, the administration of conformal cranial radiotherapy can enhance tumor control in the current era of modern…
- Trial name
- NCT05832099
- Testing
- Radiation
- Where
- Taiwan
- Volunteers
- 74 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Ischemic Stroke
Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Patients With Ischemic Stroke
The purpose of this study is to determine the impact of remote ischemic conditioning on cerebral hemodynamics in patients with ischemic stroke.
- Trial name
- RICCH-IS (NCT05915832)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Yi Yang
Stroke, Acute
aICP Measurement in Patients With Cerebral Artery Infarction / aICP MCA Infarction
Space-occupying, malignant middle cerebral artery (M-MCA) infarctions are still one of the most devastating forms of ischemic stroke, with a mortality of up to 80% in untreated patients.
- Trial name
- aICPStroke (NCT03641963)
- Testing
- Vittamed 205 Non-invasive intracranial pressure (ICP) meter
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Kantonsspital Aarau