Clinical trials: Vascular Endothelial Function
Microcirculation; Biomarkers; Myocardial Ischemia
Endothelial and Microvascular Functions in Patients With Myocardial Ischemia
Cardiovascular diseases (CVD) are responsible, throughout the world, for high mortality rates and cardiovascular morbidity. Endothelial dysfunction is the earliest marker of clinical atherosclerosis development.
- Trial name
- NCT03243968
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Hypertension, Endothelial Dysfunction
CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients.
The aim of this study is to examine how effective CPAP treatment and treatment with nebivolol are respectively on reducing blood pressure and on endothelial dysfunction in patients suffering from obstructive sleep apnea and…
- Conditions
- Hypertension, Endothelial Dysfunction, Obstructive Sleep Apnea
- Trial name
- NEBOSA (NCT01771406)
- Testing
- Nebivolol, Continuous positive airway pressure (CPAP)
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Bypass Grafting, Coronary Artery Disease
Cardiac and Endothelial Function Response to Early Exercise Training After Coronary Artery Bypass Surgery
Background: Coronary artery bypass grafting (CABG) due to coronary artery disease (CAD) is one of the main surgical procedures performed in the area of cardiology.
- Conditions
- Coronary Artery Bypass Grafting, Coronary Artery Disease, Cardiac Rehabilitation
- Trial name
- CEFREET (NCT03096158)
- Testing
- Ventilatory Muscle Training (TREMVEN), Aerobic Training (AERO), Isometric Handgrip Training (ISO)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Systemic Lupus Erythematosus, Atherosclerosis
Mycophenolate Mofetil in Systemic Lupus Erythematosus (MISSILE)
Systemic lupus erythematosus (SLE) is an independent risk factor for atherosclerosis. Endothelial dysfunction is the earliest marker of atherosclerosis and is measured by flow mediated dilation (FMD) of the brachial artery.
- Trial name
- MISSILE (NCT01101802)
- Testing
- Mycophenolate mofetil, sugar pill
- Where
- United Kingdom
- Volunteers
- 71 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Hypertension, Type 2 Diabetes Mellitus
A Comparison of Indapamide SR 1.5 mg With HCTZ 25 mg, in Combination With an ACE-inhibitor, in Patients With Mild to Moderate AHT and Type 2 DM
The aim of this study is to evaluate the effects of indapamide SR 1.5 mg on blood pressure, blood tests (glucose metabolism, lipids, minerals, and uric acid), cardiac function, endothelial and arterial function, by comparison…
- Trial name
- AISHA (NCT00980187)
- Testing
- Hydrochlorothiazide, Indapamide
- Where
- Romania
- Volunteers
- 56 people
- Sponsor
- LaborMed Pharma S.A.
Diabetes
Changes of Endothelial Function Before and After DSA in Patients With Diabetes
Endothelial dysfunction is the early step of atherosclerosis. Therefore, the investigators hypothesize that digital subtraction angiography (DSA) can damage endothelial function.
- Trial name
- NCT01556984
- Testing
- DSA assay
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Hypertension, Cardiovascular Diseases
Impact of Dairy Consumption on Hypertension: a Clinical Study
Hypertension and endothelial dysfunction are being increasingly recognized as key etiological factors in the development of atherosclerosis and subsequent cardiovascular disease (CVD).
- Trial name
- PLAT (NCT01776216)
- Testing
- Dairy diet, Control diet
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Laval University
Obesity, Atherosclerosis
Endothelial Dysfunction in Obese Children
The purpose of this study is to objectify the effect of diet and exercise on early markers of atherosclerosis in obese children.
- Trial name
- EDOC (NCT01461226)
- Testing
- Exercise training, Usual care
- Where
- 3 sites in Belgium
- Volunteers
- 61 people
- Sponsor
- University Hospital, Antwerp
Coronary Disease
The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease
Prior work (Chris, M. et al, Clinical Science 2005; 109, 55-60) has demonstrated that drinking a cup of coffee (80-100 mg of caffeine) an hour before endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery…
- Trial name
- NCT00564824
- Testing
- Caffeine
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Type 2 Diabetes
Effect of Bydureon on Carotid Atherosclerosis Progression in Type 2 Diabetes Mellitus
Investigators will be determining whether a once weekly injectable medication Bydureon versus placebo is able to reduce the development of atherosclerosis.
