Clinical trials: Vascular Insufficiency
Renal Impairment, Limb Ischemia, Critical
Ultra-low Dose Contrast for Endovascular Procedures
The purpose of this protocol is to study the safety and feasibility of using ultra-low dose iodinated contrast agent for infrainguinal endovascular revascularization procedures in patients with chronic limb-threatening lower limb…
- Trial name
- ULTRA-LOW (NCT06835127)
- Testing
- Infrainguinal peripheral endovascular revascularization
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Attikon Hospital
Varicose Veins, Venous Reflux
High Intensity Focused Ultrasound in PAtients With Varicose Veins in Singapore
The aim of the study is to evaluate the efficacy of non-invasive echotherapy for the treatment of varicose veins, within local population, using the Sonovein® device.
- Conditions
- Varicose Veins, Venous Reflux, Chronic Venous Insufficiency
- Trial name
- VESPA (NCT04339088)
- Testing
- Questionnaires
- Where
- Singapore
- Volunteers
- 15 people
- Sponsor
- Singapore General Hospital
Poor Ovarian Response
A RCT Study on Autologous Cell Injection Into the Ovaries of Patients With POR
Poor ovarian response (POR) is a pathological state where the ovaries do not respond well to the stimulation of gonadotropins. It is mainly characterized by a small number of developing follicles, a high cancellation rate of the…
- Trial name
- NCT07282288
- Testing
- PRP injection, SVF injection
- Volunteers
- 198 people
- Sponsor
- Peking University Third Hospital
Chronic Kidney Disease, Peritoneal Dialysis
Treatment of Asymptomatic Fluid Overload in Peritoneal Dialysis Patients
INTRODUCTION Peritoneal dialysis (PD) is a life-saving treatment for end-stage renal disease patients. However, cardiovascular disease remains the major cause of morbidity and mortality in PD patients.
- Trial name
- NCT02168283
- Testing
- treatment arm, Control arm
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Post-thrombotic Syndrome, Iliac Vein Compression Syndrome
Treatment of the Postthrombotic Syndrome With the Oblique Stent - TOPOS Study
Primary objective: To assess the efficacy of the stents (sinus-Obliquus stent for the common iliac vein, the sinus-XL Flex stent or sinus-Venous stent for the external iliac and common femoral veins) by evaluating different…
- Trial name
- NCT02942394
- Testing
- sinus-Obliquus Stent System
- Where
- 7 sites in Austria, Germany and 2 more
- Volunteers
- 60 people
- Sponsor
- Optimed Medizinische Instrumente GmbH
Persistent Pulmonary Hypertension, Respiratory Failure
Study of Sildenafil to Treat Newborns With Persistent Pulmonary Hypertension
The purpose of this study is to determine whether intravenous sildenafil reduces pulmonary artery pressure and improves oxygenation in near-term and term infants with persistent pulmonary hypertension.
- Trial name
- NCT01409031
- Testing
- Intravenous Sildenafil
- Where
- 7 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Cirrhosis, Hepatic Encephalopathy
Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis
The study aims to compare the potential benefit of allopurinol versus atorvastatin in reducing the risk of developing cirrhosis-related complications, delaying the onset of hepatocellular carcinoma, and improving survival.
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Ascites, Varices
- Trial name
- NCT05511766
- Testing
- Allopurinol 300 MG, Atorvastatin 20mg
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Post Thrombotic Syndrome, Deep Vein Thrombosis
Physical Activity in Children at Risk of Post-thrombotic Sequelae (PACT)
'The PACT trial' is randomized pilot trial to demonstrate the feasibility and potential effectiveness of a personal "fitness tracker" to improve adherence to an activity regimen following an initial acute DVT in children.
- Trial name
- PACT (NCT03075761)
- Testing
- Fitbit, 30-minute education session
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension, Renal Failure
The Efficacy of Color-Doppler Ultrasonography to Assess the Renal Blood Flow With the Estimation of GFR
It is generally assumed that renal blood flow is symmetric in the absence of renal artery stenosis. The importance of studying the function of both kidneys separately is because it cannot be assumed that they are functionally…
- Trial name
- NCT00470769
- Testing
- Color-Doppler Ultrasound, 99mTc-DTPA scintigraphy
- Where
- 3 sites in Italy
- Volunteers
- 2,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Venous Insufficiency
Endoluminale Obliteration Der Stammvene Mit Dem 1470nm Laser Versus VNUS Closure Fast
There is a difference concerning obliteration rate and postoperative pain after treatment of the saphenous vein with 1470nm laser or VNUS Closure Fast (=radiofrequency method) .
