Clinical trials: Vascular Endothelial Function
Type 1 Diabetes
Estrogen, Diabetes, and Endothelial Function
This study planned to learn more about women and how the drop in estradiol levels during menopause may affect their cardiovascular risk.
- Trial name
- EDEN (NCT04418908)
- Testing
- Cetrorelix acetate, 0.25 mg/day, Estradiol Patch, 0.025 Mg/24 Hours Weekly Transdermal Film, Extended Release
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Oxidative Stress
The Acute Effect of Spices on Vascular Health
The investigators aim to conduct a 3-period randomized controlled crossover study to investigate the postprandial effects of a high fat meal with spice on endothelial function, lipids/lipoproteins, immune function and plasma…
- Trial name
- NCT03064958
- Testing
- Herbs and spices, High fat meal
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Penn State University
Healthy
Spices, Inflammation and Vascular Response in Humans
The objectives of this study are: 1. To characterize the time course of herbs/spice action on endothelial function as measured by FMD over 24 h using a challenge meal paradigm. 2.
- Trial name
- SPC (NCT03926442)
- Testing
- Italian Herb meal, Cinnamon Meal, Pumpkin Spice meal
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
n-3 Polyunsaturated Fatty Acids
N-3 Polyunsaturated Fatty Acids Enriched Chicken Meet and Cardiovascular Function
Evidence from multiple experimental, epidemiological, and clinical studies indicate that n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert their cardiovascular (CV) protective effect, at least in part, by improving vascular…
- Trial name
- NCT05725486
- Testing
- N-3 PUFAs Chicken Meet, Regular Chicken Meet
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Chronic Kidney Disease
Advanced Glycation End-products, Inflammation and Vascular Health in Chronic Kidney Disease
The purpose of the study is to learn more about how advanced glycation end-products can affect insulin resistance, inflammation and blood vessel health in people with kidney disease.
- Trial name
- NCT01769963
- Testing
- Research diet
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Alabama at Birmingham
Diabetes, Atherosclerosis
Effects of Sitagliptin on Endothelial Function in Type 2 Diabetes on Background Metformin Therapy
The study is being performed to determine whether sitagliptin, a dipeptidyl peptidase-4 inhibitor, both acutely and chronically improves blood vessel function.
- Trial name
- NCT01859793
- Testing
- sitagliptin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Medical College of Wisconsin
Rheumatoid Arthritis, Psoriatic Arthritis
Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
The aim of this study is to evaluate the influence of anti tumor necrosis factor-alpha (TNF-α) treatment on blood pressure, endothelial function and immune cell phenotype in patients with rheumatoid arthritis, psoriatic arthritis…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Hypertension
- Trial name
- NCT02132234
- Testing
- Etanercept, Adalimumab, Certolizumab
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Colchicine, Diabetes Mellitus, Type 2
Dose-finding Study of Colchicine in Type 2 Diabetic Patients With Coronary Artery Disease
This study is designed to investigate dose-dependent effects of low dose colchicine on inflammatory responses, endothelial function in type 2 diabetic patients with coronary artery disease and leukocyte activation.
- Conditions
- Colchicine, Diabetes Mellitus, Type 2, Coronary Artery Disease, White Blood Cell
- Trial name
- DRC-04 (NCT03376698)
- Testing
- Colchicine 0.5 mg, Colchicine 0.25 mg
- Where
- 5 sites in Japan
- Volunteers
- 54 people
- Sponsor
- University of the Ryukyus
Coronary Artery Disease
A Randomized Controlled Trial in Women With Coronary Artery Disease Investigating the Effects of Aerobic Interval Training Versus Moderate Intensity Continuous Exercise
Heart disease is the number one killer amongst chronic diseases around the world, and it is responsible for taking the lives of an estimated 17.5 million people each year.
- Trial name
- CAT vs MICE (NCT02966158)
- Testing
- AIT Group
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University Health Network, Toronto
Cerebral Small Vessel Disease
Targeting 18kDa Translocator Protein (TSPO) to Improve Brain Endothelial Cell Function in Cerebral Small Vessel Disease
In healthy people, blood flow to particular areas in the brain increases when the area becomes more active. This ensures that the brain gets enough blood at the right place and time.
