Clinical trials: Vascular Endothelial Function
Obesity
Characterization of Brachial Arterial t-PA Release, Endothelial Function, Obesity and Inflammation
T-PA release is impaired in obese subjects. In order to have a better mechanistic understanding of t-PA release, we will compare t-PA release to Flow Mediated Vasodilation, Radial Artery Tonometry, and other markers of…
- Trial name
- P1A3B (NCT00780481)
- Testing
- Bradykinin
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Angina, Coronary Artery Disease
Exercise-training Before Coronary Artery Bypass Graft (CABG)
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small…
- Trial name
- NCT00218985
- Testing
- Exercise training
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Hypertension
Additive Beneficial Effects of Atorvastatin Combined With Amlodipine In Treatment of Hypertension
The investigators hypothesized combination therapy would be superior to monotherapy.
- Trial name
- NCT00741078
- Testing
- statin, amlodipine
- Where
- South Korea
- Sponsor
- Gachon University Gil Medical Center
Heart Failure With Reduced Ejection Fraction
Neuromodulation of Inflammation and Vascular Function in Systolic Heart Failure
Heart failure (HF) is the leading cause of death in US. It is associated with abnormal vascular function termed endothelial dysfunction.
- Trial name
- TECO-HF (NCT03945058)
- Testing
- TVS
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Oklahoma
Kidney Failure, Chronic
Effect of Exercise on Endothelial Function and Vascular Compliance in Chronic Kidney Disease
The study hypothesis is that 6 weeks of repetitive handgrip exercise will improve endothelial function and venous compliance in pre-dialysis patients with an estimated glomerular filtration rate of less than or equal to 20…
- Trial name
- NCT01068314
- Testing
- Repetitive arm exercise
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Iowa
Myocardial Infarction
Assessment of Coronary Endothelial Function in Diabetic Patients With Acute Coronary Syndrome Using 15O-water Positron Emission Tomography
Type 2 diabetes is associated with early and diffuse abnormalities of endothelial function, especially in the coronary arteries, which are a factor of poor prognosis.
- Trial name
- D-TEP (NCT02510703)
- Testing
- Coronary endothelial function measurements by quantitative method (TEP at 15O-H2O)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Reperfusion Injury, Vascular Complications
Trial to Investigate the Effect of Dapagliflozin on Ischemia Reperfusion Induced Endothelial Dysfunction
The aim of the study is to investigate the effect of dapagliflozin or placebo on acetylcholine (Ach)- or nitroglycerin (GTN)-induced vasodilation of the forearm resistance vasculature, as determined by FBF measurement before and…
- Trial name
- NCT05217654
- Testing
- Dapagliflozin 10mg
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
Sulfasalazine and Endothelial Function
Experimental studies suggest that systemic inflammation leads to endothelial dysfunction and atherosclerosis. This study will examine the effects of the anti-inflammatory drug sulfasalazine on endothelial function in patients…
- Trial name
- NCT00554203
- Testing
- Sulfasalazine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston University
Major Depressive Disorder
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age…
- Trial name
- NCT06860724
- Testing
- NG-nitro-L-arginine methyl ester (L-NAME)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Pre-Eclampsia
Can Atorvastatin Improve Vascular Function in Women With a History of Preeclampsia?
The purpose of the study is to test the hypothesis that a short course of atorvastatin can improve vascular function in women with a history of preeclampsia, compared to placebo.
- Trial name
- PVS3 (NCT01278459)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Oxford
Diabetes Mellitus, Coronary Artery Disease
Allopurinol and Endothelial Function in Diabetic CAD Patients
This is a randomized trial assessing the impact of allopurinol on endothelial function in optimally treated diabetic patients with coronary artery disease.
- Trial name
- ALLIENCE (NCT03385135)
- Testing
- Allopurinol
- Where
- Tunisia
- Volunteers
- 58 people
- Sponsor
- University Tunis El Manar
Myocardial Ischemia, Coronary Artery Disease
Peripheral Endothelial Function Assessment of Patients on Ticagrelor vs. Clopidogrel Who Have Undergone PCI
Usage of antiplatelet agents and cardiac procedures such as coronary angioplasty has dramatically improved the morbidity and mortality associated with coronary artery disease.
