Clinical trials: Vascular Endothelium
Pre-Eclampsia
Can Atorvastatin Improve Vascular Function in Women With a History of Preeclampsia?
The purpose of the study is to test the hypothesis that a short course of atorvastatin can improve vascular function in women with a history of preeclampsia, compared to placebo.
- Trial name
- PVS3 (NCT01278459)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Oxford
Type 2 Diabetes Mellitus
Free Fatty Acids and Vascular Function in Subjects With Diabetes
This study will test the hypothesis that reduction in release of free fatty acids from adipocytes will restore insulin-mediated endothelium-dependent vasodilation and skeletal muscle glucose metabolism in subject with type 2…
- Trial name
- NCT00153179
- Testing
- acipimox
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Vascular Anomaly, Generalized Lymphatic Anomaly
Identification of Biomarkers for Patients with Vascular Anomalies
The study will use blood (serum and plasma) and tissue obtained from participants undergoing prescribed surgical resection of vascular anomalies of interest proposed in this study.
- Conditions
- Vascular Anomaly, Generalized Lymphatic Anomaly, Kaposiform Hemangioendothelioma, Kaposiform Lymphangiomatosis
- Trial name
- NCT03001180
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
End-stage Kidney Disease, Diabetes Mellitus
Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula
Background Arteriovenous (AV) fistula is the most common vascular access for long-term hemodialysis in the end-stage renal disease (ESRD) patients. About 25% of these patients are diabetes mellitus.
- Conditions
- End-stage Kidney Disease, Diabetes Mellitus, Arteriovenous Fistula
- Trial name
- NCT01863914
- Testing
- Rosuvastatin
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Coronary Atherosclerosis
Endothelial Function-guided Therapy Compared to Usual Care in Patients With NOCAD
The current study is designed to test the hypothesis that compared to conventional treatment; endothelial function-guided treatment reduces adverse cardiovascular events in patients with non-obstructive coronary artery disease…
- Trial name
- EndoGET (NCT02313987)
- Where
- 2 sites in Israel
- Sponsor
- Itamar-Medical, Israel
Coronary Artery Disease, Atherosclerosis
Assessment of Stent Strut Coverage and Endothelial Function After Drug-Eluting Stents
The purpose of this study is to compare coronary endothelium function in patients with a zotarolimus-eluting versus a sirolimus-eluting or a everolimus-eluting stents with optical coherence tomography, vasoconstriction in…
- Trial name
- ASSESS (NCT01073111)
- Testing
- zotarolimus-eluting stent (ENDEAVOR®), sirolimus-eluting stents (CYPHER SELECT® PLUS), everolimus-eluting stents (PROMUS®)
- Where
- Japan
- Sponsor
- Hyogo Medical University
Heart Failure
Vascular Endothelial Function and Cardiac Resynchronization Response in Patients With Heart Failure
The purpose of this research study is to determine the role of blood vessel endothelial function in heart failure and the effect of Cardiac Resynchronization Therapy (CRT) on heart and endothelial function.
- Trial name
- NCT02783716
- Testing
- Subcutaneous adipose tissue collection, Peripheral arterial tonometry (PAT)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Endothelial Function, Diabetes Mellitus
Coreg CR, Blood Vessel Stiffness and Blood Vessel Function
We are comparing the blood pressure-lowering effects of two marketed medications, Coreg CR and Toprol XL. Although both drugs reduce blood pressure by blocking the action of noradrenaline on beta-receptors in the blood vessels…
- Conditions
- Endothelial Function, Diabetes Mellitus, Hypertension
- Trial name
- NCT00732511
- Testing
- carvedilol, metoprolol extended release
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- State University of New York - Downstate Medical Center
Diabetes Mellitus
Glitazones and Endothelial Function (GATE)
The purpose of the study is to determine if the addition of rosiglitazone to subjects with fair glucose control on other oral agents improves endothelial function, a surrogate marker of vascular health.
- Trial name
- NCT00203632
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Endothelial Function (Reactive Hyperemia)
MOVING - MOtiVation, INtervention and Vascular chanGe
Background: The impact of demographic changes on workplace has increased the importance of effective occupational preventive health programs.
