Clinical trials: Vascular Endothelial Function
Migraine With Aura, Stroke
Induction of Migraine Aura With Cilostazol
In a double blind placebo-controlled cross-over study the effect of cilostazol on aura induction and endothelial response is tested in patient with migraine with aura.
- Trial name
- NCT02253004
- Testing
- Cilostazol
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Herlev Hospital
Atherosclerosis, Hypercholesterolemia
Investigating the Effects of Lipid-therapy Intensification With Alirocumab on Endothelial Function, Carotid Arteries, Lipoprotein Particle Subfractions, Inflammation and Post-prandial Lipemia
A prospective, open-label, pilot study with 24 cardiovascular high risk patients (N=24) having insufficient Low density lipoprotein cholesterin (LDL-C) reduction despite standard of care lipid-modifying therapies (LMTs), to…
- Conditions
- Atherosclerosis, Hypercholesterolemia, Post Prandial Lipemia, Cardiovascular Diseases
- Trial name
- ALIROCKS (NCT03559309)
- Testing
- Magnet Resonance Tomography, Carotid Arteries Sonography, Flow-mediated Dilation, Fat-tolerance Test, Laboratory Testing
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
Hypertension, Mild Cognitive Impairment
CAndesartan vs LIsinopril Effects on the BRain
The aim of this study is to conduct a 1-year double blind randomized control trial comparing candesartan to lisinopril in 140 individuals with hypertension and executive mild cognitive impairment in their effects on executive…
- Trial name
- CALIBREX (NCT01984164)
- Testing
- Candesartan, Lisinopril
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Emory University
Renal Function Disorder, Diabetic Macular Edema (DME)
Impact of Intravitreal Faricimab on Renal Function in Diabetic Patients
This study aims to investigate the impact of intravitreal injection of anti-vascular endothelial growth factor (anti VEGF) Faricimab on renal function of diabetic patients.
- Conditions
- Renal Function Disorder, Diabetic Macular Edema (DME), Neovascular Age Related Macular Degeneration
- Trial name
- NCT06929507
- Testing
- Intravitreal injection of Faricimab or Aflibercept 2 mg
- Where
- 2 sites in Greece
- Volunteers
- 60 people
- Sponsor
- University Hospital, Alexandroupolis
ST-Segment Elevation Myocardial Infarction
Comparison of Ticagrelor And Clopidogrel on Inflammatory Biomarkers And Vascular Endothelial Function
1. Ticagrelor inhibits inflammation and improves vascular endothelial cell function to a greater extent than clopidogrel in ST-segment elevation myocardial infarction(STEMI) patients receiving percutaneous coronary intervention.
- Trial name
- TIGERCAVE (NCT02123004)
- Testing
- Ticagrelor, Clopidogrel
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Jinan Central Hospital
Coronary Artery Disease, Endothelial Dysfunction
Functional Change in Endothelium After Cardiac cAtheterization, With and Without Music Therapy
The purpose of this study is to determine the effect of music therapy before, during, and after cardiac catheterization is associated on (a) change in reactive hyperemia index measured before and after catheterization using…
- Trial name
- FEAT (NCT01632670)
- Testing
- Music therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Emmanouil Brilakis
Diabetes Mellitus, Type 2, Hypertension
Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents
This study is designed to determine whether there is a relationship between the way insulin and blood vessels work. The difference in the interaction between Caucasian and African American adolescents will also be examined.
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Heart Disease, Stroke
- Trial name
- NCT00374361
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Metabolic Syndrome
Acute Effects of Oral Carbohydrate and Fat Loads on Systemic Microvascular Endothelial Function in Healthy Individuals.
The present study was designed to evaluate vascular endothelial dysfunction resulting from the oral ingestion of high loads of sugar and fat meals in healthy individuals.
- Trial name
- NCT03515460
- Testing
- sugar oral load, fat oral load, sugar and fat oral load
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Diabetes Mellitus, Hypertension
The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease
The purpose of this study is to investigate whether a daily intake of dried broccoli sprouts will improve the endothelial function of the participants as measured by Flow mediated dilation (FMD) The dried sprouts are chosen…
- Conditions
- Diabetes Mellitus, Hypertension, Hypercholesterolemia, Cardiovascular Disease
- Trial name
- NCT00252018
- Testing
- Daily intake of broccoli sprouts
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Bispebjerg Hospital
Atherosclerosis
High-Density Lipoprotein (HDL) Modulation and Endothelial Function
It is well known that lowering low-density lipoprotein (LDL) (bad cholesterol) is beneficial for decreasing heart attacks and death. More recently, focus has been on trying to raise HDL (good) cholesterol.
