Clinical trials: Vascular Endothelial Function
Postural Tachycardia Syndrome
Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome
The purpose of this study is to see if people with Postural Tachycardia Syndrome (POTS) have different levels of certain chemicals in their blood than people who don't have POTS.
- Trial name
- NCT01308099
- Testing
- Blood Pressure and Blood Flow
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Carnosine
Carnosine Supplementation and Cardiovascular Function
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high…
- Trial name
- NCT05723939
- Testing
- Carnosine supplementation, Controls
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Vascular Disease
Assessment of Short-term Effect of L-Citrulline on Endothelial Function and Vasodilation in Known CAD Patients
The purpose of this study is to determine the efficacy of oral L-Citrulline on endothelial function and vasodilation in patients with coronary artery disease(CAD) by evaluating the brachial artery diameter in the antecubital area…
- Trial name
- NCT02638727
- Testing
- L-Citrulline
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
HIV Infections, Dyslipidemia
Effect of Atazanavir on Endothelial Function in HIV-Infected Patients
It is known that certain antiviral therapies, the socalled protease inhibitors, used in the treatment of HIV infection has an untowarded effect on the blood vessels, promoting early occurence of atherosclerosis.
- Trial name
- ENDOPACT (NCT00447070)
- Testing
- ATAZANAVIR
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Foundation for Cardiovascular Research, Zurich
Elevated Blood Pressure, Endothelial Dysfunction
Effectiveness of Vitamin D Supplementation
This pilot study will examine the effectiveness of vitamin D supplementation on reducing blood pressure and improving endothelial function. Premenopausal African American women will be recruited.
- Trial name
- NCT02513823
- Testing
- 2,000 International Units (IU)of vitamin D3
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Atherosclerosis, Coronary
Study of Intracoronary CD34+ Cell Administration in Patients With Early Coronary Atherosclerosis
How safe and effective are CD34+ cell intracoronary injections for treating coronary endothelial dysfunction (CED)?
- Trial name
- NCT03471611
- Testing
- Autologous CD34+ Cells, Granulocyte Colony-Stimulating Factor (G-CSF)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Subclinical Hypothyroidism
Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Hypothyroidism is risk factor in atherosclerotic cardiovascular diseases, but there is a controversy in effect of subclinical hypothyroidism on cardiovascular diseases.
- Trial name
- NCT02090907
- Testing
- Levothyroxine
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Isfahan University of Medical Sciences
Hypertension, Hypertriglyceridemia
Fish Oil Supplementation and Vascular Function in Hypertensive Patients With Hypertriglyceridemia
The objective of this study is to compare the effects of ciprofibrate versus omega-3 fatty acid supplementation on the vascular structure and function in hypertensive patients with hypertriglyceridemia.
- Trial name
- NCT01480687
- Testing
- DHA-EPA, Ciprofibrate
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- Hospital Universitario Pedro Ernesto
Spinal Cord Injury, Chronic Inflammation
Impact of Passive Heat on Metabolic, Inflammatory and Vascular Health in Persons With Spinal Cord Injury
SCI results in higher incidence of heart disease and diabetes and heart disease is the most common cause of death. Chronic inflammation, deleterious changes in vascular structure and impaired glucose metabolism are risk factors…
- Conditions
- Spinal Cord Injury, Chronic Inflammation, Glucose Metabolism, Endothelial Function
- Trial name
- SCIPHS (NCT04971408)
- Testing
- passive heat stress, Control
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Chronic Kidney Diseases, Endothelial Dysfunction
Resveratrol and Vascular Function in CKD
The proposed research is clinical study evaluating the therapeutic benefits of resveratrol on vascular function in patients with chronic kidney disease (CKD).
- Trial name
- NCT03597568
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Diana Jalal
Chest Pain
Women With Chest Pain and Normal Coronary Arteries Study
The purpose of this study is to compare the effectiveness of standard medical therapy versus usual care in women with chest pain, coronary endothelial dysfunction and unblocked coronary arteries.
- Trial name
- NCT00743197
- Testing
- Aspirin, Lisinopril, Simvastatin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Coronary Artery Disease, Hypertension
Acute Probiotic Supplementation and Endothelial Function
One in every two deaths in the United States is caused by cardiovascular disease. Despite strong mechanistic links established between a diet rich in lipids and the pathogenesis of cardiovascular disease, therapeutic advances…
- Conditions
- Coronary Artery Disease, Hypertension, Hyperlipidemias, Peripheral Vascular Diseases
- Trial name
- NCT04364074
- Testing
- Goodbelly
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Medical College of Wisconsin
Preeclampsia, Hypertensive Disorder of Pregnancy
Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy
The present study is a single-centre prospective study that will enrol pregnant women during their first trimester of pregnancy (11+0 - 13+6 weeks of gestation).
- Trial name
- EDIPE (NCT05999851)
- Testing
- Arterial applanation tonometry, In vivo endothelial glycocalyx measurement, Serum markers of angiogenesis and endothelial dysfunction
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cardiovascular Risk Factors, Blood Pressure
Effect of a Specific Phenolic Compound on Blood Pressure
The study's main objective is to investigate the effects of acute consumption of a preparation containing 100 mg of a specific phenolic compound (patent pending, P201531587) on systolic BP after ingestion of a high fat meal.
- Trial name
- PHENOLPRESS (NCT02628353)
- Testing
- phenolic compound
- Where
- Spain
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Coronary Arteriosclerosis, Endothelial Function
Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
The purpose of this study is to determine the effect of orally given paracetamol on the vascular function and on 24-hour blood pressure in patients with coronary artery disease
- Trial name
- NCT00534651
- Testing
- Paracetamol
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University of Zurich
Peripheral Vascular Disease, Lipid Disorder
Effect of Plasma Ceramides on Peripheral Vascular Function
The goal of this clinical trial is to determine the effect of elevated plasma ceramides on peripheral vascular function. Subjects will consume a high fat meal consisting of long chain fatty acids (to increase plasma ceramides) or…
- Conditions
- Peripheral Vascular Disease, Lipid Disorder, Endothelial Dysfunction
- Trial name
- NCT05107869
- Testing
- High Saturated Fat
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Obesity, Pre-hypertension
Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition
Arterial dysfunction contributes to the development of cardiovascular disease (CVD), which is currently afflicting millions of individuals.
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT02143817
- Testing
- L-citrulline supplementation, Whole Body Vibration Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Covid19, SARS-CoV Infection
Prognostic Value of Flow-mediated Dilation in Hospitalized COVID-19 Patients
This study will evaluate the associations between vascular parameters and clinical outcomes in patients hospitalized with COVID-19.
- Trial name
- NCT04714125
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- University of Sao Paulo General Hospital
Peripheral Arterial Disease, Cardiovascular Health
Heat Therapy and Peripheral Artery Disease
The purpose of the study is to assess the efficacy of a novel 8 week heat therapy intervention in intermittent claudication compared to usual care controls.
- Conditions
- Peripheral Arterial Disease, Cardiovascular Health, Vascular Function, Intermittent Claudication
- Trial name
- NCT06827691
- Testing
- Heat Therapy Intervention
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Manchester Metropolitan University
Type 2 Diabetes Mellitus
Vascular Effects of Rosiglitazone Versus Glyburide in Type 2 Diabetic Patients
The purpose of this study is to compare the vascular effects of two commonly used diabetes medications, rosiglitazone and glyburide in type 2 diabetic patients.
- Trial name
- NCT00123643
- Testing
- rosiglitazone, glyburide
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- St. Paul Heart Clinic