Clinical trials: Vascular Endothelium
Inflammatory Lung Diseases, Hemoptysis
The Expression of Serum Angiogenesis Marker in Patients Presenting With Hemoptysis
Vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) are major mediators of angiogenesis and are induced by tissue inflammation and hypoxia.
- Trial name
- NCT01171768
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Samsung Medical Center
Hyperglycemia, Cardiovascular Disease
Green Tea Confections For Managing Postprandial Hyperglycemia-Induced Vascular Endothelial Dysfunction
The objective of this study is to formulate and validate a green tea confection (i.e. "gummy" candy) as a strategy to attenuate postprandial hyperglycemia-induced impairments in vascular function.
- Trial name
- NCT01857258
- Testing
- Green Tea Concentrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Peripheral Arterial Disease
Arteriopathy and Endothelial Function
To determine whether fruit juice might reverse endothelial dysfunction and whether this reversibility has a prognosis value
- Trial name
- NCT00487617
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiovascular Disease
Blood Vessel Study
Background: The endothelium is the inner lining of blood vessels. The cells in this lining help regulate blood flow and immune system function.
- Trial name
- NCT01524549
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
COVID-19
Role of Microparticles in Covid-19 Infection
Among the distinctive features of Covid-19, numerous reports have stressed the importance of vascular damages associated with coagulopathy onset.
- Trial name
- MICO (NCT04448743)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Hypertension
Effect of Losartan on Retinal Endothelial Function in Patients With Essential Hypertension
Essential hypertension is commonly associated with impaired endothelial function. The retinal vasculature is morphologically and functionally related to the cerebral vessels because of the common origin from the internal carotid…
- Trial name
- NCT00152633
- Testing
- Losartan, Metoprolol
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension, Mild Cognitive Impairment
CAndesartan vs LIsinopril Effects on the BRain
The aim of this study is to conduct a 1-year double blind randomized control trial comparing candesartan to lisinopril in 140 individuals with hypertension and executive mild cognitive impairment in their effects on executive…
- Trial name
- CALIBREX (NCT01984164)
- Testing
- Candesartan, Lisinopril
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Emory University
Obesity, Morbid, Ischemic Heart Disease
Prevalence and Outcome of Brachial Artery Endothelial Function in Morbidly Obese Patients Undergoing Bariatric Surgery
The relation between obesity and ischemic heart disease (IHD) is under considerable debate. The reduction in all-cause mortality and, more specifically, the reduction in cardiac-related mortality seen after weight-loss surgery…
- Trial name
- NCT00808652
- Testing
- Measurement of flow mediated dilation of brachial artery.
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Sheba Medical Center
Heart Failure, Myocardial Infarction
High-intensity Exercise Training in Patients With Post-infarction Heart Failure
Introduction: Moderate-intensity endurance-training is known to reduce symptoms, increase exercise tolerance, and improve quality of life in patients with chronic heart failure.
- Trial name
- NCT00218933
- Testing
- Moderate intensity exercise training, High intensity exercise training
- Where
- Norway
- Volunteers
- 27 people
- Sponsor
- Norwegian University of Science and Technology
Advanced Solid Tumor
A First-in-human, Dose Escalation and Indication Expansion Study of BNT3212 as Monotherapy or in Combination With BNT327 in Adults With Advanced Solid Tumors
The aim of this first-in-human (FIH) open-label, multi-site study is to evaluate safety, tolerability, pharmacokinetics (PK), immunogenicity and preliminary clinical efficacy of BNT3212, including identification of the…
- Trial name
- NCT07147348
- Testing
- BNT3212, Pumitamig
- Where
- 17 sites in Australia, China
- Volunteers
- 375 people
- Sponsor
- BioNTech SE
Atherosclerosis
Effects of Corn Oil Plus Vitamin E and B6 on LIpids, PcSk9 and Endothelial Function
This will be a randomized clinical trial carried out on subjects with suboptimal control of cholesterolemia who will consume 30 g per day of a vitaminized corn oil (plus B6 and E vitamins), in order to evaluate the effects on…
- Trial name
- ECLIPSE (NCT03005535)
- Testing
- Vitaminized corn oil, Olive oil
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- University of Bologna
Hypertension, Hypertrophy, Left Ventricular
Does Allopurinol Reduce Thickening of the Left Ventricle of the Heart in Patient With Treated Hypertension?
