Clinical trials: Vascular Insufficiency
Aortic Valve Disorder, Aortic Valve Insufficiency
Clinical Trial of the Edwards Aortic Bioprosthesis, Model 11000
The purpose of this observational trial is to gather further clinical data to confirm the safety and performance of the Edwards Pericardial Aortic Bioprosthesis, Model 11000 in this trial population.
- Conditions
- Aortic Valve Disorder, Aortic Valve Insufficiency, Aortic Valve Stenosis, Heart Failure
- Trial name
- NCT01651052
- Testing
- Heart Valve Surgery
- Where
- 2 sites in Poland
- Volunteers
- 133 people
- Sponsor
- Edwards Lifesciences
Arterio-Venous Fistula, Kidney Failure, Chronic
VALUE- Vascular Access Laminate eUropean Experience. A Post Market Surveillance Study to Assess the Safety and Effectiveness of VasQ
This is a prospective single arm study enrolling patients who are scheduled for creation of a new Brachiocephalic or Radiocephalic AV fistula.
- Conditions
- Arterio-Venous Fistula, Kidney Failure, Chronic, Kidney Diseases, Renal Failure Chronic
- Trial name
- VALUE (NCT03246984)
- Testing
- VasQ
- Where
- 11 sites in France, Germany and 2 more
- Volunteers
- 80 people
- Sponsor
- Laminate Medical Technologies
Comorbidities and Coexisting Conditions, Alzheimer Disease
An Integrated Solution for Sustainable Care for Multimorbid Elderly Patients With Dementia
The CAREPATH will conduct Technical Validation and Usability (TVU) study by involving ≥ 45 target end users (16 patients with MCI or mild dementia with their informal caregivers and 16 healthcare professionals from various…
- Conditions
- Comorbidities and Coexisting Conditions, Alzheimer Disease, Dementia, Malnutrition
- Trial name
- CAREPATH (NCT05104593)
- Testing
- Intervention tested (CAREPATH)
- Where
- Spain
- Volunteers
- 204 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Acute Stroke, Ischemic Stroke, Acute
Emergent Stenting In Acute Vertebrobasilar Occlusions
In the acute posterior circulation strokes, the vertebrobasilar occlusions frequently related to worse outcomes than the anterior ones.
- Conditions
- Acute Stroke, Ischemic Stroke, Acute, Vertebro Basilar Ischemia
- Trial name
- ESVO (NCT06129721)
- Testing
- Emergent Stenting
- Where
- Vietnam
- Volunteers
- 38 people
- Sponsor
- Can Tho Stroke International Services Hospital
Chronic Kidney Diseases
Study Evaluating the Pronostic Value of Vascular Refilling Rate on Mortality in Chronic Kidney Disease Patients on Dialysis
Aim of this study is to evaluate in a population of chronic kidney disease patients on dialysis (Stage 5D) during an observational period of 3 years: the prognostic value of vascular refilling rate on mortality and on the…
- Trial name
- REMVAMIR (NCT04810338)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Montpellier
End Stage Renal Diseases, Renal Failure
Advanced Ultrasound Applications for Predicting AVF Outcomes
Haemodialysis is a renal replacement therapy that can be introduced to patients with end-stage renal disease (ESRD) to help them maintain a good healthy life.
- Conditions
- End Stage Renal Diseases, Renal Failure, Chronic Kidney Diseases
- Trial name
- AUAPAVFO (NCT04141358)
- Testing
- Advanced ultrasound measurements
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Venous Thrombosis Deep (Limbs), Post Thrombotic Syndrome
EXERT: Exercise Physiology After Thrombosis
Deep vein thrombosis (DVT) can cause long-term scarring and narrowing of veins. When there is extensive damage to the veins in the legs, groin or abdomen it can affect the way that blood is able to flow back up to the heart.
- Trial name
- NCT05296499
- Testing
- Cardiopulmonary exercise test (CPET), Exercise cardiac MRI, 6 minute walk test
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Kidney Diseases, Hypertension
Inspiratory Muscle Strength Training in Chronic Kidney Disease
More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control <130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney…
- Conditions
- Chronic Kidney Diseases, Hypertension, Aging, Blood Pressure
- Trial name
- NCT04911491
- Testing
- IMST
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Colorado, Denver
Liver Failure, Liver Failure, Acute
Use of N-Acetylcysteine During Liver Procurement
Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for…
- Conditions
- Liver Failure, Liver Failure, Acute, Liver Diseases, Carcinoma, Hepatocellular
- Trial name
- NCT01394497
- Testing
- N-acetylcystein
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera di Padova
Hemodialysis Fistula Thrombosis
Evaluation of Heparin Bonded Vascular Graft Versus Standard Graft in Prosthetic Arteriovenous Access for Hemodialysis
The majority of bridge graft fistula with polytetrafluoroethylene (PTFE) for hemodialysis access will develop stenosis at the venous anastomosis and eventually will fail.
- Trial name
- NCT00737620
- Testing
- Prosthetic AV graft implantation
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Shaare Zedek Medical Center
End Stage Kidney Disease
The Vascutek Rapidax™ II Post Market Surveillance Registry
Multicentre, prospective, observational post-market registry. To monitor and collect data on the post-market clinical safety and performance of the Vascutek Rapidax II Vascular Access Graft.
- Trial name
- NCT01977508
- Testing
- ePTFE vascular access grafts
- Where
- 3 sites in Germany
- Volunteers
- 24 people
- Sponsor
- Vascutek Ltd.
ST Elevation (STEMI) Myocardial Infarction of Other Sites
PREdisposition Genetical in Cardiac Insufficiency = Genetic Predisposition to Heart Failure
Our main goal is to create a prospective cohort of 1500 patients with a first large myocardial infarction allowing us, in a second step, to identify susceptibility genes for the progression of patients towards chronic heart…
- Trial name
- PREGICA (NCT01113268)
- Testing
- Cohort
- Where
- France
- Volunteers
- 658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Myeloma, Renal Failure
High Dose Therapy Followed by Autologous Transplantation for Myeloma Patients With Severe Renal Impairment
Multiple myeloma (MM) is a malignant plasma cell disorder, characterized by the presence of more than 10 % of clonal plasma cells in the bone marrow.
- Trial name
- IRMYG (NCT03234335)
- Testing
- Data collection
- Where
- 33 sites in Algeria, Belgium and 2 more
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Kidney Failure, Chronic, Vascular Access Devices
Efficacy of Urokinase Containing Locking Solutions for Thrombotic Dysfunction of Tunneled Hemodialysis Catheters
Thrombotic dysfunction is a common complication of tunneled cuffed catheters (TCC) leading to inadequate dialysis dose, need to catheter replacement with as consequence progressive exclusion of vascular sites.
- Trial name
- NCT02770560
- Testing
- Urokinase locking solution
- Where
- Belgium
- Volunteers
- 148 people
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Kidney Disease Stage 5
Exercise and Vascular Function in Haemodialysis Patients
The aim of this study is to evaluate whether a three month intra-dialytic exercise programme improves arterial function.
- Trial name
- NCT01591876
- Testing
- Intradialytic aerobic exercise, Progressive Muscle relaxation
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Queen Margaret University
Multiple Sclerosis, Venous Insufficiency
BRAVE-DREAMS (BRAin VEnous DRainage Exploited Against Multiple Sclerosis)
To assess in a double blinded randomized control trial (RCT) study design safety and effectiveness of balloon angioplasty of the main extracranial and extravertebral veins in multiple sclerosis (MS) associated to chronic…
- Trial name
- BRAVE-DREAMS (NCT01371760)
- Testing
- Venous PTA, Catheter Venography
- Where
- 2 sites in Italy
- Volunteers
- 212 people
- Sponsor
- S. Anna Hospital
Cardiovascular Diseases, Kidney Transplant; Complications
Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation
Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause…
- Trial name
- CRAFT-CTCA (NCT06234410)
- Testing
- Computed tomography coronary angiography (CTCA)
- Where
- 2 sites in United Kingdom
- Volunteers
- 332 people
- Sponsor
- University of Edinburgh
Cardiorenal Syndrome
Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery
Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow.
- Trial name
- DECONGEST (NCT03684876)
- Testing
- diuretic use
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Kidney Disease
New Biomarkers of Bone Mineral Metabolism as Cardiovascular Risk Factors in Chronic Kidney Disease Patients
To evaluate the relationships between bone mineral metabolism markers (osteoprotegerin, fibroblast growth factor 23) at inclusion and the occurence of cardiovascular events during a 7 year follow-up.
- Trial name
- NCT02808572
- Testing
- Plasma osteoprotegerin level, Plasma fibroblast growth factor 23 level, Vascular calcification score
- Where
- 7 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Montpellier
Essential Hypertension, Liver Cancer
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them.
- Conditions
- Essential Hypertension, Liver Cancer, Nasopharyngeal Cancer, Pancreatic Cancer
- Trial name
- NCT05638269
- Testing
- no intervention
- Where
- 50 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
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