Clinical trials: Vascular Insufficiency
Hypertension, Renal Failure
The Efficacy of Color-Doppler Ultrasonography to Assess the Renal Blood Flow With the Estimation of GFR
It is generally assumed that renal blood flow is symmetric in the absence of renal artery stenosis. The importance of studying the function of both kidneys separately is because it cannot be assumed that they are functionally…
- Trial name
- NCT00470769
- Testing
- Color-Doppler Ultrasound, 99mTc-DTPA scintigraphy
- Where
- 3 sites in Italy
- Volunteers
- 2,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Health, Hypertension
Optical Coherence Tomography And NEphropathy: The OCTANE Study
Patients with high blood pressure (hypertension) and chronic kidney disease are at an increased risk of developing heart disease and strokes.
- Conditions
- Health, Hypertension, Chronic Kidney Disease
- Trial name
- NCT02132741
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Deep Vein Thrombosis of the Lower Extremities
AI-Based Prediction Model for Iliofemoral DVT Thrombolysis
This prospective single-arm cohort study aims to develop an AI-powered prediction model for treatment outcomes in patients with acute extensive iliofemoral deep vein thrombosis (IF-DVT) undergoing stent-free pharmacomechanical…
- Trial name
- NCT07181083
- Testing
- Rheolytic thrombectomy
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Acute Kidney Injury (Nontraumatic), Hypotension Drug-Induced
AKI Risk Factors Analysis After Intentional Hypotensive Anesthesia
This project investigates intentionally hypotensive management such as NTG (nitroglycerin) or NTG+Trandate during general anesthesia in patients undergoing orthognathic surgery.
- Trial name
- NCT06259760
- Testing
- Nitroglycerin
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Diabetes, Hypertension
Real-world Aliskiren Use in Diabetic Patients
The purpose of this study is to evaluate real-world patterns of aliskiren use with a focus of change in renal function following aliskiren initiation as well as to identify "triggering events" that lead to aliskiren initiation.
- Trial name
- NCT01393860
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Novartis
Vertebrobasilar Dolichoectasia
Vertebrobasilar Dolichoectasia Treatment With Sirolimus
The aim of this pilot trial is to assess the efficacy of sirolimus in reducing wall enhancement in vertebrobasilar dolichoectasia(VBD) on 5 T high-resolution magnetic resonance vessel wall imaging(HR-VWI) via anti-inflammatory…
- Trial name
- NCT07634120
- Testing
- Sirolimus
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Huashan Hospital
Mitral Valve Insufficiency, Coronary Artery Disease
REvascularization and Valve Intervention for Ischemic Valve diseasE: REVIVE Trial
Ischemic mitral regurgitation (MR) and coronary artery disease is common and associated with significant morbidity and mortality.
- Trial name
- REVIVE (NCT04822675)
- Testing
- Percutaneous mitral valve repair, Surgical mitral valve repair/replacement
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Heart Institute Research Corporation
End Stage Renal Disease, Cardio-Renal Syndrome
Cardio-Renal Registry
Cardiovascular disease is the leading cause of morbidity and mortality among patients with chronic kidney disease (CKD). Even after adjustment for known cardiovascular risk factors, including diabetes and hypertension, mortality…
- Conditions
- End Stage Renal Disease, Cardio-Renal Syndrome, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- BHCRR (NCT06521801)
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 60,000 people
- Sponsor
- Queen Mary University of London
Valvular Stenosis, Valvular Insufficiency
Milrinone Inhaled in Cardiac Surgery
Pulmonary hypertension is an important morbidity factor in patients having to undergo cardiac surgery with cardiopulmonary bypass (ECC).
- Conditions
- Valvular Stenosis, Valvular Insufficiency, Hypertension, Pulmonary, Coronary Artery Disease
- Trial name
- NCT00819377
- Testing
- Milrinone, Normal saline
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Andre Denault
Acute Coronary Syndrome, Renal Insufficiency
Remote Ischemic Preconditioning in ACS Patients
Remote ischemic preconditioning is a process of serial blood pressure cuff inflations and deflations that are performed prior to a procedure and have been shown in various other areas (coronary bypass surgery, vascular surgery…
- Conditions
- Acute Coronary Syndrome, Renal Insufficiency, Ischemia, Myocardial
- Trial name
- NCT03329612
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Sponsor
- Henry Ford Health System
Coronary Artery Disease, Aortic Valve Disorder
Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX
The purpose of the study is to demonstrate the long term safety and effectiveness of the Carpentier-Edwards PERIMOUNT Magna Ease Valves in patients undergoing aortic valve replacement with or without concomitant procedures…
- Conditions
- Coronary Artery Disease, Aortic Valve Disorder, Heart Failure, Aortic Valve Stenosis
- Trial name
- NCT01171625
- Testing
- Implantation of CEP Magna Ease Model 3300TFX
- Where
- 13 sites in United States, Austria and 4 more
- Volunteers
- 283 people
- Sponsor
- Edwards Lifesciences
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
VExUS in Ards Patients and Association with AKI
A single-center prospective observational study will be conducted with the aim of determining the prevalence of venous congestion during ARDS using venous Doppler and the VExUS score.