- Trial name
- NCT00150722
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University of Calgary
Living Kidney Donation
Vascular Remodeling After Living Kidney Donation Study
Vascular evaluation of candidates to living kidney donation is important because there is an increased risk of end stage renal disease and cardiovascular disease after donation.
- Trial name
- EUGENIA (NCT05073913)
- Testing
- Vascular remodeling characterization
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Vitamin D3 Deficiency
Vitamins D and K Effects on Vascular Function in Obese Adults.
A prospective, randomized, placebo-controlled, double-blind study that aims to evaluate the effects of combined vitamin D3 and K2-MK7 supplementation on vascular function, sympathetic tone, metabolic biomarkers and inflammatory…
- Trial name
- NCT05689632
- Testing
- Vitamin D3 + K2-MK7, Vitamin D3
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Pedro Ernesto
Hypertension
Effect of Regular Sildenafil on Blood Pressure and Arterial Function in Hypertension
The purpose of the study is to investigate if regular treatment with sildenafil reduces blood pressure and improves blood vessel function in patients with hypertension (high blood pressure).
- Trial name
- NCT00317421
- Testing
- Sildenafil citrate
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Menopause, Atherosclerosis
Discontinuation of Postmenopausal Hormone Therapy: Impact on the Cardiovascular System and Quality of Life
Although the impact of postmenopausal hormone therapy (HT) on cardiovascular disease risk has been studied in several large randomized trials, little is known about the acute cardiovascular consequences of HT discontinuation.
- Conditions
- Menopause, Atherosclerosis, Cardiovascular Diseases, Estrogen Replacement Therapy
- Trial name
- NCT04050592
- Testing
- Estradiol
- Where
- Finland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hanna Savolainen-Peltonen
Cardiovascular Disease
MARCH Vascular Endothelium Substudy
This is a substudy of MARCH, in which we are exploring the changes in the vascular endothelium using pulse wave tonometry (a non invasive measure of cardiac health) to measure the changes in small and large arterial elasticity in…
- Trial name
- MARCH VE (NCT01585753)
- Testing
- NRTI + PI, maraviroc + PI, maraviroc + NRTI
- Where
- 6 sites in Argentina, Australia and 2 more
- Volunteers
- 34 people
- Sponsor
- Kirby Institute
Syndrome X
APEX Study: Effects of Allopurinol on Coronary and Peripheral Endothelial Function in Patients With Cardiac Syndrome X
Morbidity of patients with cardiac syndrome X (typical anginal-like chest pain and normal coronary arteriograms) is high with continuing episodes of chest pain and frequent hospital readmissions.
- Trial name
- APEX (NCT00512057)
- Testing
- allopurinol
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Endothelial Dysfunction, Obesity
Leptin Infusion and Endothelial Vasomotor Response
Adipose tissue is an active endocrine organ producing several hormones with circulatory and metabolic effects. In 1994, the hormone leptin was discovered.
- Conditions
- Endothelial Dysfunction, Obesity, Vasodilation, Venous Occlusion Plethysmography
- Trial name
- LIVARM (NCT04374500)
- Testing
- Leptin infusion plus vasodilators in healthy men, Leptin infusion in healthy men, Vasodilators in CAD patients
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Stefan Soderberg
Coronary Artery Disease
Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting
Although the long saphenous vein remains the most commonly used conduit in coronary revascularization, traditional open vein harvest may lead to significantly impaired wound healing and post-operative pain.
- Trial name
- NCT00712192
- Testing
- coronary artery bypass grafting
- Volunteers
- 34 people
- Sponsor
- Far Eastern Memorial Hospital
Aging, Endothelial Dysfunction
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic…
- Conditions
- Aging, Endothelial Dysfunction, Cardiovascular Function, Arterial Stiffness
- Trial name
- NCT05872139
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ball State University
Healthy
Effects of Acute Red Raspberry Consumption on Vascular Function in Healthy Individuals
Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content.
- Trial name
- NCT02734901
- Testing
- 400 g frozen raspberries, 200 g frozen raspberries
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf