Clinical trials: Vascular Endothelium
Obstructive Sleep Apnea, Cardiac Syndrome X
A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram
Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction.
- Conditions
- Obstructive Sleep Apnea, Cardiac Syndrome X, Endothelial Dysfunction
- Trial name
- NCT01217346
- Testing
- no intervention is involved in this study
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Myocardial Ischemia
Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting
The success of coronary artery bypass grafting is reliant on the quality of the grafts used. A new technique for harvesting veins used as grafts has been introduced.
- Trial name
- IMPROVE-CABG (NCT01834846)
- Testing
- no-touch, conventional
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Foot Ulcer
A Study Evaluating Topical Recombinant Human Vascular Endothelial Growth Factor (Telbermin) for Induction of Healing of Chronic, Diabetic Foot Ulcers
This is a Phase I, double blind, randomized, placebo-controlled study that will enroll approximately 50 adult subjects with Type 1 or Type 2 diabetes mellitus and chronic, diabetic foot ulcers.
- Trial name
- NCT00069446
- Testing
- rhuMAb VEGF (telbermin)
- Volunteers
- 50 people
- Sponsor
- Genentech, Inc.
Retinal Vein Occlusion, Macular Edema
Bevacizumab Versus Ranibizumab in Treatment of Macular Edema From Vein Occlusion
Antagonists of the vascular endothelial growth factor (VEGF) pathway are effective in treating macular edema resulting from retinal vein occlusion (RVO).
- Trial name
- CRAVE (NCT01428388)
- Testing
- Intravitreal injection of bevacizumab, Intravitreal injection of ranibizumab (0.5 mg per dose)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Barnes Retina Institute
Post-Injection Intraocular Pressure Spikes
Pre-Administration of Brimonidine in Intravitreal Anti-VEGF Therapy
In this study, investigators will be examining the intraocular pressure lowering effect of brimonidine 0.15% when administered 20min prior to intravitreal anti-VEGF injection.
- Trial name
- NCT03513172
- Testing
- topical brimonidine tartrate 0.15% (Alphagan® P; Allergan, Inc)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Endothelial Dysfunction
Endothelial Function in Human Arteries
Up to 30 patients with lower extremity disease scheduled to undergo diagnostic angiography will undergo baseline bloodwork and IVUS (intravascular ultrasound), followed by dosing with L-arginine to assess changes in endothelial…
- Trial name
- NCT00848302
- Testing
- L-arginine
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Hypertension, Endothelial Dysfunction
Effect of Berberine Hydrochloride on Blood Pressure and Vascular Endothelial Function in Patients With Hypertension
Hypertension is a progressive cardiovascular syndrome caused by multiple causes, which can lead to changes in the function and structure of the heart and blood vessels. It is the leading risk factor of cardiovascular disease.
- Conditions
- Hypertension, Endothelial Dysfunction, Blood Pressure
- Trial name
- NCT04790942
- Testing
- berberine hydrochloride, lifestyle intervention group
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jun Tao
Covid19, Hiv
Effects of COVID-19 on Endothelium in HIV-Positive Patients in Sub-Saharan Africa
Background: Coronavirus disease 2019 (COVID-19) has affected almost every country in the world, especially in terms of health system capacity and economic burden.
- Conditions
- Covid19, Hiv, ART
- Trial name
- ENDOCOVID (NCT04709302)
- Testing
- COVID-19, HIV, ART
- Where
- 3 sites in Nigeria, South Africa
- Volunteers
- 342 people
- Sponsor
- Medical University of Graz
Hypertension
Efficacy of Dietary Sodium Restriction of Improving Vascular Endothelial Function in Middle Aged and Older Adults
The investigators hypothesize that reducing salt in the diet will improve the function of blood vessels in middle aged and older adults with moderately elevated systolic blood pressure, by increasing the amount of BH4 and nitric…
- Trial name
- NCT01566084
- Testing
- Slow sodium tablets
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
COVID-19, Endothelial Dysfunction
The Effect of Dietary Intervation on Endothelial Glycocalyx in COVID-19 Patients.
