Clinical trials: Vascular Liver Disease
Veno-occlusive Disease
Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients
This study is to compare the efficacy and safety of defibrotide prophylaxis in addition to best supportive care versus best supportive care alone in the prevention of hepatic veno- occlusive disease (VOD) in adult and pediatric…
- Trial name
- NCT02851407
- Testing
- Defibrotide, Best Supportive Care
- Where
- 114 sites in United States, Australia and 12 more
- Volunteers
- 372 people
- Sponsor
- Jazz Pharmaceuticals
Intracerebral Haemorrhage, ICH
Characterization of Peri-Hemorrhagic Cerebral Edema Using Synthetic Sodium Imaging With 7-Tesla and 3-Tesla MRI
Intracerebral haemorrhage is the type of stroke with the highest mortality rate, estimated at 40% in the acute phase. Among survivors, half will experience functional disability.
- Trial name
- TIPITCH-7T (NCT07789990)
- Testing
- Sodium tissue concentration will be measured in perihematomal oedema
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Liver Cirrhosis, Venous Thromboembolism
Risk Factors and Outcomes of Acute Venous Thromboembolism in Cirrhotic
patient with liver cirrhosis was supposed to have autoanticoagulation which approved to be wrong, with absence of conventional method to detect all abnormalities in coagulation state.
- Trial name
- NCT03580577
- Testing
- thromboelastography
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability
The purpose of this research study is to perfect the technique of EVLP and learn about the safety of transplanting lungs that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and perfused…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01241942
- Testing
- Steen Solution™, Conventional Lung Transplant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill
Varices, Liver Cirrhosis
Noninvasive Diagnosis Model for High-risk Varices in Cirrhosis
This is an observational ambispective cohort study to validate the Baveno VI guideline and develop a new diagnostic model to screen high-risk varices (HRV) of liver cirrhosis using iLivTouch.
- Trial name
- NID-HRV (NCT06392503)
- Testing
- different diagnostic models
- Where
- China
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
High Blood Pressure, Liver Transplant
Mechanism of Hypertension Treatments in Liver Transplant Recipients (BLOCK LTR-HTN)
Liver transplantation is a high risk, high-cost intervention that extends life in over 8,000 patients in the US each year. Of those that receive transplants, 1 in 3 will have a complication related to their heart after…
- Conditions
- High Blood Pressure, Liver Transplant, Renal Function Abnormal
- Trial name
- NCT05275907
- Testing
- Amlodipine Besylate, Chlorthalidone
- Where
- United States
- Sponsor
- Northwestern University
Evidence of Liver Transplantation
Clinical Trial of Hydrogen-Rich Celsior Solution Applied in Aging DBD Liver/Kidney Transplantation
The purpose of this study is to investigate whether hydrogen-rich Celsior solution improve the quality of aging grafts in liver/kidney transplantation.
- Trial name
- HRCSDBD (NCT02613195)
- Testing
- Hydrogen-Rich Celsior Solution
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Portosystemic Shunt, Pulmonary Hypertension
Portosystemic Shunt-associated Pulmonary Hypertension Multi-center Prospective Cohort Study
This study aims to establish a multi-center registry cohort of portosystemic shunt-associated pulmonary hypertension, with the goal of clarifying the epidemiology, clinical features, phenotypic classification, response to…
- Trial name
- NCT07481877
- Volunteers
- 300 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Hypertension, Medicine, Chinese Traditional
The Efficacy of Qianglidingxuan Tablets in the Treatment of Hypertension
Research purpose: This study was a multicenter, randomized, double-blind, placebo-controlled, post-marketing clinical study in Chinese patients with essential hypertension to evaluate the efficacy and safety of Qianglidingxuan…
- Trial name
- NCT05521282
- Testing
- Treatment group
- Where
- China
- Volunteers
- 269 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Chronic Liver Diseases, Coagulation
Role of Coagulation, Inflammation and Vessels in Chronic Liver Disease
Chronic liver diseases represent a major public health problem and are responsible for more than 150,000 deaths in Europe each year.
