Clinical trials: Vascular Endothelial Function
Coronary Artery Disease, Endothelial Function
The Association of Platelet Function and Endothelial Function of the Brachial Artery
The proposed study is a prospective one, and will be held on consecutive individuals undergoing the non-invasive brachial artery flow-mediated dilation (FMD) ultrasound for endothelial function at the endothelial function…
- Conditions
- Coronary Artery Disease, Endothelial Function, Thrombosis
- Trial name
- NCT00363818
- Where
- 2 sites in Israel
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hypertension
Blood Pressure Lowering Effects of Grape Juice
Recent studies suggest that a diet rich in fruit and vegetables can lower blood pressure, and a number of lines of evidence suggest that grape products may have such an effect.
- Trial name
- NCT00302809
- Testing
- Concord Grape Juice
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston University
Peripheral Artery Disease
NAD Supplementation and Vascular Health in PAD
This pilot open-label clinical trial was designed to investigate whether 4-week supplementation with 1g daily NR impacts endothelial function in peripheral circulation, cerebrovascular hemodynamics, cognitive function in older…
- Trial name
- NCT06534944
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Oklahoma
Impotence
Use of Sildenafil (Viagra) in Diabetic Men With Erectile Dysfunction: the Impact on Blood Vessels
To evaluate the impact of nightly sildenafil vs placebo use on diabetic men with and without proven endothelial dysfunction and coexisting erectile concerns.
- Trial name
- NCT00199563
- Testing
- Viagra
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Obstructive Sleep Apnea
Vitamin D and SGLT-2 Inhibitor in CPAP-naive Obstructive Sleep Apnea
The purpose of this study is to determine if vitamin D supplement and SGLT-2 inhibitor treatment combination can improve cardiovascular risks in patients with OSA and hypertension, on top of lifestyle modification, before…
- Trial name
- D3DOSA (NCT06690723)
- Testing
- Dapagliflozin (Forxiga), Vitamin D3 ( Colecalciferol), Vitamin D3 plus Dapagliflozin
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- University Malaysia Sarawak
Healthy Subjects, Dyslipidaemias
Study To Evaluate The Effects Of GW856553 On Endothelial Function/Vascular Compliance In Subjects With Dyslipidaemia.
The rationale for this study is to determine whether GW856553 (7.5mg BD for 28 days) has an effect on endothelial function in dyslipidaemic subjects as assessed by venous occlusion plethysmography using brachial artery…
- Conditions
- Healthy Subjects, Dyslipidaemias, Dyslipidaemia
- Trial name
- NCT00474864
- Testing
- GW856553
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Myocardial Infarction
Additive Effect of Ezetimibe Upon Simvastatin During Myocardial Infarction
During acute coronary syndromes (ACS), the generation of inflammatory mediators negatively influences arterial wall remodeling and the endothelium-dependent vasomotor function in the coronary and systemic arterial systems.
- Trial name
- NCT00905905
- Testing
- Simvastatin, Ezetimibe-Simvastatin
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Brasilia Heart Study Group
Hypertension, Hypertrophy, Left Ventricular
Does Allopurinol Reduce Thickening of the Left Ventricle of the Heart in Patient With Treated Hypertension?
The presence of Left ventricular hypertrophy (LVH) confers high cardiovascular risk in hypertensive patients. LVH remains highly prevalent even when blood pressure (BP) is controlled.
- Trial name
- ALLAY (NCT02237339)
- Testing
- Allopurinol
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- University of Dundee
Cardiovascular Diseases, Hypertension
The Impact of KETO5 XOGenius Beverage on Markers of Physiological and Neurocognitive Health
The primary objectives of this application are to 1) investigate the effect of increased daily consumption of the Keto5 XOGenius beverage on outcomes associated with elevated risk for various neurocognitive and pathophysiological…
- Conditions
- Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet
- Trial name
- NCT06318390
- Testing
- XO Genius
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Diabetes Mellitus, Type 2, Endothelial Dysfunction
Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 Diabetes
Patients with Type 2 Diabetes Mellitus (T2DM) have changes in blood vessel health that can lead to a higher chance of developing heart attacks or strokes.
- Trial name
- SFRNDM2 (NCT05139914)
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston University
Coronary Artery Disease
Impaired Peripheral Endothelial Function and In-stent Restenosis
The investigators assessed the hypothesis that whether RH-PAT index (RHI) as a marker of endothelial dysfunction could predict occurrence of ISR after percutaneous coronary intervention (PCI).
- Trial name
- NCT02131935
- Where
- Japan
- Volunteers
- 513 people
- Sponsor
- Kumamoto University
Cardiovascular Diseases, Vascular Dilation
Thromboxane Receptor Antagonist to Improve Endothelial Function
This study evaluates whether addition of the thromboxane receptor antagonist to chronic aspirin therapy improves endothelial function and reduces non-platelet thromboxane generation in patients with established cardiovascular…
- Trial name
- TRAP (NCT03962855)
- Testing
- Ifetroban Sodium
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Jeffrey Rade
Atherosclerosis
Impact of Sarpogrelate in the Function of Endothelial Progenitor Cells
The purpose of this study is to evaluate the effects of Sarpogrelate in endothelial progenitor cells of patients with atherosclerosis.
- Trial name
- NCT01548274
- Testing
- Sarpogrelate
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Aichi Gakuin University
Exercise Anaphylaxis
The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women
The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women.
- Trial name
- NCT01314573
- Testing
- Sprint interval exercise, Maximal continuous exercise
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Healthy
Biodiesel Exhaust, Acute Vascular and Endothelial Responses
Exposure to particulate air pollution has been shown to increase cardiovascular mortality and morbidity, and in previous controlled exposure studies has been shown to have acute cardiovascular and respiratory effects.
- Trial name
- BEAVER (NCT01337882)
- Testing
- Forearm venous occlusion plethysmography study
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
High Blood Pressure
Microcirculation and Inflammatory Markers in Patients With Resistant, Stages 1/2 Hypertension and Normal Blood Pressure
Nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and inflammatory biomarkers have been used to study endothelial function in patients with resistant hypertension, stages 1 and 2 hypertension and…
- Trial name
- MICRORAH (NCT02759276)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Daniel Alexandre Bottino
Hypertension
Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome
The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels.
- Trial name
- AMORE (NCT01271374)
- Testing
- amlodipine and olmesartan, losartan and HCTZ
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- InVasc Therapeutics, Inc.
Type 1 Diabetes
Estrogen, Diabetes, and Endothelial Function
This study planned to learn more about women and how the drop in estradiol levels during menopause may affect their cardiovascular risk.
- Trial name
- EDEN (NCT04418908)
- Testing
- Cetrorelix acetate, 0.25 mg/day, Estradiol Patch, 0.025 Mg/24 Hours Weekly Transdermal Film, Extended Release
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes Mellitus, Coronary Artery Disease
Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease
Type 2 diabetes is associated with a markedly increased risk for atherosclerotic coronary arteries and cerebrovascular diseases.
- Trial name
- NCT01038050
- Testing
- Ginkgo Biloba Extract (GBE)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acute Coronary Syndrome
Ticagrelor Monotherapy Compared to Aspirin Monotherapy in Patients With History of ACS
Antiplatelet agents are cornerstones for management of ischemic heart disease. For patients suffering from acute coronary syndrome (heart attack), treatment with aspirin and ticagrelor are typically given for one year after index…
- Trial name
- FMD_ACS (NCT03881943)
- Testing
- Ticagrelor 60 mg, Aspirin 100 MG Oral Tablet, Enteric Coated
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong