Clinical trials: Vascular Endothelium
Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction
Micro-doses of Physical Activity for COPD
Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than…
- Conditions
- Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction, Vascular Stiffness, Hypertension
- Trial name
- COPD (NCT05553223)
- Testing
- Microdoses of activity
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Obesity, Pre-hypertension
Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition
Arterial dysfunction contributes to the development of cardiovascular disease (CVD), which is currently afflicting millions of individuals.
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT02143817
- Testing
- L-citrulline supplementation, Whole Body Vibration Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Covid19, SARS-CoV Infection
Prognostic Value of Flow-mediated Dilation in Hospitalized COVID-19 Patients
This study will evaluate the associations between vascular parameters and clinical outcomes in patients hospitalized with COVID-19.
- Trial name
- NCT04714125
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- University of Sao Paulo General Hospital
Peripheral Arterial Disease, Cardiovascular Health
Heat Therapy and Peripheral Artery Disease
The purpose of the study is to assess the efficacy of a novel 8 week heat therapy intervention in intermittent claudication compared to usual care controls.
- Conditions
- Peripheral Arterial Disease, Cardiovascular Health, Vascular Function, Intermittent Claudication
- Trial name
- NCT06827691
- Testing
- Heat Therapy Intervention
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Manchester Metropolitan University
Aging, Oxidative Stress
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and…
- Conditions
- Aging, Oxidative Stress, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04351113
- Testing
- MITO-AO, PB-125, Passive Leg Movement (PLM)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Joel Trinity
Type 2 Diabetes Mellitus
Vascular Effects of Rosiglitazone Versus Glyburide in Type 2 Diabetic Patients
The purpose of this study is to compare the vascular effects of two commonly used diabetes medications, rosiglitazone and glyburide in type 2 diabetic patients.
- Trial name
- NCT00123643
- Testing
- rosiglitazone, glyburide
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- St. Paul Heart Clinic
Coronary Artery Disease, Endothelial Function
The Association of Platelet Function and Endothelial Function of the Brachial Artery
The proposed study is a prospective one, and will be held on consecutive individuals undergoing the non-invasive brachial artery flow-mediated dilation (FMD) ultrasound for endothelial function at the endothelial function…
- Conditions
- Coronary Artery Disease, Endothelial Function, Thrombosis
- Trial name
- NCT00363818
- Where
- 2 sites in Israel
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hypertension
Blood Pressure Lowering Effects of Grape Juice
Recent studies suggest that a diet rich in fruit and vegetables can lower blood pressure, and a number of lines of evidence suggest that grape products may have such an effect.
- Trial name
- NCT00302809
- Testing
- Concord Grape Juice
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston University
Peripheral Artery Disease
NAD Supplementation and Vascular Health in PAD
This pilot open-label clinical trial was designed to investigate whether 4-week supplementation with 1g daily NR impacts endothelial function in peripheral circulation, cerebrovascular hemodynamics, cognitive function in older…
- Trial name
- NCT06534944
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Oklahoma
Impotence
Use of Sildenafil (Viagra) in Diabetic Men With Erectile Dysfunction: the Impact on Blood Vessels
To evaluate the impact of nightly sildenafil vs placebo use on diabetic men with and without proven endothelial dysfunction and coexisting erectile concerns.
- Trial name
- NCT00199563
- Testing
- Viagra
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Stroke, Ischemic, Periodontitis
Periodontal Treatment and Ischemic Stroke
A bulk of observational evidence suggests an association between periodontitis and recurrent vascular events in ischemic stroke survivors.
- Trial name
- NCT04956211
- Testing
- Periodontal therapy
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Acute Ischemic Stroke
Safety and Preliminary Efficacy of Allogeneic Endothelial Progenitor Cells (EPCs) in Patients With Acute Ischemic Stroke
This is a multicenter, randomized, double-blind, placebo-controlled, dose-Escalation clinical study to investigate the safety and efficacy of EPCs transplantation in Acute ischemic stroke.
- Trial name
- NCT05993884
- Testing
- iEPCs
- Where
- 2 sites in China
- Volunteers
- 27 people
- Sponsor
- Allife Medical Science and Technology Co., Ltd.
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Obstructive Sleep Apnea
Vitamin D and SGLT-2 Inhibitor in CPAP-naive Obstructive Sleep Apnea
The purpose of this study is to determine if vitamin D supplement and SGLT-2 inhibitor treatment combination can improve cardiovascular risks in patients with OSA and hypertension, on top of lifestyle modification, before…
- Trial name
- D3DOSA (NCT06690723)
- Testing
- Dapagliflozin (Forxiga), Vitamin D3 ( Colecalciferol), Vitamin D3 plus Dapagliflozin
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- University Malaysia Sarawak
Healthy Subjects, Dyslipidaemias
Study To Evaluate The Effects Of GW856553 On Endothelial Function/Vascular Compliance In Subjects With Dyslipidaemia.
The rationale for this study is to determine whether GW856553 (7.5mg BD for 28 days) has an effect on endothelial function in dyslipidaemic subjects as assessed by venous occlusion plethysmography using brachial artery…
- Conditions
- Healthy Subjects, Dyslipidaemias, Dyslipidaemia
- Trial name
- NCT00474864
- Testing
- GW856553
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Psoriasis
Chronic Plaque Psoriasis Study With Topical Formulation Of GW786034
This study is an exploratory study to evaluate the effectiveness, safety and tolerability of three concentrations of GW786034 ointment following treatment to small areas of stable psoriatic plaques.
- Trial name
- NCT00358384
- Testing
- Pazopanib, Pazopanib vehicle, Betamethasone valerate
- Where
- France
- Volunteers
- 10 people
- Sponsor
- GlaxoSmithKline
Chronic Kidney Disease
Effect of Phosphate Binders on Markers of Vascular Health in Chronic Kidney Disease Stages 3 and 4
Chronic kidney disease (CKD) patients often have high levels of a substance called fibroblast growth factor-23 (FGF-23), a phosphorus excreting hormone, which has been related to heart disease.
- Trial name
- NCT01277497
- Testing
- Sevelamer carbonate, Calcium acetate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Albany College of Pharmacy and Health Sciences
Peripheral Arterial Disease
Efficiency, Safety and Portability of Neovasculgen
In 2010, we completed a phase 1 to 2a clinical trial of pCMV-vegf165 in patients with chronic lower limb ischemia (stage 2a to 3 according to Fontaine classification modified by A. V.
- Trial name
- Neovasculgen (NCT03068585)
- Testing
- Neovasculgen (Cambiogeneplasmid)
- Where
- 3 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Artgen Biotech
Hyperlipidemias, Hypertension
The Effect of Farlong® NotoGinseng™ (Ginseng Plus®) on Cholesterol and Blood Pressure
In this randomized, placebo-controlled, double-blind parallel study in human participants with elevated LDL-C and elevated BP described here, the clinical benefits of Farlong NotoGinseng™ (Farlong Ginseng Plus® Panax Notoginseng…
- Trial name
- NCT04069715
- Testing
- Farlong NotoGinseng™ (Farlong Ginseng Plus® Panax Notoginseng extract)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- LongStar HealthPro, Inc. DBA Farlong Pharmaceutical
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