- Trial name
- VEXAKI (NCT06805409)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mitral Valve Insufficiency
TransCranial Doppler for REDUCtion of Silent strokE During MitraClip Implantation
The primary goal of the TCD-REDUCE study is to demonstrate the effectiveness of continuous transcranial Doppler sonography ("sonolysis") on the reduction of the ischemic stroke volume during MitraClip implantation.
- Trial name
- TCD-REDUCE (NCT04384198)
- Testing
- Sonolysis
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Charite University, Berlin, Germany
Acne, Bites
Implementation of a Minor Ailment Service in Community Pharmacy Practice
Self-care and self-medication are commonly the treatments of choice for the management of minor ailments. Minor ailments can be treated through community pharmacy using a Minor Ailment Service (MAS).
- Conditions
- Acne, Bites, Burns, Cold
- Trial name
- INDICA+PRO (NCT05247333)
- Testing
- Minor ailment service
- Where
- Spain
- Volunteers
- 20,987 people
- Sponsor
- Universidad de Granada
Acute Kidney Injury, Surgery-Complications
Precision Medicine in Cardiovascular Surgery Associated Acute Kidney Injury
The goal of this prospective observational study is to define a risk profile for cardiovascular surgery associated acute kidney injury (AKI), using clinical patient characteristics, operation parameters as well as blood and urine…
- Conditions
- Acute Kidney Injury, Surgery-Complications, Frailty
- Trial name
- PEAK (NCT06471621)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer
This phase II trial studies how well fludarabine phosphate, cyclophosphamide, total body irradiation, and donor stem cell transplant work in treating patients with blood cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- NCT03333486
- Testing
- Cyclophosphamide, Fludarabine Phosphate, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Roswell Park Cancer Institute
Arterial Insufficiency
Evaluation of a Paraclinical Test for the Diagnosis of Arterial Insufficiency in Diabetic Patients With Foot Ulcers
The number of people living with diabetes has quadrupled worldwide since 1990, and more than 4.5 million people in France have diabetes.
- Trial name
- INFLUX-D (NCT07732270)
- Testing
- Handheld Doppler
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Venous Insufficiency
A Study Evaluating ClariVein With a Sclerosing Agent for the Treatment of Venous Insufficiency
VICARES is a prospective randomized, controlled, multi-center, double blind study treating venous insufficiency associated with incompetent saphenous veins with 1% and 3% Sodium Tetradecyl Sulfate (STS) solution utilizing the…
- Trial name
- VICARES (NCT03311269)
- Testing
- ClariVein RES, Sodium Tetradecyl Sulfate 1% Injection, Sodium Tetradecyl Sulfate 3% Injection
- Where
- 5 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vascular Insights, LLC
Coronary Artery Disease, Cardiac Valve Insufficiency
Study on the Clinical Performance of Steelex® Sternum Set for Sternal Closure
The study is designed as a retrospective, international, multi-center cohort study to evaluate Steelex® Sternum Set for sternum closure.
- Conditions
- Coronary Artery Disease, Cardiac Valve Insufficiency, Aortic Valve Stenosis
- Trial name
- STERCCAS (NCT05439395)
- Testing
- Sternum Closure after Cardiac Surgery
- Where
- 2 sites in Germany, Spain
- Volunteers
- 229 people
- Sponsor
- Aesculap AG
Relapsed Multiple Myeloma, End-stage Renal Disease
Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Multiple Myeloma and Renal Disease
The purpose of this study is to see how the body and the cancer react to carfilzomib, including measuring the amount of the study drug in the blood at certain times following dosing.
- Trial name
- NCT01949532
- Testing
- Carfilzomib
- Where
- 13 sites in United States, Australia and 1 more
- Volunteers
- 26 people
- Sponsor
- Amgen
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