Clinical trials: Vascular Insufficiency
Hypotension, Acute Renal Failure
N-acetylcysteine Plus Deferoxamine for Patients With Hypotension
Oxidative stress is associated with kidney damage in several different situations, including hypotension. In animal models it has been shown that the combination of n-acetylcysteine plus deferoxamine is superior to its isolate…
- Trial name
- NCT00870883
- Testing
- N-acetylcysteine and deferoxamine
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasms
- Trial name
- PICSI-H (NCT04283994)
- Testing
- Survey-based Patient/Clinician Jumpstart, EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 756 people
- Sponsor
- University of Washington
Caregivers
CAREGIVER: A Trial to Improve the Burden and Distress of Caring for Persons With Decompensated Cirrhosis
The goal of this study is to enroll caretakers of patients with decompensated cirrhosis to determine if written emotional disclosure or resilience training interventions reduce distress and burden among primary informal…
- Trial name
- NCT04205396
- Testing
- Written emotional disclosure, Resilience training, No treatment
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Michigan
End-stage Kidney Failure
ACCESS HD: Comparing Catheters to Fistulas in Elderly Patients Starting Hemodialysis
This randomized controlled trial (RCT) is multi-center, parallel-arm, and open label. It will test the feasibility and safety of randomizing elderly patients with end-stage kidney failure starting hemodialysis with a…
- Trial name
- ACCESS HD (NCT02675569)
- Testing
- Catheter, Fistula
- Where
- 13 sites in Australia, Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Venous Insufficiency
Preventing the Development of Venous Insufficiency in Pregnant Women Through Use of Compression Stockings
Problem: Approximately 4 million live births occur in the United States each year. Pregnancy causes many physical changes in the mother, including venous distension, increased ability to form blood clots, and hormonal changes.
- Trial name
- NCT01793194
- Testing
- Compression Stockings
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Johns Hopkins University
Postoperative Circulatory Changes, Peripheral Vascular Diseases
Effects of Different Compression Pressure Levels on Peripheral Circulation After Surgery
After surgery, elastic compression is commonly used on the legs to support blood circulation and reduce the risk of complications such as swelling and venous thromboembolism.
- Conditions
- Postoperative Circulatory Changes, Peripheral Vascular Diseases, Venous Insufficiency of Leg
- Trial name
- COMP-PILOT (NCT07394829)
- Testing
- Pressure-Controlled Compression Device
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Agri Ibrahim Cecen University
Venous Insufficiency (Chronic)(Peripheral)
Chronic Venous Insufficiency and Balneotherapy
The aim of this clinical trial is to assess the efficacy of the balneotherapy program (therapeutic orientation: Phlebology) in terms of chronic venous disease improvement and related quality of life, in patients presented with…
- Trial name
- NCT06054737
- Testing
- SPA THERAPY
- Where
- France
- Volunteers
- 64 people
- Sponsor
- CEN Biotech
Chronic Kidney Disease, Kidney Transplant
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol.
- Conditions
- Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
- Trial name
- RESTORE (NCT07222683)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Acute Kidney Injury, Coronary Artery Disease
Erector Spinae Oxygen Saturation and AKI After OPCAB
Acute kidney injury (AKI) is a frequent and serious complication after cardiac surgery, including off-pump coronary artery bypass (OPCAB).
