Clinical trials: Vascular Liver Disease
Hepatocellular Carcinoma, Portal Vein Thrombosis
Prognostic Value Related to the Presence of Thrombosis or Portal Vein Invasion in Patients With Hepatocellular Carcinoma Submitted to Surgery
A retrospective study based on analysis of medical records of patients with hepatocellular carcinoma treated at the Hospital Sírio-Libanês (Sao Paulo-Brazil) between 2001 and 2011 with diagnosis confirmed by imaging or…
- Conditions
- Hepatocellular Carcinoma, Portal Vein Thrombosis, Hepatic Portal Vein Tumor Invasion
- Trial name
- HSL2012-06 (NCT01690715)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Sirio-Libanes
Breast Cancer, Colorectal Cancer
Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies
This is a phase I/II, non randomized, open-label, dose escalation study to investigate the safety, tolerability and preliminary efficacy of CB-103.
- Conditions
- Breast Cancer, Colorectal Cancer, Adenoid Cystic Carcinoma, Non-hodgkin Lymphoma
- Trial name
- NCT03422679
- Testing
- CB-103
- Where
- 17 sites in United States, France and 4 more
- Volunteers
- 79 people
- Sponsor
- Cellestia Biotech AG
Cardiovascular Diseases, Fatty Liver
Ultrasound Assessment of Atherosclerotic Plaque Burden and Cardiovascular Risk: A 10-Year Prospective Study
The P-SONAR study is a large, observational, prospective cohort study. The overall aim of the study is to investigate whether plaque burden estimation by 2D ultrasound of the carotid and femoral arteries may enhance…
- Conditions
- Cardiovascular Diseases, Fatty Liver, Atherosclerosis of Femoral Artery, Carotid Artery Plaque
- Trial name
- P-SONAR (NCT06933745)
- Where
- Norway
- Volunteers
- 21,029 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Coagulation Protein Disorders, Blood Loss, Surgical
Observational Study of Prophylaxis and Treatment of Acute Perioperative Bleeding With Beriplex® P/N (Probe Study)
Beriplex® P/N is made from human plasma (the liquid part of the blood) and contains the coagulation factors II, VII, IX and X which are important for blood clotting (coagulation).
- Conditions
- Coagulation Protein Disorders, Blood Loss, Surgical, Perioperative Care
- Trial name
- NCT01053169
- Testing
- Beriplex® P/N, Fresh Frozen Plasma (FFP) and Beriplex® P/N, Fresh Frozen Plasma
- Where
- 6 sites in United Kingdom
- Volunteers
- 445 people
- Sponsor
- CSL Behring
Ascites Hepatic, Cirrhosis, Liver
Continuous Passive Paracentesis for Intra-abdominal Hypertension
Liver cirrhosis patients in Intensive Care present intra-abdominal hypertension and this is an independent risk factor for increased organ disfunction and mortality.
- Conditions
- Ascites Hepatic, Cirrhosis, Liver, Hypertension, Intraabdominal, Critical Illness
- Trial name
- COPPTRIAHL (NCT04322201)
- Testing
- continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter, Ultrasound-guided intermittent large-volume paracentesis
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Obesity, Dyslipidemia
Meta-analyses of the Effect of Sucrose Versus High Fructose Corn Syrup on Cardiometabolic Risk
The rise in high fructose corn syrup (HFCS) consumption over the past 40 years since its introduction as a popular sweetener in the United States has led to much concern regarding its contribution to the rise in obesity (1)…
- Conditions
- Obesity, Dyslipidemia, Prediabetes, Dysglycemia
- Trial name
- NCT02702479
- Testing
- High Fructose Corn Syrup, Sucrose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Intra Cerebral Hemorrhage, Hypertension
Proper Timing of Control of Hypertension and Outcome in Acute Spontaneous Intracerebral Hemorrhage.
