Clinical trials: Vascular Endothelium
Adverse Childhood Experience, Endothelial Function (FMD)
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction.
- Conditions
- Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function
- Trial name
- PROMISE (NCT07244809)
- Testing
- Mitoquinone mesylate (MitoQ)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Stroke, Infarction, Middle Cerebral Artery
Autologous Bone Marrow Stromal Cell and Endothelial Progenitor Cell Transplantation in Ischemic Stroke
The purpose of this study is to evaluate the feasibility, efficacy, and safety of autologous transplantation of ex vivo expanded bone marrow stromal cells (BMSCs)and endothelial progenitor cells (EPCs) for treatment of patients…
- Trial name
- AMETIS (NCT01468064)
- Testing
- Autologous BMSCs transplantation, Autologous EPCs transplantation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Southern Medical University, China
Cardiovascular Disease
Farmed Fish Human Intervention Study
Consumption of fish can help to prevent cardiovascular disease. The precise way in which fish is beneficial is not fully understood.
- Trial name
- FISHDISH (NCT01916434)
- Testing
- High PUFA Salmon Fillets, Sustainable PUFA salmon, No salmon
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Carotid Artery Diseases, Atherosclerosis
Effect of Valsartan on Carotid Artery Disease
The EFFERVESCENT trial is designed to evaluate the effects of a specific ARB, called valsartan, on atherosclerosis. The investigators want to know if treatment with valsartan will increase the blood levels of markers responsible…
- Trial name
- NCT00208767
- Testing
- Valsartan
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Emory University
Coronary Artery Disease, Acute Coronary Syndrome
Does Montelukast Have an Affect on the Function of the Artery in Patients With Heart Disease
To evaluate the effect of the drug Montelukast on the brachial artery's function. By giving a drug like Montelukast, which blocks the effects of inflammation in the lungs arteries and controls asthma, we hope to see positive…
- Trial name
- NCT00351364
- Testing
- Montelukast Sodium
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Diabetes, Atherosclerosis
Effects of Sitagliptin on Endothelial Function in Type 2 Diabetes on Background Metformin Therapy
The study is being performed to determine whether sitagliptin, a dipeptidyl peptidase-4 inhibitor, both acutely and chronically improves blood vessel function.
- Trial name
- NCT01859793
- Testing
- sitagliptin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Medical College of Wisconsin
Hypertension
Salt Intake, Microbiota, Immune Response and Endothelial Function in Hypertension
Hypertension is a significant cardiovascular risk factor which affects 45% of the adult population. Salt intake is essential in the development and progression of hypertension.
- Trial name
- NCT04648592
- Testing
- Low salt diet plus sodium chloride supplements
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Heart Failure
Vascular Endothelial Function and Cardiac Resynchronization Response in Patients With Heart Failure
The purpose of this research study is to determine the role of blood vessel endothelial function in heart failure and the effect of Cardiac Resynchronization Therapy (CRT) on heart and endothelial function.
- Trial name
- NCT02783716
- Testing
- Subcutaneous adipose tissue collection, Peripheral arterial tonometry (PAT)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Bone Injury
The Role of Type H Vessel Formation in Induced Membrane of Patients With Critical Size Bone Defect
The goal of this clinical trial is to test the role of type H vessel and investigate the mechanism of its regulation in induced membrane created by induced membrane technique in patients with open fracture, aged between 20 and…
- Trial name
- NCT05792371
- Testing
- induced membrane technique, Bone graft (Stage II of IMT)
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Hypothyroidism, Thyroid Diseases
Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism
Hypothyroidism is a common clinical entity which is often complicated by dyslipidemia. It is also reported increased risk for incidence of atherosclerosis and resulting coronary heart disease(CHD), heart failure(HF) and…
- Conditions
- Hypothyroidism, Thyroid Diseases, Endocrine System Diseases
- Trial name
- NCT01848171
- Testing
- L-thyroxine
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Shandong Provincial Hospital
Insulin Resistance
The Effect of 12-week Circuit Training on Insulin Sensitivity and Endothelial Function in Women With Insulin Resistance
During the last 10 years many studies concerning the impact of physical training on whole-body insulin sensitivity have been published, but there is a lack of an extended investigation on the potential clinical benefits of novel…
- Trial name
- NCT04528693
- Testing
- Circuit training (combination of strength and endurance exercises)
- Where
- Poland
- Volunteers
- 49 people
- Sponsor
- Poznan University of Physical Education
Hypertension
Endothelin Receptor Function and Acute Stress
Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress.