- Conditions
- Myocardial Ischemia, Coronary Artery Disease, Endothelial Dysfunction
- Trial name
- NCT02469740
- Testing
- Ticagrelor, Clopidogrel
- Where
- Ireland
- Volunteers
- 61 people
- Sponsor
- University Hospital of Limerick
Dynamic Strength Exercise Session, Isometric Strength Exercise Session
Acute and Chronic Effects of Combined Training on BP in Hypertensives
Dynamic strength training (DST) is widely recognized for promoting neuromuscular adaptations such as increased strength and hypertrophy.
- Conditions
- Dynamic Strength Exercise Session, Isometric Strength Exercise Session, Combined Exercise Session, Control Session (CON)
- Trial name
- COMBAT-H (NCT07470450)
- Testing
- Combined strength training, Dynamic strength training, Acute Isometric Exercise Session.
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Rio Grande do Sul
Endothelial Dysfunction, Aging
Passive Mobilization and Vascular Function
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF.
- Conditions
- Endothelial Dysfunction, Aging, Bed Rest
- Trial name
- NCT03087643
- Testing
- Passive mobilization - PM
- Where
- 3 sites in Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Hypertension, Impaired Glucose Tolerance
Telmisartan and Losartan in Hypertensive IGT
Inhibition of RAS delays onset of diabetes in clinical studies. Preliminary evidence suggests that telmisartan may have unique metabolic properties compared to other ARB due to activation of PPARγ.
- Trial name
- NCT00407862
- Testing
- Telmisartan 80 mg, Losartan 50 mg
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
Cardiovascular Disease, Coronary Heart Disease
Effects of Tart Cherry and Aroniaberry Supplementation on Endothelial Function and Cardiovascular Measures in Healthy Older Adults: Interactions With Genotype and Proteome
Background: Heart disease is the leading cause of death and disabilities in the United States. Diets high in fruits and vegetables may reduce the risk of heart disease.
- Conditions
- Cardiovascular Disease, Coronary Heart Disease, Aging
- Trial name
- NCT02379403
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Blood Sugar, Endothelial Function
Comparing Blood Sugar Levels and Endothelial Function of PEAK ATP® With GlycoCarn®, PEAK ATP® and GlycoCarn® Supplements
To purpose of this study is to assess the effectiveness, safety and tolerability of PEAK ATP® with GlycoCarn®, PEAK ATP® and GlycoCarn® on levels of blood sugar and endothelial function improvement which may lead to improved…
- Trial name
- NCT01855373
- Testing
- PEAK ATP® with GlycoCarn®, PEAK ATP®, GlycoCarn®
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
HIV Infections, HIV Metabolic Cardiovascular Syndrome
Yoga for the Management of HIV-Metabolic Syndromes
We are testing the safety and efficacy of a 16-wk yoga lifestyle intervention on oral glucose tolerance, fasting lipid/lipoprotein levels, body composition, cardiovascular function, quality of life, CD4+ T-cell counts and viral…
- Conditions
- HIV Infections, HIV Metabolic Cardiovascular Syndrome, HIV Lipodystrophy, HIV Metabolic Syndromes
- Trial name
- NCT00627380
- Testing
- Yoga lifestyle intervention, Standard of care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Arterial Stiffness, Endothelial Function
Focus On Stiffness Reduction, Endothelial Function and Autonomic Nervous System
Myocardial infarction is related with endothelial function, arterial stiffness and autonomic nervous system dysfunction, but also with arterial hypertension.
- Conditions
- Arterial Stiffness, Endothelial Function, Autonomic Nervous System, Acute Coronary Syndrome
- Trial name
- FOREVER (NCT02195388)
- Testing
- comprehensive cardiac rehabilitation
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Lodz
Hypertension
Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function
Chlorthalidone will result in improved endothelial function compared to hydrochlorothiazide as measured by flow mediated vasodilatation.
- Trial name
- NCT01822860
- Testing
- Chlorthalidone 12.5 mg, Hydrochlorothiazide 25 mg
- Where
- United States
- Sponsor
- Creighton University