- Trial name
- NCT06643013
- Testing
- XBD173
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Endothelial Function
Endothelial Function Assessed With BOLD-MRI
The purpose of this study is to assess the applicability of a new SSFP-based BOLD sensitive MRI sequence in evaluating endothelial function. Endothelial function will be tested in a setting of reactive hyperemia in the forearm.
- Trial name
- EFBOLD-MRI (NCT00575120)
- Testing
- ischemia reperfusion
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Hypertension
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study
The purpose of this study is to test the effect of oral melatonin supplementation (24 mg per night for 4 weeks) on nighttime blood pressure in African Americans with a history of elevated nighttime blood pressure.
- Trial name
- NCT01114373
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Peripheral Vascular Disease, Lipid Disorder
Effect of Plasma Ceramides on Peripheral Vascular Function
The goal of this clinical trial is to determine the effect of elevated plasma ceramides on peripheral vascular function. Subjects will consume a high fat meal consisting of long chain fatty acids (to increase plasma ceramides) or…
- Conditions
- Peripheral Vascular Disease, Lipid Disorder, Endothelial Dysfunction
- Trial name
- NCT05107869
- Testing
- High Saturated Fat
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Ischaemic Heart Diseases
The Effect of Ischaemic-reperfusion on the Endogenous Fibrinolysis in Man
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle.
- Trial name
- NCT00789451
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Borderline High LDL-cholesterol
Effects of Ubiquinol and Ubiquinone on Vascular Function in Healthy Adults With Borderline High LDL-Cholesterol
This randomized, double-blind, placebo-controlled clinical trial will evaluate the effects of Ubiquinol and Ubiquinone on vascular endothelial function in generally healthy adults with borderline high LDL-cholesterol.
- Trial name
- NCT07881601
- Testing
- Ubiquinol, Ubiquinone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
Colorectal Cancer, Lung Cancer
The Effect of Monoclonal Vascular Endothelial Growth Factor (VEGF) Antibody (Bevacizumab) on Pituitary Function
The purpose of this research is to determine whether the drug, Bevacizumab (a monoclonal anti VEGF-A antibody), which is approved to treat patients with metastatic colon cancer induces hyperprolactinemia (increased prolactin…
- Conditions
- Colorectal Cancer, Lung Cancer, Breast Cancer, Glioblastoma
- Trial name
- NCT00973557
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cedars-Sinai Medical Center
Endothelial Dysfunction, Insulin Resistance
The Effects of Sedentarism on Vascular Function, Inflammation, and Insulin Resistance
The purpose of this study are twofold: 1. To understand the effects of physical inactivity (sedentarism) on vascular function, insulin resistance and inflammation; 2.
- Conditions
- Endothelial Dysfunction, Insulin Resistance, Metabolic Syndrome, Peripheral Arterial Disease
- Trial name
- Bedrest (NCT01412216)
- Testing
- Fish Oil (Omega-3 Fatty Acids)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy Women
Endothelial Function in Healthy Volunteers
The aim of this study is to measure FMD (flow-mediated dilation) in healthy volunteers aged over 50 in order to establish reference values for women aged over 50.
- Trial name
- NormFMD (NCT07837076)
- Testing
- Measurement of endothelial function using FMD
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy
Sodium vs Potassium Education to Improve Vascular Health
The goal of this clinical trial is to determine if a self-selected high potassium diet is easier to achieve and more effective at improving vascular health than a low sodium diet in generally healthy young adults who typically…
- Trial name
- NCT07221448
- Testing
- High potassium dietary education/counseling, Low sodium dietary education/counseling
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Florida State University
Coronary Artery Disease
Flaxseed Consumption, Alone and in Combination With the Mediterranean-like Diet, on Some Indicators Related to Atherosclerosis
Flaxseed consumption has beneficial effects on cardiovascular risk factors. In addition, the benefit of the Mediterranean-like diet in primary and secondary prevention of cardiovascular diseases has been shown.The purpose of this…
- Trial name
- NCT03392025
- Testing
- Flaxseed, the Mediterranean-like diet
- Where
- Iran
- Volunteers
- 87 people
- Sponsor
- Javad Nasrollahzadeh