- Trial name
- End-Stress (NCT02116335)
- Testing
- Bosentan
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Augusta University
Stable Angina
Safety and Efficacy Study of Endothelial Progenitor Cell Capture Stent With 1 Months Dual Antiplatelet Therapy
Thanks to rapid reendothelialization derived from the pro-healing property of the EPC capture stent, 1-month dual antiplatelet therapy (DAPT) is recommended after EPC capture stent implantation.
- Trial name
- INNOVATION (NCT01394848)
- Testing
- Endothelial cell capture stent with 1 month clopidogrel, Everolimus eluting stent with 12 month clopidogrel, Atorvastatin 20mg loading
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Yonsei University
Healthy Volunteers (Middle-aged Smokers)
Effects of Curcumin on Vascular Reactivity
The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk
- Trial name
- CURCUMIN (NCT01543386)
- Testing
- Curcumin
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Coronary Heart Disease
The Effect of Beer, Red Wine and Fruit Juice on Blood Vessel Function in Persons With Cardiovascular Disease
To study the effect of red wine, beer and fruit juice on endothelial function in patients with coronary Heart disease.
- Trial name
- NCT00382551
- Testing
- Moderate daily consumption of Red wine, Moderate daily consumption of beer, Moderate consumption of fruit juice rich in polyphenolics
- Where
- Denmark
- Volunteers
- 49 people
- Sponsor
- Aalborg University Hospital
Arterial Hypertension, Resistant Arterial Hypertension
Systemic Microvascular Function in Patients With Resistant Hypertension After Renal Sympathetic Denervation
It has been proposed that the modulation of the activity of the sympathetic nervous system, through renal sympathetic denervation, besides reducing blood pressure, would promote an improvement in vascular reactivity and…
- Trial name
- NCT03243045
- Testing
- Renal sympathetic denervation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
COVID, Vascular; Damage
Influence of COVID-19 on Vascular Endothelial Function
Rationale: Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) 2 could result in endothelial dysfunction with increased risk of arterial thrombotic events by downregulating the expression of angiotensin…
- Trial name
- COVAS (NCT04468412)
- Testing
- Carotid Artery Reactivity Testing
- Where
- Netherlands
- Volunteers
- 203 people
- Sponsor
- Radboud University Medical Center
Locally Advanced Non Small-Cell Lung Canger
Concurrent Chemotherapy and Radiotherapy With Nitroglycerin in Patients With Locally Advanced Non-Small Cell Lung Cancer
Nitroglycerin will increase the effectiveness of treatment with induction chemotherapy and concurrent chemo-radiotherapy by reducing chemo-radio resistance through an increased oxygen pressure in tumoral tissue.
- Trial name
- NCT00886405
- Testing
- Transdermal nitroglycerin
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- National Institute of Cancerología
Malignant Ascites
A Study of Bevacizumab to Prevent Malignant Ascites
The purpose of this study is to determine the effectiveness of using Bevacizumab in the prevention of recurrent malignant ascites. Ascites is a debilitating and unpleasant complication of several types of cancer.
- Trial name
- NCT00908219
- Testing
- Bevacizumab
- Where
- 3 sites in United States
- Sponsor
- Baylor College of Medicine
Pre-Eclampsia, Vascular Diseases
Mechanisms of Pregnancy Vascular Adaptations
The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples…
- Trial name
- NCT03806283
- Testing
- Omental Biopsy
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
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