- Trial name
- NCT01972633
- Testing
- Laser, Radiofrequency
- Where
- Austria
- Volunteers
- 140 people
- Sponsor
- Ludwig Boltzmann Institute for Operative Laparoscopy
Varicose Veins, Chronic Venous Disorder
First- or Second- Class Compression Hosiery After Endovenous Laser With Sclerotherapy and Ambulatory Phlebectomy
Investigators hypothesize that first class compression therapy during the postoperative period will improve patient adherence due to easier application and reduced discomfort.
- Conditions
- Varicose Veins, Chronic Venous Disorder, Chronic Venous Insufficiency (CVI), Venous Reflux
- Trial name
- FISCHER (NCT06913764)
- Testing
- class I compression stockings of the RAL-GZ 387 standard: 1 month using, class II compression stockings of the RAL-GZ 387 standard: 1 month using
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Moscow City Hospital named after A.K. Eramishantsev
Kidney Diseases, Coronary Artery Calcification
Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients
Vessel calcification is a recognised cardiovascular morbidity risk factor in patients with chronic kidney disease (CKD). Recent reports indicate a significant role of Matrix Gla-protein (MGP) in decreasing calcification…
- Trial name
- CACSK2 (NCT01101698)
- Testing
- Vitamin K2+10μg cholecalciferol, Vitamin D
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Congestive Heart Failure, Infections
Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?
There is evidence to suggest that patients make different end-of-life decisions if they understand the risks, benefits and alternatives of CPR and mechanical ventilation.
- Conditions
- Congestive Heart Failure, Infections, Sepsis, Acute Renal Failure
- Trial name
- NCT01878968
- Testing
- Script and CPR/Mechanical ventilation video.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Varicose Veins
Pharmacokinetic Study of Polidocanol Endovenous Microfoam (PEM)
Varicose veins are enlarged, noticeably bulging veins, which commonly occur in the legs and may cause discomfort. In this study, patients with varicose veins in the legs will be participating.
- Trial name
- NCT01428076
- Testing
- Polidocanol Endovenous Microfoam (PEM)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Boston Scientific Corporation
Atherosclerosis Cardiovascular Disease, Chronic Kidney Disease
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
The purpose of this study is to measure cardiovascular outcomes with orforglipron compared with placebo in participants with atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD).
- Trial name
- NCT07241390
- Testing
- Orforglipron
- Where
- 566 sites in Argentina, Australia and 36 more
- Volunteers
- 7,140 people
- Sponsor
- Eli Lilly and Company
End-Stage Kidney Disease
Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients…
- Trial name
- RESOLVE (NCT02823821)
- Testing
- Default dialysate sodium concentration of 137mmol/l, Default dialysate sodium concentration of 140mmol/l
- Where
- 264 sites in Australia, Canada and 4 more
- Volunteers
- 50,000 people
- Sponsor
- University of Sydney
Acute Kidney Injury, Surgery-Complications
Precision Medicine in Cardiovascular Surgery Associated Acute Kidney Injury
The goal of this prospective observational study is to define a risk profile for cardiovascular surgery associated acute kidney injury (AKI), using clinical patient characteristics, operation parameters as well as blood and urine…
- Conditions
- Acute Kidney Injury, Surgery-Complications, Frailty
- Trial name
- PEAK (NCT06471621)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Kidney Diseases, Chronic Kidney Failure
SelfWrap-Assisted Arteriovenous Fistulas
This is a single-center, prospective, single-arm clinical study to evaluate the feasibility, safety, and performance of VenoStent's SelfWrap® Bioabsorbable Perivascular Wrap on arteriovenous fistulas (AVFs).
- Conditions
- Chronic Kidney Diseases, Chronic Kidney Failure, End Stage Renal Disease, End Stage Kidney Disease
- Trial name
- SW-AVF (NCT05418816)
- Testing
- SelfWrap Bioabsorbable Perivascular Wrap
- Where
- Paraguay
- Volunteers
- 20 people
- Sponsor
- VenoStent
Acute Kidney Injury, Fluid Overload
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0
There is a growing focus on short- and long-term kidney health in neonates, including those with acute kidney injury (AKI). AKI occurs commonly in the Neonatal Intensive Care Unit (NICU) and is associated with adverse outcomes.
- Conditions
- Acute Kidney Injury, Fluid Overload, Prematurity Complications, Risk Factors
- Trial name
- AWAKEN 2 (NCT06823115)
- Where
- 125 sites in United States, Argentina and 31 more
- Volunteers
- 8,000 people
- Sponsor
- Indiana University
Hypertension, Chronic Kidney Disease.
Effect of Eplerenone in Elderly Hypertensive Early Stage Chronic Kidney Disease (CKD) Patients
The purpose of this study is to determine whether eplerenone is effective in the treatment of blood pressure, heart function, renal function in elderly hypertensive stage1 (eGFR>=90ml/min/1.73m2) and stage2 (eGFR…
- Trial name
- NCT01302236
- Testing
- Eplerenone
- Sponsor
- Jichi Medical University
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