Clinical trials: Vascular Insufficiency
Cardiopulmonary Bypass, Congenital Defects
Aprotinin in Neonates Undergoing Cardiopulmonary Bypass
This is a retrospective chart review study. The purpose of this study is to review our experience at Children's Healthcare of Atlanta in neonates receiving aprotinin.
- Conditions
- Cardiopulmonary Bypass, Congenital Defects, Hemostasis
- Trial name
- NCT00469742
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Children's Healthcare of Atlanta
Acute Kidney Injury, Uremic; Toxemia
Prognostic Role of the Uremic Toxin Indoxyl Sulfate on Vascular and Cardiac Functions During Acute Kidney Injury
Acute kidney injury (AKI) is a frequent disease in conventional hospital departments and in intensive care units. It's associated with a high risk to develop chronic kidney disease (CKD), even after a single small AKI episode.
- Conditions
- Acute Kidney Injury, Uremic; Toxemia, Vascular Dysfunction, Cardiac Dysfunction
- Trial name
- VASC-AKI (NCT05659589)
- Testing
- blood sample
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Kidney Disease (Stage 3-4), Vascular Function
Equol and Vascular Function in Women With Chronic Kidney Disease
The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired…
- Conditions
- Chronic Kidney Disease (Stage 3-4), Vascular Function, Cognitive Functions, Cerebrovascular Function
- Trial name
- NCT07194590
- Testing
- Equol
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Colorado, Denver
Kidney Failure, Chronic, Arteriovenous Fistulae
Preoperative Arteriovenous Fistula Simulation Study (ShuntSimulationStudy)
Patients suffering from end-stage renal disease (ESRD) are dependent on renal replacement therapy (dialysis). The majority of dialysis is facilitated by hemodialysis.
- Trial name
- 3S (NCT02453412)
- Testing
- AVF-simulation
- Where
- 9 sites in Netherlands
- Volunteers
- 236 people
- Sponsor
- Maastricht University Medical Center
Lymphedema
Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema
This is a randomized, controlled, parallel group, open label, clinical trial to evaluate the effectiveness of intermittent, gradient, pneumatic compression (IPC)on the healing of venous ulcers in subjects diagnosed with chronic…
- Trial name
- NCT01079299
- Testing
- Intermittent, gradient, pneumatic compression device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Calvary Hospital, Bronx, NY
Hypertension, Hemodialysis
Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease
The purpose of this study is to examine the effects of the digibind drug on hemodialysis patients with high blood pressure. Digibind is used to treat toxicity from digoxin and digoxin-like molecules which may contribute to high…
- Trial name
- NCT00852787
- Testing
- Digoxin immune fab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute on Aging (NIA)
Chronic Kidney Disease, Hypertension
Aliskiren and Muscle Sympathetic Nerve Activity
The central hypothesis of this project is that Aliskiren causes a substantial decrease in MSNA in hypertensive patients with CKD.
- Conditions
- Chronic Kidney Disease, Hypertension, Muscle Sympathetic Nerve Activity
- Trial name
- MSNA (NCT00719316)
- Testing
- Aliskiren
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Chronic Kidney Disease
Advanced Glycation End-products, Inflammation and Vascular Health in Chronic Kidney Disease
The purpose of the study is to learn more about how advanced glycation end-products can affect insulin resistance, inflammation and blood vessel health in people with kidney disease.
- Trial name
- NCT01769963
- Testing
- Research diet
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Alabama at Birmingham
Venous Insufficiency, Leg Ulcer
THERMES ET VEINES: Spa for Prevention of Leg Ulcers
The main objective of this study is to test the hypothesis that a 3 week intensive course of spa therapy can reduce the risk of leg ulcers in patients with advanced chronic venous insufficiency (C4a-b and C5 of the CEAP…
- Conditions
- Venous Insufficiency, Leg Ulcer, Varicose Ulcer
- Trial name
- NCT00838500
- Testing
- Immediate spa treatment, Late spa treatment
- Where
- 13 sites in France
- Volunteers
- 425 people
- Sponsor
- Association Francaise pour la Recherche Thermale
Deep Venous Thrombosis
The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome
The purpose of this study is to determine whether elastic compression stockings used for 2 years are effective in preventing the post-thrombotic syndrome in patients with symptomatic proximal deep venous thrombosis.
- Trial name
- NCT00143598
- Testing
- Knee-length, graduated elastic compression stocking
- Where
- 25 sites in United States, Canada
- Volunteers
- 806 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
End Stage Renal Disease, Hemodialysis
Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients
The purpose of this study is to determine whether on-line hemodiafiltration ameliorate the endothelial dysfunction compared with the low flux hemodialysis in end stage renal disease patients on maintenance hemodialysis.