The ideal management of blood pressure in BP after acute intracerebral haemorrhage is still debated and whether a higher intensive reduction of blood pressure after acute intracerebral haemorrhage may be better or not is still…
- Trial name
- NCT04167644
- Testing
- Modified Rankin Scale (mRS)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University Hospital
Liver Cancer, Surgery
Pre- Vs Postoperative Thromboprophylaxis for Liver Resection
Thromboprophylaxis for liver surgery can be commenced either preoperatively or postoperatively. Despite a clear trade-off between thrombosis and bleeding in liver surgery patients, there is no international consensus when…
- Conditions
- Liver Cancer, Surgery, Thrombosis, Deep Vein, Embolism, Pulmonary
- Trial name
- PREPOSTEROUS (NCT04731558)
- Testing
- enoxaparin or tinzaparin or dalteparin, No intervention
- Where
- 7 sites in Finland, Norway
- Volunteers
- 1,012 people
- Sponsor
- Helsinki University Central Hospital
Hemorrhoids, Liver Cirrhosis
Polidocanol Foam in Hemorrhoidal Disease in Patients With Liver Cirrhosis
Hemorrhoidal disease (HD) is a common health problem, affecting up to 38,9% of adult population. HD is also a common finding in up to 36% of cirrhotic patients, as hemorrhoidal plexus is a possible site of portosystemic venous…
- Trial name
- NCT05807425
- Testing
- Polidocanol foam sclerotherapy
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Universidade do Porto
Portopulmonary Hypertension, Pulmonary Hypertension
Efficacy and Safety of Combination Ambrisentan and Tadalafil in Patients With Portopulmonary Hypertension
The purpose of this study is to evaluate the efficacy and safety of the combination of ambrisentan and tadalafil in reducing mPAP to below 35mmHg in patients with moderate to severe Portopulmonary Hypertension (POPH) as a means…
- Conditions
- Portopulmonary Hypertension, Pulmonary Hypertension, Cirrhosis, Liver
- Trial name
- NCT03309592
- Testing
- Ambrisentan Pill, Tadalafil Pill
- Where
- United States
- Sponsor
- Ochsner Health System
Ischemia Reperfusion Injury
Tacrolimus During the Implantation and the Effect on Ischemia-reperfusion Injury in Liver Transplantation
The evaluation of the efficacy of an intraportal infusion with Tacrolimus, at the time of liver graft implantation, compared to a control group without immunosuppressive intraportal infusion (Placebo: Saline solution 0.9%) with…
- Trial name
- TAC-Infusion (NCT00609388)
- Testing
- Tacrolimus, Saline solution 0.9% (250mL)
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Medical University of Vienna
Liver Transplant; Complications, Cardiovascular Complication
Cardiovascular Outcomes in Orthotopic Liver Transplanted Patients (COLT Study)
All patients with orthotopic liver transplantation who are evaluated and followed at each participating centers will be recorded in this study. Within this register a characterization of patients and therapy will be done.
- Conditions
- Liver Transplant; Complications, Cardiovascular Complication, Cardiovascular; Attack, Cardiovascular Stroke
- Trial name
- COLT (NCT05895669)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Campania Luigi Vanvitelli
Non-Alcoholic Fatty Liver Disease, Non Alcoholic Steatohepatitis
The Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) in Adults
Nonalcoholic fatty liver disease (NAFLD) is a global health concern with a suspected increasing prevalence due to the rise in obesity and diabetes mellitus.
- Trial name
- PREV (NCT03142867)
- Testing
- non-applicable
- Where
- United States
- Volunteers
- 826 people, healthy volunteers welcome
- Sponsor
- The Geneva Foundation
Liver Tumors
Safety and Clinical Efficacy of Histotripsy for Liver Cancers Adjacent to Major Intrahepatic Vessels
Malignant liver tumors are among the most common malignancies worldwide, with over 10,000 new cases diagnosed annually in Taiwan.
- Trial name
- NCT07063771
- Testing
- Histotripsy
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer
RATIONALE: Taking part in a clinical trial may help children with cancer receive more effective treatment. PURPOSE: Determine why patients who are eligible for protocols made available through the Pediatric Oncology Group do not…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Leukemia
- Trial name
- NCT00002485
- Testing
- psychosocial assessment and care
- Where
- 31 sites in United States, Canada and 2 more
- Volunteers
- 359 people
- Sponsor
- Children's Oncology Group
Sinusoidal Obstruction Syndrome, Colorectal Liver Metastases
Prevention of the Hepatic Sinusoidal Obstruction Syndrome by Means of Anticoagulants
The purpose of the study is to determine whether anticoagulant use (i.e. salicylates, clopidogrel, low-molecular weight heparin, or coumarin derivates) is able to prevent the development of the sinusoidal obstruction syndrome…
- Trial name
- NCT00885950
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Maastricht University Medical Center
Heart Failure, Respiratory Failure
Donor Simvastatin Treatment in Organ Transplantation
The aim of the study is to investigate the effects of donor simvastatin treatment on ischemia-reperfusion injury after heart transplantation.
- Conditions
- Heart Failure, Respiratory Failure, Liver Failure, Kidney Failure
- Trial name
- SIMVA (NCT01160978)
- Testing
- Simvastatin 80mg, Control Rx
- Where
- Finland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Coagulation in Liver Transplantation
Rotational Thromboelastometry (ROTEM) TRUE-NATEM Reference Value Validation in Liver Transplantation
Background: Rotational thromboelastometry (ROTEM) has been used widely in liver transplantation for coagulation management. However, a TRUE-NATEM (TRUE-Non-Activated Rotational Thromboelastometry) reference value has never been…
- Trial name
- NCT04282889
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
PSVD With or Without SSc
PortoSinusoidal Vascular Diseases and Systemic Sclerosis
Porto-Sinusoidal Vascular Disorders (PSVD) is a heterogeneous clinico-pathological entity characterized by alterations in small liver vessels. "Nodular regenerative hyperplasia (NRH)" is the most common PSVD.
- Trial name
- NCT06032754
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Diabetes Mellitus, Type 2
Evaluation of the Integrated Radio Frequency Denervation System to Improve Glycemic Control in Type 2 Diabetic Subjects
The objective of this early feasibility study is to evaluate the safety and performance of intravascular hepatic denervation using the Metavention Integrated Radio Frequency Denervation System (iRF System) to improve glycemic…
- Trial name
- DeLIVER (NCT04285554)
- Testing
- iRF System Hepatic Denervation
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Metavention