- Trial name
- MOVING (NCT01919632)
- Testing
- health-behavior seminar and endurance exercise
- Where
- 2 sites in Germany
- Volunteers
- 330 people
- Sponsor
- Technical University of Munich
Endothelial Dysfunction
Effects of Dietary Nitrate on Age-related Vascular Function
Purpose of the study is to characterize the chronic effect of dietary nitrate on vascular function in healthy volunteers with particular emphasis on age-related alterations.
- Trial name
- NCT01729234
- Testing
- Nitrate
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Diabetes Mellitus, Type 2, Endothelial Dysfunction
Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 Diabetes
Patients with Type 2 Diabetes Mellitus (T2DM) have changes in blood vessel health that can lead to a higher chance of developing heart attacks or strokes.
- Trial name
- SFRNDM2 (NCT05139914)
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston University
Pre-eclampsia, Intra-uterine Growth Retardation
EG-VEGF : Potential Marker of Pre-eclampsia and / or Intrauterine Growth Restriction
The purpose of this study is to assess the potential prognostic value of seric concentrations of EG-VEGF for Pre-eclampsia and/or intrauterine growth restriction and will allow checking whether plasma levels of EG-VEGF at 14-18…
- Trial name
- EGEVE (NCT01490489)
- Testing
- blood sample and doppler Ultrasound of uterine arteries
- Where
- France
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Atherosclerosis, Restenosis
Blood Endothelium Progenitor Cells and Dendritic Cells as Predictive Biomarkers of In-stent Restenosis
clinically relevant in stent restenosis occurs in 5-10% of the non-diabetic patients treated with a coronary bare metal stent. Recent research has identified endothelial progenitor cells as well as dendritic cells as components…
- Trial name
- NCT00493597
- Where
- Belgium
- Volunteers
- 124 people
- Sponsor
- University Hospital, Antwerp
Healthy
Effects of the Cornelian Cherry Supplementation on the Selected Physiological Parameters in Marathon Runners
Growing body of evidence indicates favorable effects of Cornus mas (Cornelian cherry) supplements on cardiometabolic risk, including the improvement of HDL and glycemic indices, in line with vascular benefits.
- Trial name
- NCT07194720
- Testing
- Cornus mas lyophilisate
- Where
- Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Vascular Diseases
Vascular and Metabolic Consequences of Adopting a Westernized Lifestyle
The purpose of this study is to determine if short-term adoption of a Westernized lifestyle characterized by physical inactivity and increased consumption of fructose will result in metabolic and vascular dysfunction.
- Trial name
- NCT03785470
- Testing
- Fructose and physical inactivity
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hypoxemia, ARDS
Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass
More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass.
- Conditions
- Hypoxemia, ARDS, Lung Injury, Acute, Cardiopulmonary Bypass
- Trial name
- NCT05647382
- Testing
- blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhuan Zhang
Hypertension, Impaired Glucose Tolerance
Telmisartan and Losartan in Hypertensive IGT
Inhibition of RAS delays onset of diabetes in clinical studies. Preliminary evidence suggests that telmisartan may have unique metabolic properties compared to other ARB due to activation of PPARγ.
- Trial name
- NCT00407862
- Testing
- Telmisartan 80 mg, Losartan 50 mg
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
Diabetic Macular Edema
Relationship Between Dyslipidemia and The Response of Diabetic Macular Edema to Intravitreal Injection of Anti Vascular Endothelial Growth Factor Agents
Diabetic retinopathy (DR) is considered the main etiology of blindness among working-age adults, and Diabetic macular edema (DME) is the main reason for vision loss related to DR .
- Trial name
- NCT06205979
- Testing
- Ranibizumab Injection [Lucentis], Aflibercept Injection [Eylea]
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Age-Related Macular Degeneration
Sirolimus Versus Anti-Vascular Endothelial Growth Factor (antiVEGF) for Wet AMD
Phase 2 clinical trial, single site, randomized, subject-masked study to determine safety and efficacy of intravitreal injections of Sirolimus in subjects with wet Age-Related Macular Degeneration (wet AMD) with persistent…
- Trial name
- NCT02357342
- Testing
- Sirolimus, Standard of Care intravitreal injections of anti-VEGF
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Maturi, Raj K., M.D., P.C.
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