- Trial name
- NCT00532597
- Testing
- On-line hemodiafiltration, Low flux hemodialysis
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Eulji General Hospital
Chronic Kidney Diseases, Renal Failure
IntraRenal HEmoDynamics to IntegraTE CA-AKI Risk and Monitor NephroprotectiIoN by ImpElla Support.
the hypothesis is that elevation of the intrarenal resistive index (RI) characterizes patients at elevated risk for subsequent CA-AKI and integrates items of the Mehran AKI risk score into a single, readily obtainable parameter.
- Conditions
- Chronic Kidney Diseases, Renal Failure, Coronary Artery Disease
- Trial name
- NCT06599424
- Testing
- Observational
- Where
- 2 sites in Germany
- Volunteers
- 550 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Venous Thrombosis, Pulmonary Embolism
Two Weeks of Low Molecular Weight Heparin for Distal Vein Thrombosis
The purpose of this study is to determine whether a limited duration of treatment (two weeks of low molecular weight treatment) is a safe and effective treatment for distal deep vein thrombosis of the lower limb.
- Trial name
- TWISTER (NCT01252420)
- Testing
- Enoxaparin
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 330 people
- Sponsor
- Monash Medical Centre
Varicose Veins of Lower Limb, Saphenous Vein
Isolated Great Saphenous Vein Stripping for Treatment of Varicose Veins in Lower Limbs
The goal of this clinical trial is to compare two surgical approaches for treating varicose veins in the lower limbs in adults: performing varicose vein removal at the same time as great saphenous vein stripping (concomitant)…
- Conditions
- Varicose Veins of Lower Limb, Saphenous Vein, Venous Insufficiency
- Trial name
- NCT07616115
- Testing
- Great saphenous vein stripping, Varicose veins removal
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Hospital Israelita Albert Einstein
Healthy Individuals, Diabetes
Heidelberg In Vivo Confocal Microscopy to Evaluate the Ocular Surface Disorders of Healthy and Diseased Individuals
In vivo confocal microscopy (IVCM) has been used in clinical settings for more than 25 years, and is noninvasive, rapid and easily repeatable technique to investigate ocular surface disorders.
- Conditions
- Healthy Individuals, Diabetes, Hypertension, Fabry Disease
- Trial name
- NCT04025801
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
PR-0164 First in Human Clinical Trial of the PAVmed PortIO Intraosseous Infusion System
The PortIO is intended to provide non-emergent vascular access in chronic kidney disease (CKD) patients where preservation of venous anatomy is desired and iatrogenic damage to the veins should be avoided and/or patients with…
- Conditions
- Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Poor Vascular Access
- Trial name
- NCT06037265
- Testing
- PAVmed PortIO™ Intraosseous Infusion System
- Where
- 4 sites in Colombia
- Volunteers
- 15 people
- Sponsor
- PAVmed Inc.
End Stage Renal Disease, Hypertension, Renal
Efficacy of L-methylfolate and Methylcobalamine in Treating Resistant Hypertension Associated With Elevated Serum Homocysteine in Hemodialysis Patients.
The aim of the study is to evaluate the efficacy of L-methylfolate in combination with methylcobalamine in reducing homocysteine blood levels in hypertensive end-stage renal disease patients on regular hemodialysis and its…
- Trial name
- NCT05807711
- Testing
- L-Methyl Folate and methylcobalamine
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- Alexandria University
Ischemic Stroke, Vertebral Artery Stenosis
Drug-eluting Stenting Versus Medical Treatment for Extracranial Vertebral Artery Stenosis
Posterior circulation stroke accounts for 20% of all ischemic stroke. Approximately one quarter of posterior circulation strokes are due to stenosis in the vertebral artery and basilar artery.
- Trial name
- VISTA (NCT05885932)
- Testing
- Drug-eluting stenting plus aspirin and clopidogrel or ticagrelor, Aspirin and clopidogrel or ticagrelor, mono anti-platelet therapy
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Xuanwu Hospital, Beijing
Post Thrombotic Syndrome
The Use of Intermittent Pneumatic Compression Device for Symptomatic Relief in Patients With Post Thrombotic Syndrome
The use of ActiveCare+S.F.T 3rd generation (an Intermittent Pneumatic Compression Device) will improve quality of life in patients suffering from Post Thrombotic Syndrome compared to compression stockings which is the current…
- Trial name
- NCT01637428
- Testing
- ActiveCare+S.F.T 3rd generation
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Renal Insufficiency
Clinical Study of POSS-PCU Vascular Grafts for Vascular Access
This study evaluates the safety and performance of a new vascular graft made of POSS-PCU as a vascular access conduit for haemodialysis.
- Trial name
- NCT02301312
- Testing
- POSS-PCU vascular graft
- Volunteers
- 30 people
- Sponsor
- University College, London
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