The presence of Left ventricular hypertrophy (LVH) confers high cardiovascular risk in hypertensive patients. LVH remains highly prevalent even when blood pressure (BP) is controlled.
- Trial name
- ALLAY (NCT02237339)
- Testing
- Allopurinol
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- University of Dundee
Chronic Obstructive Pulmonary Disease
Efficacy of Simvastatin for the Treatment of COPD
To evaluate in patients with stable Chronic Obstructive Pulmonary Disease (COPD) the efficacy of statins (simvastatin) on: (1) endothelial function; (2) systemic inflammation; (3)BODE (B: body mass , O: bronchial obstruction, D…
- Trial name
- NCT02070133
- Testing
- Simvastatin
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Hospital Universitari Son Dureta
Kidney Failure, Chronic
Effect of Exercise on Endothelial Function and Vascular Compliance in Chronic Kidney Disease
The study hypothesis is that 6 weeks of repetitive handgrip exercise will improve endothelial function and venous compliance in pre-dialysis patients with an estimated glomerular filtration rate of less than or equal to 20…
- Trial name
- NCT01068314
- Testing
- Repetitive arm exercise
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Iowa
Peripheral Arterial Obstructive Disease, Intermittent Claudication
Angioplasty in Peripheral Arterial Disease and Endothelial Function
To investigate whether endovascular revascualrization of infrainguinal arterial obstructive disease has an effect on brachial artery reactivity
- Trial name
- PTA-PAD-FMD (NCT00660634)
- Testing
- Endovascular Revascularization
- Volunteers
- 33 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
AMD, nAMD
Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD
ABBV-RGX-314 (also known as RGX-314 and surabgene lomparvovec (sura-vec)) is being developed as a novel one-time gene therapy for the treatment of neovascular (wet) age-related macular degeneration (wet AMD).
- Conditions
- AMD, nAMD, Wet Age-related Macular Degeneration, wAMD
- Trial name
- ASCENT (NCT05407636)
- Testing
- ABBV-RGX-314 Dose 1, ABBV-RGX-314 Dose 2, Aflibercept (EYLEA®)
- Where
- 181 sites in United States, Canada and 8 more
- Volunteers
- 735 people
- Sponsor
- AbbVie
Vascular Function, Atherothrombosis
Comparison of Vascular Function in Emergency Service Professionals
Emergency Service Professionals have an increased risk of death from heart attacks when compared to the general public. All the emergency professions share similar responsibilities such as emergency call-outs and shift work.
- Trial name
- FIRECOP (NCT01813032)
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Endothelial Dysfunction, Insulin Resistance
The Effects of Sedentarism on Vascular Function, Inflammation, and Insulin Resistance
The purpose of this study are twofold: 1. To understand the effects of physical inactivity (sedentarism) on vascular function, insulin resistance and inflammation; 2.
- Conditions
- Endothelial Dysfunction, Insulin Resistance, Metabolic Syndrome, Peripheral Arterial Disease
- Trial name
- Bedrest (NCT01412216)
- Testing
- Fish Oil (Omega-3 Fatty Acids)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypertension
The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression
The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples.
- Trial name
- NCT00948363
- Testing
- Kiwi fruits, Apple
- Where
- 2 sites in Norway
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Telangiectasia
Injected Ranibizumab to Treat Macular Telangiectasia Without New Blood Vessel Formation
This study will examine whether the drug ranibizumab is an effective treatment for macular telangiectasia, a condition in which existing blood vessels near the macula (the back part of the eye responsible for sharp central…
- Trial name
- NCT00457145
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
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