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis.
- Trial name
- NCT05185934
- Testing
- Food supplement Endocalyx
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Athens
Aging, Endothelial Dysfunction
Fisetin to Improve Vascular Function in Older Adults
This is a pilot clinical trial to test the efficacy of intermittent treatment with the flavonoid compound fisetin for improving vascular endothelial function and reducing aortic stiffness in older adults.
- Conditions
- Aging, Endothelial Dysfunction, Arterial Stiffness
- Trial name
- NCT06133634
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Rheumatoid Arthritis, Inflammation
Effects of Interleukin-6 Inhibition on Vascular, Endothelial and Left Ventricular Function in Rheumatoid Arthritis
Recent studies show beneficial effect of the inhibition of interleukin-6 (IL-6) activity on vascular and left ventricular (LV) function.
- Trial name
- NCT03288584
- Testing
- Tocilizumab (Actemra®), Other biological agent, Corticosteroid and non-biological agents.
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Intermittent Claudication, Arteriosclerosis
EW-A-401 to Treat Intermittent Claudication
This study will test the safety of a drug called EW-A-401 in patients with intermittent claudication - pain and discomfort in the legs due to blockages of the arteries.
- Trial name
- NCT00080392
- Testing
- DNA Plasmid Vector, EW-A-401 DNA Plasmid Vector
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Glaucoma
Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma
Refractory glaucoma often requires vision-sparing trabeculectomy. To increase surgical success, adjunctive pharmacotherapy is utilized albeit the risk of adverse events.
- Trial name
- AvastinvsMMC (NCT02901236)
- Testing
- Standard Guarded Trabeculectomy, Mitomycin C, Bevacizumab
- Volunteers
- 40 people
- Sponsor
- Athens Vision Eye Institute
Coronary Artery Disease
EPC by Intracoronary Injection in Patients With Chronic Stable Angina
Study title:A Study for Testing Safety and Efficacy of the administration of Blood-Borne Autologous Endothelial Progenitor Cells to Alleviate Anginal Symptoms and Myocardial Ischemia in Patients with Severe Anginal Syndrome…
- Trial name
- NCT00384514
- Testing
- VesCell (TM)-Autologous EPCs/Angiogenic Cell Precursors
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- TheraVitae Ltd.
Metastatic Renal Cell Carcinoma
Vascular Endothelial Growth Factor (VEGF) Imaging Before and During Everolimus Treatment for Renal Cell Carcinoma
Everolimus indirectly inhibits angiogenesis by reducing VEGF production. VEGF can be non-invasively visualized and quantified with serial 89Zr-bevacizumab PET imaging in patients.
- Trial name
- Everolimage (NCT01028638)
- Testing
- 89Zr-bevacizumab PET scan
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- University Medical Center Groningen
Retinopathy of Prematurity Both Eyes, Retinal Disease
VEGF Concentrations After Intravitreal Bevacizumab vs Ranibizumab as a Treatment for Type 1 ROP
The Retinopathy of Prematurity (ROP) is one of the leading causes of blindness on the pediatric age worldwide. This pathology is characterized for arrest of the normal vascular and neuronal retina that because of pathological…
- Conditions
- Retinopathy of Prematurity Both Eyes, Retinal Disease, Premature Birth, Eye Diseases
- Trial name
- NCT03148132
- Testing
- Bevacizumab Injection, Ranibizumab Ophthalmic
- Where
- Mexico
- Volunteers
- 16 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Healthy
Vascular Effects of Dietary Salt in Humans With Salt-Resistant Blood Pressure
The purpose of this study is to determine the effects of dietary salt restriction on central hemodynamics and vascular function in men and women with salt resistant blood pressure.
- Trial name
- NCT03424993
- Testing
- Dietary Sodium Restriction, Control
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Endothelial Dysfunction, Insulin Resistance
The Role of Aldosterone in Circulatory Disorders Within Type 2 Diabetes
The importance of Aldosterone for endothelial function and Insulin resistance observed within patients with type 2 diabetes
- Trial name
- NCT03017703
- Testing
- Eplerenone
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
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