- Trial name
- CLUE (NCT05865691)
- Testing
- biomarker assay
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carcinoma, Hepatocellular
A Study of GPC3 Redirected Autologous T Cells for Advanced HCC
Intravenous infusion of CART cells in the treatment of solid tumors may be not a suitable choice. Because by intravenous infusion, T cells first entered into the blood circulation, but the number of T cells accumulated at the…
- Trial name
- GPC3-CART (NCT02715362)
- Testing
- TAI-GPC3-CART cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai GeneChem Co., Ltd.
Coronary Disease, Coronary Arteriosclerosis
Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease
Diet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exists, and the mediators of possible anti-atherosclerotic effects of diet are unclear.
- Conditions
- Coronary Disease, Coronary Arteriosclerosis, Myocardial Infarction, Chronic Coronary Syndrome
- Trial name
- NORDHEART (NCT06701968)
- Testing
- Healthy Nordic Diet, Usual Care
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Bleeding ,Arrhythmias, Heart Failure, Acute Renal Failure, Acute Liver Failure, Dyspnoea, Gout
Extended Drug Utilization Study Among Patients Exposed to Ticagrelor, Clopidogrel and Prasugrel
The purpose of the study is to describe patient characteristics and drug usage among patients that are prescribed ticagrelor for the first time and to compare them with patients who are prescribed clopidogrel and prasugrel for…
- Trial name
- NCT01276275
- Testing
- Risk of selected safety events
- Where
- Sweden
- Volunteers
- 7,200 people
- Sponsor
- AstraZeneca
Ischemia Reperfusion Injury
Remote Ischemic Preconditioning in Cardiac Surgery
Aim of the work : Evaluation of the role of Remote Ischemic Preconditioning (RIP) on liver function in patients undergoing on-pump cardiac surgery.
- Trial name
- NCT04647370
- Testing
- remote ischemic preconditioning
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Traumatic Brain Injury, Subarachnoid Hemorrhage
NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Liver Failure
- Trial name
- NOVEL ICP (NCT04548596)
- Testing
- Transcranial Doppler
- Where
- 3 sites in United States
- Volunteers
- 162 people
- Sponsor
- Emory University
Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney
The Effect of Remote Ischemic Postconditioning on Liver Graft and Renal Function in Patients Undergoing Living-related Liver Transplantation
The investigators are trying to evaluate the clinical effect of remote ischemic postconditioning on liver graft function and postoperative renal function in subjects undergoing living-donor liver transplantation.
- Conditions
- Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney, Remote Ischemic Postconditioning
- Trial name
- NCT01637038
- Testing
- RIPC
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Liver Failure, Liver Cirrhosis
Study of Oxidized Albumin in Liver Transplant Patients
The overall goal is to describe the oxidation state of albumin before, during and after liver transplantation. This is a pilot observational study in which the oxidative state in 10 patients undergoing liver transplantation will…
- Conditions
- Liver Failure, Liver Cirrhosis, Liver Transplant Disorder
- Trial name
- SALT (NCT06772298)
- Volunteers
- 10 people
- Sponsor
- Region Stockholm
Hepatocellular Carcinoma
CT Perfusion Parameters Predict Vascular Pattern in Hepatocellular Carcinoma
Distinct vascular patterns (ECTC or Non-ECTC) of tumors plays an important role in tumor migration, metastasis and drug resistant in hepatocellular carcinoma (HCC).
- Trial name
- NCT04715321
- Testing
- CT perfusion examination
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Haemostasis Disorders
Investigation of Systemic and Regional Haemostasis During Liver Transplantation by Comparing ClotPro® and TEG®
The purpose of the research is to compare the global and the portal haemostasis during liver transplantation by functional investigations using TEG® and ClotPro® tests.
- Trial name
- NCT04246307
- Testing
- TEG® and ClotPro® parameters
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University