- Conditions
- Acute Kidney Injury, Coronary Artery Disease, Coronary Artery Bypass, Off-Pump, Postoperative Complications
- Trial name
- NCT07760129
- Testing
- Near-infrared spectroscopy monitoring of erector spinae muscle and renal regional oxygen saturation
- Volunteers
- 138 people
- Sponsor
- Yonsei University
Complex Congenital Heart Defect, Dysfunctional RVOT Conduit
COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction
This study will demonstrate the safety and effectiveness of the Edwards Lifesciences SAPIEN 3/SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve (THV) Systems in subjects with a dysfunctional right ventricular outflow tract (RVOT)…
- Conditions
- Complex Congenital Heart Defect, Dysfunctional RVOT Conduit, Pulmonary Valve Insufficiency, Pulmonary Valve Degeneration
- Trial name
- NCT02744677
- Testing
- SAPIEN 3/SAPIEN 3 Ultra RESILIA THV, SAPIEN 3 THV, SAPIEN 3 Ultra RESILIA THV
- Where
- 27 sites in United States
- Volunteers
- 108 people
- Sponsor
- Edwards Lifesciences
Coronary Artery Disease, Myocardial Infarction
Aspirin Response in High Risk Patients With Coronary Artery Disease
Previous studies indicate that patients with cardiovascular disease have a variable response to aspirin. Despite treatment with aspirin a large number of patients suffer a myocardial infarction.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Diabetes Mellitus, Renal Insufficiency, Chronic
- Trial name
- NCT01383304
- Where
- Denmark
- Volunteers
- 906 people
- Sponsor
- University of Aarhus
Multiple Myeloma, Renal Impairment
A Phase 2 Study of Isatuximab in Combination With Bortezomib, Cyclophosphamide and Dexamethasone Followed by Isatuximab and Lenalidomide Maintenance in Newly Diagnosed Patients With Multiple Myeloma and Severe Renal Impairment
This is an Investigator-Initiated, phase 2, prospective, open-label study designed to be conducted in six hospitals in Greece. Eligible patients will initially receive an induction phase of six 28-day cycles of isatuximab in…
- Conditions
- Multiple Myeloma, Renal Impairment, Neoplasms, Plasma Cell, Neoplasms by Histologic Type
- Trial name
- NCT05147493
- Testing
- Isatuximab, Bortezomib, Cyclophosphamide
- Where
- 6 sites in Greece
- Volunteers
- 51 people
- Sponsor
- Hellenic Society of Hematology
Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy
PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia
A phase 1 study investigating the tolerability and pharmacokinetics of caffeine citrate in neonates with hypoxic ischemic encephalopathy receiving therapeutic hypothermia.
- Conditions
- Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy, Caffeine
- Trial name
- NCT05295784
- Testing
- Caffeine citrate
- Where
- 2 sites in United States
- Sponsor
- University of Arkansas
Chronic Kidney Disease, Hypertension
Sympathetic Nerve Activity in Renal Failure
The primary purpose is to assess the role of sympathetic activation for the development and progression of chronic renal failure.
- Trial name
- SNS in CRF (NCT00892892)
- Testing
- Rilmenidine, Nitrendipine
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Venous Insufficiency
Inspiratory Muscle Training Versus Calf Muscle on Venous Function
The aim of this study was to evaluate the effect of exercise training in addition to compression therapy on quality of life, venous return time, muscle strength, clinical severity, functional capacity in venous insufficiency…
- Trial name
- NCT04215133
- Testing
- exercise therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Renal Insufficiency
Exercise and Vascular Function in Chronic Kidney Disease
The purpose of this study is to investigate the effects of 12 weeks of aerobic exercise training on blood vessel function in Stages 1-4 Chronic Kidney Disease.
- Trial name
- NCT02050035
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Chronic Kidney Disease
Handgrip Exercise for Arteriovenous Fistula Maturation
The purpose of this study is to investigate whether post operative progressive forearm exercise is effective in improving arteriovenous fistula maturation in chronic kidney disease patients.
- Trial name
- NCT01061008
- Testing
- Post operative progressive handgrip exercise, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Bangor University
Liver Transplant; Complications, Ischemia Reperfusion Injury
Abdominal Regional Perfusion in Donation After Cardiac Death for Multi-Organ Transplantation
The main purpose of this study is to increase the pool of organs available for donation by performing ARP to recondition donation after cardiac death (DCD) organs prior to transplantation.
- Conditions
- Liver Transplant; Complications, Ischemia Reperfusion Injury, Cirrhosis, Liver Cancer
- Trial name
- NCT03946852
- Testing
- Abdominal Regional Perfusion
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre
Chronic Kidney Diseases, Chronic Kidney Insufficiency
The Cost Effectiveness and Evaluation of Disease Management of Chronic Kidney Disease and High Risk Population
This study is being implemented for 3 aims. The first has been to conduct a systematic literatures review on CKD intervention models and their effectiveness. Findings have been adopted in our intervention program.
- Trial name
- NCT02034149
- Testing
- general management, self-management, peer-assisted management
- Where
- Taiwan
- Volunteers
- 411 people
- Sponsor
- China Medical University Hospital
Type 2 Diabetes, Chronic Kidney Diseases
Effects of Finerenone on Vascular Stiffness and Cardiorenal Biomarkers in T2D and CKD (FIVE-STAR)
To evaluate the effects of finerenone on vascular stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease.
- Trial name
- FIVE-STAR (NCT05887817)
- Testing
- Finerenone
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Saga University
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