- Trial name
- NCT02162550
- Testing
- Bydureon
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Phoenix VA Health Care System
Aortic Coarctation, Arterial Stiffness
Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment
Background: Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty or stent implantation. Although short-term results are excellent with all three treatment modalities, long term cardiovascular (CV)…
- Conditions
- Aortic Coarctation, Arterial Stiffness, PULSE WAVE VELOCITY, Functional Magnetic Resonance Imaging
- Trial name
- LOVE-COARCT (NCT03262753)
- Testing
- Surgery, Balloon dilation, Stent
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Cardiooncology, Myeloma
Vascular Functions in Myeloma Patients During Anti-tumor Therapy
Treatment options for multiple myeloma have increased significantly over the last years with the approval of immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs).
- Conditions
- Cardiooncology, Myeloma, Endothelial Dysfunction
- Trial name
- NCT03776331
- Testing
- Flow mediated dilation
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Essen
Endothelial Dysfunction
Endothelial Function in Human Arteries
Up to 30 patients with lower extremity disease scheduled to undergo diagnostic angiography will undergo baseline bloodwork and IVUS (intravascular ultrasound), followed by dosing with L-arginine to assess changes in endothelial…
- Trial name
- NCT00848302
- Testing
- L-arginine
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Coronary Artery Disease
Effects of Egg Ingestion on Endothelial Function in Adults With Coronary Artery Disease
The purpose of this study is to determine the effects of daily consumption of eggs or egg substitute for 6 weeks on endothelial function and on cholesterol and lipoprotein levels in participants with clinically established…
- Trial name
- NCT01672567
- Testing
- Egg supplementation, Egg substitute, Control diet
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Griffin Hospital
Insulin Resistance
Effect of Salsalate on Bed Rest-Induced Vascular Dysfunction
Physical inactivity induces vascular dysfunction and glucose intolerance during five days of bed rest. This study will investigate the effects of salsalate on these responses.
- Trial name
- NCT00553995
- Testing
- salsalate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston University
NSTEMI
COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients
Colchicine has antiinflammatory properties. It has been shown to be effective in improving outcome in stable coronary disease. The exact mechanism is unclear.
- Trial name
- CODEN (NCT02095522)
- Testing
- Colchicine
- Where
- 2 sites in Israel
- Sponsor
- Tel-Aviv Sourasky Medical Center
Coronary Artery Disease
Cell Therapy for Coronary Heart Disease
Impaired contractile function after a heart attack and due to coronary heart disease is a major cause of "heart failure" limiting quality of life and prognosis, which cannot be prevented even with optimal standard therapy.
- Trial name
- NCT00289822
- Testing
- intracoronary infusion of progenitor cells
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Coronary Artery Disease, Endothelial Function
Effect of Ticagrelor on Endothelial Function
This study is to assess the function of blood vessels while being treated with different types of blood thinners to determine the effect of these medications on blood vessels.
- Trial name
- NCT01805596
- Testing
- clopidogrel, Ticagrelor
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hypertension, Coronary Arteriosclerosis
SAFE-CRP: Structural Alterations and Function of Endothelium in Cardiovascular Risk Patients
The aim of this trial is to evaluate the efficacy and safety of telmisartan 80 mg administered once daily in patients with documented coronary artery disease (CAD) and a probably cardiovascular risk profile concerning the…
- Trial name
- NCT00274105
- Testing
- telmisartan
- Where
- 2 sites in Germany
- Volunteers
- 22 people
- Sponsor
- Boehringer Ingelheim
Atherosclerosis
Arterial Function and Atherosclerosis in Essential Thrombocythemia
The aim of the study is to examine (a) whether patients with JAK2 V617F positive ET in comparison to age-and sex-matched, apparently healthy control subjects show more advanced progression of arterial stiffness, pulse-wave…
- Trial name
- NCT03828422
- Testing
- imaging
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana