Clinical trials: Vascular Endothelium
Smoking
Effect of Electronic Cigarettes on Platelets, Endothelium and Inflammation
The primary purpose of this study is to evaluate the acute effects of electronic cigarette (e-cigarette) smoking on measurable biomarkers of platelet function, vascular endothelial function and inflammation in healthy active…
- Trial name
- NCT02662075
- Testing
- E-cigarette/tobacco Smoking Exposure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Ischemia and Non-obstructive Coronary Arteries
Vascular Endothelial Inflammation and Health Status In INOCA (VISION-INOCA)
The purpose of this study is to evaluate coronary artery and peripheral vein vascular endothelial profiles in patients with ischemia with non-obstructive coronary arteries (INOCA) who undergo coronary function testing (CFT).
- Trial name
- NCT07586241
- Testing
- Invasive coronary angiography, Coronary Artery Endothelial Cell Sampling, Fitbit
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- NYU Langone Health
Hypoglycemia
Study of How Low Blood Sugar Affects the Way Blood Vessels Work
Hypothesis: Low blood sugar (hypoglycemia) decreases function of the lining of the blood vessels in normal humans. This study is designed to explore how hypoglycemia affects the function of the blood vessel lining.
- Trial name
- NCT00373854
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Corneal Neovascularization
Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization
To determine the effect of subconjunctival Bevacizumab in corneal neovascularization
- Trial name
- NCT00555594
- Testing
- Bevacizumab (Avastin)
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Liver Cancer
Floxuridine and Dexamethasone as a Hepatic Arterial Infusion and Bevacizumab in Treating Patients With Primary Liver Cancer That Cannot be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as floxuridine and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00410956
- Testing
- bevacizumab, dexamethasone, floxuridine
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cognitive Impairment, Hypertension
The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial
The purpose of this study is to examine the effects of blood pressure medications on cognition and blood flow in hypertensive elderly patients with cognitive impairment.
- Conditions
- Cognitive Impairment, Hypertension, Aging
- Trial name
- AVEC (NCT00605072)
- Testing
- candesartan, lisinopril, hydrochlorothiazide
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- University of Southern California
Coronary Artery Disease (CAD)
Predicting Plaque Growth Using Blood Flow Stress Markers: A Proof-of-Concept Study
Coronary artery disease occurs when fatty deposits (plaques) build up inside the arteries that supply blood to the heart. Some plaques remain stable, while others continue to grow or become more likely to rupture, which can lead…
- Trial name
- POSSEM (NCT07864051)
- Testing
- PCCTA scan, Endothelial cell isolation from peripheral blood sample
- Where
- United Kingdom
- Volunteers
- 270 people
- Sponsor
- Queen Mary University of London
Stroke, Cerebrovascular Disorders
Effects of Exercise on Endothelial Function in Stroke Patients
This study examines the hypothesis that 6 months of treadmill aerobic exercise training improves fibrinolysis (clot defense mechanism) and vasomotor function in chronic hemiparetic (muscular weakness or partial paralysis…
- Trial name
- NCT00604877
- Testing
- Treadmill Exercise, Stretching/ROM
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Aging (NIA)
Obstructive Sleep Apnea of Adult
Endothelial Function in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA), a condition that affects a quarter of the Western adults, triples the risk for cardiovascular diseases and increases all-cause mortality.
- Trial name
- NCT03122639
- Testing
- Atorvastatin 10mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Columbia University
Macular Degeneration, Regional Blood Flow
The Effect of a Single Intravitreal Anti-VEGF Therapy on Optic Nerve Head Perfusion
Age related macula degeneration is one of the most common sight threatening diseases of the elderly. The so called wet form of AMD is caused by choroidal neovascularisation (CNV) of pathological vessels, which lead to leakage…
- Conditions
- Macular Degeneration, Regional Blood Flow, Vascular Endothelial Growth Factor
- Trial name
- NCT00709657
- Testing
- ranibizumab, bevacizumab or pegaptanib
- Where
- Austria
- Volunteers
- 8 people
- Sponsor
- Medical University of Vienna
Coronary Arteriosclerosis, Endothelial Function
Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
The purpose of this study is to determine the effect of orally given paracetamol on the vascular function and on 24-hour blood pressure in patients with coronary artery disease
- Trial name
- NCT00534651
- Testing
- Paracetamol
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University of Zurich
Cardiovascular Disease
Farmed Fish Human Intervention Study
Consumption of fish can help to prevent cardiovascular disease. The precise way in which fish is beneficial is not fully understood.
- Trial name
- FISHDISH (NCT01916434)
- Testing
- High PUFA Salmon Fillets, Sustainable PUFA salmon, No salmon
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Peripheral Artery Disease
Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral Artery Disease TENS-PAD Study / TENS-AOMI
Purpose: The investigators team recently carried out a proof of concept study testing the efficacy of one single 45-minute session of 10 Hz TENS prior to walking, versus placebo.
- Trial name
- TENS-PAD (NCT02678403)
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- 4 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Toulouse
Airway Inflammation
Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?
The purpose of this study is to examine biological pathways of altered blood vessel function resulting from breathing airborne particulate.
- Trial name
- NCT00814281
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Marywood University
Vascular Health
FLAVIOLA Health Study
Atherosclerosis progressively occurs with increasing age in the general population. So far most dietary intervention studies with flavanols were performed over short time frames and in small groups of young healthy and older…
- Trial name
- FHS (NCT01799005)
- Testing
- Flavanol (410 mg), Control (no flavanols)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
CompREhensive Diagnostic Assessment of Coronary Endothelial Function Impairment and Vasospasm With CoNtinuous ThErmodilution in Patients With Suspected Coronary Microvascular and Vasomotor Dysfunction
The goal of this observational study is to learn more about the diagnosis of coronary endothelium function and coronary vasospasm using a dedicated invasive protocol in patients who has angina without obstruction in their main…
- Trial name
- REDEFINE-CMD (NCT07337005)
- Testing
- Invasive coronary physiological measurements
- Volunteers
- 100 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Retinopathy of Prematurity
Pan-VEGF Blockade for the Treatment of Retinopathy of Prematurity (BLOCK-ROP)
The purpose of this study is to determine whether a single intravitreal (into the gel of the eye) injection of Avastin 0.625mg or 0.75mg is equivalent (non-inferior) to treatment with standard of care laser in infants with Type I…
- Trial name
- BLOCK-ROP (NCT01232777)
- Testing
- Bevacizumab
- Where
- 19 sites in United States, Canada
- Sponsor
- Vision Research Foundation
Age Related Macular Degeneration
Effect of Intravitreal Anti-VEGF on Retinal Vessels Diameter
Patients who will be scheduled for intravitreal injection of Ranibizumab or Bevacizumab will be recruited in this prospective self-controlled trial.
- Trial name
- NCT01626339
- Testing
- Intravitreal Ranibizumab, Intravitreal bevacizumab
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- University of Malaya
Endothelial Dysfunction
The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function
The purpose of this study is to test if watermelon juice supplementation improves vascular dysfunction experience during hyperglycemia.
- Trial name
- WMJ (NCT04092439)
- Testing
- Watermelon Juice
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Macular Degeneration
Vascular Endothelial Growth Factor VEGF Trap-Eye:Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration(AMD)
This study is a phase 3, double-masked, randomized, study of the efficacy and safety of VEGF Trap-Eye in patients with neovascular age-related macular degeneration.
- Trial name
- VIEW1 (NCT00509795)
- Testing
- ranibizumab, aflibercept injection (VEGF Trap-Eye, BAY86-5321)
- Where
- 188 sites in United States, Canada
- Volunteers
- 1,217 people
- Sponsor
- Regeneron Pharmaceuticals
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